Motif ID: Mtf1

Z-value: 1.111


Transcription factors associated with Mtf1:

Gene SymbolEntrez IDGene Name
Mtf1 ENSMUSG00000028890.7 Mtf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mtf1mm10_v2_chr4_+_124802543_1248026780.019.4e-01Click!


Activity profile for motif Mtf1.

activity profile for motif Mtf1


Sorted Z-values histogram for motif Mtf1

Sorted Z-values for motif Mtf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mtf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 78 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_94172618 41.399 ENSMUST00000034214.6
 Mt2
metallothionein 2
chr8_+_94179089 26.554 ENSMUST00000034215.6
 Mt1
metallothionein 1
chr11_-_32222233 11.041 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr17_+_85620816 5.650 ENSMUST00000175898.2
 Six3
sine oculis-related homeobox 3
chr11_+_63133068 4.865 ENSMUST00000108700.1
 Pmp22
peripheral myelin protein 22
chr11_+_63132569 4.327 ENSMUST00000108701.1
 Pmp22
peripheral myelin protein 22
chr1_+_135729147 3.997 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr1_+_157412352 3.933 ENSMUST00000061537.5
 2810025M15Rik
RIKEN cDNA 2810025M15 gene
chr1_-_169531343 3.371 ENSMUST00000028000.7
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr2_+_119112793 3.225 ENSMUST00000140939.1
ENSMUST00000028795.3
 Rad51

RAD51 homolog

chr14_-_26170283 3.183 ENSMUST00000100809.4
 Plac9b
placenta specific 9b
chr13_+_23934434 3.043 ENSMUST00000072391.1
 Hist1h2aa
histone cluster 1, H2aa
chr1_-_169531447 2.912 ENSMUST00000111368.1
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr1_+_131867224 2.207 ENSMUST00000112386.1
ENSMUST00000027693.7
 Rab7l1

RAB7, member RAS oncogene family-like 1

chr4_+_129984833 2.068 ENSMUST00000120204.1
 Bai2
brain-specific angiogenesis inhibitor 2
chr6_-_39118211 2.067 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr4_+_129985098 2.017 ENSMUST00000106017.1
ENSMUST00000121049.1
 Bai2

brain-specific angiogenesis inhibitor 2

chr1_+_167618246 1.787 ENSMUST00000111380.1
 Rxrg
retinoid X receptor gamma
chr5_-_125341043 1.747 ENSMUST00000111390.1
ENSMUST00000086075.6
 Scarb1

scavenger receptor class B, member 1

chr19_-_4201591 1.571 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.7 68.0 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.2 11.0 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.5 9.2 GO:0032060 bleb assembly(GO:0032060)
0.2 6.3 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
1.9 5.7 GO:0097402 neuroblast migration(GO:0097402)
0.6 4.0 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.1 4.0 GO:0070527 platelet aggregation(GO:0070527)
1.1 3.2 GO:0051105 regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
0.0 3.0 GO:0006342 chromatin silencing(GO:0006342)
0.0 1.8 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.6 1.7 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.1 1.6 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.1 1.3 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.0 1.1 GO:0051353 positive regulation of oxidoreductase activity(GO:0051353)
0.3 1.0 GO:0034334 adherens junction maintenance(GO:0034334)
0.2 1.0 GO:1990564 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721) protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 1.0 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1 0.9 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.9 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.8 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 25.4 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 10.4 GO:0000139 Golgi membrane(GO:0000139)
0.4 9.2 GO:0043218 compact myelin(GO:0043218)
1.0 6.3 GO:0031262 Ndc80 complex(GO:0031262)
0.3 4.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 3.2 GO:0000800 lateral element(GO:0000800)
0.1 1.7 GO:0031528 microvillus membrane(GO:0031528)
0.3 1.6 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 1.0 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.8 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 0.6 GO:0031526 brush border membrane(GO:0031526)
0.0 0.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.4 GO:0045098 type III intermediate filament(GO:0045098)
0.0 0.3 GO:0097539 ciliary transition fiber(GO:0097539)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 35.9 GO:0008270 zinc ion binding(GO:0008270)
0.5 27.6 GO:0005507 copper ion binding(GO:0005507)
0.1 10.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 5.7 GO:0001222 transcription corepressor binding(GO:0001222)
0.2 4.0 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.5 3.2 GO:0000150 recombinase activity(GO:0000150)
0.1 2.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 1.8 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.6 1.7 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.4 1.6 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 1.3 GO:0031386 protein tag(GO:0031386)
0.3 1.0 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 1.0 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.9 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.2 0.7 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 0.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 0.6 GO:0042895 antibiotic transporter activity(GO:0042895)
0.0 0.6 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 0.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.5 GO:0003680 AT DNA binding(GO:0003680)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.0 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 4.8 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.9 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.5 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.4 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.4 PID_ATM_PATHWAY ATM pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 3.2 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 2.9 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 1.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.7 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.6 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.0 0.9 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.5 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling