Motif ID: Mbd2

Z-value: 1.072


Transcription factors associated with Mbd2:

Gene SymbolEntrez IDGene Name
Mbd2 ENSMUSG00000024513.10 Mbd2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mbd2mm10_v2_chr18_+_70568189_70568398-0.181.8e-01Click!


Activity profile for motif Mbd2.

activity profile for motif Mbd2


Sorted Z-values histogram for motif Mbd2

Sorted Z-values for motif Mbd2



Network of associatons between targets according to the STRING database.



First level regulatory network of Mbd2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_108003414 8.633 ENSMUST00000109887.1
ENSMUST00000109891.2
 Bcl11b

B cell leukemia/lymphoma 11B

chr5_+_30588078 7.739 ENSMUST00000066295.2
 Kcnk3
potassium channel, subfamily K, member 3
chr11_-_75796048 6.392 ENSMUST00000021209.7
 Doc2b
double C2, beta
chr14_-_39472825 5.965 ENSMUST00000168810.2
ENSMUST00000173780.1
ENSMUST00000166968.2
 Nrg3


neuregulin 3


chr5_+_37028329 5.642 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr4_-_120747248 5.623 ENSMUST00000030376.7
 Kcnq4
potassium voltage-gated channel, subfamily Q, member 4
chr1_+_75375271 5.483 ENSMUST00000087122.5
 Speg
SPEG complex locus
chr6_-_126740151 4.750 ENSMUST00000112242.1
 Kcna6
potassium voltage-gated channel, shaker-related, subfamily, member 6
chr18_-_58209926 4.726 ENSMUST00000025497.6
 Fbn2
fibrillin 2
chr19_+_56722372 4.651 ENSMUST00000038949.4
 Adrb1
adrenergic receptor, beta 1
chr13_+_110395041 4.624 ENSMUST00000022212.7
 Plk2
polo-like kinase 2
chr13_+_46418266 4.471 ENSMUST00000037923.3
 Rbm24
RNA binding motif protein 24
chr5_+_36868467 4.452 ENSMUST00000031003.7
 Ppp2r2c
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform
chr11_+_7063423 4.268 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr15_-_28025834 4.040 ENSMUST00000090247.5
 Trio
triple functional domain (PTPRF interacting)
chr10_+_13966268 3.761 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr9_-_51008936 3.640 ENSMUST00000176824.1
ENSMUST00000176663.1
ENSMUST00000041375.10
 Sik2


salt inducible kinase 2


chr11_+_104231573 3.583 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau


chr13_-_52981027 3.579 ENSMUST00000071065.7
 Nfil3
nuclear factor, interleukin 3, regulated
chr7_-_126082406 3.537 ENSMUST00000073935.5
 Gsg1l
GSG1-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 164 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 13.4 GO:1900034 regulation of cellular response to heat(GO:1900034)
1.9 11.5 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.8 7.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.4 6.4 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 5.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
1.4 5.6 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.3 5.4 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
1.6 4.7 GO:1900133 renin secretion into blood stream(GO:0002001) regulation of renin secretion into blood stream(GO:1900133)
0.9 4.7 GO:0071692 protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.3 4.6 GO:0032486 Rap protein signal transduction(GO:0032486)
0.2 4.5 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.9 4.4 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.2 4.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
1.4 4.3 GO:0060596 mammary placode formation(GO:0060596)
0.3 4.3 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.1 3.6 GO:0016578 histone deubiquitination(GO:0016578)
0.1 3.6 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 3.6 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.2 3.5 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.1 3.3 GO:0043496 regulation of protein homodimerization activity(GO:0043496)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 13.4 GO:0045298 tubulin complex(GO:0045298)
0.1 10.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 10.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 6.8 GO:0005769 early endosome(GO:0005769)
0.1 6.4 GO:0031201 SNARE complex(GO:0031201)
0.0 6.3 GO:0030027 lamellipodium(GO:0030027)
0.0 6.3 GO:0060076 excitatory synapse(GO:0060076)
0.2 6.0 GO:0071565 nBAF complex(GO:0071565)
0.1 5.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 5.1 GO:0019898 extrinsic component of membrane(GO:0019898)
0.4 4.7 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 4.6 GO:0005814 centriole(GO:0005814)
0.2 4.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
1.1 4.4 GO:1990032 parallel fiber(GO:1990032)
0.2 4.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 3.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 3.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 3.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 3.6 GO:0009986 cell surface(GO:0009986)
0.2 3.5 GO:0032279 asymmetric synapse(GO:0032279)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 13.4 GO:0099609 microtubule lateral binding(GO:0099609)
0.7 7.7 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 6.5 GO:0005509 calcium ion binding(GO:0005509)
0.1 6.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 6.4 GO:0048365 Rac GTPase binding(GO:0048365)
0.4 6.0 GO:0045499 chemorepellent activity(GO:0045499)
0.1 5.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.8 5.0 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 4.9 GO:0000287 magnesium ion binding(GO:0000287)
1.6 4.7 GO:0051379 epinephrine binding(GO:0051379)
0.3 4.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.3 4.7 GO:0050811 GABA receptor binding(GO:0050811)
0.3 4.6 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.6 4.4 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.2 4.4 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 4.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.7 4.3 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.3 4.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.4 3.9 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 3.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 12.5 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 6.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.4 6.0 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 5.0 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 4.9 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 4.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 4.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 4.3 PID_LKB1_PATHWAY LKB1 signaling events
0.1 2.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.0 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 1.6 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.6 PID_P53_REGULATION_PATHWAY p53 pathway
0.2 1.5 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 1.5 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 1.5 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.5 ST_GAQ_PATHWAY G alpha q Pathway
0.1 1.4 PID_IGF1_PATHWAY IGF1 pathway
0.1 1.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 1.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.2 PID_IL6_7_PATHWAY IL6-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 13.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 10.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
1.1 7.7 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.4 4.7 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 4.4 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 4.4 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.4 4.3 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 2.9 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 2.9 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.4 2.8 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.1 2.5 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 2.0 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.2 1.7 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.1 1.6 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 1.6 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 1.3 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.1 1.3 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.1 1.3 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 1.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects