Motif ID: Mybl2

Z-value: 1.927


Transcription factors associated with Mybl2:

Gene SymbolEntrez IDGene Name
Mybl2 ENSMUSG00000017861.5 Mybl2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mybl2mm10_v2_chr2_+_163054682_1630546930.891.9e-19Click!


Activity profile for motif Mybl2.

activity profile for motif Mybl2


Sorted Z-values histogram for motif Mybl2

Sorted Z-values for motif Mybl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Mybl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_169531343 23.516 ENSMUST00000028000.7
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr2_+_13573927 22.238 ENSMUST00000141365.1
ENSMUST00000028062.2
 Vim

vimentin

chr18_+_5591860 21.929 ENSMUST00000025081.5
ENSMUST00000159390.1
 Zeb1

zinc finger E-box binding homeobox 1

chr1_-_169531447 19.139 ENSMUST00000111368.1
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr14_-_67715585 18.450 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr19_-_41802028 18.358 ENSMUST00000026150.8
ENSMUST00000177495.1
ENSMUST00000163265.1
 Arhgap19


Rho GTPase activating protein 19


chr1_+_57995971 18.207 ENSMUST00000027202.8
 Sgol2
shugoshin-like 2 (S. pombe)
chr13_+_51645232 16.634 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr1_+_191821444 16.125 ENSMUST00000027931.7
 Nek2
NIMA (never in mitosis gene a)-related expressed kinase 2
chr4_-_124936852 15.305 ENSMUST00000030690.5
ENSMUST00000084296.3
 Cdca8

cell division cycle associated 8

chr11_-_106999369 13.763 ENSMUST00000106768.1
ENSMUST00000144834.1
 Kpna2

karyopherin (importin) alpha 2

chr16_+_14163275 13.475 ENSMUST00000023359.6
ENSMUST00000117958.1
 Nde1

nuclear distribution gene E homolog 1 (A nidulans)

chr2_+_25372315 12.749 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr3_-_36571952 12.192 ENSMUST00000029270.3
 Ccna2
cyclin A2
chr9_+_65890237 11.896 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr10_+_84838143 11.474 ENSMUST00000095388.4
 Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr6_+_113531675 10.820 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr4_-_116627921 10.118 ENSMUST00000030456.7
 Nasp
nuclear autoantigenic sperm protein (histone-binding)
chr11_-_106999482 10.068 ENSMUST00000018506.6
 Kpna2
karyopherin (importin) alpha 2
chr13_-_23551648 10.062 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 168 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 37.2 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
1.2 30.9 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
4.4 22.2 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.7 22.1 GO:0007099 centriole replication(GO:0007099)
2.4 21.9 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.9 20.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.4 18.4 GO:0035307 positive regulation of protein dephosphorylation(GO:0035307)
4.5 18.2 GO:0030997 regulation of centriole-centriole cohesion(GO:0030997)
0.9 16.7 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.4 16.6 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.8 16.2 GO:0007080 mitotic metaphase plate congression(GO:0007080)
1.8 14.0 GO:0071557 histone H3-K27 demethylation(GO:0071557)
2.3 13.6 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.4 13.2 GO:0016572 histone phosphorylation(GO:0016572)
0.9 12.9 GO:0007100 mitotic centrosome separation(GO:0007100)
0.1 12.8 GO:0006413 translational initiation(GO:0006413)
0.7 11.8 GO:0051451 myoblast migration(GO:0051451)
2.3 11.5 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
1.5 10.8 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.9 10.4 GO:0070836 caveola assembly(GO:0070836)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.6 51.8 GO:0031262 Ndc80 complex(GO:0031262)
0.0 31.7 GO:0005730 nucleolus(GO:0005730)
0.3 25.3 GO:0005643 nuclear pore(GO:0005643)
5.6 22.2 GO:0045098 type III intermediate filament(GO:0045098)
0.3 22.1 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 19.6 GO:0005667 transcription factor complex(GO:0005667)
0.3 16.7 GO:0005871 kinesin complex(GO:0005871)
0.3 16.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.9 15.5 GO:0031616 spindle pole centrosome(GO:0031616)
3.1 15.3 GO:0032133 chromosome passenger complex(GO:0032133)
0.5 13.6 GO:0030992 intraciliary transport particle B(GO:0030992)
0.4 13.6 GO:0000788 nuclear nucleosome(GO:0000788)
1.8 12.7 GO:0001940 male pronucleus(GO:0001940)
1.7 11.8 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.5 10.4 GO:0005682 U5 snRNP(GO:0005682)
0.3 10.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 10.2 GO:0005814 centriole(GO:0005814)
3.0 9.1 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 8.7 GO:0000790 nuclear chromatin(GO:0000790)
0.3 8.6 GO:0005680 anaphase-promoting complex(GO:0005680)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 27.3 GO:0042393 histone binding(GO:0042393)
5.6 22.2 GO:1990254 keratin filament binding(GO:1990254)
0.4 21.9 GO:0070888 E-box binding(GO:0070888)
0.7 21.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.4 19.2 GO:0051879 Hsp90 protein binding(GO:0051879)
0.3 17.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 16.7 GO:0003777 microtubule motor activity(GO:0003777)
4.2 16.6 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
2.0 14.0 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 13.8 GO:0019903 protein phosphatase binding(GO:0019903)
0.2 12.2 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.4 10.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.5 10.4 GO:0070300 phosphatidic acid binding(GO:0070300)
3.2 9.7 GO:0051870 methotrexate binding(GO:0051870)
0.9 9.7 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
0.0 9.4 GO:0015631 tubulin binding(GO:0015631)
1.5 9.1 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.5 9.0 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 8.3 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.2 8.2 GO:0070063 RNA polymerase binding(GO:0070063)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 54.2 PID_AURORA_B_PATHWAY Aurora B signaling
0.8 23.8 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3 18.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.4 16.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.4 14.6 PID_BARD1_PATHWAY BARD1 signaling events
0.3 14.4 PID_PLK1_PATHWAY PLK1 signaling events
0.9 12.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 10.2 PID_E2F_PATHWAY E2F transcription factor network
0.2 9.7 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 4.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.2 4.1 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 4.0 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 3.7 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 3.4 NABA_COLLAGENS Genes encoding collagen proteins
0.3 3.3 PID_ALK2_PATHWAY ALK2 signaling events
0.1 3.1 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.7 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.2 2.3 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 1.3 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 98.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.7 28.6 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4 25.6 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 23.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
1.0 22.2 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.1 18.3 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.7 16.7 REACTOME_KINESINS Genes involved in Kinesins
0.2 12.7 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.9 12.2 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
1.1 10.8 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.6 9.7 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 5.0 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 4.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.4 4.4 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.3 4.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 4.1 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 3.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 3.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 3.4 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 3.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation