Motif ID: Isl2

Z-value: 0.767


Transcription factors associated with Isl2:

Gene SymbolEntrez IDGene Name
Isl2 ENSMUSG00000032318.6 Isl2



Activity profile for motif Isl2.

activity profile for motif Isl2


Sorted Z-values histogram for motif Isl2

Sorted Z-values for motif Isl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 181 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_53771499 3.381 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chrX_-_60893430 2.416 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr17_+_17402672 2.400 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr11_+_103649498 2.265 ENSMUST00000057870.2
 Rprml
reprimo-like
chr16_-_16829276 2.219 ENSMUST00000023468.5
 Spag6
sperm associated antigen 6
chr15_+_16778101 2.141 ENSMUST00000026432.6
 Cdh9
cadherin 9
chr12_-_10900296 2.054 ENSMUST00000085735.2
 Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr13_-_58354862 1.668 ENSMUST00000043605.5
 Kif27
kinesin family member 27
chr4_+_102589687 1.654 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr7_+_100159241 1.640 ENSMUST00000032967.3
 Lipt2
lipoyl(octanoyl) transferase 2 (putative)
chrX_+_164373363 1.636 ENSMUST00000033751.7
 Figf
c-fos induced growth factor
chr17_-_48432723 1.618 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr12_+_109546409 1.582 ENSMUST00000143847.1
 Meg3
maternally expressed 3
chr10_-_63927434 1.570 ENSMUST00000079279.3
 Gm10118
predicted gene 10118
chr17_+_12119274 1.501 ENSMUST00000024594.2
 Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr8_+_25911670 1.485 ENSMUST00000120653.1
ENSMUST00000126226.1
 Kcnu1

potassium channel, subfamily U, member 1

chr4_-_14621805 1.464 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr14_+_4198185 1.463 ENSMUST00000180184.1
 Gm2974
predicted gene 2974
chr10_-_77166545 1.453 ENSMUST00000081654.6
 Col18a1
collagen, type XVIII, alpha 1
chr6_-_136941887 1.436 ENSMUST00000111891.1
 Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.9 GO:0019532 oxalate transport(GO:0019532)
0.1 2.4 GO:0007530 sex determination(GO:0007530)
0.1 2.4 GO:0097352 autophagosome maturation(GO:0097352)
0.6 1.9 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.0 1.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 1.7 GO:0021591 ventricular system development(GO:0021591)
0.5 1.6 GO:0009106 lipoate metabolic process(GO:0009106)
0.5 1.6 GO:0016554 cytidine to uridine editing(GO:0016554)
0.5 1.6 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
0.1 1.5 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 1.5 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.2 1.4 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 1.3 GO:0042407 cristae formation(GO:0042407)
0.2 1.2 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 1.2 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.3 1.1 GO:0072592 regulation of integrin biosynthetic process(GO:0045113) oxygen metabolic process(GO:0072592)
0.2 1.1 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 1.1 GO:0006825 copper ion transport(GO:0006825)
0.0 1.1 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 1.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.5 GO:0005581 collagen trimer(GO:0005581)
0.0 1.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 1.3 GO:0061617 MICOS complex(GO:0061617)
0.0 1.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.3 1.1 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.3 1.1 GO:0071438 invadopodium membrane(GO:0071438)
0.1 1.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 1.0 GO:0000974 Prp19 complex(GO:0000974)
0.0 1.0 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.9 GO:0032587 ruffle membrane(GO:0032587)
0.1 0.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.8 GO:0032433 filopodium tip(GO:0032433)
0.1 0.7 GO:0005638 lamin filament(GO:0005638)
0.1 0.6 GO:0001740 Barr body(GO:0001740)
0.0 0.6 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.6 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.9 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 2.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 1.9 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.5 1.6 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.4 1.6 GO:0004126 cytidine deaminase activity(GO:0004126)
0.5 1.5 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.1 1.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2 1.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 1.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 1.2 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 1.2 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.4 1.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.2 1.1 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 1.1 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.2 1.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.2 1.0 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.2 0.9 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.9 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 0.8 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.7 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 1.6 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 1.2 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.1 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.6 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.5 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.5 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 3.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.6 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.5 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 1.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.1 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.1 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 1.0 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 0.9 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.9 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 0.8 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 0.8 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.7 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.7 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.6 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus