Motif ID: Mef2b

Z-value: 0.653


Transcription factors associated with Mef2b:

Gene SymbolEntrez IDGene Name
Mef2b ENSMUSG00000079033.3 Mef2b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2bmm10_v2_chr8_+_70152754_701527810.257.1e-02Click!


Activity profile for motif Mef2b.

activity profile for motif Mef2b


Sorted Z-values histogram for motif Mef2b

Sorted Z-values for motif Mef2b



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2b

PNG image of the network

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Top targets:


Showing 1 to 20 of 168 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 4.442 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chrY_-_1286563 3.998 ENSMUST00000091190.5
 Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr7_-_142899985 3.306 ENSMUST00000000219.3
 Th
tyrosine hydroxylase
chr5_+_24985840 2.728 ENSMUST00000075081.6
 1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr7_-_103843154 2.723 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr2_-_172043466 2.696 ENSMUST00000087950.3
 Cbln4
cerebellin 4 precursor protein
chr18_+_60963517 2.523 ENSMUST00000115295.2
ENSMUST00000039904.6
 Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr5_-_128953303 2.330 ENSMUST00000111346.1
 Rimbp2
RIMS binding protein 2
chr13_+_5861489 2.205 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr6_+_137410721 2.001 ENSMUST00000167002.1
 Ptpro
protein tyrosine phosphatase, receptor type, O
chr12_-_111672290 1.920 ENSMUST00000001304.7
 Ckb
creatine kinase, brain
chr2_-_57124003 1.856 ENSMUST00000112629.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr9_-_110742577 1.848 ENSMUST00000006005.7
 Pth1r
parathyroid hormone 1 receptor
chr1_+_187609028 1.753 ENSMUST00000110939.1
 Esrrg
estrogen-related receptor gamma
chr7_-_144738478 1.702 ENSMUST00000121758.1
 Ano1
anoctamin 1, calcium activated chloride channel
chr9_+_34904913 1.452 ENSMUST00000045091.6
 Kirrel3
kin of IRRE like 3 (Drosophila)
chr18_+_50030977 1.347 ENSMUST00000145726.1
ENSMUST00000128377.1
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr8_+_31089471 1.317 ENSMUST00000036631.7
ENSMUST00000170204.1
 Dusp26

dual specificity phosphatase 26 (putative)

chr2_-_79908428 1.296 ENSMUST00000102652.3
ENSMUST00000102651.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr4_-_9643638 1.244 ENSMUST00000108333.1
ENSMUST00000108334.1
ENSMUST00000108335.1
ENSMUST00000152526.1
ENSMUST00000103004.3
 Asph




aspartate-beta-hydroxylase





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 4.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 4.0 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.8 3.3 GO:0042414 epinephrine metabolic process(GO:0042414)
0.2 3.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.6 2.8 GO:0015705 iodide transport(GO:0015705)
0.5 2.7 GO:0015671 oxygen transport(GO:0015671)
0.2 2.5 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.4 2.1 GO:0090669 snoRNA guided rRNA pseudouridine synthesis(GO:0000454) telomerase RNA stabilization(GO:0090669)
0.4 2.0 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.4 2.0 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.5 1.9 GO:0051866 general adaptation syndrome(GO:0051866)
0.3 1.9 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.2 1.8 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.1 1.8 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.0 1.8 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.3 1.5 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.4 1.3 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.0 1.3 GO:0032611 interleukin-1 beta production(GO:0032611)
0.4 1.2 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.4 1.2 GO:0060023 soft palate development(GO:0060023)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
1.1 3.3 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 3.0 GO:0034707 chloride channel complex(GO:0034707)
0.0 2.8 GO:0001650 fibrillar center(GO:0001650)
0.3 2.7 GO:0005833 hemoglobin complex(GO:0005833)
0.0 2.6 GO:0043209 myelin sheath(GO:0043209)
0.8 2.5 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.0 2.2 GO:0005814 centriole(GO:0005814)
0.5 2.1 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.3 2.0 GO:0035976 AP1 complex(GO:0035976)
0.0 2.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.9 GO:0031526 brush border membrane(GO:0031526)
0.0 1.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 1.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 1.2 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.2 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.1 GO:0036126 sperm flagellum(GO:0036126)
0.1 0.9 GO:0098536 deuterosome(GO:0098536)
0.1 0.8 GO:0031595 nuclear proteasome complex(GO:0031595)
0.1 0.8 GO:0002178 palmitoyltransferase complex(GO:0002178)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.7 3.3 GO:0035240 dopamine binding(GO:0035240)
0.5 3.2 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.7 2.8 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.7 2.7 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.2 2.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.3 2.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 2.0 GO:0035497 cAMP response element binding(GO:0035497)
0.1 2.0 GO:0017147 Wnt-protein binding(GO:0017147)
0.5 1.9 GO:0004111 creatine kinase activity(GO:0004111)
0.1 1.8 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 1.8 GO:0017046 peptide hormone binding(GO:0017046)
0.4 1.3 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 1.2 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 1.1 GO:0051082 unfolded protein binding(GO:0051082)
0.1 1.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.9 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.2 0.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.8 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 0.8 GO:0034185 apolipoprotein binding(GO:0034185)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 3.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 2.4 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 2.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 2.0 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 2.0 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.8 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.8 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 0.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.6 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 0.6 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.6 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.6 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.0 0.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.5 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.4 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.3 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.3 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.3 PID_BARD1_PATHWAY BARD1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.3 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 3.2 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 2.7 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.1 2.6 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 2.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.1 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 1.3 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.1 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.9 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 0.8 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.8 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 0.7 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.6 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.5 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.5 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.4 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism