Motif ID: Jun

Z-value: 0.454


Transcription factors associated with Jun:

Gene SymbolEntrez IDGene Name
Jun ENSMUSG00000052684.3 Jun

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Junmm10_v2_chr4_-_95052170_95052181-0.123.7e-01Click!


Activity profile for motif Jun.

activity profile for motif Jun


Sorted Z-values histogram for motif Jun

Sorted Z-values for motif Jun



Network of associatons between targets according to the STRING database.



First level regulatory network of Jun

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_109573907 2.049 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chr3_-_88503187 1.911 ENSMUST00000120377.1
 Lmna
lamin A
chr2_-_77703252 1.539 ENSMUST00000171063.1
 Zfp385b
zinc finger protein 385B
chr7_+_139834148 1.537 ENSMUST00000026548.7
 Gpr123
G protein-coupled receptor 123
chr6_+_7555053 1.529 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr3_-_88503331 1.452 ENSMUST00000029699.6
 Lmna
lamin A
chr2_+_25395866 1.137 ENSMUST00000028328.2
 Entpd2
ectonucleoside triphosphate diphosphohydrolase 2
chr7_-_142372210 1.064 ENSMUST00000084412.5
 Ifitm10
interferon induced transmembrane protein 10
chr18_+_61639542 0.945 ENSMUST00000183083.1
ENSMUST00000183087.1
 Gm20748

predicted gene, 20748

chr17_+_43953191 0.936 ENSMUST00000044792.4
 Rcan2
regulator of calcineurin 2
chr6_+_17463927 0.918 ENSMUST00000115442.1
 Met
met proto-oncogene
chr13_+_75839868 0.887 ENSMUST00000022082.7
 Glrx
glutaredoxin
chr15_-_97767798 0.867 ENSMUST00000129223.2
ENSMUST00000126854.2
ENSMUST00000135080.1
 Rapgef3


Rap guanine nucleotide exchange factor (GEF) 3


chr10_-_76725978 0.843 ENSMUST00000001147.4
 Col6a1
collagen, type VI, alpha 1
chr7_-_31042078 0.821 ENSMUST00000162116.1
ENSMUST00000159924.1
ENSMUST00000159753.1
ENSMUST00000160689.1
ENSMUST00000162733.1
ENSMUST00000162087.1
ENSMUST00000009831.7
 Fxyd5






FXYD domain-containing ion transport regulator 5






chr6_+_17463749 0.796 ENSMUST00000115443.1
 Met
met proto-oncogene
chr19_-_11818806 0.795 ENSMUST00000075304.6
 Stx3
syntaxin 3
chr15_-_11037968 0.791 ENSMUST00000058007.5
 Rxfp3
relaxin family peptide receptor 3
chr10_+_128933782 0.783 ENSMUST00000099112.2
 Itga7
integrin alpha 7
chr1_-_180193475 0.770 ENSMUST00000160482.1
ENSMUST00000170472.1
 Adck3

aarF domain containing kinase 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 3.4 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 2.0 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.3 1.9 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 1.7 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.4 1.6 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.0 1.6 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.5 1.5 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.0 1.5 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.1 1.3 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.2 1.1 GO:0060161 positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.1 1.1 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.2 0.9 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.2 0.9 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.1 0.8 GO:0098967 synaptic vesicle docking(GO:0016081) exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.0 0.8 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.8 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.8 GO:0034113 heterotypic cell-cell adhesion(GO:0034113)
0.0 0.8 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.7 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.2 0.6 GO:0030321 transepithelial chloride transport(GO:0030321)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.4 GO:0005638 lamin filament(GO:0005638)
0.5 2.4 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
0.0 1.8 GO:0009925 basal plasma membrane(GO:0009925)
0.1 1.1 GO:0002080 acrosomal membrane(GO:0002080)
0.1 1.0 GO:0044754 autolysosome(GO:0044754)
0.0 1.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.9 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 0.9 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.9 GO:0005581 collagen trimer(GO:0005581)
0.3 0.8 GO:0005927 muscle tendon junction(GO:0005927)
0.0 0.8 GO:0005605 basal lamina(GO:0005605)
0.0 0.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.7 GO:0032420 stereocilium(GO:0032420)
0.2 0.6 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 0.6 GO:0097513 myosin II filament(GO:0097513)
0.1 0.6 GO:0097227 sperm annulus(GO:0097227)
0.1 0.4 GO:0098842 postsynaptic early endosome(GO:0098842)
0.0 0.4 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.1 0.3 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 0.3 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 2.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.5 1.9 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.3 1.7 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.2 1.6 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 1.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.5 GO:0002039 p53 binding(GO:0002039)
0.3 1.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 1.1 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.1 1.1 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.3 0.9 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038) protein-disulfide reductase (glutathione) activity(GO:0019153)
0.2 0.9 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.2 0.8 GO:0004966 galanin receptor activity(GO:0004966)
0.1 0.8 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 0.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.8 GO:0043236 laminin binding(GO:0043236)
0.0 0.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 0.6 GO:0035240 dopamine binding(GO:0035240)
0.1 0.6 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 PID_ARF6_PATHWAY Arf6 signaling events
0.0 2.3 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 2.0 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 1.6 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.5 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.1 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 1.0 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.8 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.8 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.4 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.4 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 0.3 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.2 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.2 PID_BCR_5PATHWAY BCR signaling pathway
0.0 0.2 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.1 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.6 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 2.7 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 2.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.0 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.0 1.6 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 1.2 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 1.1 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 0.8 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.8 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 0.6 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 0.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.5 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.4 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.4 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.4 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.2 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.2 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation