Motif ID: Mafb

Z-value: 0.586


Transcription factors associated with Mafb:

Gene SymbolEntrez IDGene Name
Mafb ENSMUSG00000074622.3 Mafb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafbmm10_v2_chr2_-_160367057_1603670730.123.8e-01Click!


Activity profile for motif Mafb.

activity profile for motif Mafb


Sorted Z-values histogram for motif Mafb

Sorted Z-values for motif Mafb



Network of associatons between targets according to the STRING database.



First level regulatory network of Mafb

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_120202104 4.946 ENSMUST00000033198.5
 Crym
crystallin, mu
chr4_-_136886187 3.957 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr18_+_65873478 3.522 ENSMUST00000025395.8
ENSMUST00000173530.1
 Grp

gastrin releasing peptide

chr2_+_170731807 3.261 ENSMUST00000029075.4
 Dok5
docking protein 5
chr9_-_77347816 3.080 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
 Mlip



muscular LMNA-interacting protein



chr3_+_65109343 2.660 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr19_-_5510467 2.541 ENSMUST00000070172.4
 Snx32
sorting nexin 32
chr19_+_26753588 2.480 ENSMUST00000177116.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr15_-_33687840 2.401 ENSMUST00000042021.3
 Tspyl5
testis-specific protein, Y-encoded-like 5
chr9_-_77347787 2.316 ENSMUST00000184848.1
ENSMUST00000184415.1
 Mlip

muscular LMNA-interacting protein

chr14_+_80000292 2.273 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr17_+_3532554 2.253 ENSMUST00000168560.1
 Cldn20
claudin 20
chr7_-_141010759 2.106 ENSMUST00000026565.6
 Ifitm3
interferon induced transmembrane protein 3
chr10_+_40349265 2.025 ENSMUST00000044672.4
ENSMUST00000095743.2
 Cdk19

cyclin-dependent kinase 19

chr1_-_136260873 1.968 ENSMUST00000086395.5
 Gpr25
G protein-coupled receptor 25
chr4_+_102421518 1.949 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr5_-_92042999 1.943 ENSMUST00000069937.4
ENSMUST00000086978.5
 Cdkl2

cyclin-dependent kinase-like 2 (CDC2-related kinase)

chr9_-_18473559 1.929 ENSMUST00000034647.4
 Zfp558
zinc finger protein 558
chr11_-_116307168 1.873 ENSMUST00000124281.1
 Exoc7
exocyst complex component 7
chr10_-_62379852 1.864 ENSMUST00000143236.1
ENSMUST00000133429.1
ENSMUST00000132926.1
ENSMUST00000116238.2
 Hk1



hexokinase 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.4 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
1.0 4.9 GO:0070327 thyroid hormone transport(GO:0070327)
0.8 4.2 GO:0051012 microtubule sliding(GO:0051012)
0.2 4.0 GO:0006958 complement activation, classical pathway(GO:0006958)
1.2 3.5 GO:0061744 motor behavior(GO:0061744) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.2 3.3 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.0 3.3 GO:0006334 nucleosome assembly(GO:0006334)
0.0 2.9 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.2 2.7 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.3 2.5 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 2.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 2.3 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 2.2 GO:0007605 sensory perception of sound(GO:0007605)
0.1 2.1 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 2.0 GO:0007416 synapse assembly(GO:0007416)
0.3 1.9 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 1.9 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.9 GO:0035635 entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535)
0.0 1.9 GO:0015807 L-amino acid transport(GO:0015807)
0.6 1.8 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.8 GO:0016605 PML body(GO:0016605)
0.1 4.0 GO:0005581 collagen trimer(GO:0005581)
0.2 2.7 GO:1990635 proximal dendrite(GO:1990635)
0.1 2.6 GO:0097228 sperm principal piece(GO:0097228)
0.0 2.6 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.2 2.3 GO:0042581 specific granule(GO:0042581)
0.1 2.1 GO:0071564 npBAF complex(GO:0071564)
0.1 1.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.7 GO:0032040 small-subunit processome(GO:0032040)
0.0 1.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 1.5 GO:0032584 growth cone membrane(GO:0032584)
0.3 1.4 GO:1990357 terminal web(GO:1990357)
0.1 1.4 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 1.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.2 1.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 1.3 GO:0044754 secondary lysosome(GO:0005767) autolysosome(GO:0044754)
0.1 1.3 GO:0005771 multivesicular body(GO:0005771)
0.0 1.3 GO:0032391 photoreceptor connecting cilium(GO:0032391)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.1 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.5 4.9 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 4.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2 3.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 2.7 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 2.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2 2.1 GO:0015643 toxic substance binding(GO:0015643)
0.1 2.0 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.4 1.9 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 1.9 GO:0043015 gamma-tubulin binding(GO:0043015)
0.5 1.8 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.4 1.8 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.4 1.8 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 1.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.8 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 1.7 GO:0005158 insulin receptor binding(GO:0005158)
0.0 1.6 GO:0005262 calcium channel activity(GO:0005262)
0.4 1.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 1.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 1.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 2.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 2.0 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 1.9 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 1.8 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.4 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.2 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.2 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.1 PID_ARF_3PATHWAY Arf1 pathway
0.1 1.0 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 0.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.7 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.7 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.6 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.5 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.3 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 4.0 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 3.5 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.2 3.2 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 3.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.9 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.6 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 2.1 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 2.0 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.9 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.8 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 1.7 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 1.5 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 1.4 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.1 1.4 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 1.2 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.1 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 1.0 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 0.9 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 0.9 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism