Motif ID: Klf7
Z-value: 0.521
Transcription factors associated with Klf7:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Klf7 | ENSMUSG00000025959.7 | Klf7 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Klf7 | mm10_v2_chr1_-_64121389_64121452 | -0.57 | 4.5e-06 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 5.4 | GO:0002457 | T cell antigen processing and presentation(GO:0002457) |
| 1.0 | 3.0 | GO:0060598 | dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598) |
| 0.9 | 4.4 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.7 | 3.3 | GO:0036151 | phosphatidylcholine acyl-chain remodeling(GO:0036151) |
| 0.5 | 2.0 | GO:2001045 | negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 0.3 | 1.6 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 0.2 | 0.6 | GO:0090204 | protein localization to nuclear pore(GO:0090204) negative regulation of vascular endothelial growth factor production(GO:1904046) |
| 0.2 | 0.8 | GO:0098914 | membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914) |
| 0.2 | 0.5 | GO:0048496 | maintenance of organ identity(GO:0048496) |
| 0.1 | 1.0 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 0.1 | 0.4 | GO:0036090 | cleavage furrow ingression(GO:0036090) |
| 0.1 | 0.8 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.1 | 1.1 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
| 0.1 | 0.5 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 0.1 | 2.1 | GO:0030953 | astral microtubule organization(GO:0030953) |
| 0.1 | 0.3 | GO:0002586 | positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588) |
| 0.1 | 0.7 | GO:0071169 | establishment of protein localization to chromatin(GO:0071169) |
| 0.1 | 0.4 | GO:0051643 | endoplasmic reticulum localization(GO:0051643) |
| 0.1 | 0.6 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 0.1 | 0.3 | GO:0021852 | pyramidal neuron migration(GO:0021852) |
| 0.1 | 0.3 | GO:0021577 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
| 0.1 | 0.8 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.1 | 0.6 | GO:0050957 | equilibrioception(GO:0050957) |
| 0.1 | 2.7 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.1 | 0.4 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.1 | 0.2 | GO:0006273 | lagging strand elongation(GO:0006273) |
| 0.0 | 0.7 | GO:1904948 | olfactory behavior(GO:0042048) midbrain dopaminergic neuron differentiation(GO:1904948) |
| 0.0 | 0.4 | GO:0035330 | regulation of hippo signaling(GO:0035330) |
| 0.0 | 0.4 | GO:0071318 | cellular response to ATP(GO:0071318) |
| 0.0 | 0.3 | GO:0006451 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.0 | 0.1 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
| 0.0 | 0.1 | GO:0048539 | bone marrow development(GO:0048539) |
| 0.0 | 0.2 | GO:0051151 | negative regulation of smooth muscle cell differentiation(GO:0051151) |
| 0.0 | 0.1 | GO:0060406 | positive regulation of penile erection(GO:0060406) |
| 0.0 | 0.9 | GO:0043551 | regulation of phosphatidylinositol 3-kinase activity(GO:0043551) |
| 0.0 | 0.4 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
| 0.0 | 0.2 | GO:0035845 | photoreceptor cell outer segment organization(GO:0035845) |
| 0.0 | 0.8 | GO:0015914 | phospholipid transport(GO:0015914) |
| 0.0 | 1.2 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.0 | GO:0031590 | wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591) |
| 0.0 | 0.3 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
| 0.0 | 0.5 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.9 | GO:0097543 | ciliary inversin compartment(GO:0097543) |
| 0.3 | 2.8 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.2 | 0.9 | GO:0097651 | phosphatidylinositol 3-kinase complex, class I(GO:0097651) |
| 0.1 | 3.3 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.1 | 0.6 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.1 | 4.4 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 0.7 | GO:0031933 | telomeric heterochromatin(GO:0031933) |
| 0.1 | 0.3 | GO:0061702 | inflammasome complex(GO:0061702) |
| 0.1 | 0.5 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.1 | 0.6 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
| 0.1 | 0.2 | GO:1990047 | spindle matrix(GO:1990047) |
| 0.1 | 0.7 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 0.2 | GO:1902636 | kinociliary basal body(GO:1902636) |
| 0.0 | 0.4 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 0.4 | GO:0070938 | contractile ring(GO:0070938) |
| 0.0 | 0.1 | GO:0005745 | m-AAA complex(GO:0005745) |
| 0.0 | 0.3 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.0 | 1.1 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 1.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 0.1 | GO:0097255 | R2TP complex(GO:0097255) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 4.4 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 1.1 | 3.3 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
| 0.8 | 5.4 | GO:0032453 | histone demethylase activity (H3-K4 specific)(GO:0032453) |
| 0.2 | 0.8 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.2 | 0.6 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.1 | 0.9 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.1 | 2.0 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 1.0 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.1 | 0.6 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.1 | 0.5 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.1 | 0.8 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.1 | 1.1 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 0.4 | GO:0046790 | virion binding(GO:0046790) |
| 0.0 | 0.3 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.0 | 0.1 | GO:0031686 | A1 adenosine receptor binding(GO:0031686) |
| 0.0 | 0.2 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
| 0.0 | 0.8 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.0 | 0.7 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 1.1 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 0.4 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 1.7 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.0 | 0.5 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 0.3 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 0.1 | GO:0017169 | CDP-alcohol phosphatidyltransferase activity(GO:0017169) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.1 | 2.0 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 3.0 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.5 | PID_NFKAPPAB_ATYPICAL_PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 0.9 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.0 | 1.0 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.8 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 0.8 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.4 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 7.1 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 1.1 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 0.7 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 2.0 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.3 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.5 | REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.0 | 0.9 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 1.0 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 0.8 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.4 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 0.8 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.1 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 0.3 | REACTOME_KINESINS | Genes involved in Kinesins |
