Motif ID: Mnx1_Lhx6_Lmx1a

Z-value: 0.834

Transcription factors associated with Mnx1_Lhx6_Lmx1a:

Gene SymbolEntrez IDGene Name
Lhx6 ENSMUSG00000026890.13 Lhx6
Lmx1a ENSMUSG00000026686.8 Lmx1a
Mnx1 ENSMUSG00000001566.8 Mnx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lmx1amm10_v2_chr1_+_167689108_1676892390.724.6e-10Click!
Lhx6mm10_v2_chr2_-_36105271_36105434-0.029.0e-01Click!


Activity profile for motif Mnx1_Lhx6_Lmx1a.

activity profile for motif Mnx1_Lhx6_Lmx1a


Sorted Z-values histogram for motif Mnx1_Lhx6_Lmx1a

Sorted Z-values for motif Mnx1_Lhx6_Lmx1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Mnx1_Lhx6_Lmx1a

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_61902669 18.839 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr2_+_20737306 15.893 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr5_+_139543889 13.314 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr15_+_25773985 8.934 ENSMUST00000125667.1
 Myo10
myosin X
chr2_+_25372315 8.928 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr14_-_118052235 8.276 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr9_+_65890237 7.857 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr3_-_88410295 7.486 ENSMUST00000056370.7
 Pmf1
polyamine-modulated factor 1
chr9_+_118478344 6.529 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr14_-_48665098 6.212 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr1_-_172027269 6.086 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr9_+_118478182 6.065 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr5_+_92809372 5.922 ENSMUST00000113054.2
 Shroom3
shroom family member 3
chr4_-_97778042 5.919 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr6_-_147264124 5.580 ENSMUST00000052296.6
 Pthlh
parathyroid hormone-like peptide
chr7_-_49636847 5.418 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr5_-_62766153 5.277 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_+_55782500 5.095 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chrX_-_60893430 4.920 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr11_-_3931960 4.810 ENSMUST00000109990.1
ENSMUST00000020710.4
ENSMUST00000109989.3
ENSMUST00000109991.1
ENSMUST00000109993.2
 Tcn2




transcobalamin 2





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 18.8 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
1.7 13.8 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
4.2 12.6 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.8 12.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
3.1 9.4 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
2.3 9.2 GO:0015889 cobalamin transport(GO:0015889)
0.2 9.1 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
2.1 8.6 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.4 8.3 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 8.1 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.4 6.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.5 6.0 GO:0006982 response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449)
0.9 5.6 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.4 5.4 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 5.4 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.5 5.3 GO:0060539 diaphragm development(GO:0060539)
0.1 5.3 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
1.0 5.0 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.2 4.9 GO:0007530 sex determination(GO:0007530)
0.0 4.4 GO:0043488 regulation of mRNA stability(GO:0043488)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 18.8 GO:0002102 podosome(GO:0002102)
0.0 12.0 GO:0005615 extracellular space(GO:0005615)
2.4 9.4 GO:0060187 cell pole(GO:0060187)
0.2 8.9 GO:0016459 myosin complex(GO:0016459)
0.1 8.5 GO:0070469 respiratory chain(GO:0070469)
0.1 8.5 GO:0043296 apical junction complex(GO:0043296)
0.3 8.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 7.9 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
1.2 7.5 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.1 7.5 GO:0000792 heterochromatin(GO:0000792)
0.3 4.4 GO:0042788 polysomal ribosome(GO:0042788)
0.9 3.8 GO:0008623 CHRAC(GO:0008623)
0.0 3.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 3.7 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 3.6 GO:0016607 nuclear speck(GO:0016607)
0.0 3.5 GO:0043198 dendritic shaft(GO:0043198)
0.2 2.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.5 2.4 GO:0031523 Myb complex(GO:0031523)
0.3 2.4 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.4 2.3 GO:0098536 deuterosome(GO:0098536)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.6 GO:0003779 actin binding(GO:0003779)
0.0 15.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 12.9 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.2 12.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 10.7 GO:0051015 actin filament binding(GO:0051015)
0.7 10.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
1.3 9.2 GO:0031419 cobalamin binding(GO:0031419)
0.6 8.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.3 8.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 7.7 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.6 7.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.5 6.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.6 6.0 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.3 6.0 GO:1900750 glutathione peroxidase activity(GO:0004602) glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 6.0 GO:0030507 spectrin binding(GO:0030507)
0.8 5.6 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.6 5.6 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 5.5 GO:0005109 frizzled binding(GO:0005109)
0.0 5.1 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 5.1 GO:0016779 nucleotidyltransferase activity(GO:0016779)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 8.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 7.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 6.5 PID_ARF6_PATHWAY Arf6 signaling events
0.2 5.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 4.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 3.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 3.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 2.4 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 2.4 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 2.3 PID_E2F_PATHWAY E2F transcription factor network
0.1 2.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 2.0 PID_PLK1_PATHWAY PLK1 signaling events
0.1 1.9 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.9 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 1.7 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 1.6 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 1.4 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.4 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 1.3 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 17.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 10.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 8.9 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 6.0 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 5.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 5.0 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 4.7 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.0 4.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 3.7 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 3.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.2 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 3.0 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.7 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 2.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 2.0 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.9 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 1.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 1.4 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.4 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.3 1.3 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis