Motif ID: Klf4_Sp3
Z-value: 1.492
Transcription factors associated with Klf4_Sp3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Klf4 | ENSMUSG00000003032.8 | Klf4 |
| Sp3 | ENSMUSG00000027109.10 | Sp3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sp3 | mm10_v2_chr2_-_72980402_72980471 | -0.29 | 3.1e-02 | Click! |
| Klf4 | mm10_v2_chr4_-_55532453_55532485 | -0.11 | 4.2e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 1,117 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 19.8 | GO:0090394 | negative regulation of excitatory postsynaptic potential(GO:0090394) |
| 0.3 | 17.8 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.6 | 17.7 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.7 | 15.1 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 1.6 | 14.6 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
| 1.3 | 14.2 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 2.2 | 11.0 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 0.5 | 10.8 | GO:0032986 | protein-DNA complex disassembly(GO:0032986) |
| 0.4 | 10.8 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 0.3 | 10.5 | GO:0043044 | ATP-dependent chromatin remodeling(GO:0043044) |
| 0.2 | 10.4 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.2 | 10.3 | GO:0050830 | defense response to Gram-positive bacterium(GO:0050830) |
| 0.4 | 10.2 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 1.4 | 10.1 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.7 | 10.1 | GO:0007220 | Notch receptor processing(GO:0007220) |
| 0.5 | 9.9 | GO:0045116 | protein neddylation(GO:0045116) |
| 2.0 | 9.8 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
| 0.8 | 9.7 | GO:0060052 | neurofilament cytoskeleton organization(GO:0060052) |
| 0.2 | 9.4 | GO:0009060 | aerobic respiration(GO:0009060) |
| 1.8 | 9.1 | GO:0006680 | glucosylceramide catabolic process(GO:0006680) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 392 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 46.1 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 22.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 1.1 | 18.7 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.3 | 18.6 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 1.1 | 16.9 | GO:0043196 | varicosity(GO:0043196) |
| 0.6 | 16.2 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.9 | 15.8 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.2 | 14.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 14.2 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.3 | 12.4 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.2 | 12.4 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.2 | 11.7 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.4 | 11.6 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.3 | 11.5 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.2 | 11.1 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 11.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.3 | 10.8 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.2 | 10.4 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 10.4 | GO:0043204 | perikaryon(GO:0043204) |
| 0.3 | 9.5 | GO:0035861 | site of double-strand break(GO:0035861) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 592 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 37.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 35.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.6 | 30.5 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.6 | 23.7 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.7 | 20.2 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.3 | 16.2 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.6 | 15.3 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.3 | 15.1 | GO:0019003 | GDP binding(GO:0019003) |
| 0.2 | 15.1 | GO:0008565 | protein transporter activity(GO:0008565) |
| 1.1 | 14.9 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.6 | 14.4 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.3 | 14.0 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.4 | 13.8 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.4 | 12.8 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.3 | 12.6 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.9 | 12.4 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
| 0.2 | 12.4 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.9 | 12.2 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 3.0 | 11.9 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 2.4 | 11.9 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 83 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 30.2 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.7 | 22.2 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.1 | 21.0 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.5 | 19.1 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.2 | 16.7 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.4 | 13.9 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.5 | 13.5 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
| 0.3 | 13.5 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.2 | 12.9 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.7 | 11.7 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.5 | 11.3 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.2 | 10.5 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.2 | 7.6 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
| 0.2 | 7.5 | PID_NFAT_3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.2 | 6.6 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 6.0 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.4 | 5.6 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.2 | 5.3 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.2 | 5.1 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
| 0.1 | 5.1 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 172 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 35.2 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.4 | 35.0 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.3 | 32.4 | REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 1.0 | 23.3 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.6 | 20.8 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.4 | 20.8 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.5 | 18.7 | REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 0.9 | 18.3 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.5 | 17.8 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 17.6 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.2 | 17.0 | REACTOME_RNA_POL_I_TRANSCRIPTION | Genes involved in RNA Polymerase I Transcription |
| 0.8 | 16.3 | REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.5 | 16.0 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.6 | 15.9 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.9 | 14.0 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.9 | 13.8 | REACTOME_RAF_MAP_KINASE_CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.9 | 12.6 | REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS | Genes involved in NRIF signals cell death from the nucleus |
| 0.5 | 12.5 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.2 | 10.2 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.4 | 8.6 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
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