Motif ID: Lhx8

Z-value: 0.569


Transcription factors associated with Lhx8:

Gene SymbolEntrez IDGene Name
Lhx8 ENSMUSG00000096225.2 Lhx8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx8mm10_v2_chr3_-_154330543_154330576-0.331.4e-02Click!


Activity profile for motif Lhx8.

activity profile for motif Lhx8


Sorted Z-values histogram for motif Lhx8

Sorted Z-values for motif Lhx8



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx8

PNG image of the network

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Top targets:


Showing 1 to 20 of 104 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_91090697 3.278 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090728 3.229 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr13_-_66851513 3.093 ENSMUST00000169322.1
 Gm17404
predicted gene, 17404
chr13_-_66227573 2.962 ENSMUST00000167981.2
 Gm10772
predicted gene 10772
chr18_+_23415400 2.709 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr2_+_65620829 2.666 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr3_-_73056943 2.399 ENSMUST00000059407.7
 Slitrk3
SLIT and NTRK-like family, member 3
chr13_-_66852017 2.376 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr2_-_52558539 2.169 ENSMUST00000102760.3
ENSMUST00000102761.2
 Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr15_+_21111452 2.126 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr6_-_136173492 1.837 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr5_+_137553517 1.746 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
 Actl6b




actin-like 6B




chr5_-_139129662 1.643 ENSMUST00000026973.7
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr17_-_90088343 1.616 ENSMUST00000173917.1
 Nrxn1
neurexin I
chr1_+_72284367 1.604 ENSMUST00000027380.5
ENSMUST00000141783.1
 Tmem169

transmembrane protein 169

chr13_+_5861489 1.432 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chrX_+_101640056 1.235 ENSMUST00000119299.1
ENSMUST00000044475.4
 Ogt

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

chr8_+_34054622 1.191 ENSMUST00000149618.1
 Gm9951
predicted gene 9951
chr13_-_62466709 1.188 ENSMUST00000076195.5
 Zfp935
zinc finger protein 935
chr2_-_45110336 0.918 ENSMUST00000028229.6
ENSMUST00000152232.1
 Zeb2

zinc finger E-box binding homeobox 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.5 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.0 2.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.2 2.2 GO:0019227 neuronal action potential propagation(GO:0019227) detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) action potential propagation(GO:0098870)
0.0 2.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.5 1.8 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.4 1.6 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.1 1.6 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 1.3 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.4 1.2 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.4 1.2 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 1.2 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 0.9 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.2 0.9 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.9 GO:0008090 retrograde axonal transport(GO:0008090)
0.3 0.8 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.0 0.8 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.8 GO:0007601 visual perception(GO:0007601)
0.2 0.7 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.2 0.6 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.0 0.5 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.2 2.7 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 2.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 1.8 GO:0043083 synaptic cleft(GO:0043083)
0.1 1.7 GO:0016514 SWI/SNF complex(GO:0016514)
0.2 1.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.6 GO:0042588 zymogen granule(GO:0042588)
0.2 0.9 GO:0031673 H zone(GO:0031673)
0.1 0.8 GO:0005922 connexon complex(GO:0005922)
0.0 0.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.8 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.7 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.5 GO:0005839 proteasome core complex(GO:0005839)
0.1 0.4 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.5 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 2.9 GO:0030165 PDZ domain binding(GO:0030165)
0.2 2.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 1.8 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.4 1.6 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 1.6 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.4 1.2 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.2 1.2 GO:0004043 L-aminoadipate-semialdehyde dehydrogenase activity(GO:0004043)
0.0 0.9 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.9 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.4 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.6 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.4 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 1.6 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 1.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.9 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 0.8 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.4 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.3 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors