Motif ID: Myb

Z-value: 2.104


Transcription factors associated with Myb:

Gene SymbolEntrez IDGene Name
Myb ENSMUSG00000019982.8 Myb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mybmm10_v2_chr10_-_21160925_211609840.879.3e-18Click!


Activity profile for motif Myb.

activity profile for motif Myb


Sorted Z-values histogram for motif Myb

Sorted Z-values for motif Myb



Network of associatons between targets according to the STRING database.



First level regulatory network of Myb

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_118437331 27.887 ENSMUST00000006565.6
 Cdc20
cell division cycle 20
chr2_+_118814237 25.166 ENSMUST00000028803.7
ENSMUST00000126045.1
 Knstrn

kinetochore-localized astrin/SPAG5 binding

chr2_+_118814195 23.489 ENSMUST00000110842.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr2_+_118813995 22.134 ENSMUST00000134661.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr2_-_127831817 20.870 ENSMUST00000028858.7
 Bub1
budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)
chr5_+_123749696 19.991 ENSMUST00000031366.7
 Kntc1
kinetochore associated 1
chr6_+_124829540 19.539 ENSMUST00000150120.1
 Cdca3
cell division cycle associated 3
chr6_+_124829582 17.797 ENSMUST00000024270.7
 Cdca3
cell division cycle associated 3
chr9_+_72438534 17.131 ENSMUST00000034746.8
 Mns1
meiosis-specific nuclear structural protein 1
chr9_+_72438519 16.277 ENSMUST00000184604.1
 Mns1
meiosis-specific nuclear structural protein 1
chr14_+_46760526 14.974 ENSMUST00000067426.4
 Cdkn3
cyclin-dependent kinase inhibitor 3
chrX_+_58030999 14.612 ENSMUST00000088631.4
ENSMUST00000088629.3
 Zic3

zinc finger protein of the cerebellum 3

chr10_+_84838143 14.379 ENSMUST00000095388.4
 Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr17_-_33890584 14.178 ENSMUST00000114361.2
ENSMUST00000173492.1
 Kifc1

kinesin family member C1

chr19_+_36409719 14.168 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr17_-_70851189 14.152 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr18_+_60925612 13.918 ENSMUST00000102888.3
ENSMUST00000025519.4
 Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr2_-_172370506 13.833 ENSMUST00000109139.1
ENSMUST00000028997.7
ENSMUST00000109140.3
 Aurka


aurora kinase A


chr1_-_191575534 13.394 ENSMUST00000027933.5
 Dtl
denticleless homolog (Drosophila)
chr14_-_54577578 13.110 ENSMUST00000054487.8
 Ajuba
ajuba LIM protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 168 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.5 80.7 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
2.1 35.0 GO:0030953 astral microtubule organization(GO:0030953)
2.1 33.4 GO:0070986 left/right axis specification(GO:0070986)
5.5 32.9 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
4.0 27.9 GO:0000279 M phase(GO:0000279)
9.0 27.1 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
4.0 23.8 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 21.5 GO:0051301 cell division(GO:0051301)
7.0 20.9 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
1.4 19.5 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.2 18.8 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.5 17.0 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.0 16.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.6 16.3 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
3.2 16.0 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.5 14.8 GO:0007099 centriole replication(GO:0007099)
0.8 14.6 GO:0000920 cell separation after cytokinesis(GO:0000920)
2.9 14.4 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
4.6 13.8 GO:0060282 positive regulation of oocyte development(GO:0060282)
1.9 13.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 70.8 GO:0035371 microtubule plus-end(GO:0035371)
0.1 49.6 GO:0005813 centrosome(GO:0005813)
0.3 34.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.5 33.2 GO:0005882 intermediate filament(GO:0005882)
3.0 32.6 GO:0005642 annulate lamellae(GO:0005642)
0.3 32.4 GO:0000776 kinetochore(GO:0000776)
1.1 27.4 GO:0005680 anaphase-promoting complex(GO:0005680)
1.5 27.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.3 24.7 GO:0005814 centriole(GO:0005814)
0.4 24.6 GO:0005871 kinesin complex(GO:0005871)
5.2 20.9 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.4 20.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
6.7 20.0 GO:1990423 RZZ complex(GO:1990423)
0.1 19.8 GO:0030027 lamellipodium(GO:0030027)
6.5 19.5 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.2 16.9 GO:0031519 PcG protein complex(GO:0031519)
0.6 15.6 GO:0034451 centriolar satellite(GO:0034451)
4.6 13.8 GO:0042585 germinal vesicle(GO:0042585)
1.9 13.4 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.5 12.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 32.9 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 30.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
2.1 29.5 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
4.6 27.9 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 26.7 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.3 24.6 GO:0003777 microtubule motor activity(GO:0003777)
1.6 19.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
1.0 16.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.3 15.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.6 14.2 GO:0070410 co-SMAD binding(GO:0070410)
2.8 13.8 GO:0035174 histone serine kinase activity(GO:0035174)
1.0 13.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.4 12.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 11.8 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.1 11.7 GO:0042393 histone binding(GO:0042393)
2.8 11.2 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.3 11.1 GO:0017025 TBP-class protein binding(GO:0017025)
1.8 10.9 GO:0008494 translation activator activity(GO:0008494)
2.7 10.7 GO:0097100 supercoiled DNA binding(GO:0097100)
0.0 10.7 GO:0019904 protein domain specific binding(GO:0019904)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 89.9 PID_PLK1_PATHWAY PLK1 signaling events
1.0 60.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.8 19.5 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 18.0 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.4 12.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 12.0 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.3 11.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.4 11.6 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.2 10.4 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.2 9.3 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.2 6.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 6.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.5 5.0 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.2 4.9 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 4.9 PID_CMYB_PATHWAY C-MYB transcription factor network
0.2 4.7 PID_ATM_PATHWAY ATM pathway
0.2 4.6 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 4.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 3.3 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 3.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 99.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
1.5 41.7 REACTOME_KINESINS Genes involved in Kinesins
1.5 37.3 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
1.3 32.9 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.7 19.5 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.4 16.0 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.3 15.7 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.5 15.5 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.4 14.2 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 11.9 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.2 11.8 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.4 10.8 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
1.3 10.7 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2 10.7 REACTOME_AMYLOIDS Genes involved in Amyloids
0.2 10.6 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.3 9.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.6 7.5 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.3 7.1 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 6.4 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.3 5.0 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling