Motif ID: Meox1

Z-value: 0.781


Transcription factors associated with Meox1:

Gene SymbolEntrez IDGene Name
Meox1 ENSMUSG00000001493.9 Meox1



Activity profile for motif Meox1.

activity profile for motif Meox1


Sorted Z-values histogram for motif Meox1

Sorted Z-values for motif Meox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Meox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 127 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_14621805 6.837 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr15_-_8710734 6.077 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_-_36811361 6.001 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr15_-_8710409 5.081 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr7_-_140154712 4.873 ENSMUST00000059241.7
 Sprn
shadow of prion protein
chr8_+_66386292 4.755 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr5_+_107403496 4.735 ENSMUST00000049146.5
 Ephx4
epoxide hydrolase 4
chr15_+_92597104 4.648 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr5_-_134747241 4.424 ENSMUST00000015138.9
 Eln
elastin
chr15_-_37458523 4.133 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr15_-_37459327 3.866 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr3_-_59220150 3.489 ENSMUST00000170388.1
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr4_-_14621494 3.446 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr4_-_14621669 3.227 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr3_-_113577743 3.070 ENSMUST00000067980.5
 Amy1
amylase 1, salivary
chr3_-_121263314 2.787 ENSMUST00000029777.7
 Tmem56
transmembrane protein 56
chr9_-_95750335 2.724 ENSMUST00000053785.3
 Trpc1
transient receptor potential cation channel, subfamily C, member 1
chr11_-_98053415 2.639 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr3_+_13946368 2.587 ENSMUST00000171075.1
ENSMUST00000108372.2
 Ralyl

RALY RNA binding protein-like

chr14_+_27238018 2.390 ENSMUST00000049206.5
 Arhgef3
Rho guanine nucleotide exchange factor (GEF) 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 13.5 GO:0019532 oxalate transport(GO:0019532)
2.8 11.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 8.0 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
2.0 6.0 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.0 5.1 GO:1902593 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.3 4.8 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 4.4 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 4.4 GO:0007416 synapse assembly(GO:0007416)
1.2 3.5 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.4 3.3 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.2 3.3 GO:0048240 sperm capacitation(GO:0048240)
0.0 3.1 GO:0016052 carbohydrate catabolic process(GO:0016052)
0.3 2.7 GO:0046541 saliva secretion(GO:0046541)
0.8 2.4 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.4 2.4 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 2.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.4 1.9 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.6 1.8 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.1 1.8 GO:0016486 peptide hormone processing(GO:0016486)
0.4 1.7 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 30.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 6.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 4.9 GO:0031225 anchored component of membrane(GO:0031225)
0.1 4.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
1.5 4.4 GO:0071953 elastic fiber(GO:0071953)
0.1 3.9 GO:0031672 A band(GO:0031672)
0.4 3.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 2.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 2.2 GO:0001650 fibrillar center(GO:0001650)
0.1 2.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.9 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.8 GO:0030141 secretory granule(GO:0030141)
0.0 1.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.3 1.6 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.2 1.5 GO:0097443 sorting endosome(GO:0097443)
0.2 1.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 1.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 1.1 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 1.1 GO:0042629 mast cell granule(GO:0042629)
0.3 1.0 GO:0098835 presynaptic endosome(GO:0098830) presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 13.5 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
1.9 11.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 8.0 GO:0043014 alpha-tubulin binding(GO:0043014)
2.0 6.0 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.5 3.5 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.5 3.3 GO:0070699 type II activin receptor binding(GO:0070699)
1.0 3.1 GO:0016160 alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.1 3.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 3.0 GO:0042287 MHC protein binding(GO:0042287)
0.2 2.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 2.4 GO:0070412 R-SMAD binding(GO:0070412)
0.1 2.4 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 2.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.9 GO:0030165 PDZ domain binding(GO:0030165)
0.6 1.8 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 1.8 GO:0051082 unfolded protein binding(GO:0051082)
0.1 1.7 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 1.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 1.6 GO:0000150 recombinase activity(GO:0000150)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.0 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 4.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.8 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 2.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.8 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.1 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.1 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 0.7 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.6 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 25.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.4 8.0 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 5.2 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.4 3.5 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 2.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.4 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 2.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.5 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 1.4 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 1.2 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 0.9 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.6 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.5 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.5 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 0.4 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.4 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions