Motif ID: Lhx5_Lmx1b_Lhx1

Z-value: 0.485

Transcription factors associated with Lhx5_Lmx1b_Lhx1:

Gene SymbolEntrez IDGene Name
Lhx1 ENSMUSG00000018698.9 Lhx1
Lhx5 ENSMUSG00000029595.7 Lhx5
Lmx1b ENSMUSG00000038765.7 Lmx1b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx5mm10_v2_chr5_+_120431770_120431905-0.239.2e-02Click!
Lhx1mm10_v2_chr11_-_84525514_84525542-0.182.0e-01Click!
Lmx1bmm10_v2_chr2_-_33640480_33640511-0.095.2e-01Click!


Activity profile for motif Lhx5_Lmx1b_Lhx1.

activity profile for motif Lhx5_Lmx1b_Lhx1


Sorted Z-values histogram for motif Lhx5_Lmx1b_Lhx1

Sorted Z-values for motif Lhx5_Lmx1b_Lhx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx5_Lmx1b_Lhx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_93595877 4.545 ENSMUST00000048982.4
 Prickle1
prickle homolog 1 (Drosophila)
chr3_+_121953213 3.851 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr4_+_102589687 3.680 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr14_+_80000292 2.993 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr18_-_66860458 2.874 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr11_-_87359011 2.735 ENSMUST00000055438.4
 Ppm1e
protein phosphatase 1E (PP2C domain containing)
chr13_+_67833235 2.683 ENSMUST00000060609.7
 Gm10037
predicted gene 10037
chrX_-_143933089 2.436 ENSMUST00000087313.3
 Dcx
doublecortin
chr1_-_158356258 2.307 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr5_+_13398688 2.247 ENSMUST00000125629.1
 Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr5_-_118244861 2.154 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
 Rnft2



ring finger protein, transmembrane 2



chr16_+_11406618 2.101 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr7_+_66365905 2.075 ENSMUST00000107486.1
 Gm10974
predicted gene 10974
chr7_-_45103747 1.878 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr2_+_68104671 1.845 ENSMUST00000042456.3
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr13_+_77135513 1.768 ENSMUST00000168779.1
 2210408I21Rik
RIKEN cDNA 2210408I21 gene
chr4_-_14621805 1.630 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr13_+_46502113 1.581 ENSMUST00000119341.1
 Cap2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr15_-_67113909 1.549 ENSMUST00000092640.5
 St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr8_-_67910911 1.442 ENSMUST00000093468.5
 Psd3
pleckstrin and Sec7 domain containing 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.1 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
1.5 4.5 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.3 3.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 3.0 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.6 2.9 GO:0002024 diet induced thermogenesis(GO:0002024)
0.2 2.7 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.8 2.5 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.4 2.5 GO:0019532 oxalate transport(GO:0019532)
0.1 2.5 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.4 2.2 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.2 1.8 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 1.6 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.2 1.5 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.0 1.5 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 1.4 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.2 1.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.4 1.1 GO:0046110 xanthine metabolic process(GO:0046110)
0.1 1.1 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 1.1 GO:0001578 microtubule bundle formation(GO:0001578)
0.2 1.0 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 4.0 GO:0000139 Golgi membrane(GO:0000139)
0.2 3.0 GO:0042581 specific granule(GO:0042581)
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 1.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 1.3 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 1.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 1.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.3 0.8 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.1 0.8 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.8 GO:0043194 axon initial segment(GO:0043194)
0.1 0.7 GO:0090543 Flemming body(GO:0090543)
0.0 0.6 GO:0031143 pseudopodium(GO:0031143)
0.0 0.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.5 GO:0071004 U2-type prespliceosome(GO:0071004)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 4.9 GO:0030165 PDZ domain binding(GO:0030165)
0.0 3.4 GO:0008017 microtubule binding(GO:0008017)
1.0 2.9 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.2 2.5 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 2.5 GO:0030275 LRR domain binding(GO:0030275)
0.0 2.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 2.2 GO:0038191 neuropilin binding(GO:0038191)
0.4 1.9 GO:0019770 IgG receptor activity(GO:0019770)
0.5 1.8 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 1.6 GO:0008179 adenylate cyclase binding(GO:0008179)
0.5 1.5 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.4 1.5 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 1.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 1.1 GO:0030151 molybdenum ion binding(GO:0030151)
0.1 1.1 GO:0002162 dystroglycan binding(GO:0002162)
0.0 1.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.8 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 0.8 GO:0034056 estrogen response element binding(GO:0034056)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.7 PID_FGF_PATHWAY FGF signaling pathway
0.0 2.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.9 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.4 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.0 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.8 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.7 PID_BCR_5PATHWAY BCR signaling pathway
0.0 0.6 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.5 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.0 0.5 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.5 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.3 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.3 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 4.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 3.8 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.2 2.6 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 2.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 2.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.9 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 1.6 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.2 1.5 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.5 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.3 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 1.0 REACTOME_ARMS_MEDIATED_ACTIVATION Genes involved in ARMS-mediated activation
0.0 1.0 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.8 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 0.7 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.6 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.5 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.5 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.4 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis