Motif ID: Meis2

Z-value: 1.151


Transcription factors associated with Meis2:

Gene SymbolEntrez IDGene Name
Meis2 ENSMUSG00000027210.14 Meis2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Meis2mm10_v2_chr2_-_116065047_116065133-0.076.0e-01Click!


Activity profile for motif Meis2.

activity profile for motif Meis2


Sorted Z-values histogram for motif Meis2

Sorted Z-values for motif Meis2



Network of associatons between targets according to the STRING database.



First level regulatory network of Meis2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_57197435 8.744 ENSMUST00000111550.1
 Ablim1
actin-binding LIM protein 1
chr19_-_57197496 8.741 ENSMUST00000111544.1
 Ablim1
actin-binding LIM protein 1
chr19_-_57197377 8.626 ENSMUST00000111546.1
 Ablim1
actin-binding LIM protein 1
chr7_+_48959089 8.476 ENSMUST00000183659.1
 Nav2
neuron navigator 2
chr19_-_57197556 8.282 ENSMUST00000099294.2
 Ablim1
actin-binding LIM protein 1
chr4_+_128058962 8.122 ENSMUST00000184063.1
 Csmd2
CUB and Sushi multiple domains 2
chr5_-_100159261 7.878 ENSMUST00000139520.1
 Tmem150c
transmembrane protein 150C
chr3_-_82074639 7.863 ENSMUST00000029635.8
 Gucy1b3
guanylate cyclase 1, soluble, beta 3
chr4_+_42922253 7.760 ENSMUST00000139100.1
 N28178
expressed sequence N28178
chr9_-_121495678 6.671 ENSMUST00000035120.4
 Cck
cholecystokinin
chr18_+_36939178 6.314 ENSMUST00000115662.2
 Pcdha2
protocadherin alpha 2
chr6_-_121081589 6.198 ENSMUST00000077159.5
 Mical3
microtubule associated monooxygenase, calponin and LIM domain containing 3
chr17_+_8924109 6.053 ENSMUST00000149440.1
 Pde10a
phosphodiesterase 10A
chr19_+_42247544 5.950 ENSMUST00000122375.1
 Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr2_+_158667119 5.866 ENSMUST00000045503.4
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr2_+_71981184 5.700 ENSMUST00000090826.5
ENSMUST00000102698.3
 Rapgef4

Rap guanine nucleotide exchange factor (GEF) 4

chr3_-_127499095 5.686 ENSMUST00000182594.1
 Ank2
ankyrin 2, brain
chr6_+_49822710 5.509 ENSMUST00000031843.6
 Npy
neuropeptide Y
chr9_+_53771499 5.319 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr9_+_120539801 5.300 ENSMUST00000047687.7
 Entpd3
ectonucleoside triphosphate diphosphohydrolase 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 167 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 24.5 GO:0030032 lamellipodium assembly(GO:0030032)
0.8 12.2 GO:0032098 regulation of appetite(GO:0032098)
2.1 10.7 GO:1903587 negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.1 10.5 GO:0008643 carbohydrate transport(GO:0008643)
0.3 10.4 GO:0006376 mRNA splice site selection(GO:0006376)
3.0 9.0 GO:0046168 glycerol-3-phosphate catabolic process(GO:0046168)
2.1 8.5 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
2.6 7.9 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
0.3 7.6 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 6.4 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.1 6.2 GO:0030042 actin filament depolymerization(GO:0030042)
0.3 6.1 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 6.1 GO:0098656 anion transmembrane transport(GO:0098656)
0.8 5.9 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.5 5.9 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
1.4 5.7 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.6 5.7 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2 5.7 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.4 5.3 GO:0009143 nucleoside triphosphate catabolic process(GO:0009143)
1.7 5.0 GO:0042196 dichloromethane metabolic process(GO:0018900) chlorinated hydrocarbon metabolic process(GO:0042196) halogenated hydrocarbon metabolic process(GO:0042197)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 30.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 15.5 GO:0000139 Golgi membrane(GO:0000139)
0.1 10.7 GO:0043204 perikaryon(GO:0043204)
1.8 9.0 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
1.7 8.5 GO:0044316 cone cell pedicle(GO:0044316)
0.2 7.9 GO:0048786 presynaptic active zone(GO:0048786)
0.1 7.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.5 7.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 7.0 GO:0001650 fibrillar center(GO:0001650)
0.5 6.7 GO:0043203 axon hillock(GO:0043203)
0.5 5.9 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.3 5.9 GO:0001891 phagocytic cup(GO:0001891)
0.5 5.7 GO:0044666 MLL3/4 complex(GO:0044666)
0.2 5.7 GO:0031430 M band(GO:0031430)
0.4 5.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.4 4.8 GO:0097542 ciliary tip(GO:0097542)
0.1 4.6 GO:0035861 site of double-strand break(GO:0035861)
0.3 4.5 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 4.5 GO:0016607 nuclear speck(GO:0016607)
0.1 4.2 GO:0032809 neuronal cell body membrane(GO:0032809)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 123 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 26.9 GO:0003779 actin binding(GO:0003779)
0.4 10.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.5 10.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 10.2 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.2 10.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.4 9.7 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 9.1 GO:0008201 heparin binding(GO:0008201)
1.8 9.0 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.1 8.0 GO:0030507 spectrin binding(GO:0030507)
0.7 7.9 GO:0004016 adenylate cyclase activity(GO:0004016)
1.9 7.6 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441)
0.3 7.6 GO:0030552 cAMP binding(GO:0030552)
0.0 6.9 GO:0017124 SH3 domain binding(GO:0017124)
0.3 6.4 GO:0071949 FAD binding(GO:0071949)
0.9 6.1 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.5 5.9 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 5.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.3 5.7 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 5.4 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.3 5.3 GO:0008253 5'-nucleotidase activity(GO:0008253)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 4.1 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 4.1 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 3.6 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 3.4 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 3.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.9 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 2.9 SIG_CHEMOTAXIS Genes related to chemotaxis
0.1 2.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 2.6 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 1.9 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 1.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 1.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 1.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.2 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.2 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.0 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.0 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.9 NABA_COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 29.7 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.4 13.9 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.3 9.0 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.3 9.0 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.2 5.9 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.2 5.0 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.2 4.7 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 4.3 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 4.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 4.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 3.1 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 3.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 2.9 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 2.8 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 2.7 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.2 2.6 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 2.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.3 2.5 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 2.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.2 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)