Motif ID: Klf1

Z-value: 2.604


Transcription factors associated with Klf1:

Gene SymbolEntrez IDGene Name
Klf1 ENSMUSG00000054191.7 Klf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf1mm10_v2_chr8_+_84901928_84901992-0.583.4e-06Click!


Activity profile for motif Klf1.

activity profile for motif Klf1


Sorted Z-values histogram for motif Klf1

Sorted Z-values for motif Klf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_139325616 27.054 ENSMUST00000110865.1
 Adap1
ArfGAP with dual PH domains 1
chr6_+_5725639 26.370 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr7_+_44310213 22.793 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr15_+_83791939 22.686 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr7_-_103813913 22.496 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr10_-_81025521 21.413 ENSMUST00000144640.1
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr12_-_4841583 20.323 ENSMUST00000020964.5
 Fkbp1b
FK506 binding protein 1b
chr7_-_46179929 19.636 ENSMUST00000033123.6
 Abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr2_-_162661075 18.979 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chr11_+_104231515 18.906 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr11_+_104231465 18.422 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr19_+_4099998 18.198 ENSMUST00000049658.7
 Pitpnm1
phosphatidylinositol transfer protein, membrane-associated 1
chr4_+_47208005 17.817 ENSMUST00000082303.6
ENSMUST00000102917.4
 Col15a1

collagen, type XV, alpha 1

chr11_+_104231390 17.778 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr9_-_107710475 17.742 ENSMUST00000080560.3
 Sema3f
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr14_+_70554056 17.592 ENSMUST00000022691.7
 Hr
hairless
chr10_+_127078886 16.965 ENSMUST00000039259.6
 Agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr11_+_62575981 16.325 ENSMUST00000102643.1
 Trpv2
transient receptor potential cation channel, subfamily V, member 2
chr11_+_120721452 16.138 ENSMUST00000018156.5
 Rac3
RAS-related C3 botulinum substrate 3
chr12_+_105336922 16.089 ENSMUST00000180503.1
 2810011L19Rik
RIKEN cDNA 2810011L19 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 627 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.4 67.0 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.8 57.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 36.1 GO:0071805 potassium ion transmembrane transport(GO:0071805)
3.5 34.8 GO:0010459 negative regulation of heart rate(GO:0010459)
3.1 30.8 GO:0046959 habituation(GO:0046959)
0.4 28.8 GO:0030032 lamellipodium assembly(GO:0030032)
3.1 28.3 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
2.3 24.9 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
1.5 23.1 GO:0033623 regulation of integrin activation(GO:0033623)
0.9 22.7 GO:0022038 corpus callosum development(GO:0022038)
2.0 22.1 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
7.0 20.9 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
1.4 20.7 GO:0048266 behavioral response to pain(GO:0048266)
0.8 20.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
5.0 19.9 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
1.2 19.9 GO:0007252 I-kappaB phosphorylation(GO:0007252)
3.9 19.4 GO:1902287 trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
2.1 19.3 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.7 18.6 GO:0016578 histone deubiquitination(GO:0016578)
2.3 18.4 GO:0033564 anterior/posterior axon guidance(GO:0033564)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 246 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 105.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.9 82.4 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
6.2 62.1 GO:0045298 tubulin complex(GO:0045298)
1.1 59.0 GO:0034704 calcium channel complex(GO:0034704)
0.3 54.0 GO:0014069 postsynaptic density(GO:0014069)
0.2 50.8 GO:0030425 dendrite(GO:0030425)
0.4 36.8 GO:0008021 synaptic vesicle(GO:0008021)
0.2 36.8 GO:0000139 Golgi membrane(GO:0000139)
0.7 34.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
8.7 34.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 33.0 GO:0005770 late endosome(GO:0005770)
0.6 31.9 GO:0031941 filamentous actin(GO:0031941)
0.1 30.6 GO:0005768 endosome(GO:0005768)
1.7 28.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
8.8 26.4 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
1.0 25.9 GO:0071565 nBAF complex(GO:0071565)
1.6 25.7 GO:0005614 interstitial matrix(GO:0005614)
1.3 25.3 GO:0032279 asymmetric synapse(GO:0032279)
0.5 23.3 GO:0016235 aggresome(GO:0016235)
1.2 22.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 372 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 84.1 GO:0005096 GTPase activator activity(GO:0005096)
9.7 67.6 GO:0099609 microtubule lateral binding(GO:0099609)
0.3 66.1 GO:0003924 GTPase activity(GO:0003924)
0.7 35.5 GO:0005267 potassium channel activity(GO:0005267)
8.7 34.6 GO:0031720 haptoglobin binding(GO:0031720)
0.5 34.4 GO:0030276 clathrin binding(GO:0030276)
8.3 33.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
2.1 29.1 GO:0031005 filamin binding(GO:0031005)
1.9 29.1 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.6 28.8 GO:0015485 cholesterol binding(GO:0015485)
1.7 28.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.5 27.3 GO:0005262 calcium channel activity(GO:0005262)
3.7 25.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
1.8 23.9 GO:0045294 alpha-catenin binding(GO:0045294)
1.8 23.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.5 23.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
1.6 22.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
1.2 22.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.2 22.1 GO:0050811 GABA receptor binding(GO:0050811)
0.2 20.8 GO:0030165 PDZ domain binding(GO:0030165)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 65.1 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
1.0 41.9 PID_ARF6_PATHWAY Arf6 signaling events
0.9 37.8 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.4 30.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
1.6 27.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.5 22.9 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.5 21.3 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.5 20.2 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.5 19.4 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.5 18.0 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.5 15.7 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.3 14.4 PID_INSULIN_PATHWAY Insulin Pathway
0.4 12.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.3 10.6 PID_SHP2_PATHWAY SHP2 signaling
0.3 10.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.5 8.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.3 8.3 PID_BCR_5PATHWAY BCR signaling pathway
0.3 7.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.6 7.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 7.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 74.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
3.2 73.7 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.5 61.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.6 49.1 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
1.1 47.2 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
1.3 36.1 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.9 34.3 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
1.0 29.0 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
1.4 28.7 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.5 27.7 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH Genes involved in NCAM signaling for neurite out-growth
1.1 25.9 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.7 24.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.8 21.8 REACTOME_KERATAN_SULFATE_KERATIN_METABOLISM Genes involved in Keratan sulfate/keratin metabolism
0.8 20.3 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.7 20.2 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
1.4 18.9 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
1.0 17.3 REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS Genes involved in NRIF signals cell death from the nucleus
2.3 16.3 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.9 16.0 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.7 15.7 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing