Motif ID: Mef2b

Z-value: 0.653


Transcription factors associated with Mef2b:

Gene SymbolEntrez IDGene Name
Mef2b ENSMUSG00000079033.3 Mef2b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2bmm10_v2_chr8_+_70152754_701527810.257.1e-02Click!


Activity profile for motif Mef2b.

activity profile for motif Mef2b


Sorted Z-values histogram for motif Mef2b

Sorted Z-values for motif Mef2b



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2b

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 4.442 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chrY_-_1286563 3.998 ENSMUST00000091190.5
Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr7_-_142899985 3.306 ENSMUST00000000219.3
Th
tyrosine hydroxylase
chr5_+_24985840 2.728 ENSMUST00000075081.6
1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr7_-_103843154 2.723 ENSMUST00000063957.4
Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr2_-_172043466 2.696 ENSMUST00000087950.3
Cbln4
cerebellin 4 precursor protein
chr18_+_60963517 2.523 ENSMUST00000115295.2
ENSMUST00000039904.6
Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr5_-_128953303 2.330 ENSMUST00000111346.1
Rimbp2
RIMS binding protein 2
chr13_+_5861489 2.205 ENSMUST00000000080.6
Klf6
Kruppel-like factor 6
chr6_+_137410721 2.001 ENSMUST00000167002.1
Ptpro
protein tyrosine phosphatase, receptor type, O
chr12_-_111672290 1.920 ENSMUST00000001304.7
Ckb
creatine kinase, brain
chr2_-_57124003 1.856 ENSMUST00000112629.1
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr9_-_110742577 1.848 ENSMUST00000006005.7
Pth1r
parathyroid hormone 1 receptor
chr1_+_187609028 1.753 ENSMUST00000110939.1
Esrrg
estrogen-related receptor gamma
chr7_-_144738478 1.702 ENSMUST00000121758.1
Ano1
anoctamin 1, calcium activated chloride channel
chr9_+_34904913 1.452 ENSMUST00000045091.6
Kirrel3
kin of IRRE like 3 (Drosophila)
chr18_+_50030977 1.347 ENSMUST00000145726.1
ENSMUST00000128377.1
Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr8_+_31089471 1.317 ENSMUST00000036631.7
ENSMUST00000170204.1
Dusp26

dual specificity phosphatase 26 (putative)

chr2_-_79908428 1.296 ENSMUST00000102652.3
ENSMUST00000102651.3
Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr4_-_9643638 1.244 ENSMUST00000108333.1
ENSMUST00000108334.1
ENSMUST00000108335.1
ENSMUST00000152526.1
ENSMUST00000103004.3
Asph




aspartate-beta-hydroxylase




chr3_+_96596628 1.235 ENSMUST00000058943.7
Ankrd34a
ankyrin repeat domain 34A
chr17_+_34039437 1.227 ENSMUST00000131134.1
ENSMUST00000087497.4
ENSMUST00000114255.1
ENSMUST00000114252.1
Col11a2



collagen, type XI, alpha 2



chrX_+_142825698 1.198 ENSMUST00000112888.1
Tmem164
transmembrane protein 164
chr9_+_99629496 1.182 ENSMUST00000131095.1
ENSMUST00000078367.5
ENSMUST00000112885.2
Dzip1l


DAZ interacting protein 1-like


chr7_+_81862674 1.133 ENSMUST00000119543.1
Tm6sf1
transmembrane 6 superfamily member 1
chr7_-_144738520 1.128 ENSMUST00000118556.2
ENSMUST00000033393.8
Ano1

anoctamin 1, calcium activated chloride channel

chr13_-_113663670 1.083 ENSMUST00000054650.4
Hspb3
heat shock protein 3
chrX_+_75096039 1.071 ENSMUST00000131155.1
ENSMUST00000132000.1
Dkc1

dyskeratosis congenita 1, dyskerin

chr2_-_79908389 1.070 ENSMUST00000090756.4
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr17_-_58991343 1.067 ENSMUST00000025064.7
2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr4_-_95052188 1.066 ENSMUST00000107094.1
Jun
Jun oncogene
chr7_-_100514800 1.063 ENSMUST00000054923.7
Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr9_+_99629823 1.062 ENSMUST00000112886.2
Dzip1l
DAZ interacting protein 1-like
chr9_-_110654161 1.039 ENSMUST00000133191.1
ENSMUST00000167320.1
Nbeal2

neurobeachin-like 2

chrX_+_75095854 1.010 ENSMUST00000033776.8
Dkc1
dyskeratosis congenita 1, dyskerin
chr4_-_95052170 0.962 ENSMUST00000058555.2
Jun
Jun oncogene
chr3_-_20155069 0.949 ENSMUST00000184552.1
ENSMUST00000178328.1
Gyg

glycogenin

chr2_+_164486856 0.933 ENSMUST00000109349.2
Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr18_+_76059458 0.889 ENSMUST00000167921.1
Zbtb7c
zinc finger and BTB domain containing 7C
chrX_+_10717451 0.885 ENSMUST00000156321.1
Mid1ip1
Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chrX_+_10717390 0.884 ENSMUST00000115524.1
ENSMUST00000008179.6
Mid1ip1

Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))

chr3_+_40800013 0.850 ENSMUST00000026858.5
ENSMUST00000170825.1
Plk4

polo-like kinase 4

chr2_-_80128834 0.847 ENSMUST00000102654.4
ENSMUST00000102655.3
Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr18_-_25753852 0.841 ENSMUST00000025117.6
ENSMUST00000115816.2
Celf4

CUGBP, Elav-like family member 4

chr10_-_128549125 0.838 ENSMUST00000177163.1
ENSMUST00000176683.1
ENSMUST00000176010.1
Rpl41


ribosomal protein L41


chr3_-_138143352 0.837 ENSMUST00000098580.2
Mttp
microsomal triglyceride transfer protein
chr13_-_23698454 0.826 ENSMUST00000102967.1
Hist1h4c
histone cluster 1, H4c
chrX_-_48208870 0.798 ENSMUST00000088935.3
Zdhhc9
zinc finger, DHHC domain containing 9
chr10_-_128549102 0.793 ENSMUST00000176906.1
Rpl41
ribosomal protein L41
chr1_-_172329261 0.791 ENSMUST00000062387.2
Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9
chr5_+_21785253 0.766 ENSMUST00000030769.5
Psmc2
proteasome (prosome, macropain) 26S subunit, ATPase 2
chr2_-_94264713 0.746 ENSMUST00000129661.1
E530001K10Rik
RIKEN cDNA E530001K10 gene
chr3_+_32817520 0.742 ENSMUST00000072312.5
ENSMUST00000108228.1
Usp13

ubiquitin specific peptidase 13 (isopeptidase T-3)

chr3_-_150073620 0.737 ENSMUST00000057740.5
Rpsa-ps10
ribosomal protein SA, pseudogene 10
chrX_-_93832106 0.722 ENSMUST00000045748.6
Pdk3
pyruvate dehydrogenase kinase, isoenzyme 3
chr3_+_68584154 0.674 ENSMUST00000182997.1
Schip1
schwannomin interacting protein 1
chr4_+_5724304 0.637 ENSMUST00000108380.1
Fam110b
family with sequence similarity 110, member B
chr19_-_36919606 0.621 ENSMUST00000057337.7
Fgfbp3
fibroblast growth factor binding protein 3
chr2_+_118663235 0.608 ENSMUST00000099557.3
Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chr16_-_23127702 0.607 ENSMUST00000115338.1
ENSMUST00000115337.1
ENSMUST00000023598.8
Rfc4


replication factor C (activator 1) 4


chr15_-_81843699 0.600 ENSMUST00000092020.2
Gm8444
predicted gene 8444
chr5_-_3596071 0.590 ENSMUST00000121877.1
Rbm48
RNA binding motif protein 48
chr3_-_113574758 0.586 ENSMUST00000106540.1
Amy1
amylase 1, salivary
chr4_+_62663620 0.570 ENSMUST00000126338.1
Rgs3
regulator of G-protein signaling 3
chr3_+_89459118 0.568 ENSMUST00000029564.5
Pmvk
phosphomevalonate kinase
chr1_+_75375271 0.560 ENSMUST00000087122.5
Speg
SPEG complex locus
chr3_+_89459325 0.548 ENSMUST00000107410.1
Pmvk
phosphomevalonate kinase
chr2_-_94264745 0.547 ENSMUST00000134563.1
E530001K10Rik
RIKEN cDNA E530001K10 gene
chr11_-_79504078 0.544 ENSMUST00000164465.2
Omg
oligodendrocyte myelin glycoprotein
chr9_-_108649349 0.543 ENSMUST00000013338.8
Arih2
ariadne homolog 2 (Drosophila)
chr3_-_98814434 0.521 ENSMUST00000029463.6
Hsd3b6
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6
chr5_+_33018816 0.517 ENSMUST00000019109.7
Ywhah
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr7_+_140763739 0.514 ENSMUST00000026552.7
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr11_-_83649349 0.513 ENSMUST00000001008.5
Ccl3
chemokine (C-C motif) ligand 3
chr16_+_4968936 0.504 ENSMUST00000090457.5
4930451G09Rik
RIKEN cDNA 4930451G09 gene
chr13_-_23934156 0.490 ENSMUST00000052776.2
Hist1h2ba
histone cluster 1, H2ba
chr6_-_136941887 0.484 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr5_-_16731074 0.481 ENSMUST00000073014.5
Gm8991
predicted pseudogene 8991
chr6_-_136941694 0.476 ENSMUST00000032344.5
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr6_+_48589560 0.471 ENSMUST00000181661.1
Gm5111
predicted gene 5111
chr12_+_69241832 0.470 ENSMUST00000063445.6
Klhdc1
kelch domain containing 1
chr2_+_120463566 0.452 ENSMUST00000028749.7
ENSMUST00000110721.1
Capn3

calpain 3

chr3_-_158562199 0.439 ENSMUST00000106044.1
Lrrc7
leucine rich repeat containing 7
chr17_+_91236787 0.433 ENSMUST00000057074.8
Gm6741
predicted gene 6741
chr10_-_88605017 0.427 ENSMUST00000119185.1
ENSMUST00000121629.1
Mybpc1

myosin binding protein C, slow-type

chr3_+_138143429 0.420 ENSMUST00000040321.6
Trmt10a
tRNA methyltransferase 10A
chr6_-_126939524 0.414 ENSMUST00000144954.1
ENSMUST00000112221.1
ENSMUST00000112220.1
Rad51ap1


RAD51 associated protein 1


chr7_+_101896817 0.412 ENSMUST00000143835.1
Anapc15
anaphase prompoting complex C subunit 15
chr4_+_141368116 0.402 ENSMUST00000006380.4
Fam131c
family with sequence similarity 131, member C
chr16_-_56712825 0.399 ENSMUST00000136394.1
Tfg
Trk-fused gene
chr19_-_34879452 0.376 ENSMUST00000036584.5
Pank1
pantothenate kinase 1
chr1_-_191183244 0.371 ENSMUST00000027941.8
Atf3
activating transcription factor 3
chr2_+_91255954 0.369 ENSMUST00000134699.1
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr3_+_96833218 0.366 ENSMUST00000128789.1
Pdzk1
PDZ domain containing 1
chr5_+_25759987 0.365 ENSMUST00000128727.1
ENSMUST00000088244.4
Actr3b

ARP3 actin-related protein 3B

chr9_-_36797303 0.361 ENSMUST00000115086.5
Ei24
etoposide induced 2.4 mRNA
chr10_+_80629646 0.340 ENSMUST00000085435.5
Csnk1g2
casein kinase 1, gamma 2
chr3_+_146852359 0.332 ENSMUST00000038090.5
ENSMUST00000170055.1
Ttll7

tubulin tyrosine ligase-like family, member 7

chr9_-_54647199 0.331 ENSMUST00000128163.1
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chrX_-_47892502 0.326 ENSMUST00000077569.4
ENSMUST00000101616.2
ENSMUST00000088973.4
Smarca1


SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1


chr10_+_90576872 0.325 ENSMUST00000182550.1
ENSMUST00000099364.5
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr2_+_91096744 0.323 ENSMUST00000132741.2
Spi1
spleen focus forming virus (SFFV) proviral integration oncogene
chr9_-_36797273 0.323 ENSMUST00000163192.3
Ei24
etoposide induced 2.4 mRNA
chr2_+_164486455 0.322 ENSMUST00000069385.8
ENSMUST00000143690.1
Dbndd2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr3_+_137341067 0.318 ENSMUST00000122064.1
Emcn
endomucin
chr3_+_96645579 0.302 ENSMUST00000119365.1
ENSMUST00000029744.5
Itga10

integrin, alpha 10

chr16_-_17201490 0.286 ENSMUST00000090192.5
ENSMUST00000115700.1
Ube2l3

ubiquitin-conjugating enzyme E2L 3

chr8_-_105943382 0.286 ENSMUST00000038896.7
Lcat
lecithin cholesterol acyltransferase
chr6_-_124965485 0.279 ENSMUST00000112439.2
Cops7a
COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)
chr1_+_171437535 0.278 ENSMUST00000043839.4
F11r
F11 receptor
chr1_-_12991109 0.277 ENSMUST00000115403.2
ENSMUST00000115402.1
Slco5a1

solute carrier organic anion transporter family, member 5A1

chr4_+_156215920 0.269 ENSMUST00000105572.1
2310042D19Rik
RIKEN cDNA 2310042D19 gene
chr8_-_67515606 0.269 ENSMUST00000032981.5
Gm9755
predicted pseudogene 9755
chr7_-_102100227 0.263 ENSMUST00000106937.1
Art5
ADP-ribosyltransferase 5
chr6_-_124965403 0.254 ENSMUST00000129446.1
ENSMUST00000032220.8
Cops7a

COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)

chr19_+_21272276 0.251 ENSMUST00000025659.4
Zfand5
zinc finger, AN1-type domain 5
chr5_-_122614445 0.243 ENSMUST00000127220.1
ENSMUST00000031426.7
Ift81

intraflagellar transport 81

chr5_+_140419248 0.241 ENSMUST00000100507.3
Eif3b
eukaryotic translation initiation factor 3, subunit B
chr3_-_65958236 0.241 ENSMUST00000029416.7
Ccnl1
cyclin L1
chr10_-_70592782 0.239 ENSMUST00000162251.1
Phyhipl
phytanoyl-CoA hydroxylase interacting protein-like
chr11_+_75655873 0.236 ENSMUST00000108431.2
Myo1c
myosin IC
chr13_-_23369156 0.234 ENSMUST00000125328.1
ENSMUST00000145451.1
ENSMUST00000050101.2
Zfp322a


zinc finger protein 322A


chr8_-_46211284 0.221 ENSMUST00000034049.4
Slc25a4
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
chrX_+_159303266 0.214 ENSMUST00000112491.1
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr3_+_137341103 0.214 ENSMUST00000119475.1
Emcn
endomucin
chr12_+_86361112 0.205 ENSMUST00000116402.3
Esrrb
estrogen related receptor, beta
chr17_+_29032664 0.192 ENSMUST00000130216.1
Srsf3
serine/arginine-rich splicing factor 3
chr16_-_93603803 0.186 ENSMUST00000023669.5
ENSMUST00000113951.2
Setd4

SET domain containing 4

chr13_+_20090500 0.170 ENSMUST00000165249.2
Elmo1
engulfment and cell motility 1
chr11_+_77462325 0.166 ENSMUST00000102493.1
Coro6
coronin 6
chr13_+_20090538 0.161 ENSMUST00000072519.5
Elmo1
engulfment and cell motility 1
chr2_+_172440556 0.157 ENSMUST00000029005.3
Rtfdc1
replication termination factor 2 domain containing 1
chr11_+_105178765 0.156 ENSMUST00000106939.2
Tlk2
tousled-like kinase 2 (Arabidopsis)
chr19_+_8723478 0.154 ENSMUST00000180819.1
ENSMUST00000181422.1
Snhg1

small nucleolar RNA host gene (non-protein coding) 1

chr8_+_119666498 0.154 ENSMUST00000024107.5
Wfdc1
WAP four-disulfide core domain 1
chrX_-_165004829 0.151 ENSMUST00000114890.2
Gm17604
predicted gene, 17604
chr11_-_101417615 0.134 ENSMUST00000070395.8
Aarsd1
alanyl-tRNA synthetase domain containing 1
chr14_-_61439831 0.120 ENSMUST00000022496.7
Kpna3
karyopherin (importin) alpha 3
chr6_-_136171722 0.116 ENSMUST00000053880.6
Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr17_+_28692568 0.113 ENSMUST00000114752.1
Mapk14
mitogen-activated protein kinase 14
chr15_+_94629148 0.112 ENSMUST00000080141.4
Tmem117
transmembrane protein 117
chr7_+_30121915 0.110 ENSMUST00000098596.3
ENSMUST00000153792.1
Zfp382

zinc finger protein 382

chr8_+_19682268 0.102 ENSMUST00000153710.1
ENSMUST00000127799.1
Gm6483

predicted gene 6483

chr17_-_14694223 0.098 ENSMUST00000170872.1
Thbs2
thrombospondin 2
chr6_+_42286676 0.088 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr6_+_42286709 0.082 ENSMUST00000163936.1
Clcn1
chloride channel 1
chrX_-_8252304 0.081 ENSMUST00000115594.1
Ftsj1
FtsJ homolog 1 (E. coli)
chr4_-_131967824 0.080 ENSMUST00000146443.1
ENSMUST00000135579.1
Epb4.1

erythrocyte protein band 4.1

chr17_-_25837082 0.069 ENSMUST00000183929.1
ENSMUST00000184865.1
ENSMUST00000026831.7
Rhbdl1


rhomboid, veinlet-like 1 (Drosophila)


chr11_-_101424519 0.065 ENSMUST00000107257.1
ENSMUST00000107259.3
ENSMUST00000107252.2
ENSMUST00000093933.4
Gm27029

Ptges3l

predicted gene, 27029

prostaglandin E synthase 3 (cytosolic)-like

chr4_+_129287614 0.061 ENSMUST00000102599.3
Sync
syncoilin
chr4_+_43493345 0.058 ENSMUST00000030181.5
ENSMUST00000107922.2
Ccdc107

coiled-coil domain containing 107

chr11_+_77801291 0.054 ENSMUST00000100794.3
Myo18a
myosin XVIIIA
chr10_+_111972664 0.045 ENSMUST00000163048.1
ENSMUST00000174653.1
Krr1

KRR1, small subunit (SSU) processome component, homolog (yeast)

chr1_-_64121456 0.044 ENSMUST00000142009.1
ENSMUST00000114086.1
Klf7

Kruppel-like factor 7 (ubiquitous)

chr4_+_119108711 0.031 ENSMUST00000030398.3
Slc2a1
solute carrier family 2 (facilitated glucose transporter), member 1
chr15_+_91673175 0.028 ENSMUST00000060642.6
Lrrk2
leucine-rich repeat kinase 2
chr8_-_111992258 0.027 ENSMUST00000034427.5
ENSMUST00000139820.1
Adat1

adenosine deaminase, tRNA-specific 1

chr9_+_69397897 0.027 ENSMUST00000034761.8
ENSMUST00000125938.1
Narg2

NMDA receptor-regulated gene 2

chr8_+_94857450 0.027 ENSMUST00000109521.3
Polr2c
polymerase (RNA) II (DNA directed) polypeptide C
chr11_+_94328242 0.022 ENSMUST00000021227.5
Ankrd40
ankyrin repeat domain 40
chr19_-_37176055 0.021 ENSMUST00000142973.1
ENSMUST00000154376.1
Cpeb3

cytoplasmic polyadenylation element binding protein 3

chr16_-_92400067 0.017 ENSMUST00000023672.8
Rcan1
regulator of calcineurin 1
chr9_+_75051977 0.012 ENSMUST00000170310.1
ENSMUST00000166549.1
Arpp19

cAMP-regulated phosphoprotein 19

chr3_+_108653979 0.005 ENSMUST00000106613.1
Clcc1
chloride channel CLIC-like 1
chr3_-_154597045 0.005 ENSMUST00000052774.1
ENSMUST00000170461.1
ENSMUST00000122976.1
Tyw3


tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)


chr5_+_8660059 0.004 ENSMUST00000047753.4
Abcb1a
ATP-binding cassette, sub-family B (MDR/TAP), member 1A
chr4_+_119108795 0.004 ENSMUST00000134105.1
ENSMUST00000144329.1
Slc2a1

solute carrier family 2 (facilitated glucose transporter), member 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:0042414 epinephrine metabolic process(GO:0042414)
0.7 4.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.6 2.8 GO:0015705 iodide transport(GO:0015705)
0.5 2.7 GO:0015671 oxygen transport(GO:0015671)
0.5 1.9 GO:0051866 general adaptation syndrome(GO:0051866)
0.4 1.3 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.4 2.1 GO:0090669 snoRNA guided rRNA pseudouridine synthesis(GO:0000454) telomerase RNA stabilization(GO:0090669)
0.4 1.2 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.4 1.2 GO:0060023 soft palate development(GO:0060023)
0.4 2.0 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.4 2.0 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.3 1.0 GO:0070889 platelet alpha granule organization(GO:0070889)
0.3 1.9 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.3 1.5 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.3 1.1 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.2 0.7 GO:0035523 protein K29-linked deubiquitination(GO:0035523) protein K6-linked deubiquitination(GO:0044313)
0.2 2.5 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.2 0.7 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.2 3.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 0.8 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.2 1.0 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.2 1.8 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.2 0.5 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.1 0.9 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
0.1 0.8 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 1.8 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.1 0.4 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1 0.9 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.1 0.7 GO:0071494 cellular response to UV-C(GO:0071494)
0.1 0.6 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1 4.0 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 0.2 GO:0015866 ADP transport(GO:0015866)
0.1 0.8 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.5 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 0.6 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 0.3 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.1 0.8 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 0.3 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.1 0.5 GO:0043615 astrocyte cell migration(GO:0043615)
0.1 0.4 GO:0015879 carnitine transport(GO:0015879)
0.1 0.2 GO:0090282 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931) positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.0 0.2 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.2 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 0.8 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.1 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.5 GO:0006706 steroid catabolic process(GO:0006706)
0.0 0.3 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.7 GO:0001553 luteinization(GO:0001553)
0.0 0.2 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 1.8 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.5 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.5 GO:0019369 drug metabolic process(GO:0017144) arachidonic acid metabolic process(GO:0019369)
0.0 0.1 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 0.1 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.0 0.0 GO:2000468 regulation of peroxidase activity(GO:2000468)
0.0 0.4 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.3 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.8 GO:0010107 potassium ion import(GO:0010107)
0.0 1.3 GO:0032611 interleukin-1 beta production(GO:0032611)
0.0 0.4 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.4 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.2 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.3 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 1.1 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.3 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.5 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.5 GO:0048670 regulation of collateral sprouting(GO:0048670)
0.0 0.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.2 GO:1902969 mitotic DNA replication(GO:1902969)
0.0 0.2 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.0 GO:0042908 xenobiotic transport(GO:0042908)
0.0 0.6 GO:0051384 response to glucocorticoid(GO:0051384)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.8 2.5 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.5 2.1 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.3 2.7 GO:0005833 hemoglobin complex(GO:0005833)
0.3 2.0 GO:0035976 AP1 complex(GO:0035976)
0.1 0.9 GO:0098536 deuterosome(GO:0098536)
0.1 1.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.5 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 0.6 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 0.3 GO:0090537 CERF complex(GO:0090537)
0.1 0.2 GO:0045160 myosin I complex(GO:0045160)
0.1 0.8 GO:0031595 nuclear proteasome complex(GO:0031595)
0.1 3.0 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.4 GO:0005859 muscle myosin complex(GO:0005859)
0.1 1.2 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.8 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 1.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.0 GO:0044753 amphisome(GO:0044753)
0.0 1.9 GO:0031526 brush border membrane(GO:0031526)
0.0 0.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 2.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 2.2 GO:0005814 centriole(GO:0005814)
0.0 0.4 GO:0043194 axon initial segment(GO:0043194)
0.0 0.2 GO:0097225 sperm midpiece(GO:0097225)
0.0 4.0 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.0 2.8 GO:0001650 fibrillar center(GO:0001650)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.3 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 1.1 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.3 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.6 GO:0014704 intercalated disc(GO:0014704)
0.0 1.2 GO:0043198 dendritic shaft(GO:0043198)
0.0 2.6 GO:0043209 myelin sheath(GO:0043209)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.8 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.7 2.7 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.7 3.3 GO:0035240 dopamine binding(GO:0035240)
0.5 1.9 GO:0004111 creatine kinase activity(GO:0004111)
0.5 3.2 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.4 1.3 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.3 2.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.2 2.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 0.6 GO:0016160 alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.2 0.7 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.2 0.5 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.2 0.5 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.2 0.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.7 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 1.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.4 GO:0005124 scavenger receptor binding(GO:0005124)
0.1 0.8 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.1 0.3 GO:0070615 nucleosome-dependent ATPase activity(GO:0070615)
0.1 2.0 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.9 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 1.8 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 0.3 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.1 0.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.3 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.1 0.7 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.1 0.3 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.4 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.4 GO:0051525 NFAT protein binding(GO:0051525)
0.1 0.3 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.1 2.0 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 1.8 GO:0017046 peptide hormone binding(GO:0017046)
0.1 0.5 GO:0031432 titin binding(GO:0031432)
0.1 0.6 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.4 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 4.0 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.8 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.1 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.3 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.3 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.5 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 1.2 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 0.6 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.8 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.1 GO:0051082 unfolded protein binding(GO:0051082)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 3.9 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 2.4 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.0 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.8 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.3 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 3.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.3 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.6 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 1.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.6 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.6 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.3 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.6 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.0 0.8 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 0.3 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.5 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.4 PID_ATF2_PATHWAY ATF-2 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.3 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 3.2 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 2.1 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 2.6 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 2.7 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.1 0.8 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 0.7 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.1 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.5 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 2.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.3 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.3 REACTOME_LIPOPROTEIN_METABOLISM Genes involved in Lipoprotein metabolism
0.0 0.4 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.6 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 1.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 0.8 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.3 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.9 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.3 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis