Motif ID: Junb_Jund

Z-value: 1.471

Transcription factors associated with Junb_Jund:

Gene SymbolEntrez IDGene Name
Junb ENSMUSG00000052837.5 Junb
Jund ENSMUSG00000071076.5 Jund

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Junbmm10_v2_chr8_-_84978709_849787480.491.5e-04Click!
Jundmm10_v2_chr8_+_70697739_70697739-0.239.7e-02Click!


Activity profile for motif Junb_Jund.

activity profile for motif Junb_Jund


Sorted Z-values histogram for motif Junb_Jund

Sorted Z-values for motif Junb_Jund



Network of associatons between targets according to the STRING database.



First level regulatory network of Junb_Jund

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_155276297 24.776 ENSMUST00000029128.3
 Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
chr7_-_142095266 18.788 ENSMUST00000039926.3
 Dusp8
dual specificity phosphatase 8
chr14_+_66344369 18.164 ENSMUST00000118426.1
ENSMUST00000121955.1
ENSMUST00000120229.1
ENSMUST00000134440.1
 Stmn4



stathmin-like 4



chr6_+_54681687 18.053 ENSMUST00000046276.6
 2410066E13Rik
RIKEN cDNA 2410066E13 gene
chr14_+_66344296 17.769 ENSMUST00000152093.1
ENSMUST00000074523.6
 Stmn4

stathmin-like 4

chr9_-_98032983 15.164 ENSMUST00000162295.1
 Clstn2
calsyntenin 2
chr9_-_98033181 12.854 ENSMUST00000035027.6
 Clstn2
calsyntenin 2
chr13_-_54688264 12.469 ENSMUST00000150626.1
ENSMUST00000134177.1
 Rnf44

ring finger protein 44

chr9_+_40269273 9.544 ENSMUST00000176185.1
 Scn3b
sodium channel, voltage-gated, type III, beta
chr2_+_118663235 9.157 ENSMUST00000099557.3
 Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chr6_-_124464772 9.113 ENSMUST00000008297.4
 Clstn3
calsyntenin 3
chr9_+_40269202 9.100 ENSMUST00000114956.3
ENSMUST00000049941.5
 Scn3b

sodium channel, voltage-gated, type III, beta

chr13_+_110395041 8.960 ENSMUST00000022212.7
 Plk2
polo-like kinase 2
chr4_-_150652097 8.954 ENSMUST00000117997.1
ENSMUST00000037827.3
 Slc45a1

solute carrier family 45, member 1

chr1_-_79440039 8.750 ENSMUST00000049972.4
 Scg2
secretogranin II
chr11_-_30198232 8.386 ENSMUST00000102838.3
 Sptbn1
spectrin beta, non-erythrocytic 1
chr13_-_54688246 8.270 ENSMUST00000122935.1
ENSMUST00000128257.1
 Rnf44

ring finger protein 44

chr4_+_32238950 8.069 ENSMUST00000037416.6
 Bach2
BTB and CNC homology 2
chr7_+_139248477 7.899 ENSMUST00000093993.3
ENSMUST00000172136.1
 Pwwp2b

PWWP domain containing 2B

chr11_-_76571527 7.573 ENSMUST00000072740.6
 Abr
active BCR-related gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 322 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 51.2 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
2.5 30.0 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.4 29.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 25.2 GO:0016567 protein ubiquitination(GO:0016567)
2.1 18.6 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
1.9 17.2 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.8 16.9 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.9 15.7 GO:0061000 negative regulation of dendritic spine development(GO:0061000)
0.4 15.5 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
1.5 13.9 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.6 13.4 GO:0006198 cAMP catabolic process(GO:0006198)
4.4 13.2 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
1.7 12.0 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.5 11.2 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.2 11.0 GO:0008089 anterograde axonal transport(GO:0008089)
0.1 10.1 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.8 9.9 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.4 9.4 GO:0071625 vocalization behavior(GO:0071625)
0.5 9.3 GO:0001553 luteinization(GO:0001553)
0.8 9.1 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 106.6 GO:0014069 postsynaptic density(GO:0014069)
0.0 47.7 GO:0005794 Golgi apparatus(GO:0005794)
1.7 24.8 GO:0044754 autolysosome(GO:0044754)
0.9 24.1 GO:0031430 M band(GO:0031430)
0.5 18.9 GO:0055038 recycling endosome membrane(GO:0055038)
1.2 18.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.5 18.4 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 18.1 GO:0030141 secretory granule(GO:0030141)
0.3 15.5 GO:0005776 autophagosome(GO:0005776)
0.1 14.8 GO:0001650 fibrillar center(GO:0001650)
0.2 13.1 GO:0031594 neuromuscular junction(GO:0031594)
0.1 11.9 GO:0016324 apical plasma membrane(GO:0016324)
0.1 9.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
1.7 8.4 GO:0032437 cuticular plate(GO:0032437)
0.4 7.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 7.6 GO:0008021 synaptic vesicle(GO:0008021)
1.2 7.5 GO:0000235 astral microtubule(GO:0000235)
0.1 7.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.4 7.2 GO:0000421 autophagosome membrane(GO:0000421)
0.1 7.1 GO:0030667 secretory granule membrane(GO:0030667)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 200 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 58.8 GO:0015631 tubulin binding(GO:0015631)
0.2 42.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 30.2 GO:0005509 calcium ion binding(GO:0005509)
3.3 26.4 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.3 20.8 GO:0015459 potassium channel regulator activity(GO:0015459)
2.7 18.6 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.5 18.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 17.2 GO:0030276 clathrin binding(GO:0030276)
0.1 14.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.4 13.9 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.6 13.9 GO:0031489 myosin V binding(GO:0031489)
0.0 13.9 GO:0008289 lipid binding(GO:0008289)
0.8 13.2 GO:0045499 chemorepellent activity(GO:0045499)
0.1 12.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.9 11.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.5 11.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 11.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.5 10.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.4 10.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 9.4 GO:0005249 voltage-gated potassium channel activity(GO:0005249)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 20.0 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 16.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.4 10.9 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.2 10.4 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.3 10.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.3 9.7 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 9.4 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.1 7.6 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.2 6.9 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 6.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 5.9 PID_LKB1_PATHWAY LKB1 signaling events
0.1 5.4 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.2 5.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.3 5.1 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.2 5.1 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.2 5.0 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.5 4.2 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 3.9 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 3.2 ST_GA13_PATHWAY G alpha 13 Pathway
0.2 3.1 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 36.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.3 26.0 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.3 13.4 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 11.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 10.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.4 10.5 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 8.3 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.5 7.6 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.3 7.1 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 6.9 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.2 6.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 6.1 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.8 5.9 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.4 5.7 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.3 5.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.3 5.4 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.2 5.4 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.4 5.3 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2 5.3 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.5 4.8 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle