Motif ID: Mef2c
Z-value: 0.708
Transcription factors associated with Mef2c:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Mef2c | ENSMUSG00000005583.10 | Mef2c |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mef2c | mm10_v2_chr13_+_83573577_83573607 | 0.28 | 3.8e-02 | Click! |
Top targets:
Showing 1 to 20 of 177 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 75 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 12.4 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.9 | 9.8 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 1.0 | 5.7 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
| 0.0 | 5.3 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.5 | 4.8 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) |
| 0.9 | 4.6 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.3 | 4.1 | GO:0045161 | neuronal ion channel clustering(GO:0045161) |
| 0.0 | 3.9 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
| 0.3 | 3.8 | GO:0001553 | luteinization(GO:0001553) |
| 0.6 | 2.9 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
| 0.3 | 2.5 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
| 0.8 | 2.4 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) |
| 0.1 | 2.4 | GO:0007614 | short-term memory(GO:0007614) |
| 0.8 | 2.3 | GO:0007521 | muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111) |
| 0.3 | 2.3 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.0 | 2.2 | GO:0030641 | regulation of cellular pH(GO:0030641) |
| 0.2 | 2.1 | GO:0014883 | transition between fast and slow fiber(GO:0014883) |
| 0.0 | 2.0 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.3 | 1.8 | GO:0010747 | positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) |
| 0.1 | 1.7 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 41 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.8 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.1 | 4.9 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
| 0.0 | 4.9 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.2 | 4.1 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 4.0 | GO:0032587 | ruffle membrane(GO:0032587) |
| 1.0 | 2.9 | GO:0043512 | inhibin A complex(GO:0043512) |
| 0.0 | 2.7 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.1 | 2.6 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.8 | 2.5 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.5 | 2.1 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
| 0.0 | 2.1 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 2.0 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 2.0 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 1.7 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 1.6 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.1 | 1.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 1.4 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 1.4 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.1 | 1.3 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 1.2 | GO:0005911 | cell-cell junction(GO:0005911) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 53 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 12.4 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.2 | 10.9 | GO:0030507 | spectrin binding(GO:0030507) |
| 1.4 | 5.7 | GO:0017095 | heparan sulfate 6-O-sulfotransferase activity(GO:0017095) |
| 0.7 | 4.1 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.2 | 4.1 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.2 | 3.9 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.1 | 3.8 | GO:0042805 | actinin binding(GO:0042805) |
| 0.1 | 3.6 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.8 | 2.5 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 0.5 | 2.4 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.1 | 2.3 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 2.3 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.1 | 2.0 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.1 | 1.8 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.1 | 1.7 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.1 | 1.5 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.0 | 1.5 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.0 | 1.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.5 | 1.4 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
| 0.4 | 1.4 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
Gene overrepresentation in C2:CP category:
Showing 1 to 16 of 16 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.9 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 6.1 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 3.2 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
| 0.1 | 2.9 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.1 | 2.5 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 1.9 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.1 | 1.3 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 1.2 | PID_CDC42_PATHWAY | CDC42 signaling events |
| 0.0 | 0.9 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.8 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 0.8 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.7 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 0.6 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.5 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.5 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.0 | 0.5 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 21 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.8 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 5.7 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 3.6 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 3.4 | REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.7 | 2.9 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 2.2 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 2.2 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 2.0 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 1.8 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 1.2 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 1.2 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 0.9 | REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.0 | 0.9 | REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.0 | 0.6 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 0.5 | REACTOME_PLC_BETA_MEDIATED_EVENTS | Genes involved in PLC beta mediated events |
| 0.0 | 0.5 | REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.0 | 0.5 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 0.5 | REACTOME_NOD1_2_SIGNALING_PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 0.4 | REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.0 | 0.4 | REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
