Motif ID: Mecp2

Z-value: 2.762


Transcription factors associated with Mecp2:

Gene SymbolEntrez IDGene Name
Mecp2 ENSMUSG00000031393.10 Mecp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mecp2mm10_v2_chrX_-_74085586_74085652-0.162.4e-01Click!


Activity profile for motif Mecp2.

activity profile for motif Mecp2


Sorted Z-values histogram for motif Mecp2

Sorted Z-values for motif Mecp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Mecp2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_86033777 25.456 ENSMUST00000016172.7
 Celsr1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr6_-_72788952 24.077 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr10_-_42583628 23.402 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr11_+_112782182 22.257 ENSMUST00000000579.2
 Sox9
SRY-box containing gene 9
chr13_-_56252163 21.238 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr8_-_87959560 20.619 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr11_+_98412461 20.425 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr11_-_12037391 20.115 ENSMUST00000093321.5
 Grb10
growth factor receptor bound protein 10
chr14_-_118237016 20.006 ENSMUST00000170662.1
 Sox21
SRY-box containing gene 21
chr6_+_128362919 19.914 ENSMUST00000073316.6
 Foxm1
forkhead box M1
chr16_+_33684460 19.840 ENSMUST00000152782.1
ENSMUST00000179453.1
 Heg1

HEG homolog 1 (zebrafish)

chr19_+_7268296 19.602 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr6_-_72789240 19.546 ENSMUST00000069536.5
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr7_-_25250720 18.687 ENSMUST00000116343.2
ENSMUST00000045847.8
 Erf

Ets2 repressor factor

chr14_-_67715585 18.478 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr2_+_59612034 17.395 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr11_-_100850724 16.687 ENSMUST00000004143.2
 Stat5b
signal transducer and activator of transcription 5B
chr11_-_68386821 16.390 ENSMUST00000021284.3
 Ntn1
netrin 1
chr2_+_91457501 16.328 ENSMUST00000028689.3
 Lrp4
low density lipoprotein receptor-related protein 4
chr4_+_8690399 16.093 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,076 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 43.0 GO:0010216 maintenance of DNA methylation(GO:0010216)
13.6 40.8 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
5.2 36.2 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838)
3.0 35.6 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
1.3 35.4 GO:0035329 hippo signaling(GO:0035329)
5.9 35.2 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.6 33.5 GO:0051225 spindle assembly(GO:0051225)
11.0 33.0 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
11.0 32.9 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
2.2 32.5 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
1.1 30.6 GO:0006270 DNA replication initiation(GO:0006270)
1.4 30.1 GO:0038092 nodal signaling pathway(GO:0038092)
4.9 29.5 GO:0003383 apical constriction(GO:0003383)
2.7 29.3 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
2.2 28.4 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
3.5 28.3 GO:0010032 meiotic chromosome condensation(GO:0010032)
7.1 28.2 GO:0021603 cranial nerve formation(GO:0021603)
2.3 28.1 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
2.0 27.4 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.3 26.7 GO:0051028 mRNA transport(GO:0051028)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 339 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 344.5 GO:0005634 nucleus(GO:0005634)
0.1 204.7 GO:0005654 nucleoplasm(GO:0005654)
0.7 148.4 GO:0005667 transcription factor complex(GO:0005667)
0.8 130.7 GO:0044798 nuclear transcription factor complex(GO:0044798)
1.0 80.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.8 60.7 GO:0005844 polysome(GO:0005844)
4.7 60.5 GO:0043219 lateral loop(GO:0043219)
0.3 53.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 50.7 GO:0005694 chromosome(GO:0005694)
0.5 48.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.9 43.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
3.9 39.2 GO:0000796 condensin complex(GO:0000796)
0.2 38.0 GO:0016607 nuclear speck(GO:0016607)
0.2 34.0 GO:0005681 spliceosomal complex(GO:0005681)
3.0 33.2 GO:0016600 flotillin complex(GO:0016600)
6.5 32.4 GO:0097149 centralspindlin complex(GO:0097149)
1.3 31.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
10.5 31.5 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.4 29.8 GO:0000922 spindle pole(GO:0000922)
1.2 28.5 GO:0001741 XY body(GO:0001741)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 570 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 174.4 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.8 140.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 107.9 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.2 76.0 GO:0003677 DNA binding(GO:0003677)
0.5 73.5 GO:0001067 regulatory region DNA binding(GO:0000975) regulatory region nucleic acid binding(GO:0001067) transcription regulatory region DNA binding(GO:0044212)
0.5 71.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.8 61.0 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
1.1 51.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
2.4 51.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.7 46.1 GO:0003777 microtubule motor activity(GO:0003777)
0.3 45.3 GO:0043565 sequence-specific DNA binding(GO:0043565)
1.4 32.6 GO:0008266 poly(U) RNA binding(GO:0008266)
2.6 31.5 GO:0050693 LBD domain binding(GO:0050693)
0.2 31.2 GO:0003682 chromatin binding(GO:0003682)
0.7 27.6 GO:0030332 cyclin binding(GO:0030332)
3.4 27.5 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
3.0 26.8 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.3 25.6 GO:0042393 histone binding(GO:0042393)
2.8 25.5 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
2.8 25.1 GO:0061676 importin-alpha family protein binding(GO:0061676)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 138.4 PID_PLK1_PATHWAY PLK1 signaling events
1.6 72.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
1.8 72.0 PID_AURORA_B_PATHWAY Aurora B signaling
1.1 70.6 PID_E2F_PATHWAY E2F transcription factor network
1.1 65.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
2.0 60.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.9 58.0 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.9 53.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
3.5 48.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
1.4 42.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.8 42.0 PID_CMYB_PATHWAY C-MYB transcription factor network
0.5 33.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.8 30.8 PID_BMP_PATHWAY BMP receptor signaling
0.8 29.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.9 29.2 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.5 29.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.8 28.2 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
3.1 27.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
1.6 26.8 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.9 26.5 ST_G_ALPHA_I_PATHWAY G alpha i Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 167 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 108.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
1.9 61.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
2.6 57.8 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
1.7 52.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
2.8 45.5 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
1.4 43.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
1.6 37.1 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
1.3 35.8 REACTOME_KINESINS Genes involved in Kinesins
1.2 31.1 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 30.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
3.0 30.0 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
1.3 29.3 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
1.9 29.1 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.2 28.9 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.8 28.7 REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING Genes involved in G-protein beta:gamma signalling
1.5 27.8 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.5 25.9 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.4 25.5 REACTOME_MITOTIC_G2_G2_M_PHASES Genes involved in Mitotic G2-G2/M phases
0.8 25.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
2.3 24.8 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling