Motif ID: Klf7

Z-value: 0.521


Transcription factors associated with Klf7:

Gene SymbolEntrez IDGene Name
Klf7 ENSMUSG00000025959.7 Klf7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf7mm10_v2_chr1_-_64121389_64121452-0.574.5e-06Click!


Activity profile for motif Klf7.

activity profile for motif Klf7


Sorted Z-values histogram for motif Klf7

Sorted Z-values for motif Klf7



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf7

PNG image of the network

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Top targets:


Showing 1 to 20 of 87 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_897782 5.353 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr5_+_140607334 4.421 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr2_+_119047116 3.300 ENSMUST00000152380.1
ENSMUST00000099542.2
 Casc5

cancer susceptibility candidate 5

chr2_+_172550991 2.979 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr15_+_99074968 2.732 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr2_+_119047129 2.691 ENSMUST00000153300.1
ENSMUST00000028799.5
 Casc5

cancer susceptibility candidate 5

chr12_+_118846329 2.688 ENSMUST00000063918.2
 Sp8
trans-acting transcription factor 8
chr5_+_33658123 2.122 ENSMUST00000074849.6
ENSMUST00000079534.4
 Tacc3

transforming, acidic coiled-coil containing protein 3

chr18_+_35118880 1.981 ENSMUST00000042345.6
 Ctnna1
catenin (cadherin associated protein), alpha 1
chr1_-_120121030 1.743 ENSMUST00000027634.6
 Dbi
diazepam binding inhibitor
chr1_-_138847579 1.635 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr1_-_120120937 1.596 ENSMUST00000151708.1
 Dbi
diazepam binding inhibitor
chr5_+_137778849 1.161 ENSMUST00000126126.1
ENSMUST00000031739.4
 Ppp1r35

protein phosphatase 1, regulatory subunit 35

chr2_-_151973387 1.083 ENSMUST00000109863.1
 Fam110a
family with sequence similarity 110, member A
chr11_-_40733373 1.077 ENSMUST00000020579.8
 Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr13_+_21722057 1.062 ENSMUST00000110476.3
 Hist1h2bm
histone cluster 1, H2bm
chr10_+_79682169 1.062 ENSMUST00000020550.5
 Cdc34
cell division cycle 34
chr11_-_70654624 1.038 ENSMUST00000018437.2
 Pfn1
profilin 1
chr12_-_4592927 0.982 ENSMUST00000170816.1
 Gm3625
predicted gene 3625
chr11_+_68432112 0.937 ENSMUST00000021283.7
 Pik3r5
phosphoinositide-3-kinase, regulatory subunit 5, p101

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 5.4 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.9 4.4 GO:0007386 compartment pattern specification(GO:0007386)
0.7 3.3 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
1.0 3.0 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.1 2.7 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 2.1 GO:0030953 astral microtubule organization(GO:0030953)
0.5 2.0 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.3 1.6 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 1.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 1.1 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 1.0 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.9 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.2 0.8 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.1 0.8 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.8 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.8 GO:0015914 phospholipid transport(GO:0015914)
0.1 0.7 GO:0071169 establishment of protein localization to chromatin(GO:0071169)
0.0 0.7 GO:1904948 olfactory behavior(GO:0042048) midbrain dopaminergic neuron differentiation(GO:1904948)
0.2 0.6 GO:0090204 protein localization to nuclear pore(GO:0090204) negative regulation of vascular endothelial growth factor production(GO:1904046)
0.1 0.6 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 3.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.3 2.8 GO:0005915 zonula adherens(GO:0005915)
0.0 1.1 GO:0000786 nucleosome(GO:0000786)
0.0 1.0 GO:0072562 blood microparticle(GO:0072562)
0.3 0.9 GO:0097543 ciliary inversin compartment(GO:0097543)
0.2 0.9 GO:0097651 phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.1 0.7 GO:0031933 telomeric heterochromatin(GO:0031933)
0.1 0.7 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 0.6 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 0.6 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 0.5 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.4 GO:0070938 contractile ring(GO:0070938)
0.1 0.3 GO:0061702 inflammasome complex(GO:0061702)
0.0 0.3 GO:0035253 ciliary rootlet(GO:0035253)
0.1 0.2 GO:1990047 spindle matrix(GO:1990047)
0.0 0.2 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.1 GO:0005745 m-AAA complex(GO:0005745)
0.0 0.1 GO:0097255 R2TP complex(GO:0097255)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 5.4 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
1.5 4.4 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
1.1 3.3 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.1 2.0 GO:0017166 vinculin binding(GO:0017166)
0.0 1.7 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 1.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 1.0 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.9 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 0.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.8 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 0.6 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.1 0.6 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 0.5 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.5 GO:0030552 cAMP binding(GO:0030552)
0.1 0.4 GO:0046790 virion binding(GO:0046790)
0.0 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.3 GO:0005138 interleukin-6 receptor binding(GO:0005138)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 2.0 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 1.0 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.9 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.8 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.5 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.1 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 4.4 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 2.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.1 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.0 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.9 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 0.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.5 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.4 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.3 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.3 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors