Motif ID: Max_Mycn

Z-value: 2.709

Transcription factors associated with Max_Mycn:

Gene SymbolEntrez IDGene Name
Max ENSMUSG00000059436.6 Max
Mycn ENSMUSG00000037169.8 Mycn

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Maxmm10_v2_chr12_-_76962178_76962248-0.367.8e-03Click!
Mycnmm10_v2_chr12_-_12940600_129406160.162.5e-01Click!


Activity profile for motif Max_Mycn.

activity profile for motif Max_Mycn


Sorted Z-values histogram for motif Max_Mycn

Sorted Z-values for motif Max_Mycn



Network of associatons between targets according to the STRING database.



First level regulatory network of Max_Mycn

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_135251209 26.437 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr5_+_140607334 24.003 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr4_-_137796350 21.858 ENSMUST00000030551.4
 Alpl
alkaline phosphatase, liver/bone/kidney
chr4_-_143299498 21.174 ENSMUST00000030317.7
 Pdpn
podoplanin
chr7_+_144896523 20.978 ENSMUST00000033389.5
 Fgf15
fibroblast growth factor 15
chr4_-_143299463 19.274 ENSMUST00000119654.1
 Pdpn
podoplanin
chr12_+_117843873 17.520 ENSMUST00000176735.1
ENSMUST00000177339.1
 Cdca7l

cell division cycle associated 7 like

chr11_-_89302545 16.962 ENSMUST00000061728.3
 Nog
noggin
chr10_+_127063599 15.886 ENSMUST00000120226.1
ENSMUST00000133115.1
 Cdk4

cyclin-dependent kinase 4

chr8_+_27260327 15.526 ENSMUST00000033880.5
 Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
chr14_-_79301623 15.380 ENSMUST00000022595.7
 Rgcc
regulator of cell cycle
chr10_-_30842765 15.312 ENSMUST00000019924.8
 Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr8_-_46294592 15.145 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr11_-_94601862 15.129 ENSMUST00000103164.3
 Acsf2
acyl-CoA synthetase family member 2
chr16_+_30065333 14.533 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr10_-_77113676 14.316 ENSMUST00000072755.4
ENSMUST00000105409.1
 Col18a1

collagen, type XVIII, alpha 1

chr17_+_46496753 14.195 ENSMUST00000046497.6
 Dnph1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
chr5_+_114130386 14.159 ENSMUST00000031587.6
 Ung
uracil DNA glycosylase
chr2_+_156840966 14.023 ENSMUST00000109564.1
 Tgif2
TGFB-induced factor homeobox 2
chr11_-_12026732 13.746 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 636 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 43.4 GO:0006414 translational elongation(GO:0006414)
8.1 40.4 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
9.1 36.4 GO:0046073 dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
5.5 33.0 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
3.4 30.5 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
7.2 28.9 GO:0010288 response to lead ion(GO:0010288)
2.5 27.8 GO:0006228 UTP biosynthetic process(GO:0006228)
8.8 26.4 GO:1990523 bone regeneration(GO:1990523)
6.6 26.2 GO:0035905 ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.8 26.2 GO:0046677 response to antibiotic(GO:0046677)
0.8 24.2 GO:0048255 mRNA stabilization(GO:0048255)
4.8 24.0 GO:0007386 compartment pattern specification(GO:0007386)
0.5 21.7 GO:0016925 protein sumoylation(GO:0016925)
1.8 21.2 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
1.5 20.9 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
5.1 20.5 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
4.0 20.0 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
1.6 18.8 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
1.0 18.5 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
1.1 18.2 GO:0038092 nodal signaling pathway(GO:0038092)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 260 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 125.9 GO:0005739 mitochondrion(GO:0005739)
0.1 113.2 GO:0005576 extracellular region(GO:0005576)
0.2 66.1 GO:0005925 focal adhesion(GO:0005925)
0.6 50.0 GO:0022626 cytosolic ribosome(GO:0022626)
0.9 48.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 47.0 GO:0005759 mitochondrial matrix(GO:0005759)
0.7 37.5 GO:0000791 euchromatin(GO:0000791)
4.1 36.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
3.2 35.2 GO:0005642 annulate lamellae(GO:0005642)
1.6 33.0 GO:0031527 filopodium membrane(GO:0031527)
0.7 32.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
5.0 29.9 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
7.2 28.9 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.4 28.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
1.8 25.3 GO:0035686 sperm fibrous sheath(GO:0035686)
1.5 25.3 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.2 23.2 GO:0001650 fibrillar center(GO:0001650)
0.2 19.1 GO:0016363 nuclear matrix(GO:0016363)
2.6 18.3 GO:0097422 tubular endosome(GO:0097422)
0.4 18.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 414 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 74.6 GO:0003735 structural constituent of ribosome(GO:0003735)
2.9 70.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 49.0 GO:0003723 RNA binding(GO:0003723)
1.0 46.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
3.7 40.2 GO:0015250 water channel activity(GO:0015250)
0.7 32.6 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 30.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.8 29.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.6 28.3 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
1.2 28.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.7 27.5 GO:0045182 translation regulator activity(GO:0045182)
9.1 27.3 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
1.4 25.7 GO:0051920 peroxiredoxin activity(GO:0051920)
6.3 25.3 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.4 22.2 GO:0019955 cytokine binding(GO:0019955)
5.2 20.9 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
1.7 20.3 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
6.7 20.0 GO:0035939 microsatellite binding(GO:0035939)
3.2 19.4 GO:0043426 MRF binding(GO:0043426)
0.7 19.2 GO:0008432 JUN kinase binding(GO:0008432)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 154.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.7 54.4 PID_INSULIN_PATHWAY Insulin Pathway
3.5 48.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
1.0 30.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.4 28.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.7 26.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.2 23.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.4 22.2 PID_BMP_PATHWAY BMP receptor signaling
0.7 21.6 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.5 19.9 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.6 17.7 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.5 17.6 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.3 16.8 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.2 15.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.6 15.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.3 11.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.3 11.0 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.3 11.0 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.5 10.6 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.6 10.3 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 63.7 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
1.3 61.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.9 48.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.5 48.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.7 43.2 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION Genes involved in 3' -UTR-mediated translational regulation
1.7 35.8 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
1.6 35.8 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
2.5 34.8 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
1.3 33.9 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.4 33.1 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.4 28.3 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.3 27.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
1.6 26.7 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
1.5 24.7 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.9 24.3 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.4 21.2 REACTOME_TRANSLATION Genes involved in Translation
0.4 21.1 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
1.3 21.0 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.7 21.0 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.7 20.0 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo