Motif ID: Myog_Tcf12

Z-value: 1.091

Transcription factors associated with Myog_Tcf12:

Gene SymbolEntrez IDGene Name
Myog ENSMUSG00000026459.4 Myog
Tcf12 ENSMUSG00000032228.10 Tcf12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf12mm10_v2_chr9_-_72111651_72111712-0.384.7e-03Click!


Activity profile for motif Myog_Tcf12.

activity profile for motif Myog_Tcf12


Sorted Z-values histogram for motif Myog_Tcf12

Sorted Z-values for motif Myog_Tcf12



Network of associatons between targets according to the STRING database.



First level regulatory network of Myog_Tcf12

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91269759 9.725 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr2_-_122611238 8.400 ENSMUST00000028624.8
 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr4_-_64046925 8.029 ENSMUST00000107377.3
 Tnc
tenascin C
chr16_-_22439719 8.008 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr4_+_154960915 7.132 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr16_-_22439570 6.765 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr8_+_94152607 6.706 ENSMUST00000034211.8
 Mt3
metallothionein 3
chr2_-_71546745 6.259 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr12_-_119238794 5.911 ENSMUST00000026360.8
 Itgb8
integrin beta 8
chr5_+_75075464 5.834 ENSMUST00000160104.1
ENSMUST00000040477.3
 Gsx2

GS homeobox 2

chr5_-_135251209 5.677 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr12_+_108334341 5.583 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr13_+_83504032 5.317 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr15_-_71727815 5.124 ENSMUST00000022953.8
 Fam135b
family with sequence similarity 135, member B
chr2_+_70562007 5.093 ENSMUST00000094934.4
 Gad1
glutamate decarboxylase 1
chr6_-_148444336 4.894 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr13_-_60177357 4.182 ENSMUST00000065086.4
 Gas1
growth arrest specific 1
chr2_+_70562147 4.101 ENSMUST00000148210.1
 Gad1
glutamate decarboxylase 1
chr4_+_125490688 4.098 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr11_+_117809653 4.055 ENSMUST00000026649.7
ENSMUST00000177131.1
ENSMUST00000132298.1
 Syngr2

Gm20708
synaptogyrin 2

predicted gene 20708

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 302 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 16.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.2 13.6 GO:0030032 lamellipodium assembly(GO:0030032)
1.3 9.2 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1 8.6 GO:0048709 oligodendrocyte differentiation(GO:0048709)
2.8 8.4 GO:0006601 creatine biosynthetic process(GO:0006601)
1.6 8.1 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
2.0 8.0 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.5 7.9 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.2 7.6 GO:1902476 chloride transmembrane transport(GO:1902476)
1.8 7.1 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
1.2 6.9 GO:0043654 recognition of apoptotic cell(GO:0043654)
2.2 6.7 GO:0097212 lysosomal membrane organization(GO:0097212)
2.1 6.3 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.4 6.0 GO:0001573 ganglioside metabolic process(GO:0001573)
1.9 5.7 GO:1990523 bone regeneration(GO:1990523)
0.9 5.7 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
0.5 5.6 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
1.8 5.4 GO:0071374 cellular response to parathyroid hormone stimulus(GO:0071374)
0.5 5.0 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.8 4.8 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 9.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.6 8.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 8.0 GO:0060077 inhibitory synapse(GO:0060077)
2.6 7.9 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.5 7.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 6.9 GO:0097060 synaptic membrane(GO:0097060)
0.1 6.5 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3 6.0 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.5 5.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
1.9 5.7 GO:0043512 inhibin A complex(GO:0043512)
0.3 5.7 GO:0001891 phagocytic cup(GO:0001891)
0.2 5.6 GO:0031430 M band(GO:0031430)
0.0 5.4 GO:0008021 synaptic vesicle(GO:0008021)
1.7 5.0 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.0 5.0 GO:0005884 actin filament(GO:0005884)
0.0 4.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 4.1 GO:0031527 filopodium membrane(GO:0031527)
0.0 3.9 GO:0030017 sarcomere(GO:0030017)
0.3 3.7 GO:0032426 stereocilium tip(GO:0032426)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 210 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 9.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 9.9 GO:0003779 actin binding(GO:0003779)
1.3 9.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
1.6 8.1 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
1.3 8.0 GO:0045545 syndecan binding(GO:0045545)
2.0 7.9 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.3 7.8 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 7.5 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
1.0 6.9 GO:0001849 complement component C1q binding(GO:0001849)
0.1 6.9 GO:0003727 single-stranded RNA binding(GO:0003727)
0.3 6.7 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 6.4 GO:0030507 spectrin binding(GO:0030507)
0.8 5.9 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.6 5.8 GO:0034711 inhibin binding(GO:0034711)
1.1 5.7 GO:0042289 MHC class II protein binding(GO:0042289)
0.3 5.3 GO:0003680 AT DNA binding(GO:0003680)
0.3 5.3 GO:0045499 chemorepellent activity(GO:0045499)
0.1 5.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.5 4.9 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
1.4 4.3 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 14.1 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.4 11.8 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.3 8.5 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.2 8.4 NABA_COLLAGENS Genes encoding collagen proteins
0.4 8.3 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 7.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 7.3 PID_CDC42_PATHWAY CDC42 signaling events
0.3 5.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 5.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 5.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 5.3 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.2 4.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 4.4 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 4.2 PID_ALK1_PATHWAY ALK1 signaling events
0.1 3.0 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 2.7 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 2.7 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 2.6 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 2.3 PID_LKB1_PATHWAY LKB1 signaling events
0.0 2.3 PID_RHOA_REG_PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.7 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.6 14.9 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.4 10.2 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.4 10.0 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.3 8.1 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.2 7.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 7.6 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.3 6.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
1.4 5.7 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.7 5.1 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 5.0 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.1 4.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 4.0 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 3.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.4 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 2.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 2.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.3 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 2.1 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation