Motif ID: Klf15

Z-value: 1.151


Transcription factors associated with Klf15:

Gene SymbolEntrez IDGene Name
Klf15 ENSMUSG00000030087.5 Klf15

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf15mm10_v2_chr6_+_90462562_904625870.283.7e-02Click!


Activity profile for motif Klf15.

activity profile for motif Klf15


Sorted Z-values histogram for motif Klf15

Sorted Z-values for motif Klf15



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf15

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56971762 13.755 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr18_-_89769479 10.550 ENSMUST00000097495.3
 Dok6
docking protein 6
chr18_-_66291770 8.540 ENSMUST00000130300.1
 Ccbe1
collagen and calcium binding EGF domains 1
chr1_-_56972437 7.784 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr5_+_137288273 7.224 ENSMUST00000024099.4
ENSMUST00000085934.3
 Ache

acetylcholinesterase

chr17_+_46297917 7.205 ENSMUST00000166617.1
ENSMUST00000170271.1
 Dlk2

delta-like 2 homolog (Drosophila)

chr11_+_50602072 7.105 ENSMUST00000040523.8
 Adamts2
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
chr6_-_148444336 6.748 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr3_+_118433797 6.509 ENSMUST00000180593.1
ENSMUST00000181926.1
ENSMUST00000181060.1
ENSMUST00000181310.1
 Gm26871



predicted gene, 26871



chr5_+_130448801 6.065 ENSMUST00000111288.2
 Caln1
calneuron 1
chr3_+_117575268 5.895 ENSMUST00000039564.6
 4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr11_+_69765970 5.259 ENSMUST00000108642.1
ENSMUST00000156932.1
 Zbtb4

zinc finger and BTB domain containing 4

chrX_-_136868537 5.023 ENSMUST00000058814.6
 Rab9b
RAB9B, member RAS oncogene family
chr2_-_5714490 4.830 ENSMUST00000044009.7
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr7_+_46396439 4.789 ENSMUST00000025202.6
 Kcnc1
potassium voltage gated channel, Shaw-related subfamily, member 1
chr11_+_69765899 4.675 ENSMUST00000108640.1
ENSMUST00000108639.1
 Zbtb4

zinc finger and BTB domain containing 4

chr10_-_127666598 4.600 ENSMUST00000099157.3
 Nab2
Ngfi-A binding protein 2
chr6_-_53068562 4.517 ENSMUST00000074541.5
 Jazf1
JAZF zinc finger 1
chr2_+_140395309 4.416 ENSMUST00000110067.1
ENSMUST00000110064.1
ENSMUST00000110063.1
ENSMUST00000110062.1
ENSMUST00000078027.5
ENSMUST00000043836.7
 Macrod2





MACRO domain containing 2





chr10_-_54075730 4.385 ENSMUST00000105469.1
ENSMUST00000003843.8
 Man1a

mannosidase 1, alpha


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 162 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 21.5 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4 8.6 GO:0006491 N-glycan processing(GO:0006491)
2.1 8.5 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
1.2 8.5 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
1.3 7.9 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
1.2 7.2 GO:0019695 choline metabolic process(GO:0019695)
0.4 7.1 GO:0030574 collagen catabolic process(GO:0030574)
1.8 7.0 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.2 6.4 GO:0030325 adrenal gland development(GO:0030325)
0.2 6.2 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.2 5.9 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.7 5.6 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.2 5.0 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 5.0 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.7 4.8 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.4 4.8 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.1 4.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.8 3.8 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
0.4 3.8 GO:0030322 stabilization of membrane potential(GO:0030322)
0.3 3.8 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 17.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 9.5 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 7.9 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 7.9 GO:0032587 ruffle membrane(GO:0032587)
0.0 7.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.5 7.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 6.7 GO:0016604 nuclear body(GO:0016604)
0.0 6.6 GO:0001650 fibrillar center(GO:0001650)
0.2 6.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
1.2 5.8 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.1 5.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 5.2 GO:0030175 filopodium(GO:0030175)
0.1 5.0 GO:0045335 phagocytic vesicle(GO:0045335)
1.6 4.9 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.1 4.8 GO:0030673 axolemma(GO:0030673)
0.1 4.7 GO:0005795 Golgi stack(GO:0005795)
0.0 4.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
1.3 3.8 GO:0098855 HCN channel complex(GO:0098855)
0.6 3.7 GO:0008091 spectrin(GO:0008091)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.6 GO:0005158 insulin receptor binding(GO:0005158)
0.3 10.2 GO:0070412 R-SMAD binding(GO:0070412)
0.4 9.9 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 8.5 GO:0005518 collagen binding(GO:0005518)
0.9 7.9 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
1.8 7.2 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.1 7.1 GO:0019213 deacetylase activity(GO:0019213)
0.2 6.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.2 6.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 6.0 GO:0017124 SH3 domain binding(GO:0017124)
0.4 5.9 GO:0045499 chemorepellent activity(GO:0045499)
0.0 5.4 GO:0005096 GTPase activator activity(GO:0005096)
0.6 5.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.2 5.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 5.0 GO:0019003 GDP binding(GO:0019003)
0.1 4.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.3 4.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.0 3.8 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.3 3.8 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.3 3.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 8.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 7.4 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 6.7 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.2 5.6 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 4.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 4.1 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 4.1 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.3 3.9 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 3.6 PID_INSULIN_PATHWAY Insulin Pathway
0.1 3.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 3.5 PID_LKB1_PATHWAY LKB1 signaling events
0.0 3.2 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.2 3.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 2.6 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 2.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.1 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 2.1 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 2.0 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 2.0 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 8.0 REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS Genes involved in Post NMDA receptor activation events
0.3 7.2 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 6.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.5 3.8 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 3.8 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 3.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 3.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 3.3 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 3.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 3.0 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.2 2.7 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.4 2.6 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.2 2.6 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.1 2.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 2.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 2.3 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 2.3 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.7 2.2 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.3 2.0 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway