Motif ID: Maf_Nrl

Z-value: 0.635

Transcription factors associated with Maf_Nrl:

Gene SymbolEntrez IDGene Name
Maf ENSMUSG00000055435.6 Maf
Nrl ENSMUSG00000040632.9 Nrl

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafmm10_v2_chr8_-_115707778_115707794-0.367.7e-03Click!


Activity profile for motif Maf_Nrl.

activity profile for motif Maf_Nrl


Sorted Z-values histogram for motif Maf_Nrl

Sorted Z-values for motif Maf_Nrl



Network of associatons between targets according to the STRING database.



First level regulatory network of Maf_Nrl

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_136260873 3.652 ENSMUST00000086395.5
 Gpr25
G protein-coupled receptor 25
chr15_-_93519499 3.448 ENSMUST00000109255.2
 Prickle1
prickle homolog 1 (Drosophila)
chr15_-_67113909 3.393 ENSMUST00000092640.5
 St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr13_+_83504032 2.792 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr5_+_110544326 2.775 ENSMUST00000040001.7
 Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr2_-_118373347 2.672 ENSMUST00000039160.2
 Gpr176
G protein-coupled receptor 176
chr15_+_89453913 2.159 ENSMUST00000023291.5
 Mapk8ip2
mitogen-activated protein kinase 8 interacting protein 2
chr7_-_75308373 2.061 ENSMUST00000085164.5
 Sv2b
synaptic vesicle glycoprotein 2 b
chr14_-_102982630 2.038 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130
chr14_-_49525840 2.022 ENSMUST00000138884.1
ENSMUST00000074368.4
ENSMUST00000123534.1
 Slc35f4


solute carrier family 35, member F4


chr2_-_151632471 1.989 ENSMUST00000137936.1
ENSMUST00000146172.1
ENSMUST00000094456.3
ENSMUST00000148755.1
ENSMUST00000109875.1
ENSMUST00000028951.7
ENSMUST00000109877.3
 Snph






syntaphilin






chr7_+_121707189 1.931 ENSMUST00000065310.2
 1700069B07Rik
RIKEN cDNA 1700069B07 gene
chr19_+_38264761 1.911 ENSMUST00000087252.5
 Lgi1
leucine-rich repeat LGI family, member 1
chr7_+_29309429 1.860 ENSMUST00000137848.1
 Dpf1
D4, zinc and double PHD fingers family 1
chr15_+_83779999 1.771 ENSMUST00000046168.5
 Mpped1
metallophosphoesterase domain containing 1
chr3_-_120886691 1.716 ENSMUST00000182099.1
ENSMUST00000183168.1
ENSMUST00000183276.1
ENSMUST00000182124.1
 6530403H02Rik



RIKEN cDNA 6530403H02 gene



chr6_+_110645572 1.696 ENSMUST00000071076.6
ENSMUST00000172951.1
 Grm7

glutamate receptor, metabotropic 7

chr15_+_83779975 1.677 ENSMUST00000163723.1
 Mpped1
metallophosphoesterase domain containing 1
chr3_-_79145875 1.642 ENSMUST00000118340.1
 Rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
chr13_+_42709482 1.619 ENSMUST00000066928.5
ENSMUST00000148891.1
 Phactr1

phosphatase and actin regulator 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 3.4 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.1 3.4 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 3.2 GO:0030818 negative regulation of cAMP biosynthetic process(GO:0030818)
0.9 2.8 GO:2000111 cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.4 2.6 GO:0072318 clathrin coat disassembly(GO:0072318)
0.2 2.2 GO:0046958 nonassociative learning(GO:0046958)
0.0 2.0 GO:0045806 negative regulation of endocytosis(GO:0045806)
0.2 1.9 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.3 1.7 GO:0001661 conditioned taste aversion(GO:0001661)
0.5 1.6 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0 1.6 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.4 1.5 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 1.5 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 1.5 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.5 1.4 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.4 1.3 GO:0048014 Tie signaling pathway(GO:0048014)
0.3 1.3 GO:0015671 oxygen transport(GO:0015671)
0.4 1.2 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.2 1.2 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.2 1.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.3 GO:0014069 postsynaptic density(GO:0014069)
0.0 4.1 GO:0031965 nuclear membrane(GO:0031965)
0.0 3.4 GO:0005770 late endosome(GO:0005770)
0.0 3.1 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 2.1 GO:0009925 basal plasma membrane(GO:0009925)
0.1 1.9 GO:0071565 nBAF complex(GO:0071565)
0.0 1.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 1.7 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 1.6 GO:0043195 terminal bouton(GO:0043195)
0.1 1.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.3 1.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.2 1.3 GO:0005833 hemoglobin complex(GO:0005833)
0.0 1.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.4 1.2 GO:0043512 inhibin A complex(GO:0043512)
0.1 1.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.3 1.1 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.1 1.1 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 1.1 GO:0070852 cell body fiber(GO:0070852)
0.1 1.1 GO:0030057 desmosome(GO:0030057)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.3 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 3.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.8 3.4 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.2 2.8 GO:0003680 AT DNA binding(GO:0003680)
0.0 2.5 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 2.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.6 1.7 GO:0070905 serine binding(GO:0070905)
0.2 1.6 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.2 1.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 1.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 1.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.4 GO:0043621 protein self-association(GO:0043621)
0.3 1.3 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.3 1.2 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.2 1.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.4 1.1 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.3 1.1 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 1.1 GO:0031749 D2 dopamine receptor binding(GO:0031749)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.9 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 2.9 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 2.1 PID_SHP2_PATHWAY SHP2 signaling
0.0 1.6 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.6 PID_ALK1_PATHWAY ALK1 signaling events
0.0 1.5 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.0 1.5 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.2 PID_BMP_PATHWAY BMP receptor signaling
0.1 1.1 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.1 1.1 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 1.0 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 1.0 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.8 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 0.6 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.6 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 0.5 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.5 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.9 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 2.8 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 2.8 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 2.6 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 2.3 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 2.1 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 1.3 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.3 1.2 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 1.2 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.4 1.1 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.1 1.1 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 1.1 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 1.1 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 0.8 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.8 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.8 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.8 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.7 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation