Motif ID: Klf8

Z-value: 1.035


Transcription factors associated with Klf8:

Gene SymbolEntrez IDGene Name
Klf8 ENSMUSG00000041649.7 Klf8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf8mm10_v2_chrX_+_153237748_153237748-0.491.7e-04Click!


Activity profile for motif Klf8.

activity profile for motif Klf8


Sorted Z-values histogram for motif Klf8

Sorted Z-values for motif Klf8



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf8

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_70851189 14.731 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr6_-_72788952 12.711 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr9_-_8004585 9.664 ENSMUST00000086580.5
ENSMUST00000065353.6
 Yap1

yes-associated protein 1

chr2_-_36105271 8.994 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
 Lhx6


LIM homeobox protein 6


chr13_-_60177357 8.724 ENSMUST00000065086.4
 Gas1
growth arrest specific 1
chr18_-_74961252 8.092 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr7_+_4119525 7.516 ENSMUST00000119661.1
ENSMUST00000129423.1
 Ttyh1

tweety homolog 1 (Drosophila)

chr7_+_4119556 7.510 ENSMUST00000079415.5
 Ttyh1
tweety homolog 1 (Drosophila)
chr14_-_103843685 7.501 ENSMUST00000172237.1
 Ednrb
endothelin receptor type B
chr7_-_127026479 7.406 ENSMUST00000032916.4
 Maz
MYC-associated zinc finger protein (purine-binding transcription factor)
chr4_+_46450892 7.220 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr2_+_172550991 7.171 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr1_-_20820213 6.678 ENSMUST00000053266.9
 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr18_-_78206408 6.409 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr13_+_48261427 5.665 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr1_+_172499948 5.602 ENSMUST00000111230.1
 Tagln2
transgelin 2
chr7_-_144939823 5.521 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr19_+_25610533 5.376 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr10_+_4710119 5.325 ENSMUST00000105588.1
ENSMUST00000105589.1
 Esr1

estrogen receptor 1 (alpha)

chr7_+_144838590 4.236 ENSMUST00000105898.1
 Fgf3
fibroblast growth factor 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 17.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.3 15.0 GO:1902476 chloride transmembrane transport(GO:1902476)
4.2 12.7 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
1.8 10.6 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
1.6 9.7 GO:0060242 contact inhibition(GO:0060242)
1.5 9.0 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.9 8.7 GO:0042473 outer ear morphogenesis(GO:0042473)
2.0 8.1 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
2.5 7.5 GO:0014826 vein smooth muscle contraction(GO:0014826)
1.1 7.4 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
2.4 7.2 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.3 7.2 GO:0043486 histone exchange(GO:0043486)
0.2 6.8 GO:0009299 mRNA transcription(GO:0009299)
0.2 6.7 GO:0006270 DNA replication initiation(GO:0006270)
0.8 6.6 GO:0072615 interleukin-17 secretion(GO:0072615)
2.1 6.4 GO:0071918 urea transmembrane transport(GO:0071918)
1.5 6.2 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.8 5.5 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.7 5.4 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
1.3 5.3 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 18.9 GO:0005667 transcription factor complex(GO:0005667)
5.0 15.0 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 12.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 12.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
3.2 9.7 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
3.2 9.7 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.3 9.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
1.1 6.8 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.4 6.7 GO:0042555 MCM complex(GO:0042555)
0.8 5.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 5.2 GO:0031965 nuclear membrane(GO:0031965)
0.7 4.0 GO:0061689 tricellular tight junction(GO:0061689)
0.8 3.9 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.4 3.9 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
1.2 3.7 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.6 3.4 GO:0005859 muscle myosin complex(GO:0005859)
0.4 3.4 GO:0031415 NatA complex(GO:0031415)
1.0 3.0 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 3.0 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.9 2.8 GO:0005588 collagen type V trimer(GO:0005588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 29.4 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.8 17.9 GO:0070410 co-SMAD binding(GO:0070410)
3.8 15.0 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 12.4 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.4 12.1 GO:0070064 proline-rich region binding(GO:0070064)
2.0 8.1 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
2.5 7.5 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 7.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 7.3 GO:0004386 helicase activity(GO:0004386)
0.3 6.8 GO:0003746 translation elongation factor activity(GO:0003746)
1.7 6.6 GO:0008142 oxysterol binding(GO:0008142)
1.1 6.4 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 6.1 GO:0042393 histone binding(GO:0042393)
0.1 5.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 5.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
1.8 5.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.2 4.0 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.6 3.9 GO:0019841 retinol binding(GO:0019841)
0.2 3.9 GO:0051861 glycolipid binding(GO:0051861)
0.1 3.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 25.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 20.5 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.4 19.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 7.6 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 7.6 PID_E2F_PATHWAY E2F transcription factor network
0.1 5.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 5.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 4.6 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 4.0 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.2 3.7 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 3.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 3.5 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 3.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 3.0 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 2.5 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 2.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.3 ST_GAQ_PATHWAY G alpha q Pathway
0.1 2.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.9 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.8 PID_RHOA_REG_PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 20.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.4 13.5 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.6 9.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.3 9.7 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.3 9.7 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 7.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 7.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 6.3 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 6.2 REACTOME_TRANSLATION Genes involved in Translation
0.1 4.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.4 4.2 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.3 3.9 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 3.8 REACTOME_KINESINS Genes involved in Kinesins
0.1 3.7 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.1 3.6 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.1 3.4 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.2 3.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 2.5 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 2.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 2.2 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters