Motif ID: Lhx2_Hoxc5

Z-value: 0.785

Transcription factors associated with Lhx2_Hoxc5:

Gene SymbolEntrez IDGene Name
Hoxc5 ENSMUSG00000022485.3 Hoxc5
Lhx2 ENSMUSG00000000247.5 Lhx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx2mm10_v2_chr2_+_38341068_38341092-0.421.3e-03Click!


Activity profile for motif Lhx2_Hoxc5.

activity profile for motif Lhx2_Hoxc5


Sorted Z-values histogram for motif Lhx2_Hoxc5

Sorted Z-values for motif Lhx2_Hoxc5



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx2_Hoxc5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_14621805 5.991 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr18_+_37435602 4.471 ENSMUST00000055495.5
 Pcdhb12
protocadherin beta 12
chr2_+_65620829 3.744 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr19_-_32196393 3.703 ENSMUST00000151822.1
 Sgms1
sphingomyelin synthase 1
chrM_+_10167 3.561 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr8_+_66386292 3.462 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr14_-_64455903 3.220 ENSMUST00000067927.7
 Msra
methionine sulfoxide reductase A
chrX_+_170009892 3.148 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chr19_-_11604828 3.102 ENSMUST00000025582.4
 Ms4a6d
membrane-spanning 4-domains, subfamily A, member 6D
chr10_-_86732409 2.880 ENSMUST00000070435.4
 Fabp3-ps1
fatty acid binding protein 3, muscle and heart, pseudogene 1
chr14_+_69347587 2.692 ENSMUST00000064831.5
 Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr7_-_45103747 2.637 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr4_-_138396438 2.570 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr9_+_53771499 2.563 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr5_-_106926245 2.538 ENSMUST00000117588.1
 Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr7_-_140154712 2.505 ENSMUST00000059241.7
 Sprn
shadow of prion protein
chr5_-_118244861 2.505 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
 Rnft2



ring finger protein, transmembrane 2



chr3_+_9403049 2.496 ENSMUST00000180874.1
ENSMUST00000181331.1
ENSMUST00000181930.1
 C030034L19Rik


RIKEN cDNA C030034L19 gene


chr4_-_42034726 2.489 ENSMUST00000084677.2
 Gm21093
predicted gene, 21093
chr18_+_37355271 2.467 ENSMUST00000051163.1
 Pcdhb8
protocadherin beta 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 199 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 9.8 GO:0019532 oxalate transport(GO:0019532)
0.0 6.9 GO:0007416 synapse assembly(GO:0007416)
0.3 4.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.5 4.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4 4.0 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.2 3.5 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 3.2 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.4 2.7 GO:0021886 hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
0.2 2.5 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 2.4 GO:0048240 sperm capacitation(GO:0048240)
0.8 2.3 GO:0071492 cellular response to UV-A(GO:0071492)
0.3 2.3 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.2 2.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.7 2.2 GO:0046110 xanthine metabolic process(GO:0046110)
0.5 2.1 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.0 2.1 GO:0070167 regulation of biomineral tissue development(GO:0070167)
0.5 2.0 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 2.0 GO:0015809 arginine transport(GO:0015809)
0.0 2.0 GO:0007568 aging(GO:0007568)
0.3 1.8 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026) regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 8.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 8.2 GO:0070469 respiratory chain(GO:0070469)
0.1 4.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 3.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.4 3.7 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 3.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.9 2.7 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.1 2.6 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 2.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 2.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 2.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.1 GO:0030667 secretory granule membrane(GO:0030667)
0.0 2.1 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 2.0 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.9 GO:0042383 sarcolemma(GO:0042383)
0.5 1.8 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 1.8 GO:0016235 aggresome(GO:0016235)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 151 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 9.8 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.2 7.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 4.9 GO:0042287 MHC protein binding(GO:0042287)
0.1 4.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.7 3.7 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 3.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
1.1 3.2 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 2.9 GO:0003924 GTPase activity(GO:0003924)
0.4 2.7 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.5 2.6 GO:0019770 IgG receptor activity(GO:0019770)
0.0 2.5 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.2 2.4 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 2.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 2.3 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.5 2.2 GO:0030151 molybdenum ion binding(GO:0030151)
0.1 2.2 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 2.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 2.0 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 2.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.7 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 2.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.1 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway
0.1 1.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.8 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.6 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 1.5 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 1.3 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.1 1.3 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.2 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 1.2 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.1 PID_ARF_3PATHWAY Arf1 pathway
0.0 1.1 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 1.0 PID_NFAT_3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.8 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.8 PID_CXCR4_PATHWAY CXCR4-mediated signaling events
0.0 0.7 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 5.9 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.3 4.2 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 3.3 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 2.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.9 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.8 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 1.7 REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.1 1.6 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 1.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.5 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 1.3 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.3 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.2 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 1.2 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.0 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis