Motif ID: Isl1

Z-value: 0.369


Transcription factors associated with Isl1:

Gene SymbolEntrez IDGene Name
Isl1 ENSMUSG00000042258.7 Isl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Isl1mm10_v2_chr13_-_116309639_1163096990.066.5e-01Click!


Activity profile for motif Isl1.

activity profile for motif Isl1


Sorted Z-values histogram for motif Isl1

Sorted Z-values for motif Isl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 116 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_154960915 2.728 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr1_-_56978534 1.647 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr14_-_118052235 1.418 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr7_-_25250720 1.270 ENSMUST00000116343.2
ENSMUST00000045847.8
 Erf

Ets2 repressor factor

chr3_-_49757257 1.197 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr15_-_50889691 1.196 ENSMUST00000165201.2
ENSMUST00000184458.1
 Trps1

trichorhinophalangeal syndrome I (human)

chr4_-_14621805 1.161 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr6_-_144209558 1.023 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr6_-_144209471 1.014 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr15_-_93519499 1.004 ENSMUST00000109255.2
 Prickle1
prickle homolog 1 (Drosophila)
chr6_-_144209448 0.990 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr7_+_45017953 0.916 ENSMUST00000044111.7
 Rras
Harvey rat sarcoma oncogene, subgroup R
chr9_+_35423582 0.860 ENSMUST00000154652.1
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr8_-_105568298 0.789 ENSMUST00000005849.5
 Agrp
agouti related protein
chr8_+_84723003 0.785 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene
chr10_-_13388753 0.783 ENSMUST00000105546.1
 Phactr2
phosphatase and actin regulator 2
chr14_-_12345847 0.782 ENSMUST00000022262.4
 Fezf2
Fez family zinc finger 2
chr14_+_124005355 0.768 ENSMUST00000166105.1
 Gm17615
predicted gene, 17615
chr5_-_37824580 0.714 ENSMUST00000063116.9
 Msx1
msh homeobox 1
chr15_+_62037986 0.674 ENSMUST00000182956.1
ENSMUST00000182075.1
ENSMUST00000180432.2
ENSMUST00000181416.2
ENSMUST00000181657.2
 Pvt1




plasmacytoma variant translocation 1





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.0 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.7 2.7 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.4 2.5 GO:0019532 oxalate transport(GO:0019532)
0.2 2.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 1.9 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.2 1.4 GO:0006570 tyrosine metabolic process(GO:0006570)
0.3 1.3 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.1 1.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.3 1.0 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.1 1.0 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 0.9 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.9 GO:0060325 face morphogenesis(GO:0060325)
0.1 0.8 GO:0008343 adult feeding behavior(GO:0008343)
0.2 0.7 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.0 0.7 GO:0034605 cellular response to heat(GO:0034605)
0.2 0.6 GO:0006597 spermine biosynthetic process(GO:0006597)
0.2 0.6 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 0.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.6 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 0.6 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.5 GO:0005667 transcription factor complex(GO:0005667)
0.1 1.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 1.0 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.8 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.7 GO:0016235 aggresome(GO:0016235)
0.0 0.6 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.2 GO:1990357 terminal web(GO:1990357)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 2.5 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 1.9 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 1.4 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 1.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.0 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.9 GO:0019003 GDP binding(GO:0019003)
0.0 0.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 0.6 GO:0019808 polyamine binding(GO:0019808)
0.1 0.6 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 0.6 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 0.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.4 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.3 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.1 0.2 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.1 0.2 GO:0019002 GMP binding(GO:0019002)
0.0 0.2 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.7 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.9 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.9 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.8 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.1 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 2.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 0.9 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.9 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.5 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.5 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.4 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.3 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.3 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 0.2 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.2 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis