Motif ID: Mnt

Z-value: 0.820


Transcription factors associated with Mnt:

Gene SymbolEntrez IDGene Name
Mnt ENSMUSG00000000282.6 Mnt

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mntmm10_v2_chr11_+_74830920_748310050.384.4e-03Click!


Activity profile for motif Mnt.

activity profile for motif Mnt


Sorted Z-values histogram for motif Mnt

Sorted Z-values for motif Mnt



Network of associatons between targets according to the STRING database.



First level regulatory network of Mnt

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_121495678 8.669 ENSMUST00000035120.4
 Cck
cholecystokinin
chr2_+_4300462 6.493 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr11_+_69095217 6.364 ENSMUST00000101004.2
 Per1
period circadian clock 1
chr3_-_89773221 5.450 ENSMUST00000038450.1
 4632404H12Rik
RIKEN cDNA 4632404H12 gene
chr5_-_136170634 5.321 ENSMUST00000041048.1
 Orai2
ORAI calcium release-activated calcium modulator 2
chrX_-_51681703 5.182 ENSMUST00000088172.5
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr17_-_66077022 5.058 ENSMUST00000150766.1
ENSMUST00000038116.5
 Ankrd12

ankyrin repeat domain 12

chr6_+_17463749 4.933 ENSMUST00000115443.1
 Met
met proto-oncogene
chr12_+_24651346 4.616 ENSMUST00000020982.5
 Klf11
Kruppel-like factor 11
chr19_-_58860975 4.481 ENSMUST00000066285.4
 Hspa12a
heat shock protein 12A
chr6_+_17463927 4.405 ENSMUST00000115442.1
 Met
met proto-oncogene
chr4_-_155992604 4.348 ENSMUST00000052185.3
 B3galt6
UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6
chr16_-_43979050 4.333 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23

chr15_-_53902472 4.283 ENSMUST00000078673.6
 Samd12
sterile alpha motif domain containing 12
chr15_+_81811414 4.189 ENSMUST00000023024.7
 Tef
thyrotroph embryonic factor
chr17_-_90455872 4.126 ENSMUST00000174337.1
ENSMUST00000172466.1
 Nrxn1

neurexin I

chr14_-_78536762 4.009 ENSMUST00000123853.1
 Akap11
A kinase (PRKA) anchor protein 11
chr11_+_3332426 3.919 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr4_-_148038769 3.801 ENSMUST00000030879.5
ENSMUST00000137724.1
 Clcn6

chloride channel 6

chr12_+_70825492 3.781 ENSMUST00000057859.7
 Frmd6
FERM domain containing 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 287 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.4 GO:0008643 carbohydrate transport(GO:0008643)
2.1 14.5 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.4 11.6 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.4 10.5 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.9 8.7 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.2 7.4 GO:0097352 autophagosome maturation(GO:0097352)
0.2 6.9 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
1.3 6.6 GO:0097167 circadian regulation of translation(GO:0097167)
0.3 6.5 GO:0021859 pyramidal neuron differentiation(GO:0021859)
1.0 5.9 GO:0055091 phospholipid homeostasis(GO:0055091)
0.1 5.9 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 5.7 GO:0006024 glycosaminoglycan biosynthetic process(GO:0006024)
1.8 5.5 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
1.8 5.5 GO:0043379 memory T cell differentiation(GO:0043379)
0.2 5.4 GO:0018345 protein palmitoylation(GO:0018345)
0.5 5.3 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.3 5.3 GO:0002115 store-operated calcium entry(GO:0002115)
0.9 5.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.6 4.8 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.8 4.2 GO:1902683 regulation of receptor localization to synapse(GO:1902683)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.5 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.2 11.6 GO:0009925 basal plasma membrane(GO:0009925)
0.0 11.6 GO:0000139 Golgi membrane(GO:0000139)
0.0 8.9 GO:0097060 synaptic membrane(GO:0097060)
0.6 8.7 GO:0043203 axon hillock(GO:0043203)
0.0 8.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.8 7.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 6.7 GO:0030426 growth cone(GO:0030426)
0.1 6.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.4 5.9 GO:1990635 proximal dendrite(GO:1990635)
1.1 5.5 GO:1990761 growth cone lamellipodium(GO:1990761)
0.1 5.3 GO:0030139 endocytic vesicle(GO:0030139)
0.2 5.2 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 5.1 GO:0005770 late endosome(GO:0005770)
0.1 4.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.6 4.4 GO:0033263 CORVET complex(GO:0033263)
0.4 4.2 GO:0071141 SMAD protein complex(GO:0071141)
0.5 4.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 3.9 GO:0030117 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.1 3.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 197 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 15.6 GO:0005351 sugar:proton symporter activity(GO:0005351)
3.1 12.5 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.6 11.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.4 9.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 9.4 GO:0051018 protein kinase A binding(GO:0051018)
0.2 9.0 GO:0015485 cholesterol binding(GO:0015485)
0.5 8.9 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 8.5 GO:0008017 microtubule binding(GO:0008017)
0.8 7.4 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.2 5.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 5.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.4 5.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 5.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 5.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
1.3 5.2 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.4 5.1 GO:0097109 neuroligin family protein binding(GO:0097109)
0.3 4.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 4.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.5 4.3 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0 4.1 GO:0008565 protein transporter activity(GO:0008565)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.3 PID_ARF6_PATHWAY Arf6 signaling events
0.1 10.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 7.7 PID_FOXO_PATHWAY FoxO family signaling
0.0 5.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 5.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.3 5.2 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 5.1 PID_LKB1_PATHWAY LKB1 signaling events
0.1 3.5 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 3.5 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 3.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 3.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 2.7 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 2.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 2.5 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 2.3 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.3 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.2 2.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.2 1.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.9 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.2 1.6 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.5 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.5 11.6 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 7.3 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.2 6.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 6.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 6.6 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.3 6.0 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 5.2 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.2 4.3 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 3.9 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 3.7 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.4 3.5 REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS Genes involved in Acetylcholine Binding And Downstream Events
0.2 3.5 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 3.4 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 3.3 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 3.0 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 3.0 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 2.9 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2 2.9 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 2.8 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression