Motif ID: Mybl1

Z-value: 1.560


Transcription factors associated with Mybl1:

Gene SymbolEntrez IDGene Name
Mybl1 ENSMUSG00000025912.10 Mybl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mybl1mm10_v2_chr1_-_9700209_97003290.446.6e-04Click!


Activity profile for motif Mybl1.

activity profile for motif Mybl1


Sorted Z-values histogram for motif Mybl1

Sorted Z-values for motif Mybl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mybl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_94172618 15.804 ENSMUST00000034214.6
 Mt2
metallothionein 2
chr2_+_118814237 13.326 ENSMUST00000028803.7
ENSMUST00000126045.1
 Knstrn

kinetochore-localized astrin/SPAG5 binding

chr2_+_118814195 12.544 ENSMUST00000110842.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr2_+_118813995 12.492 ENSMUST00000134661.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr4_-_118437331 10.594 ENSMUST00000006565.6
 Cdc20
cell division cycle 20
chr14_+_46760526 10.405 ENSMUST00000067426.4
 Cdkn3
cyclin-dependent kinase inhibitor 3
chr6_+_124829540 9.534 ENSMUST00000150120.1
 Cdca3
cell division cycle associated 3
chr5_+_75075464 9.245 ENSMUST00000160104.1
ENSMUST00000040477.3
 Gsx2

GS homeobox 2

chr9_+_78191966 9.232 ENSMUST00000034903.5
 Gsta4
glutathione S-transferase, alpha 4
chr7_+_126862431 8.866 ENSMUST00000132808.1
 Hirip3
HIRA interacting protein 3
chr15_-_88978958 8.821 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr6_+_124829582 8.797 ENSMUST00000024270.7
 Cdca3
cell division cycle associated 3
chr4_-_43499608 8.650 ENSMUST00000136005.1
ENSMUST00000054538.6
 Arhgef39

Rho guanine nucleotide exchange factor (GEF) 39

chr14_+_65806066 8.234 ENSMUST00000139644.1
 Pbk
PDZ binding kinase
chr11_-_106999369 7.963 ENSMUST00000106768.1
ENSMUST00000144834.1
 Kpna2

karyopherin (importin) alpha 2

chr9_+_7764041 7.923 ENSMUST00000052865.9
 Tmem123
transmembrane protein 123
chr3_+_137623672 7.786 ENSMUST00000053855.7
 Ddit4l
DNA-damage-inducible transcript 4-like
chr12_-_99883429 7.620 ENSMUST00000046485.3
 Efcab11
EF-hand calcium binding domain 11
chr4_-_117182623 7.334 ENSMUST00000065896.2
 Kif2c
kinesin family member 2C
chr2_-_105399286 7.308 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 254 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 38.4 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
3.2 19.0 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.7 17.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 17.0 GO:0051301 cell division(GO:0051301)
3.3 16.3 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
2.3 15.8 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.5 14.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 13.6 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
3.0 12.0 GO:0003360 brainstem development(GO:0003360)
1.5 10.6 GO:0000279 M phase(GO:0000279)
0.2 10.3 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.1 9.7 GO:0000082 G1/S transition of mitotic cell cycle(GO:0000082)
1.9 9.5 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.5 9.3 GO:0045793 positive regulation of cell size(GO:0045793)
0.7 8.9 GO:0048853 forebrain morphogenesis(GO:0048853)
0.9 8.8 GO:0071397 cellular response to cholesterol(GO:0071397)
0.8 8.7 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.2 8.7 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.4 8.1 GO:0044458 motile cilium assembly(GO:0044458)
0.4 8.0 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 45.7 GO:0035371 microtubule plus-end(GO:0035371)
0.2 21.6 GO:0005913 cell-cell adherens junction(GO:0005913)
1.8 19.3 GO:0005642 annulate lamellae(GO:0005642)
0.6 18.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 17.4 GO:0005643 nuclear pore(GO:0005643)
0.6 15.2 GO:0005680 anaphase-promoting complex(GO:0005680)
4.0 12.0 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 11.7 GO:0005681 spliceosomal complex(GO:0005681)
0.1 10.5 GO:0005901 caveola(GO:0005901)
0.2 9.6 GO:0005871 kinesin complex(GO:0005871)
0.1 9.6 GO:0000776 kinetochore(GO:0000776)
0.1 8.8 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 8.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 7.5 GO:0005814 centriole(GO:0005814)
0.2 7.1 GO:0035861 site of double-strand break(GO:0035861)
0.0 6.7 GO:0009897 external side of plasma membrane(GO:0009897)
2.2 6.6 GO:0070557 PCNA-p21 complex(GO:0070557)
2.0 5.9 GO:1990423 RZZ complex(GO:1990423)
0.2 5.8 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.2 5.7 GO:0000242 pericentriolar material(GO:0000242)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 167 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 18.7 GO:0017070 U6 snRNA binding(GO:0017070)
0.6 17.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
5.4 16.3 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.3 15.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
2.0 12.0 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
1.8 10.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 10.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 9.6 GO:0070491 repressing transcription factor binding(GO:0070491)
1.2 9.5 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.6 9.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 9.4 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.4 9.2 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
1.6 8.1 GO:0032027 myosin light chain binding(GO:0032027)
0.1 7.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.1 6.9 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.6 6.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 6.9 GO:0003682 chromatin binding(GO:0003682)
2.2 6.6 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.4 6.0 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 6.0 GO:0003777 microtubule motor activity(GO:0003777)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 19.7 PID_PLK1_PATHWAY PLK1 signaling events
0.6 17.2 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 9.4 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.2 7.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.7 6.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 6.1 PID_E2F_PATHWAY E2F transcription factor network
0.2 5.2 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 5.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 5.1 PID_ATR_PATHWAY ATR signaling pathway
0.1 5.0 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 4.6 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.3 4.1 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 3.5 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 3.5 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.7 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 2.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.2 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 2.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.7 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 33.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.7 19.0 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.7 18.5 REACTOME_KINESINS Genes involved in Kinesins
0.2 15.6 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.8 12.3 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.6 10.6 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.4 9.5 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.3 8.7 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 8.4 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 8.2 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 8.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.2 7.4 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.3 6.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 6.5 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.2 6.5 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
1.5 5.9 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.2 5.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 5.8 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 5.8 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 5.3 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex