Motif ID: Lef1

Z-value: 1.827


Transcription factors associated with Lef1:

Gene SymbolEntrez IDGene Name
Lef1 ENSMUSG00000027985.8 Lef1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lef1mm10_v2_chr3_+_131110350_1311104710.601.1e-06Click!


Activity profile for motif Lef1.

activity profile for motif Lef1


Sorted Z-values histogram for motif Lef1

Sorted Z-values for motif Lef1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lef1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_98169542 24.004 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr3_-_57575760 23.046 ENSMUST00000029380.7
 Wwtr1
WW domain containing transcription regulator 1
chr2_+_70474923 22.023 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chr3_-_57575907 20.600 ENSMUST00000120977.1
 Wwtr1
WW domain containing transcription regulator 1
chr7_-_115824699 19.467 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr2_+_73271925 18.356 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr17_-_70851189 16.752 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr19_-_59170978 15.612 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr7_-_37772868 14.395 ENSMUST00000176205.1
 Zfp536
zinc finger protein 536
chr2_-_26092149 13.093 ENSMUST00000114159.2
 Nacc2
nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
chr10_-_92165159 12.681 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr19_+_55742242 12.241 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
 Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box






chr5_+_75075464 12.180 ENSMUST00000160104.1
ENSMUST00000040477.3
 Gsx2

GS homeobox 2

chr12_-_119238794 11.680 ENSMUST00000026360.8
 Itgb8
integrin beta 8
chr7_+_45216671 11.620 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr2_+_71528657 11.604 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr18_-_62756275 11.115 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr7_-_116038734 10.916 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr8_-_46294592 10.595 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr7_-_37773555 10.545 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 170 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 48.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
6.2 43.6 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
4.5 35.6 GO:0048625 myoblast fate commitment(GO:0048625)
2.8 30.4 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
8.0 24.0 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
1.0 23.6 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.4 22.6 GO:0060612 adipose tissue development(GO:0060612)
5.9 17.6 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.7 14.5 GO:0001967 suckling behavior(GO:0001967)
1.4 14.4 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
4.8 14.3 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.1 13.8 GO:0006261 DNA-dependent DNA replication(GO:0006261)
1.0 13.1 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.6 12.5 GO:0030903 notochord development(GO:0030903)
1.0 12.2 GO:0048853 forebrain morphogenesis(GO:0048853)
0.1 12.1 GO:0030326 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
3.9 11.6 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
2.9 11.6 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.4 11.4 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
1.0 11.3 GO:0060539 diaphragm development(GO:0060539)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 149.3 GO:0005634 nucleus(GO:0005634)
0.3 143.8 GO:0005667 transcription factor complex(GO:0005667)
4.0 35.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.3 21.0 GO:0017053 transcriptional repressor complex(GO:0017053)
3.4 13.8 GO:0008623 CHRAC(GO:0008623)
0.5 13.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 11.9 GO:0072686 mitotic spindle(GO:0072686)
0.5 11.7 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
3.9 11.6 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.2 9.4 GO:0005871 kinesin complex(GO:0005871)
2.9 8.8 GO:0042585 germinal vesicle(GO:0042585)
1.5 8.7 GO:0000235 astral microtubule(GO:0000235)
0.5 8.3 GO:0016580 Sin3 complex(GO:0016580)
1.0 8.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
3.8 7.6 GO:1990907 beta-catenin-TCF complex(GO:1990907)
1.9 7.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.5 7.1 GO:0031105 septin complex(GO:0031105)
0.6 6.9 GO:0044294 dendritic growth cone(GO:0044294)
1.1 5.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 4.7 GO:0032993 protein-DNA complex(GO:0032993)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 111.5 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.5 83.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.1 43.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.2 31.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 26.1 GO:0043565 sequence-specific DNA binding(GO:0043565)
1.7 25.8 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
3.0 24.0 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.5 23.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2 17.5 GO:0003777 microtubule motor activity(GO:0003777)
1.0 16.8 GO:0070410 co-SMAD binding(GO:0070410)
0.9 16.4 GO:0070411 I-SMAD binding(GO:0070411)
2.0 15.6 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
1.3 15.3 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 15.2 GO:0003677 DNA binding(GO:0003677)
0.8 14.5 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.1 14.5 GO:0051015 actin filament binding(GO:0051015)
0.4 11.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
1.7 11.7 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 11.7 GO:0000975 regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212)
1.9 11.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 104.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 21.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.3 20.2 PID_PLK1_PATHWAY PLK1 signaling events
0.2 15.5 PID_E2F_PATHWAY E2F transcription factor network
0.3 14.3 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.3 13.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.7 11.7 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3 10.7 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.3 7.1 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 6.4 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.2 6.0 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.6 5.9 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 5.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.2 5.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 4.5 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.2 4.3 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 3.8 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 3.7 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 3.7 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 3.5 PID_CASPASE_PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 58.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.4 15.5 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 14.4 REACTOME_MEIOSIS Genes involved in Meiosis
0.7 12.8 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.5 12.5 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 8.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 8.2 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.3 7.6 REACTOME_KINESINS Genes involved in Kinesins
1.3 7.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 7.2 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 6.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 6.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.3 5.5 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 5.4 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.4 5.3 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.3 5.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.0 5.0 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE Genes involved in Signaling by FGFR in disease
0.4 3.5 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 3.0 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 2.9 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL