Motif ID: Klf6_Patz1

Z-value: 1.212

Transcription factors associated with Klf6_Patz1:

Gene SymbolEntrez IDGene Name
Klf6 ENSMUSG00000000078.6 Klf6
Patz1 ENSMUSG00000020453.11 Patz1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf6mm10_v2_chr13_+_5861489_58615010.321.7e-02Click!
Patz1mm10_v2_chr11_+_3289168_3289281-0.321.9e-02Click!


Activity profile for motif Klf6_Patz1.

activity profile for motif Klf6_Patz1


Sorted Z-values histogram for motif Klf6_Patz1

Sorted Z-values for motif Klf6_Patz1



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf6_Patz1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_102296618 13.106 ENSMUST00000107132.2
ENSMUST00000073234.2
 Atxn7l3

ataxin 7-like 3

chr7_+_44310213 7.597 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr11_-_95514570 6.133 ENSMUST00000058866.7
 Nxph3
neurexophilin 3
chr14_-_20794009 6.087 ENSMUST00000100837.3
ENSMUST00000080440.6
ENSMUST00000071816.6
 Camk2g


calcium/calmodulin-dependent protein kinase II gamma


chr5_+_37028329 5.893 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr14_-_39472825 5.642 ENSMUST00000168810.2
ENSMUST00000173780.1
ENSMUST00000166968.2
 Nrg3


neuregulin 3


chr2_-_24763047 5.570 ENSMUST00000100348.3
ENSMUST00000041342.5
ENSMUST00000114447.1
ENSMUST00000102939.2
ENSMUST00000070864.7
 Cacna1b




calcium channel, voltage-dependent, N type, alpha 1B subunit




chr11_+_67455339 5.489 ENSMUST00000108681.1
 Gas7
growth arrest specific 7
chr6_-_85502858 5.348 ENSMUST00000161546.1
ENSMUST00000161078.1
 Fbxo41

F-box protein 41

chr1_-_155417394 5.238 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr6_-_85502980 5.234 ENSMUST00000159062.1
 Fbxo41
F-box protein 41
chr19_+_6418731 5.231 ENSMUST00000113462.1
ENSMUST00000077182.6
ENSMUST00000113461.1
 Nrxn2


neurexin II


chr6_-_119848059 5.019 ENSMUST00000184864.1
 Erc1
ELKS/RAB6-interacting/CAST family member 1
chr16_+_44173271 4.940 ENSMUST00000088356.4
ENSMUST00000169582.1
 Gm608

predicted gene 608

chr5_-_89883321 4.743 ENSMUST00000163159.1
ENSMUST00000061427.5
 Adamts3

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3

chr12_+_12262139 4.611 ENSMUST00000069066.6
ENSMUST00000069005.8
 Fam49a

family with sequence similarity 49, member A

chrX_+_13071470 4.597 ENSMUST00000169594.2
 Usp9x
ubiquitin specific peptidase 9, X chromosome
chr11_+_119942763 4.445 ENSMUST00000026436.3
ENSMUST00000106231.1
ENSMUST00000075180.5
ENSMUST00000103021.3
ENSMUST00000106233.1
 Baiap2




brain-specific angiogenesis inhibitor 1-associated protein 2




chr10_-_127620960 4.374 ENSMUST00000121829.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr16_+_44173239 4.335 ENSMUST00000119746.1
 Gm608
predicted gene 608

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 728 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 33.5 GO:0071625 vocalization behavior(GO:0071625)
0.5 13.2 GO:0016578 histone deubiquitination(GO:0016578)
0.7 12.6 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.6 12.6 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.2 11.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
1.2 10.9 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.1 10.8 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
2.4 9.6 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
1.0 9.6 GO:0010459 negative regulation of heart rate(GO:0010459)
0.8 9.3 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
1.3 7.8 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.9 7.4 GO:0035608 protein deglutamylation(GO:0035608)
0.5 7.0 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.3 6.9 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.5 6.8 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.3 6.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.9 6.3 GO:0097324 melanocyte migration(GO:0097324)
0.4 6.3 GO:0086018 SA node cell action potential(GO:0086015) SA node cell to atrial cardiac muscle cell signalling(GO:0086018) SA node cell to atrial cardiac muscle cell communication(GO:0086070)
1.2 6.2 GO:0007256 activation of JNKK activity(GO:0007256)
1.0 6.2 GO:0032229 negative regulation of synaptic transmission, GABAergic(GO:0032229)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 253 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 47.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 30.6 GO:0016021 integral component of membrane(GO:0016021)
0.4 27.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.4 23.5 GO:0042734 presynaptic membrane(GO:0042734)
0.3 19.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 17.2 GO:0005768 endosome(GO:0005768)
0.2 15.0 GO:0055037 recycling endosome(GO:0055037)
0.5 13.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
1.0 12.9 GO:0008385 IkappaB kinase complex(GO:0008385)
0.7 12.6 GO:0000124 SAGA complex(GO:0000124)
0.4 12.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.4 11.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.6 11.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 11.5 GO:0044306 neuron projection terminus(GO:0044306)
0.0 10.9 GO:0000139 Golgi membrane(GO:0000139)
0.1 10.5 GO:0060076 excitatory synapse(GO:0060076)
0.3 9.4 GO:0035861 site of double-strand break(GO:0035861)
0.2 9.4 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.2 9.1 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.9 8.9 GO:0045298 tubulin complex(GO:0045298)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 432 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 38.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.2 31.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 22.8 GO:0017124 SH3 domain binding(GO:0017124)
0.1 20.4 GO:0005096 GTPase activator activity(GO:0005096)
0.4 14.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.8 12.2 GO:0045499 chemorepellent activity(GO:0045499)
0.3 12.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 11.6 GO:0008017 microtubule binding(GO:0008017)
0.6 11.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.5 11.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 11.2 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.8 10.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 10.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 10.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
2.5 10.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
1.4 9.9 GO:0099609 microtubule lateral binding(GO:0099609)
3.2 9.6 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.2 9.4 GO:0005246 calcium channel regulator activity(GO:0005246)
1.2 9.3 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
2.8 8.5 GO:0000822 inositol hexakisphosphate binding(GO:0000822)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 19.5 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.7 17.0 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.8 13.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.4 13.3 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.4 13.2 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.4 11.9 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 10.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 8.0 PID_LKB1_PATHWAY LKB1 signaling events
0.4 7.9 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 7.4 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 7.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.2 6.6 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.2 5.3 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 5.2 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway
0.3 4.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.2 3.4 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 3.4 PID_SHP2_PATHWAY SHP2 signaling
0.1 3.2 SIG_CHEMOTAXIS Genes related to chemotaxis
0.1 3.2 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 3.1 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 24.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 14.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
1.2 12.0 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.3 10.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.5 10.1 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.4 9.9 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 8.7 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES Genes involved in Transmission across Chemical Synapses
0.3 8.2 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.6 7.7 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.6 7.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 7.5 REACTOME_DAG_AND_IP3_SIGNALING Genes involved in DAG and IP3 signaling
0.2 6.5 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.4 6.4 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 6.4 REACTOME_CIRCADIAN_CLOCK Genes involved in Circadian Clock
0.1 5.7 REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM Genes involved in Heparan sulfate/heparin (HS-GAG) metabolism
0.4 5.6 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 5.5 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 5.4 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 5.4 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.3 5.3 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC