Motif ID: Meox2

Z-value: 0.740


Transcription factors associated with Meox2:

Gene SymbolEntrez IDGene Name
Meox2 ENSMUSG00000036144.5 Meox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Meox2mm10_v2_chr12_+_37108533_371085460.321.7e-02Click!


Activity profile for motif Meox2.

activity profile for motif Meox2


Sorted Z-values histogram for motif Meox2

Sorted Z-values for motif Meox2



Network of associatons between targets according to the STRING database.



First level regulatory network of Meox2

PNG image of the network

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Top targets:


Showing 1 to 20 of 153 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_26119811 7.431 ENSMUST00000173617.1
 Duxbl2
doubl homeobox B-like 2
chr14_+_25980039 7.349 ENSMUST00000173155.1
 Duxbl1
double homeobox B-like 1
chr14_+_26259109 5.752 ENSMUST00000174494.1
 Duxbl3
double homeobox B-like 3
chr16_+_42907563 5.519 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr13_+_104229366 3.737 ENSMUST00000022227.6
 Cenpk
centromere protein K
chr17_+_75005523 3.053 ENSMUST00000001927.5
 Ltbp1
latent transforming growth factor beta binding protein 1
chr14_+_25979401 2.869 ENSMUST00000173580.1
 Duxbl1
double homeobox B-like 1
chr8_+_12395287 2.802 ENSMUST00000180353.1
 Sox1
SRY-box containing gene 1
chr15_-_99651580 2.527 ENSMUST00000171908.1
ENSMUST00000171702.1
ENSMUST00000109581.2
ENSMUST00000169810.1
ENSMUST00000023756.5
 Racgap1




Rac GTPase-activating protein 1




chr8_-_46294592 2.396 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr9_-_36726374 2.365 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr5_-_62766153 2.343 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_-_98339921 2.337 ENSMUST00000065793.5
 Phgdh
3-phosphoglycerate dehydrogenase
chr3_+_66219909 2.329 ENSMUST00000029421.5
 Ptx3
pentraxin related gene
chr14_+_26119173 2.298 ENSMUST00000174564.1
 Duxbl2
doubl homeobox B-like 2
chr14_+_26258786 2.298 ENSMUST00000172517.1
 Duxbl3
double homeobox B-like 3
chr8_-_4779513 2.195 ENSMUST00000022945.7
 Shcbp1
Shc SH2-domain binding protein 1
chr10_-_116972609 2.085 ENSMUST00000092165.4
 Gm10271
predicted gene 10271
chr3_+_127553462 2.058 ENSMUST00000043108.4
 4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr19_+_59458372 1.994 ENSMUST00000062216.3
 Emx2
empty spiracles homeobox 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.7 GO:0045580 regulation of T cell differentiation(GO:0045580)
0.1 5.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 3.1 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.2 2.8 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.8 2.5 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.6 2.4 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.3 2.4 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.1 2.4 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.8 2.3 GO:0006566 threonine metabolic process(GO:0006566)
0.5 2.3 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.0 2.2 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.2 2.0 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 1.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 1.7 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 1.7 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 1.6 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.0 1.6 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.1 1.5 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 1.4 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.3 1.3 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 GO:0070469 respiratory chain(GO:0070469)
0.0 3.2 GO:0000776 kinetochore(GO:0000776)
1.0 3.1 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.5 2.5 GO:0097149 centralspindlin complex(GO:0097149)
0.0 2.1 GO:0005814 centriole(GO:0005814)
0.0 2.0 GO:0005657 replication fork(GO:0005657)
0.0 1.9 GO:0000922 spindle pole(GO:0000922)
0.2 1.6 GO:0030478 actin cap(GO:0030478)
0.0 1.4 GO:0072686 mitotic spindle(GO:0072686)
0.1 1.3 GO:0097431 mitotic spindle pole(GO:0097431)
0.2 1.2 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.2 0.9 GO:0008623 CHRAC(GO:0008623)
0.2 0.9 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 0.8 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 0.8 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.6 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.6 GO:0005844 polysome(GO:0005844)
0.0 0.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.4 GO:0070552 BRISC complex(GO:0070552)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 4.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 4.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 3.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.8 3.1 GO:0050436 microfibril binding(GO:0050436)
0.8 2.4 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 2.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.3 2.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 2.3 GO:0051287 NAD binding(GO:0051287)
0.0 1.6 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 1.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.5 GO:0042169 SH2 domain binding(GO:0042169)
0.0 1.3 GO:0008200 ion channel inhibitor activity(GO:0008200)
0.0 1.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 1.2 GO:0000150 recombinase activity(GO:0000150)
0.0 1.2 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 1.1 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.0 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.3 0.9 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.2 0.9 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.9 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 2.7 PID_ARF6_PATHWAY Arf6 signaling events
0.3 2.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.3 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.2 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 1.0 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.8 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.7 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.4 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 2.4 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 2.3 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 2.2 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.6 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.3 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 0.9 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.9 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.7 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.5 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.2 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle