Motif ID: Msx2_Hoxd4

Z-value: 1.114

Transcription factors associated with Msx2_Hoxd4:

Gene SymbolEntrez IDGene Name
Msx2 ENSMUSG00000021469.8 Msx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx2mm10_v2_chr13_-_53473074_53473074-0.321.7e-02Click!


Activity profile for motif Msx2_Hoxd4.

activity profile for motif Msx2_Hoxd4


Sorted Z-values histogram for motif Msx2_Hoxd4

Sorted Z-values for motif Msx2_Hoxd4



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx2_Hoxd4

PNG image of the network

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Top targets:


Showing 1 to 20 of 166 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_62766153 10.848 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_4017727 9.099 ENSMUST00000177457.1
 Frmd4a
FERM domain containing 4A
chr6_-_36811361 8.670 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr15_+_21111452 8.308 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr14_-_88471396 6.717 ENSMUST00000061628.5
 Pcdh20
protocadherin 20
chr1_+_159737510 6.711 ENSMUST00000111669.3
 Tnr
tenascin R
chr3_+_62419668 6.592 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr1_-_190170671 6.490 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr1_-_190170178 5.689 ENSMUST00000177288.1
 Prox1
prospero-related homeobox 1
chr15_-_79285502 5.523 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr2_-_63184253 5.441 ENSMUST00000075052.3
ENSMUST00000112454.1
 Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr3_-_85741389 4.805 ENSMUST00000094148.4
 Fam160a1
family with sequence similarity 160, member A1
chr11_+_103133333 4.695 ENSMUST00000124928.1
ENSMUST00000062530.4
 Hexim2

hexamethylene bis-acetamide inducible 2

chr11_+_103133303 4.689 ENSMUST00000107037.1
 Hexim2
hexamethylene bis-acetamide inducible 2
chr3_-_49757257 4.562 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr1_-_163725123 4.178 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr5_-_62765618 3.770 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_-_63184170 3.565 ENSMUST00000112452.1
 Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr6_-_136171722 3.519 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr12_+_74297474 3.500 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
4.1 12.2 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.3 9.4 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.2 9.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 9.1 GO:0051291 protein heterooligomerization(GO:0051291)
2.9 8.7 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.3 7.6 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
1.7 6.7 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.3 6.6 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 6.6 GO:0007416 synapse assembly(GO:0007416)
0.3 5.5 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.2 5.5 GO:0070207 protein homotrimerization(GO:0070207)
0.2 4.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 4.4 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.1 4.2 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.9 3.5 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.9 3.4 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.0 3.3 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
1.1 3.2 GO:2000016 negative regulation of determination of dorsal identity(GO:2000016)
0.0 3.1 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 29.6 GO:0016021 integral component of membrane(GO:0016021)
0.0 12.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 10.4 GO:0031594 neuromuscular junction(GO:0031594)
0.0 9.4 GO:0016607 nuclear speck(GO:0016607)
0.1 9.0 GO:0005923 bicellular tight junction(GO:0005923)
2.2 6.7 GO:0072534 perineuronal net(GO:0072534)
1.4 5.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.6 5.5 GO:0071439 clathrin complex(GO:0071439)
0.0 4.0 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 3.8 GO:0005911 cell-cell junction(GO:0005911)
0.2 3.5 GO:0043083 synaptic cleft(GO:0043083)
0.4 3.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 3.2 GO:0042588 zymogen granule(GO:0042588)
0.2 2.5 GO:0044327 dendritic spine head(GO:0044327)
0.0 2.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 2.3 GO:0071564 npBAF complex(GO:0071564)
0.0 2.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 1.9 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 1.8 GO:0005815 microtubule organizing center(GO:0005815)
0.0 1.8 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 22.7 GO:0005509 calcium ion binding(GO:0005509)
0.3 14.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
1.0 12.2 GO:0050693 LBD domain binding(GO:0050693)
1.2 9.4 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 9.1 GO:0030674 protein binding, bridging(GO:0030674)
0.5 9.0 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
2.9 8.7 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.4 6.7 GO:0046625 sphingolipid binding(GO:0046625)
0.1 5.5 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.0 5.2 GO:0005543 phospholipid binding(GO:0005543)
0.0 4.6 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 3.7 GO:0008276 protein methyltransferase activity(GO:0008276)
0.4 3.5 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.3 3.4 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 3.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 3.3 GO:0005096 GTPase activator activity(GO:0005096)
0.5 3.2 GO:0098821 BMP receptor activity(GO:0098821)
0.5 3.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 3.1 GO:0043014 alpha-tubulin binding(GO:0043014)
1.0 3.0 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 14.6 PID_ARF6_PATHWAY Arf6 signaling events
0.5 8.7 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 7.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 5.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 3.6 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 3.2 PID_BMP_PATHWAY BMP receptor signaling
0.0 2.6 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 2.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 2.2 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 2.0 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 1.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.5 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.3 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.2 PID_MYC_PATHWAY C-MYC pathway
0.0 1.0 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.8 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.8 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.6 PID_NFAT_3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 9.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 8.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.9 5.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 3.5 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.2 3.1 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.4 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 2.2 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 2.0 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.2 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.1 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.0 0.8 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events