Motif ID: Mafa

Z-value: 1.200


Transcription factors associated with Mafa:

Gene SymbolEntrez IDGene Name
Mafa ENSMUSG00000047591.4 Mafa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafamm10_v2_chr15_-_75747922_75747922-0.447.9e-04Click!


Activity profile for motif Mafa.

activity profile for motif Mafa


Sorted Z-values histogram for motif Mafa

Sorted Z-values for motif Mafa



Network of associatons between targets according to the STRING database.



First level regulatory network of Mafa

PNG image of the network

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Top targets:


Showing 1 to 20 of 86 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_98032983 19.816 ENSMUST00000162295.1
 Clstn2
calsyntenin 2
chr9_-_98033181 17.624 ENSMUST00000035027.6
 Clstn2
calsyntenin 2
chr14_+_119138415 15.414 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr1_-_169747634 14.449 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr16_-_17576631 12.798 ENSMUST00000164545.1
ENSMUST00000164490.1
ENSMUST00000172164.1
 Slc7a4


solute carrier family 7 (cationic amino acid transporter, y+ system), member 4


chr1_-_136260873 12.553 ENSMUST00000086395.5
 Gpr25
G protein-coupled receptor 25
chr4_+_102254993 11.672 ENSMUST00000106908.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr4_+_102254739 11.211 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr7_+_54835959 10.830 ENSMUST00000082373.6
 Luzp2
leucine zipper protein 2
chr1_-_38836090 7.886 ENSMUST00000147695.1
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr8_-_70487314 7.708 ENSMUST00000045286.7
 Tmem59l
transmembrane protein 59-like
chr11_-_66525964 6.842 ENSMUST00000066679.6
 Shisa6
shisa homolog 6 (Xenopus laevis)
chr11_-_66525795 6.675 ENSMUST00000123454.1
 Shisa6
shisa homolog 6 (Xenopus laevis)
chr10_+_58813359 6.467 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chrX_-_73869804 6.383 ENSMUST00000066576.5
ENSMUST00000114430.1
 L1cam

L1 cell adhesion molecule

chr12_+_3365108 5.704 ENSMUST00000020999.5
 Kif3c
kinesin family member 3C
chr5_-_142509653 5.661 ENSMUST00000110784.1
 Radil
Ras association and DIL domains
chr16_-_74411292 5.219 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr16_-_74411776 5.104 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr19_+_27217011 5.081 ENSMUST00000164746.1
ENSMUST00000172302.1
 Vldlr

very low density lipoprotein receptor


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 37.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.8 22.9 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
2.6 15.4 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 13.8 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.7 13.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.4 12.8 GO:0003333 amino acid transmembrane transport(GO:0003333)
3.4 10.3 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
2.0 10.0 GO:0034436 glycoprotein transport(GO:0034436)
0.0 8.9 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.1 7.9 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.5 7.1 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.6 6.4 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.1 5.7 GO:0072384 organelle transport along microtubule(GO:0072384)
0.1 5.7 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.3 4.5 GO:0008272 sulfate transport(GO:0008272)
0.1 4.5 GO:0048663 neuron fate commitment(GO:0048663)
0.5 4.3 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.1 4.3 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.6 4.2 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.4 4.2 GO:0046543 development of secondary female sexual characteristics(GO:0046543)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 42.7 GO:0016021 integral component of membrane(GO:0016021)
0.1 37.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.9 22.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.3 13.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 10.3 GO:0030673 axolemma(GO:0030673)
0.8 10.0 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.9 7.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.5 6.4 GO:0044294 dendritic growth cone(GO:0044294)
0.0 6.2 GO:0001650 fibrillar center(GO:0001650)
0.6 5.7 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 4.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 3.3 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.2 2.9 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 2.9 GO:0043679 axon terminus(GO:0043679)
0.1 2.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 1.9 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.1 1.6 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 1.5 GO:0005769 early endosome(GO:0005769)
0.0 1.4 GO:0008180 COP9 signalosome(GO:0008180)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 25.9 GO:0005509 calcium ion binding(GO:0005509)
0.7 22.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
3.9 15.4 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.4 14.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 12.8 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
1.1 10.3 GO:0008046 axon guidance receptor activity(GO:0008046)
3.3 10.0 GO:0034437 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
0.2 7.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 6.6 GO:0004930 G-protein coupled receptor activity(GO:0004930)
1.1 6.4 GO:0033691 sialic acid binding(GO:0033691)
0.1 5.7 GO:0019894 kinesin binding(GO:0019894)
0.0 5.6 GO:0017137 Rab GTPase binding(GO:0017137)
1.4 4.3 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 4.3 GO:0002039 p53 binding(GO:0002039)
0.0 4.1 GO:0005543 phospholipid binding(GO:0005543)
0.1 3.6 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.6 3.3 GO:0070728 leucine binding(GO:0070728)
0.5 3.2 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.1 3.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 2.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.5 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 6.4 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.2 5.7 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.3 4.3 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.2 2.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 0.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 23.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.4 15.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 14.4 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.3 10.3 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.2 6.4 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.2 5.7 REACTOME_KINESINS Genes involved in Kinesins
0.2 4.3 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 2.9 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 2.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.9 2.8 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.2 2.5 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.2 2.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.2 2.2 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 2.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.6 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 1.1 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.3 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds