Motif ID: Mtf1

Z-value: 1.111


Transcription factors associated with Mtf1:

Gene SymbolEntrez IDGene Name
Mtf1 ENSMUSG00000028890.7 Mtf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mtf1mm10_v2_chr4_+_124802543_1248026780.019.4e-01Click!


Activity profile for motif Mtf1.

activity profile for motif Mtf1


Sorted Z-values histogram for motif Mtf1

Sorted Z-values for motif Mtf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mtf1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_94172618 41.399 ENSMUST00000034214.6
 Mt2
metallothionein 2
chr8_+_94179089 26.554 ENSMUST00000034215.6
 Mt1
metallothionein 1
chr11_-_32222233 11.041 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr17_+_85620816 5.650 ENSMUST00000175898.2
 Six3
sine oculis-related homeobox 3
chr11_+_63133068 4.865 ENSMUST00000108700.1
 Pmp22
peripheral myelin protein 22
chr11_+_63132569 4.327 ENSMUST00000108701.1
 Pmp22
peripheral myelin protein 22
chr1_+_135729147 3.997 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr1_+_157412352 3.933 ENSMUST00000061537.5
 2810025M15Rik
RIKEN cDNA 2810025M15 gene
chr1_-_169531343 3.371 ENSMUST00000028000.7
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr2_+_119112793 3.225 ENSMUST00000140939.1
ENSMUST00000028795.3
 Rad51

RAD51 homolog

chr14_-_26170283 3.183 ENSMUST00000100809.4
 Plac9b
placenta specific 9b
chr13_+_23934434 3.043 ENSMUST00000072391.1
 Hist1h2aa
histone cluster 1, H2aa
chr1_-_169531447 2.912 ENSMUST00000111368.1
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr1_+_131867224 2.207 ENSMUST00000112386.1
ENSMUST00000027693.7
 Rab7l1

RAB7, member RAS oncogene family-like 1

chr4_+_129984833 2.068 ENSMUST00000120204.1
 Bai2
brain-specific angiogenesis inhibitor 2
chr6_-_39118211 2.067 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr4_+_129985098 2.017 ENSMUST00000106017.1
ENSMUST00000121049.1
 Bai2

brain-specific angiogenesis inhibitor 2

chr1_+_167618246 1.787 ENSMUST00000111380.1
 Rxrg
retinoid X receptor gamma
chr5_-_125341043 1.747 ENSMUST00000111390.1
ENSMUST00000086075.6
 Scarb1

scavenger receptor class B, member 1

chr19_-_4201591 1.571 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A
chr3_+_107895821 1.548 ENSMUST00000004134.4
 Gstm5
glutathione S-transferase, mu 5
chr3_+_107895916 1.460 ENSMUST00000172247.1
ENSMUST00000167387.1
 Gstm5

glutathione S-transferase, mu 5

chr7_+_119793987 1.442 ENSMUST00000033218.8
ENSMUST00000106520.1
 2610020H08Rik

RIKEN cDNA 2610020H08 gene

chr7_+_119794102 1.398 ENSMUST00000084644.2
 2610020H08Rik
RIKEN cDNA 2610020H08 gene
chr12_-_4592927 1.208 ENSMUST00000170816.1
 Gm3625
predicted gene 3625
chr19_-_4839286 1.055 ENSMUST00000037246.5
 Ccs
copper chaperone for superoxide dismutase
chr17_-_56626872 1.048 ENSMUST00000047226.8
 Lonp1
lon peptidase 1, mitochondrial
chr2_-_130664565 1.027 ENSMUST00000089559.4
 Ddrgk1
DDRGK domain containing 1
chr18_+_14424821 1.024 ENSMUST00000069552.5
 Gm5160
predicted gene 5160
chr3_+_107896247 0.982 ENSMUST00000169365.1
 Gstm5
glutathione S-transferase, mu 5
chr6_+_145746739 0.961 ENSMUST00000111704.1
 Rassf8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr19_-_4615647 0.907 ENSMUST00000113822.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr3_-_94412883 0.888 ENSMUST00000181305.1
 1700040D17Rik
RIKEN cDNA 1700040D17 gene
chr9_-_112187898 0.882 ENSMUST00000178410.1
ENSMUST00000172380.3
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr19_-_4615453 0.831 ENSMUST00000053597.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr12_+_103532435 0.792 ENSMUST00000021631.5
 Ppp4r4
protein phosphatase 4, regulatory subunit 4
chr11_+_99047311 0.745 ENSMUST00000140772.1
 Igfbp4
insulin-like growth factor binding protein 4
chr10_+_77606217 0.706 ENSMUST00000129492.1
ENSMUST00000141228.2
 Sumo3

SMT3 suppressor of mif two 3 homolog 3 (yeast)

chr9_+_109832998 0.687 ENSMUST00000119376.1
ENSMUST00000122343.1
 Nme6

NME/NM23 nucleoside diphosphate kinase 6

chr12_+_33957645 0.642 ENSMUST00000049089.5
 Twist1
twist basic helix-loop-helix transcription factor 1
chr7_+_5056856 0.631 ENSMUST00000131368.1
ENSMUST00000123956.1
 Ccdc106

coiled-coil domain containing 106

chr16_+_18348181 0.623 ENSMUST00000115614.2
ENSMUST00000115613.1
ENSMUST00000090103.3
 Arvcf


armadillo repeat gene deleted in velo-cardio-facial syndrome


chr2_+_31759932 0.557 ENSMUST00000028190.6
 Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr1_-_166309585 0.542 ENSMUST00000168347.1
 5330438I03Rik
RIKEN cDNA 5330438I03 gene
chr8_+_106210936 0.504 ENSMUST00000071592.5
 Prmt7
protein arginine N-methyltransferase 7
chr1_-_166002591 0.499 ENSMUST00000111429.4
ENSMUST00000176800.1
 Pou2f1

POU domain, class 2, transcription factor 1

chr9_+_78175898 0.494 ENSMUST00000180974.1
 C920006O11Rik
RIKEN cDNA C920006O11 gene
chr5_-_99978914 0.485 ENSMUST00000112939.3
ENSMUST00000171786.1
ENSMUST00000072750.6
ENSMUST00000019128.8
ENSMUST00000172361.1
 Hnrnpd




heterogeneous nuclear ribonucleoprotein D




chr10_+_77606044 0.460 ENSMUST00000020501.8
 Sumo3
SMT3 suppressor of mif two 3 homolog 3 (yeast)
chr8_-_70776650 0.458 ENSMUST00000034296.8
 Pik3r2
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
chr1_+_75400070 0.449 ENSMUST00000113589.1
 Speg
SPEG complex locus
chr17_-_56716788 0.421 ENSMUST00000067931.5
 Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr5_+_115506668 0.403 ENSMUST00000067268.8
ENSMUST00000086523.3
 Pxn

paxillin

chr1_-_166002613 0.385 ENSMUST00000177358.1
ENSMUST00000160908.1
ENSMUST00000027850.8
ENSMUST00000160260.2
 Pou2f1



POU domain, class 2, transcription factor 1



chr4_+_133574728 0.370 ENSMUST00000030662.2
 Gpatch3
G patch domain containing 3
chr2_-_119787504 0.362 ENSMUST00000110793.1
ENSMUST00000099529.2
ENSMUST00000048493.5
 Rpap1


RNA polymerase II associated protein 1


chr5_-_34637203 0.335 ENSMUST00000114331.3
 Mfsd10
major facilitator superfamily domain containing 10
chr10_+_70245083 0.327 ENSMUST00000046807.6
 Slc16a9
solute carrier family 16 (monocarboxylic acid transporters), member 9
chr8_-_106210924 0.256 ENSMUST00000035925.5
 Slc7a6os
solute carrier family 7, member 6 opposite strand
chr5_-_34637107 0.222 ENSMUST00000124668.1
ENSMUST00000001109.4
ENSMUST00000155577.1
ENSMUST00000114329.1
 Mfsd10



major facilitator superfamily domain containing 10



chr2_+_150323702 0.211 ENSMUST00000133235.2
 Gm10130
predicted gene 10130
chr8_+_106211016 0.208 ENSMUST00000109297.1
 Prmt7
protein arginine N-methyltransferase 7
chr9_-_14381242 0.194 ENSMUST00000167549.1
 Endod1
endonuclease domain containing 1
chr2_+_29889720 0.183 ENSMUST00000113767.1
 Odf2
outer dense fiber of sperm tails 2
chr10_+_77606571 0.171 ENSMUST00000099538.5
 Sumo3
SMT3 suppressor of mif two 3 homolog 3 (yeast)
chr5_+_30869579 0.170 ENSMUST00000046349.7
 Tmem214
transmembrane protein 214
chr5_+_30869623 0.156 ENSMUST00000114716.1
 Tmem214
transmembrane protein 214
chr2_+_29889785 0.151 ENSMUST00000113763.1
ENSMUST00000113757.1
ENSMUST00000113756.1
ENSMUST00000133233.1
ENSMUST00000113759.2
ENSMUST00000113755.1
ENSMUST00000137558.1
ENSMUST00000046571.7
 Odf2







outer dense fiber of sperm tails 2







chr10_-_39899238 0.143 ENSMUST00000178563.1
 AA474331
expressed sequence AA474331
chr7_+_132610620 0.133 ENSMUST00000033241.5
 Lhpp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr3_-_121815212 0.123 ENSMUST00000029770.5
 Abcd3
ATP-binding cassette, sub-family D (ALD), member 3
chr18_-_84589491 0.120 ENSMUST00000125763.1
 Zfp407
zinc finger protein 407
chr10_+_81136223 0.117 ENSMUST00000048128.8
 Zbtb7a
zinc finger and BTB domain containing 7a
chr8_+_13159135 0.084 ENSMUST00000033824.6
 Lamp1
lysosomal-associated membrane protein 1
chr15_-_83149307 0.080 ENSMUST00000100375.4
 Poldip3
polymerase (DNA-directed), delta interacting protein 3
chr4_-_93335510 0.053 ENSMUST00000066774.4
 Tusc1
tumor suppressor candidate 1
chr12_+_24572276 0.051 ENSMUST00000085553.5
 Grhl1
grainyhead-like 1 (Drosophila)
chr13_-_45964964 0.006 ENSMUST00000180110.1
ENSMUST00000091628.3
ENSMUST00000167708.2
 Atxn1


ataxin 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
9.7 68.0 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
1.9 5.7 GO:0097402 neuroblast migration(GO:0097402)
1.1 3.2 GO:0051105 regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
0.6 1.7 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.6 4.0 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.5 9.2 GO:0032060 bleb assembly(GO:0032060)
0.3 1.0 GO:0034334 adherens junction maintenance(GO:0034334)
0.2 0.6 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) regulation of oxidative phosphorylation uncoupler activity(GO:2000275) cell proliferation involved in heart valve development(GO:2000793)
0.2 1.0 GO:1990564 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721) protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.2 6.3 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.2 0.5 GO:1901355 response to rapamycin(GO:1901355)
0.2 11.0 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.1 0.7 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.1 0.9 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1 1.6 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.1 0.4 GO:1900275 negative regulation of phospholipase C activity(GO:1900275)
0.1 0.6 GO:0042891 antibiotic transport(GO:0042891)
0.1 0.7 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.1 0.7 GO:0006228 UTP biosynthetic process(GO:0006228)
0.1 1.3 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.1 4.0 GO:0070527 platelet aggregation(GO:0070527)
0.0 1.8 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.8 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.1 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.3 GO:0046415 urate metabolic process(GO:0046415)
0.0 1.1 GO:0051353 positive regulation of oxidoreductase activity(GO:0051353)
0.0 1.0 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.1 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626) regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323)
0.0 3.0 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.4 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.9 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.5 GO:0042993 positive regulation of transcription factor import into nucleus(GO:0042993)
0.0 0.1 GO:0002934 desmosome organization(GO:0002934)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 6.3 GO:0031262 Ndc80 complex(GO:0031262)
0.4 9.2 GO:0043218 compact myelin(GO:0043218)
0.3 4.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.3 1.6 GO:0030896 checkpoint clamp complex(GO:0030896)
0.2 3.2 GO:0000800 lateral element(GO:0000800)
0.1 0.4 GO:0045098 type III intermediate filament(GO:0045098)
0.1 1.7 GO:0031528 microvillus membrane(GO:0031528)
0.0 25.4 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 10.4 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.3 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 1.0 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.8 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 0.6 GO:0031526 brush border membrane(GO:0031526)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.5 27.6 GO:0005507 copper ion binding(GO:0005507)
0.5 3.2 GO:0000150 recombinase activity(GO:0000150)
0.4 1.6 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.3 1.0 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.2 5.7 GO:0001222 transcription corepressor binding(GO:0001222)
0.2 1.8 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 0.7 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.2 4.0 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 10.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.3 GO:0031386 protein tag(GO:0031386)
0.1 0.6 GO:0042895 antibiotic transporter activity(GO:0042895)
0.1 2.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 0.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 35.9 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.5 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.9 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.4 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.1 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.4 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.4 GO:0017166 vinculin binding(GO:0017166)
0.0 1.0 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.6 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.4 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 11.0 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 4.8 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.9 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.5 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.4 PID_ATM_PATHWAY ATM pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 1.7 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 2.9 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 6.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.6 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.0 0.5 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.9 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 1.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway