Motif ID: Isl2

Z-value: 0.767


Transcription factors associated with Isl2:

Gene SymbolEntrez IDGene Name
Isl2 ENSMUSG00000032318.6 Isl2



Activity profile for motif Isl2.

activity profile for motif Isl2


Sorted Z-values histogram for motif Isl2

Sorted Z-values for motif Isl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_53771499 3.381 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chrX_-_60893430 2.416 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr17_+_17402672 2.400 ENSMUST00000115576.2
Lix1
limb expression 1 homolog (chicken)
chr11_+_103649498 2.265 ENSMUST00000057870.2
Rprml
reprimo-like
chr16_-_16829276 2.219 ENSMUST00000023468.5
Spag6
sperm associated antigen 6
chr15_+_16778101 2.141 ENSMUST00000026432.6
Cdh9
cadherin 9
chr12_-_10900296 2.054 ENSMUST00000085735.2
Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr13_-_58354862 1.668 ENSMUST00000043605.5
Kif27
kinesin family member 27
chr4_+_102589687 1.654 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr7_+_100159241 1.640 ENSMUST00000032967.3
Lipt2
lipoyl(octanoyl) transferase 2 (putative)
chrX_+_164373363 1.636 ENSMUST00000033751.7
Figf
c-fos induced growth factor
chr17_-_48432723 1.618 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr12_+_109546409 1.582 ENSMUST00000143847.1
Meg3
maternally expressed 3
chr10_-_63927434 1.570 ENSMUST00000079279.3
Gm10118
predicted gene 10118
chr17_+_12119274 1.501 ENSMUST00000024594.2
Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr8_+_25911670 1.485 ENSMUST00000120653.1
ENSMUST00000126226.1
Kcnu1

potassium channel, subfamily U, member 1

chr4_-_14621805 1.464 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr14_+_4198185 1.463 ENSMUST00000180184.1
Gm2974
predicted gene 2974
chr10_-_77166545 1.453 ENSMUST00000081654.6
Col18a1
collagen, type XVIII, alpha 1
chr6_-_136941887 1.436 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr1_+_110099295 1.422 ENSMUST00000134301.1
Cdh7
cadherin 7, type 2
chr15_-_37459327 1.367 ENSMUST00000119730.1
ENSMUST00000120746.1
Ncald

neurocalcin delta

chr1_-_9944103 1.341 ENSMUST00000182498.1
ENSMUST00000182742.1
ENSMUST00000182580.1
Snhg6


small nucleolar RNA host gene (non-protein coding) 6


chr4_-_14621669 1.332 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr6_-_89595647 1.266 ENSMUST00000032172.8
ENSMUST00000113550.3
Chchd6

coiled-coil-helix-coiled-coil-helix domain containing 6

chr17_+_20570362 1.245 ENSMUST00000095633.3
Gm5145
predicted pseudogene 5145
chrX_+_136245065 1.245 ENSMUST00000048687.4
Wbp5
WW domain binding protein 5
chrY_-_1245753 1.220 ENSMUST00000154004.1
Uty
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr19_+_5490475 1.204 ENSMUST00000116560.2
Cfl1
cofilin 1, non-muscle
chr17_-_53867041 1.179 ENSMUST00000061311.7
Mrps36-ps1
mitichondrial ribosomal protein S36, pseudogene 1
chr16_-_76403673 1.173 ENSMUST00000052867.7
Gm9843
predicted gene 9843
chr14_+_5517172 1.169 ENSMUST00000178220.1
Gm3488
predicted gene, 3488
chr14_+_5164535 1.169 ENSMUST00000179659.1
Gm3317
predicted gene 3317
chr3_-_79841729 1.149 ENSMUST00000168038.1
Tmem144
transmembrane protein 144
chrX_+_96455359 1.141 ENSMUST00000033553.7
Heph
hephaestin
chr3_-_33082004 1.130 ENSMUST00000108225.3
Pex5l
peroxisomal biogenesis factor 5-like
chr11_+_69838514 1.115 ENSMUST00000133967.1
ENSMUST00000094065.4
Tmem256

transmembrane protein 256

chrX_-_134111852 1.111 ENSMUST00000033610.6
Nox1
NADPH oxidase 1
chr5_-_24902315 1.099 ENSMUST00000131486.1
Prkag2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr4_-_14621494 1.087 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr14_+_3667518 1.069 ENSMUST00000112801.3
Gm3020
predicted gene 3020
chr4_+_3940747 1.056 ENSMUST00000119403.1
Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr18_+_23753708 0.995 ENSMUST00000115830.1
Mapre2
microtubule-associated protein, RP/EB family, member 2
chr9_+_108560422 0.976 ENSMUST00000081111.8
Impdh2
inosine 5'-phosphate dehydrogenase 2
chr5_-_3647806 0.970 ENSMUST00000119783.1
ENSMUST00000007559.8
Gatad1

GATA zinc finger domain containing 1

chr2_+_115581667 0.970 ENSMUST00000166472.1
ENSMUST00000110918.2
BC052040

cDNA sequence BC052040

chr11_+_5520652 0.938 ENSMUST00000063084.9
Xbp1
X-box binding protein 1
chr11_-_101278927 0.931 ENSMUST00000168089.1
ENSMUST00000017332.3
Coa3

cytochrome C oxidase assembly factor 3

chr10_+_102158858 0.927 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr3_-_51408925 0.925 ENSMUST00000038108.6
Ndufc1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1
chr14_-_31323884 0.914 ENSMUST00000048603.7
Dnah1
dynein, axonemal, heavy chain 1
chr19_+_25406661 0.897 ENSMUST00000146647.1
Kank1
KN motif and ankyrin repeat domains 1
chr17_-_26099257 0.889 ENSMUST00000053575.3
Gm8186
predicted gene 8186
chr14_-_7473073 0.881 ENSMUST00000167833.2
Gm3752
predicted gene 3752
chr14_+_3348089 0.871 ENSMUST00000178722.1
Gm2956
predicted gene 2956
chr13_+_67833235 0.869 ENSMUST00000060609.7
Gm10037
predicted gene 10037
chr14_-_6411578 0.861 ENSMUST00000179312.1
Gm3591
predicted gene 3591
chr8_+_114133635 0.848 ENSMUST00000147605.1
ENSMUST00000134593.1
Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr9_-_102354685 0.844 ENSMUST00000035129.7
ENSMUST00000085169.5
Ephb1

Eph receptor B1

chr17_+_70561739 0.838 ENSMUST00000097288.2
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr9_-_100506844 0.836 ENSMUST00000112874.3
Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chr14_+_4741737 0.828 ENSMUST00000178748.1
Gm3252
predicted gene 3252
chr3_-_62605140 0.812 ENSMUST00000058535.5
Gpr149
G protein-coupled receptor 149
chr10_+_116143881 0.810 ENSMUST00000105271.2
Ptprr
protein tyrosine phosphatase, receptor type, R
chr10_+_94576254 0.794 ENSMUST00000117929.1
Tmcc3
transmembrane and coiled coil domains 3
chr17_+_78916473 0.786 ENSMUST00000063817.4
ENSMUST00000180077.1
1110001A16Rik

RIKEN cDNA 1110001A16 gene

chr5_-_87490869 0.783 ENSMUST00000147854.1
Ugt2a1
UDP glucuronosyltransferase 2 family, polypeptide A1
chr14_+_3428103 0.782 ENSMUST00000178060.1
Gm3005
predicted gene 3005
chr3_+_103171655 0.775 ENSMUST00000005830.8
Bcas2
breast carcinoma amplified sequence 2
chr14_+_4126066 0.766 ENSMUST00000167397.2
Gm8108
predicted gene 8108
chr8_+_114133557 0.760 ENSMUST00000073521.5
ENSMUST00000066514.6
Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr14_+_3825596 0.750 ENSMUST00000178256.1
Gm3002
predicted gene 3002
chr13_+_48513570 0.746 ENSMUST00000065465.1
A830005F24Rik
RIKEN cDNA A830005F24 gene
chr12_+_87443896 0.743 ENSMUST00000161023.1
ENSMUST00000160488.1
ENSMUST00000077462.7
ENSMUST00000160880.1
Slirp



SRA stem-loop interacting RNA binding protein



chr14_-_5863663 0.741 ENSMUST00000178594.1
Gm8237
predicted gene 8237
chr15_+_84232030 0.733 ENSMUST00000023072.6
Parvb
parvin, beta
chr14_-_6874257 0.723 ENSMUST00000178298.1
ENSMUST00000179374.1
Gm3667
Gm3629
predicted gene 3667
predicted gene 3629
chr14_+_4871156 0.713 ENSMUST00000166410.2
Gm3264
predicted gene 3264
chr3_-_67463828 0.713 ENSMUST00000058981.2
Lxn
latexin
chr15_-_35938009 0.707 ENSMUST00000156915.1
Cox6c
cytochrome c oxidase subunit VIc
chrM_+_9452 0.699 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr1_+_12718496 0.691 ENSMUST00000088585.3
Sulf1
sulfatase 1
chr5_-_118244861 0.689 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
Rnft2



ring finger protein, transmembrane 2



chr2_+_163658370 0.683 ENSMUST00000164399.1
ENSMUST00000064703.6
ENSMUST00000099105.2
ENSMUST00000152418.1
ENSMUST00000126182.1
ENSMUST00000131228.1
Pkig





protein kinase inhibitor, gamma





chr10_-_80918212 0.682 ENSMUST00000057623.7
ENSMUST00000179022.1
Lmnb2

lamin B2

chr14_-_6266620 0.671 ENSMUST00000096172.5
Gm3411
predicted gene 3411
chr4_-_88722454 0.653 ENSMUST00000094993.2
Klhl9
kelch-like 9
chr11_+_58171648 0.649 ENSMUST00000020820.1
Mrpl22
mitochondrial ribosomal protein L22
chr4_+_105157339 0.648 ENSMUST00000064139.7
Ppap2b
phosphatidic acid phosphatase type 2B
chr18_-_43477764 0.641 ENSMUST00000057110.9
Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr19_-_44552831 0.640 ENSMUST00000166808.1
Gm20538
predicted gene 20538
chr10_-_61784014 0.637 ENSMUST00000020283.4
H2afy2
H2A histone family, member Y2
chr5_+_15516489 0.637 ENSMUST00000178227.1
Gm21847
predicted gene, 21847
chr15_-_35938186 0.623 ENSMUST00000014457.8
Cox6c
cytochrome c oxidase subunit VIc
chr7_+_28881656 0.620 ENSMUST00000066880.4
Capn12
calpain 12
chr14_+_4665094 0.619 ENSMUST00000169675.2
Gm3239
predicted gene 3239
chrM_+_8600 0.615 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr14_+_58893465 0.604 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr12_+_10390756 0.599 ENSMUST00000020947.5
Rdh14
retinol dehydrogenase 14 (all-trans and 9-cis)
chr11_-_80779989 0.595 ENSMUST00000041065.7
ENSMUST00000070997.5
Myo1d

myosin ID

chr15_-_10485385 0.588 ENSMUST00000168690.1
Brix1
BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)
chr14_+_4430992 0.585 ENSMUST00000164603.1
ENSMUST00000166848.1
Gm3173

predicted gene 3173

chr6_+_134640940 0.577 ENSMUST00000062755.8
Loh12cr1
loss of heterozygosity, 12, chromosomal region 1 homolog (human)
chr8_-_125492710 0.569 ENSMUST00000108775.1
Sipa1l2
signal-induced proliferation-associated 1 like 2
chr3_+_89459118 0.567 ENSMUST00000029564.5
Pmvk
phosphomevalonate kinase
chr14_+_27039001 0.565 ENSMUST00000035336.3
Il17rd
interleukin 17 receptor D
chr2_-_150255591 0.564 ENSMUST00000063463.5
Gm21994
predicted gene 21994
chr7_+_19119853 0.563 ENSMUST00000053109.3
Fbxo46
F-box protein 46
chr14_-_19569553 0.557 ENSMUST00000112595.2
Gm2237
predicted gene 2237
chr8_-_9976294 0.541 ENSMUST00000095476.4
Lig4
ligase IV, DNA, ATP-dependent
chr1_+_45981548 0.532 ENSMUST00000085632.2
Rpl23a-ps1
ribosomal protein 23A, pseudogene 1
chr1_+_72284367 0.523 ENSMUST00000027380.5
ENSMUST00000141783.1
Tmem169

transmembrane protein 169

chr9_+_70012540 0.511 ENSMUST00000118198.1
ENSMUST00000119905.1
ENSMUST00000119413.1
ENSMUST00000140305.1
ENSMUST00000122087.1
Gtf2a2




general transcription factor II A, 2




chr8_-_61902669 0.507 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr15_-_10485890 0.504 ENSMUST00000169050.1
ENSMUST00000022855.5
Brix1

BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)

chr8_+_107031218 0.497 ENSMUST00000034388.9
Vps4a
vacuolar protein sorting 4a (yeast)
chr3_-_9004422 0.495 ENSMUST00000063496.7
Tpd52
tumor protein D52
chr8_+_93810832 0.475 ENSMUST00000034198.8
ENSMUST00000125716.1
Gnao1

guanine nucleotide binding protein, alpha O

chr14_-_6741430 0.468 ENSMUST00000100904.4
Gm3636
predicted gene 3636
chr8_+_88118747 0.467 ENSMUST00000095214.3
Cnep1r1
CTD nuclear envelope phosphatase 1 regulatory subunit 1
chr9_+_72806874 0.443 ENSMUST00000055535.8
Prtg
protogenin homolog (Gallus gallus)
chr17_+_85028347 0.433 ENSMUST00000024944.7
Slc3a1
solute carrier family 3, member 1
chr9_-_22117123 0.429 ENSMUST00000013966.6
Elof1
elongation factor 1 homolog (ELF1, S. cerevisiae)
chr4_-_136053343 0.405 ENSMUST00000102536.4
Rpl11
ribosomal protein L11
chr1_-_72874877 0.401 ENSMUST00000027377.8
Igfbp5
insulin-like growth factor binding protein 5
chr18_-_36766198 0.396 ENSMUST00000061522.7
Dnd1
dead end homolog 1 (zebrafish)
chr12_-_99883429 0.393 ENSMUST00000046485.3
Efcab11
EF-hand calcium binding domain 11
chr7_+_126976338 0.391 ENSMUST00000032920.3
Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr10_+_69208546 0.391 ENSMUST00000164034.1
Rhobtb1
Rho-related BTB domain containing 1
chr12_-_87444017 0.379 ENSMUST00000091090.4
2700073G19Rik
RIKEN cDNA 2700073G19 gene
chr11_-_98018308 0.349 ENSMUST00000107561.2
Cacnb1
calcium channel, voltage-dependent, beta 1 subunit
chr1_-_185329331 0.338 ENSMUST00000027921.4
ENSMUST00000110975.1
ENSMUST00000110974.3
Iars2


isoleucine-tRNA synthetase 2, mitochondrial


chr2_+_125136692 0.328 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr8_+_95703037 0.327 ENSMUST00000073139.7
ENSMUST00000080666.7
Ndrg4

N-myc downstream regulated gene 4

chr15_-_100424092 0.324 ENSMUST00000154676.1
Slc11a2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr17_+_56613392 0.302 ENSMUST00000080492.5
Rpl36
ribosomal protein L36
chr17_+_74489492 0.296 ENSMUST00000024873.6
Yipf4
Yip1 domain family, member 4
chr4_-_86669492 0.295 ENSMUST00000149700.1
Plin2
perilipin 2
chr3_+_41024369 0.291 ENSMUST00000099121.3
Larp1b
La ribonucleoprotein domain family, member 1B
chr9_+_58629102 0.273 ENSMUST00000176250.1
Nptn
neuroplastin
chr14_-_104522615 0.260 ENSMUST00000022716.2
Rnf219
ring finger protein 219
chr1_-_172027269 0.259 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr3_+_83055516 0.258 ENSMUST00000150268.1
ENSMUST00000122128.1
Plrg1

pleiotropic regulator 1, PRL1 homolog (Arabidopsis)

chr1_-_139377094 0.250 ENSMUST00000131586.1
ENSMUST00000145244.1
Crb1

crumbs homolog 1 (Drosophila)

chr9_+_119341294 0.232 ENSMUST00000039784.5
Acaa1a
acetyl-Coenzyme A acyltransferase 1A
chr9_+_108290433 0.219 ENSMUST00000035227.6
Nicn1
nicolin 1
chr10_+_88379217 0.204 ENSMUST00000130301.1
ENSMUST00000020251.8
Gnptab

N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits

chr1_-_127840290 0.194 ENSMUST00000061512.2
Map3k19
mitogen-activated protein kinase kinase kinase 19
chr5_+_146948640 0.193 ENSMUST00000146511.1
ENSMUST00000132102.1
Gtf3a

general transcription factor III A

chr8_+_64947177 0.192 ENSMUST00000079896.7
ENSMUST00000026595.5
Tmem192

transmembrane protein 192

chr4_+_134102581 0.171 ENSMUST00000074690.4
ENSMUST00000070246.2
ENSMUST00000156750.1
Ubxn11


UBX domain protein 11


chr8_-_21906412 0.164 ENSMUST00000051965.4
Defb11
defensin beta 11
chr3_+_41563356 0.151 ENSMUST00000163764.1
Phf17
PHD finger protein 17
chr15_+_10486008 0.145 ENSMUST00000022856.8
ENSMUST00000100775.3
ENSMUST00000169519.1
Rad1


RAD1 homolog (S. pombe)


chr5_-_88675190 0.137 ENSMUST00000133532.1
ENSMUST00000150438.1
Grsf1

G-rich RNA sequence binding factor 1

chr13_+_104229366 0.134 ENSMUST00000022227.6
Cenpk
centromere protein K
chr4_+_136172367 0.128 ENSMUST00000061721.5
E2f2
E2F transcription factor 2
chr4_+_47386216 0.127 ENSMUST00000107725.2
Tgfbr1
transforming growth factor, beta receptor I
chr8_-_54724317 0.125 ENSMUST00000129132.2
ENSMUST00000150488.1
ENSMUST00000127511.2
Wdr17


WD repeat domain 17


chr16_-_35939082 0.125 ENSMUST00000081933.7
ENSMUST00000114885.1
Dtx3l

deltex 3-like (Drosophila)

chr12_+_102128718 0.120 ENSMUST00000159329.1
Slc24a4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr5_+_66968559 0.118 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr18_-_34651703 0.109 ENSMUST00000025228.5
ENSMUST00000133181.1
Cdc23

CDC23 cell division cycle 23

chr11_-_82908360 0.103 ENSMUST00000103213.3
Nle1
notchless homolog 1 (Drosophila)
chr3_-_20242173 0.090 ENSMUST00000001921.1
Cpa3
carboxypeptidase A3, mast cell
chr17_-_56005566 0.089 ENSMUST00000043785.6
Stap2
signal transducing adaptor family member 2
chr10_-_13324160 0.081 ENSMUST00000105545.4
Phactr2
phosphatase and actin regulator 2
chr3_+_138374121 0.081 ENSMUST00000171054.1
Adh6-ps1
alcohol dehydrogenase 6 (class V), pseudogene 1
chr15_-_100424208 0.074 ENSMUST00000154331.1
Slc11a2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr5_+_66968961 0.073 ENSMUST00000132991.1
Limch1
LIM and calponin homology domains 1
chr10_-_85127977 0.063 ENSMUST00000050813.2
Mterfd3
MTERF domain containing 3
chr9_+_119341487 0.056 ENSMUST00000175743.1
ENSMUST00000176397.1
Acaa1a

acetyl-Coenzyme A acyltransferase 1A

chr3_-_67515487 0.050 ENSMUST00000178314.1
ENSMUST00000054825.4
Rarres1

retinoic acid receptor responder (tazarotene induced) 1

chr19_+_8802486 0.040 ENSMUST00000172175.1
Zbtb3
zinc finger and BTB domain containing 3
chr6_+_145934113 0.031 ENSMUST00000032383.7
Sspn
sarcospan
chr4_+_145510759 0.027 ENSMUST00000105742.1
ENSMUST00000136309.1
Gm13225

predicted gene 13225

chrX_-_103981242 0.027 ENSMUST00000121153.1
ENSMUST00000070705.4
Rlim

ring finger protein, LIM domain interacting

chr9_-_107872403 0.026 ENSMUST00000183035.1
Rbm6
RNA binding motif protein 6
chr10_-_127311740 0.019 ENSMUST00000037290.5
ENSMUST00000171564.1
Mars

methionine-tRNA synthetase

chr10_-_31445921 0.014 ENSMUST00000000305.5
Tpd52l1
tumor protein D52-like 1
chr17_+_56005672 0.000 ENSMUST00000133998.1
Mpnd
MPN domain containing

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.6 3.9 GO:0019532 oxalate transport(GO:0019532)
0.5 1.6 GO:0009106 lipoate metabolic process(GO:0009106)
0.5 1.6 GO:0016554 cytidine to uridine editing(GO:0016554)
0.5 1.6 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
0.3 0.9 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.3 0.9 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.3 0.8 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.3 1.1 GO:0072592 regulation of integrin biosynthetic process(GO:0045113) oxygen metabolic process(GO:0072592)
0.3 0.8 GO:0048162 preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162)
0.2 1.4 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.2 0.8 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.2 1.0 GO:0006177 GMP biosynthetic process(GO:0006177)
0.2 0.7 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.2 0.7 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 0.8 GO:2001015 negative regulation of skeletal muscle cell differentiation(GO:2001015)
0.2 0.5 GO:0009838 abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.2 1.1 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.2 0.8 GO:0052695 cellular glucuronidation(GO:0052695)
0.2 1.2 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 0.6 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.1 0.4 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.1 0.4 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.1 1.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 2.4 GO:0007530 sex determination(GO:0007530)
0.1 0.3 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.1 0.6 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.1 0.5 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.1 0.3 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 1.5 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.1 0.4 GO:0015692 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)
0.1 1.3 GO:0042407 cristae formation(GO:0042407)
0.1 2.4 GO:0097352 autophagosome maturation(GO:0097352)
0.1 0.9 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.1 0.9 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.1 0.8 GO:0070842 aggresome assembly(GO:0070842)
0.1 0.2 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.1 1.1 GO:0006825 copper ion transport(GO:0006825)
0.1 0.4 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 0.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.3 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.1 0.6 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.1 GO:1905223 epicardium morphogenesis(GO:1905223)
0.0 0.7 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0 1.2 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 1.7 GO:0021591 ventricular system development(GO:0021591)
0.0 1.0 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.5 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 1.1 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 0.5 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
0.0 0.4 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.3 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.0 0.4 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.0 0.1 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.0 0.9 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 1.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.5 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 1.5 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 0.1 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.0 0.3 GO:0008206 bile acid metabolic process(GO:0008206)
0.0 0.5 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.3 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.3 1.1 GO:0071438 invadopodium membrane(GO:0071438)
0.1 1.3 GO:0061617 MICOS complex(GO:0061617)
0.1 0.5 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.1 0.4 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 0.7 GO:0005638 lamin filament(GO:0005638)
0.1 0.6 GO:0001740 Barr body(GO:0001740)
0.1 0.5 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.1 0.4 GO:0070826 paraferritin complex(GO:0070826)
0.1 1.0 GO:0000974 Prp19 complex(GO:0000974)
0.1 1.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.3 GO:0060187 cell pole(GO:0060187)
0.1 0.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 1.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.2 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.5 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.0 0.8 GO:0032433 filopodium tip(GO:0032433)
0.0 0.6 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.0 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.6 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.1 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 6.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.5 GO:0005581 collagen trimer(GO:0005581)
0.0 0.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.9 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.4 GO:0031526 brush border membrane(GO:0031526)
0.0 0.5 GO:0002102 podosome(GO:0002102)
0.0 0.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.6 GO:0005871 kinesin complex(GO:0005871)
0.0 0.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.5 1.5 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.4 1.6 GO:0004126 cytidine deaminase activity(GO:0004126)
0.4 1.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.4 3.9 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.2 1.0 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.2 1.1 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 1.1 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.2 1.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 0.6 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.2 0.9 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.2 1.2 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.2 1.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 0.8 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.8 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 0.7 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.3 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.1 0.5 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 1.9 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.4 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 0.5 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.3 GO:0008410 CoA-transferase activity(GO:0008410)
0.1 1.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.8 GO:0042923 neuropeptide binding(GO:0042923)
0.1 2.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.7 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 0.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.4 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.1 0.9 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 0.2 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 1.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.6 GO:0008106 alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.0 0.4 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 1.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:0008097 5S rRNA binding(GO:0008097)
0.0 0.5 GO:0017025 RNA polymerase II repressing transcription factor binding(GO:0001103) TBP-class protein binding(GO:0017025)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025) type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.4 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 1.2 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 0.2 GO:0045503 dynein light chain binding(GO:0045503)
0.0 0.4 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.5 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0 0.6 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.6 GO:0003743 translation initiation factor activity(GO:0003743)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 1.2 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 2.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.7 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 0.5 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.5 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.1 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.6 PID_FGF_PATHWAY FGF signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 0.9 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 3.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.8 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.1 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 1.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.0 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 0.8 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.9 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.5 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 1.1 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 4.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.7 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 2.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.5 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.0 0.7 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.5 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.5 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.0 0.1 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.5 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases