Motif ID: Klf13

Z-value: 0.527


Transcription factors associated with Klf13:

Gene SymbolEntrez IDGene Name
Klf13 ENSMUSG00000052040.9 Klf13

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf13mm10_v2_chr7_-_63938862_63938933-0.312.3e-02Click!


Activity profile for motif Klf13.

activity profile for motif Klf13


Sorted Z-values histogram for motif Klf13

Sorted Z-values for motif Klf13



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf13

PNG image of the network

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Top targets:


Showing 1 to 20 of 104 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_56722372 2.369 ENSMUST00000038949.4
 Adrb1
adrenergic receptor, beta 1
chr11_+_70026815 1.839 ENSMUST00000135916.2
 Dlg4
discs, large homolog 4 (Drosophila)
chr18_+_37955544 1.738 ENSMUST00000070709.2
ENSMUST00000177058.1
ENSMUST00000169360.2
ENSMUST00000163591.2
ENSMUST00000091932.5
 Rell2




RELT-like 2




chr12_-_14152038 1.724 ENSMUST00000020926.6
 Fam84a
family with sequence similarity 84, member A
chr10_-_62340514 1.601 ENSMUST00000099691.4
 Hk1
hexokinase 1
chr18_+_37955126 1.577 ENSMUST00000176902.1
ENSMUST00000176104.1
 Rell2

RELT-like 2

chr7_-_16874845 1.435 ENSMUST00000181501.1
 9330104G04Rik
RIKEN cDNA 9330104G04 gene
chr12_-_79172609 1.374 ENSMUST00000055262.6
 Vti1b
vesicle transport through interaction with t-SNAREs 1B
chr5_-_139736291 1.346 ENSMUST00000044642.10
 Micall2
MICAL-like 2
chr5_+_35757875 1.299 ENSMUST00000101280.3
ENSMUST00000054598.5
ENSMUST00000114205.1
ENSMUST00000114206.2
 Ablim2



actin-binding LIM protein 2



chr17_-_87282771 1.289 ENSMUST00000161759.1
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr8_-_94876269 1.288 ENSMUST00000046461.7
 Dok4
docking protein 4
chr15_-_64922290 1.222 ENSMUST00000023007.5
 Adcy8
adenylate cyclase 8
chr17_+_87282880 1.170 ENSMUST00000041110.5
ENSMUST00000125875.1
 Ttc7

tetratricopeptide repeat domain 7

chr17_-_35910032 1.155 ENSMUST00000141662.1
ENSMUST00000056034.6
ENSMUST00000077494.6
ENSMUST00000149277.1
ENSMUST00000061052.5
 Atat1




alpha tubulin acetyltransferase 1




chr9_-_18473559 1.063 ENSMUST00000034647.4
 Zfp558
zinc finger protein 558
chr4_-_126736236 1.034 ENSMUST00000048194.7
 Tfap2e
transcription factor AP-2, epsilon
chr11_+_116532441 0.993 ENSMUST00000106386.1
ENSMUST00000145737.1
ENSMUST00000155102.1
ENSMUST00000063446.6
 Sphk1



sphingosine kinase 1



chr6_+_83795022 0.978 ENSMUST00000113851.1
 Nagk
N-acetylglucosamine kinase
chr7_+_16875302 0.968 ENSMUST00000108493.1
 Dact3
dapper homolog 3, antagonist of beta-catenin (xenopus)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.4 2.8 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.8 2.5 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.8 2.4 GO:1900133 renin secretion into blood stream(GO:0002001) regulation of renin secretion into blood stream(GO:1900133)
0.6 1.8 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.1 1.8 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 1.7 GO:0032456 endocytic recycling(GO:0032456)
0.2 1.6 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 1.5 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.1 1.4 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 1.2 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 1.2 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 1.0 GO:0046512 sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520)
0.1 1.0 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.2 0.7 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.2 0.6 GO:0010957 negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137) regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 0.6 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.1 0.6 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.6 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0005604 basement membrane(GO:0005604)
0.1 2.5 GO:0035861 site of double-strand break(GO:0035861)
0.2 1.8 GO:0097427 microtubule bundle(GO:0097427)
0.1 1.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 1.6 GO:0097228 sperm principal piece(GO:0097228)
0.1 1.4 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 1.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.9 GO:0032420 stereocilium(GO:0032420)
0.0 0.7 GO:0005811 lipid particle(GO:0005811)
0.1 0.6 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 0.6 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.6 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 0.5 GO:0044194 cytolytic granule(GO:0044194)
0.1 0.5 GO:0099524 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
0.1 0.5 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.4 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0005518 collagen binding(GO:0005518)
0.9 2.8 GO:0045127 N-acetylglucosamine kinase activity(GO:0045127)
0.2 2.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.8 2.4 GO:0051379 epinephrine binding(GO:0051379)
0.3 1.8 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2 1.8 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.3 1.6 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.2 1.4 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 1.3 GO:0031005 filamin binding(GO:0031005)
0.0 1.3 GO:0005158 insulin receptor binding(GO:0005158)
0.2 1.2 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.2 1.0 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 1.0 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.6 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.1 0.6 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.6 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.5 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 0.5 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 2.5 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.3 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 1.2 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 1.0 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 0.6 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.5 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.5 PID_IFNG_PATHWAY IFN-gamma pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.2 2.4 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.6 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 1.2 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 1.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.6 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.5 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.5 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.0 0.3 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.2 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway