Motif ID: Maz_Zfp281

Z-value: 1.745

Transcription factors associated with Maz_Zfp281:

Gene SymbolEntrez IDGene Name
Maz ENSMUSG00000030678.6 Maz
Zfp281 ENSMUSG00000041483.8 Zfp281

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mazmm10_v2_chr7_-_127026479_1270264960.741.2e-10Click!
Zfp281mm10_v2_chr1_+_136624901_1366249490.211.3e-01Click!


Activity profile for motif Maz_Zfp281.

activity profile for motif Maz_Zfp281


Sorted Z-values histogram for motif Maz_Zfp281

Sorted Z-values for motif Maz_Zfp281



Network of associatons between targets according to the STRING database.



First level regulatory network of Maz_Zfp281

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_98169542 19.100 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr16_+_84774123 19.062 ENSMUST00000114195.1
 Jam2
junction adhesion molecule 2
chr8_+_12395287 18.938 ENSMUST00000180353.1
 Sox1
SRY-box containing gene 1
chr4_+_154960915 17.511 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr6_+_134929089 16.324 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
 RP23-45G16.5


RP23-45G16.5


chr7_+_19094594 16.192 ENSMUST00000049454.5
 Six5
sine oculis-related homeobox 5
chr7_-_144939823 15.436 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr14_-_118052235 15.342 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr17_+_85620816 15.340 ENSMUST00000175898.2
 Six3
sine oculis-related homeobox 3
chr10_-_120476469 15.070 ENSMUST00000072777.7
ENSMUST00000159699.1
 Hmga2

high mobility group AT-hook 2

chr11_-_88718223 14.932 ENSMUST00000107909.1
 Msi2
musashi RNA-binding protein 2
chr1_-_138847579 14.714 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr11_-_102579071 14.526 ENSMUST00000107080.1
 Gm11627
predicted gene 11627
chr11_-_102579461 14.269 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chr5_+_108694222 14.036 ENSMUST00000013633.8
ENSMUST00000112560.3
 Fgfrl1

fibroblast growth factor receptor-like 1

chr10_+_108332173 13.848 ENSMUST00000095313.3
 Pawr
PRKC, apoptosis, WT1, regulator
chr11_-_88718165 13.695 ENSMUST00000107908.1
 Msi2
musashi RNA-binding protein 2
chr17_+_85613432 13.683 ENSMUST00000176081.1
 Six3
sine oculis-related homeobox 3
chr2_+_71529085 13.664 ENSMUST00000152711.1
 Dlx1
distal-less homeobox 1
chr6_+_134929118 12.813 ENSMUST00000185152.1
ENSMUST00000184504.1
 RP23-45G16.5

RP23-45G16.5


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,128 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 44.1 GO:0038092 nodal signaling pathway(GO:0038092)
12.3 37.0 GO:0097402 neuroblast migration(GO:0097402)
3.6 35.9 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
2.9 35.1 GO:0021978 telencephalon regionalization(GO:0021978)
2.2 31.2 GO:0014841 skeletal muscle satellite cell proliferation(GO:0014841)
6.1 30.4 GO:0035262 gonad morphogenesis(GO:0035262)
10.1 30.2 GO:0030421 defecation(GO:0030421)
1.4 30.0 GO:0050434 positive regulation of viral transcription(GO:0050434)
4.8 29.0 GO:0070094 positive regulation of glucagon secretion(GO:0070094)
9.2 27.6 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
2.5 27.6 GO:0006105 succinate metabolic process(GO:0006105)
8.9 26.8 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.7 24.6 GO:0051310 metaphase plate congression(GO:0051310)
4.8 24.1 GO:0048382 mesendoderm development(GO:0048382)
3.4 23.9 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
2.4 23.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
5.8 23.4 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
1.4 22.7 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
3.2 22.4 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
1.2 22.4 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 339 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 578.0 GO:0005634 nucleus(GO:0005634)
0.5 181.1 GO:0005667 transcription factor complex(GO:0005667)
0.9 69.0 GO:0005844 polysome(GO:0005844)
1.0 48.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 40.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.8 38.7 GO:0000791 euchromatin(GO:0000791)
2.8 30.5 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 26.0 GO:0000228 nuclear chromosome(GO:0000228)
0.2 25.6 GO:0000775 chromosome, centromeric region(GO:0000775)
1.2 24.4 GO:0010369 chromocenter(GO:0010369)
0.3 21.2 GO:0000793 condensed chromosome(GO:0000793)
3.3 19.5 GO:0031262 Ndc80 complex(GO:0031262)
1.6 18.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
1.4 18.1 GO:0097542 ciliary tip(GO:0097542)
0.4 18.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 17.6 GO:0005681 spliceosomal complex(GO:0005681)
3.4 16.8 GO:0097149 centralspindlin complex(GO:0097149)
0.9 16.6 GO:0097470 ribbon synapse(GO:0097470)
1.5 16.3 GO:0005915 zonula adherens(GO:0005915)
2.2 15.4 GO:0001740 Barr body(GO:0001740)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 564 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 155.1 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.3 146.7 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.6 78.7 GO:0001047 core promoter binding(GO:0001047)
0.9 69.9 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 55.2 GO:0003677 DNA binding(GO:0003677)
0.8 53.6 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.9 51.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
2.7 43.8 GO:0003680 AT DNA binding(GO:0003680)
1.6 37.1 GO:0001222 transcription corepressor binding(GO:0001222)
1.5 36.7 GO:0008266 poly(U) RNA binding(GO:0008266)
1.5 35.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
1.0 33.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
1.1 29.4 GO:0071837 HMG box domain binding(GO:0071837)
0.8 27.5 GO:0070888 E-box binding(GO:0070888)
0.7 26.8 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
4.4 26.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
3.2 25.8 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
5.1 25.7 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
3.5 24.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.8 23.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 81.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.9 76.7 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
1.3 60.8 PID_AURORA_B_PATHWAY Aurora B signaling
1.2 55.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.9 53.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
3.5 49.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.9 48.0 PID_BMP_PATHWAY BMP receptor signaling
0.9 44.9 PID_PLK1_PATHWAY PLK1 signaling events
1.3 41.1 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.4 37.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
1.2 35.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.5 33.5 PID_CDC42_PATHWAY CDC42 signaling events
0.6 31.7 PID_IL12_2PATHWAY IL12-mediated signaling events
0.6 28.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.4 28.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.9 27.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.6 21.0 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
1.1 18.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.7 16.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.7 15.2 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 158 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 83.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 61.2 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION Genes involved in Class I MHC mediated antigen processing & presentation
1.6 49.4 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
1.6 43.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
1.2 40.9 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
1.6 37.8 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.3 36.1 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
1.1 35.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.8 35.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
1.0 24.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.5 24.8 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.5 24.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
1.2 24.5 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.8 22.9 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.3 22.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
1.5 20.9 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.9 20.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.5 19.4 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.6 17.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.9 17.6 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters