Motif ID: Mef2d_Mef2a

Z-value: 1.210

Transcription factors associated with Mef2d_Mef2a:

Gene SymbolEntrez IDGene Name
Mef2a ENSMUSG00000030557.10 Mef2a
Mef2d ENSMUSG00000001419.11 Mef2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2dmm10_v2_chr3_+_88142328_881424830.516.3e-05Click!
Mef2amm10_v2_chr7_-_67372846_673728580.472.7e-04Click!


Activity profile for motif Mef2d_Mef2a.

activity profile for motif Mef2d_Mef2a


Sorted Z-values histogram for motif Mef2d_Mef2a

Sorted Z-values for motif Mef2d_Mef2a



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2d_Mef2a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_83573577 21.474 ENSMUST00000185052.1
 Mef2c
myocyte enhancer factor 2C
chr13_-_113663670 14.452 ENSMUST00000054650.4
 Hspb3
heat shock protein 3
chr9_-_112232449 13.732 ENSMUST00000035085.5
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr13_+_5861489 13.606 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr5_+_24985840 11.721 ENSMUST00000075081.6
 1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr19_+_38264761 10.857 ENSMUST00000087252.5
 Lgi1
leucine-rich repeat LGI family, member 1
chr6_-_136171722 10.800 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr1_-_134234492 9.975 ENSMUST00000169927.1
 Adora1
adenosine A1 receptor
chr5_-_128953303 9.908 ENSMUST00000111346.1
 Rimbp2
RIMS binding protein 2
chr9_+_34904913 9.897 ENSMUST00000045091.6
 Kirrel3
kin of IRRE like 3 (Drosophila)
chr1_+_75375271 9.626 ENSMUST00000087122.5
 Speg
SPEG complex locus
chr7_+_91090697 9.337 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr11_+_111066154 9.268 ENSMUST00000042970.2
 Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
chr7_+_91090728 9.153 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr11_-_83649349 7.370 ENSMUST00000001008.5
 Ccl3
chemokine (C-C motif) ligand 3
chr13_+_42680565 6.966 ENSMUST00000128646.1
 Phactr1
phosphatase and actin regulator 1
chrX_-_51681703 6.963 ENSMUST00000088172.5
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr3_-_56183678 6.852 ENSMUST00000029374.6
 Nbea
neurobeachin
chr1_-_64122256 6.775 ENSMUST00000135075.1
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr16_+_7069825 6.656 ENSMUST00000056416.7
 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 22.6 GO:0034605 cellular response to heat(GO:0034605)
7.2 21.5 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
1.3 18.5 GO:0045161 neuronal ion channel clustering(GO:0045161)
2.3 13.6 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
4.0 12.1 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.0 11.5 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
2.2 10.9 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
2.7 10.8 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 10.2 GO:0001578 microtubule bundle formation(GO:0001578)
3.3 10.0 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
2.0 9.9 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.2 9.1 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.1 8.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 8.3 GO:0060541 respiratory system development(GO:0060541)
0.8 7.4 GO:0043615 astrocyte cell migration(GO:0043615)
0.1 7.0 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.1 6.8 GO:0050806 positive regulation of synaptic transmission(GO:0050806)
1.3 6.6 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.1 6.5 GO:0007613 memory(GO:0007613)
0.1 6.4 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 23.3 GO:0016607 nuclear speck(GO:0016607)
0.1 21.4 GO:0001650 fibrillar center(GO:0001650)
0.2 18.9 GO:0014704 intercalated disc(GO:0014704)
0.9 18.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 18.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.9 15.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 14.0 GO:0005911 cell-cell junction(GO:0005911)
0.6 13.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.6 12.2 GO:0032279 asymmetric synapse(GO:0032279)
0.1 11.2 GO:0016605 PML body(GO:0016605)
3.6 10.9 GO:0043512 inhibin A complex(GO:0043512)
0.1 10.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 8.5 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 7.9 GO:0043198 dendritic shaft(GO:0043198)
1.6 6.4 GO:0090537 CERF complex(GO:0090537)
0.0 5.4 GO:0016324 apical plasma membrane(GO:0016324)
0.1 5.3 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.6 5.1 GO:0001520 outer dense fiber(GO:0001520)
1.7 5.0 GO:0000802 transverse filament(GO:0000802)
0.1 4.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 21.5 GO:0035198 miRNA binding(GO:0035198)
0.8 18.5 GO:0004385 guanylate kinase activity(GO:0004385)
1.5 15.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
2.4 14.5 GO:0070699 type II activin receptor binding(GO:0070699)
3.4 13.6 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.7 12.5 GO:0030275 LRR domain binding(GO:0030275)
0.1 11.8 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 11.8 GO:0008017 microtubule binding(GO:0008017)
0.4 11.5 GO:0042805 actinin binding(GO:0042805)
0.1 11.5 GO:0005516 calmodulin binding(GO:0005516)
0.2 11.1 GO:0051018 protein kinase A binding(GO:0051018)
1.7 10.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
1.4 10.0 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.6 10.0 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
1.2 9.3 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.3 8.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.3 7.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.2 7.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 6.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 6.5 GO:0048365 Rac GTPase binding(GO:0048365)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 20.2 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 14.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 13.1 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.2 13.0 PID_FGF_PATHWAY FGF signaling pathway
0.2 11.0 PID_REELIN_PATHWAY Reelin signaling pathway
0.3 10.9 PID_ALK1_PATHWAY ALK1 signaling events
0.3 7.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 6.9 PID_IL12_2PATHWAY IL12-mediated signaling events
0.2 6.5 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.2 6.3 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 5.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.4 4.3 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 3.6 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 3.4 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 2.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.3 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 2.1 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.9 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 1.7 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 21.9 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.5 13.6 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.4 13.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.3 12.1 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.5 12.0 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
2.7 10.9 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.8 10.9 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.2 9.5 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
0.3 7.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 6.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.5 6.5 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.2 5.1 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 5.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 4.5 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 4.5 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 4.5 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.1 4.3 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.1 4.2 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.3 3.9 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 3.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins