Motif ID: Klf16_Sp8

Z-value: 1.269

Transcription factors associated with Klf16_Sp8:

Gene SymbolEntrez IDGene Name
Klf16 ENSMUSG00000035397.8 Klf16
Sp8 ENSMUSG00000048562.6 Sp8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp8mm10_v2_chr12_+_118846329_1188463290.762.0e-11Click!
Klf16mm10_v2_chr10_-_80577285_80577327-0.582.9e-06Click!


Activity profile for motif Klf16_Sp8.

activity profile for motif Klf16_Sp8


Sorted Z-values histogram for motif Klf16_Sp8

Sorted Z-values for motif Klf16_Sp8



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf16_Sp8

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_25622525 19.197 ENSMUST00000110457.1
ENSMUST00000137601.1
 Myo10

myosin X

chr11_+_101468164 16.944 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr7_+_45216671 16.503 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr19_+_6084983 16.392 ENSMUST00000025704.2
 Cdca5
cell division cycle associated 5
chr7_-_38107490 15.686 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr11_+_117849223 14.584 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr18_+_82914632 14.540 ENSMUST00000071233.6
 Zfp516
zinc finger protein 516
chr10_-_127534540 14.289 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr11_+_78322965 14.056 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr17_-_32166879 13.387 ENSMUST00000087723.3
 Notch3
notch 3
chr17_-_70851189 12.654 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr7_-_4752972 12.317 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr5_+_108694222 12.194 ENSMUST00000013633.8
ENSMUST00000112560.3
 Fgfrl1

fibroblast growth factor receptor-like 1

chr9_-_119578981 12.176 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr4_-_41695442 12.131 ENSMUST00000102961.3
ENSMUST00000064443.6
 Cntfr

ciliary neurotrophic factor receptor

chr18_+_49979514 11.950 ENSMUST00000179937.1
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr3_+_69004711 11.695 ENSMUST00000042901.8
 Smc4
structural maintenance of chromosomes 4
chr17_-_28350747 11.630 ENSMUST00000080572.7
ENSMUST00000156862.1
 Tead3

TEA domain family member 3

chr18_+_49979427 11.589 ENSMUST00000148989.2
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr3_+_34649987 11.500 ENSMUST00000099151.2
 Sox2
SRY-box containing gene 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,117 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.9 55.4 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
2.2 48.6 GO:0030903 notochord development(GO:0030903)
1.7 36.7 GO:0038092 nodal signaling pathway(GO:0038092)
0.8 36.3 GO:0051310 metaphase plate congression(GO:0051310)
1.1 33.9 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.1 30.6 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
3.6 29.1 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.9 29.1 GO:0006270 DNA replication initiation(GO:0006270)
2.0 25.5 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
1.1 24.4 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
4.9 24.3 GO:0007386 compartment pattern specification(GO:0007386)
0.5 23.9 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
1.0 23.6 GO:0034508 centromere complex assembly(GO:0034508)
2.3 22.9 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
1.0 21.1 GO:0044458 motile cilium assembly(GO:0044458)
5.1 20.6 GO:0003360 brainstem development(GO:0003360)
2.1 20.6 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
1.6 20.5 GO:1902459 positive regulation of stem cell population maintenance(GO:1902459)
6.7 20.1 GO:0030421 defecation(GO:0030421)
1.4 19.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 338 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 185.2 GO:0005634 nucleus(GO:0005634)
0.5 172.4 GO:0005667 transcription factor complex(GO:0005667)
0.2 65.2 GO:0016607 nuclear speck(GO:0016607)
0.7 61.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.8 53.8 GO:0005844 polysome(GO:0005844)
1.0 48.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
3.4 34.3 GO:0000796 condensin complex(GO:0000796)
0.2 31.3 GO:0000785 chromatin(GO:0000785)
0.3 26.9 GO:0005814 centriole(GO:0005814)
5.3 26.7 GO:0032133 chromosome passenger complex(GO:0032133)
0.5 25.5 GO:0005657 replication fork(GO:0005657)
7.9 23.7 GO:0071149 TEAD-2-YAP complex(GO:0071149)
1.4 23.6 GO:0010369 chromocenter(GO:0010369)
0.4 23.4 GO:0005902 microvillus(GO:0005902)
1.3 23.3 GO:0031616 spindle pole centrosome(GO:0031616)
1.0 21.2 GO:0016580 Sin3 complex(GO:0016580)
6.9 20.6 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.3 20.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 19.6 GO:0000776 kinetochore(GO:0000776)
1.7 19.0 GO:1990907 beta-catenin-TCF complex(GO:1990907)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 555 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 85.1 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.5 83.1 GO:0001047 core promoter binding(GO:0001047)
0.4 68.5 GO:0042393 histone binding(GO:0042393)
0.1 57.9 GO:0003677 DNA binding(GO:0003677)
1.1 43.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3 43.7 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.2 41.5 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.8 39.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.9 37.0 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.4 35.3 GO:0003697 single-stranded DNA binding(GO:0003697)
1.1 32.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 31.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.8 29.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.4 29.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
1.3 28.8 GO:0070410 co-SMAD binding(GO:0070410)
2.0 27.5 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
2.9 26.5 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.5 26.3 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
1.2 25.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 23.5 GO:0051015 actin filament binding(GO:0051015)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 88.8 PID_AURORA_B_PATHWAY Aurora B signaling
1.3 70.9 PID_PLK1_PATHWAY PLK1 signaling events
0.9 63.9 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.7 56.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.7 56.0 PID_E2F_PATHWAY E2F transcription factor network
0.9 52.0 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
3.7 51.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.7 39.2 PID_ILK_PATHWAY Integrin-linked kinase signaling
1.2 35.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.4 31.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.5 24.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.7 22.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.5 20.4 PID_FGF_PATHWAY FGF signaling pathway
0.4 19.8 PID_AP1_PATHWAY AP-1 transcription factor network
0.3 19.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.4 17.8 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.8 16.8 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.5 15.8 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.5 15.7 PID_BARD1_PATHWAY BARD1 signaling events
0.2 15.7 WNT_SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 161 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 70.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.7 57.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
1.7 53.1 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
2.3 46.6 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.5 37.8 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
1.2 36.6 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.8 31.5 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
1.1 30.7 REACTOME_KINESINS Genes involved in Kinesins
0.2 26.2 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 25.3 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
1.4 24.6 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
1.4 24.5 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.9 23.7 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
1.6 22.8 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.7 20.2 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 19.7 REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.2 19.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 17.7 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.9 16.9 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.8 16.6 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components