Motif ID: Mzf1

Z-value: 0.993


Transcription factors associated with Mzf1:

Gene SymbolEntrez IDGene Name
Mzf1 ENSMUSG00000030380.10 Mzf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mzf1mm10_v2_chr7_-_13053684_130536840.191.6e-01Click!


Activity profile for motif Mzf1.

activity profile for motif Mzf1


Sorted Z-values histogram for motif Mzf1

Sorted Z-values for motif Mzf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mzf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_104367549 6.057 ENSMUST00000106830.2
 Dab1
disabled 1
chr10_-_109010955 5.021 ENSMUST00000105276.1
ENSMUST00000064054.7
 Syt1

synaptotagmin I

chr4_-_68954351 4.834 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr14_-_39472825 4.652 ENSMUST00000168810.2
ENSMUST00000173780.1
ENSMUST00000166968.2
 Nrg3


neuregulin 3


chr12_+_105336922 4.391 ENSMUST00000180503.1
 2810011L19Rik
RIKEN cDNA 2810011L19 gene
chr1_-_154725920 4.283 ENSMUST00000004214.8
 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr17_+_28142267 4.150 ENSMUST00000043503.3
 Scube3
signal peptide, CUB domain, EGF-like 3
chr3_+_96596628 3.945 ENSMUST00000058943.7
 Ankrd34a
ankyrin repeat domain 34A
chr11_+_105589970 3.688 ENSMUST00000168598.1
ENSMUST00000100330.3
 Tanc2

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

chr6_-_126740151 3.622 ENSMUST00000112242.1
 Kcna6
potassium voltage-gated channel, shaker-related, subfamily, member 6
chr11_+_70018421 3.591 ENSMUST00000108588.1
 Dlg4
discs, large homolog 4 (Drosophila)
chr1_+_167001457 3.421 ENSMUST00000126198.1
 Fam78b
family with sequence similarity 78, member B
chr11_+_70018728 3.352 ENSMUST00000018700.6
ENSMUST00000134376.2
 Dlg4

discs, large homolog 4 (Drosophila)

chr6_-_13838432 3.306 ENSMUST00000115492.1
 Gpr85
G protein-coupled receptor 85
chr1_+_66321708 3.290 ENSMUST00000114013.1
 Map2
microtubule-associated protein 2
chr10_+_13966268 3.220 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr14_-_102982630 3.220 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130
chr11_-_95514570 3.147 ENSMUST00000058866.7
 Nxph3
neurexophilin 3
chr9_+_34486125 3.137 ENSMUST00000115148.2
ENSMUST00000183580.1
 Kirrel3
RP24-225I21.1
kin of IRRE like 3 (Drosophila)
RP24-225I21.1
chr6_+_110645572 3.043 ENSMUST00000071076.6
ENSMUST00000172951.1
 Grm7

glutamate receptor, metabotropic 7


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 315 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 13.5 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.2 9.8 GO:0007019 microtubule depolymerization(GO:0007019)
0.5 8.1 GO:0071625 vocalization behavior(GO:0071625)
0.3 6.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
2.0 6.1 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.5 5.5 GO:0045161 neuronal ion channel clustering(GO:0045161)
1.8 5.4 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.3 5.4 GO:1903861 regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861)
0.6 5.0 GO:0005513 detection of calcium ion(GO:0005513)
0.6 5.0 GO:0071420 cellular response to histamine(GO:0071420)
0.4 5.0 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.5 4.4 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
1.1 4.3 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.6 4.2 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.2 4.0 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.8 3.9 GO:0007256 activation of JNKK activity(GO:0007256)
0.4 3.9 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
0.5 3.8 GO:0099645 protein localization to postsynaptic specialization membrane(GO:0099633) neurotransmitter receptor localization to postsynaptic specialization membrane(GO:0099645)
0.4 3.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.6 3.5 GO:0035435 phosphate ion transmembrane transport(GO:0035435)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 143 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 34.4 GO:0060076 excitatory synapse(GO:0060076)
0.8 15.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.2 15.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 13.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 9.5 GO:0030427 site of polarized growth(GO:0030427)
0.5 7.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.4 6.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 6.1 GO:0043034 costamere(GO:0043034)
0.2 5.8 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 5.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 5.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 5.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 5.0 GO:0071565 nBAF complex(GO:0071565)
0.3 4.7 GO:0031045 dense core granule(GO:0031045)
0.1 4.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 4.0 GO:0008385 IkappaB kinase complex(GO:0008385)
0.4 3.9 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 3.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.8 3.8 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.9 3.5 GO:0090537 CERF complex(GO:0090537)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 202 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.7 GO:0005096 GTPase activator activity(GO:0005096)
1.5 11.8 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 10.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.7 10.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.5 9.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 8.8 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 8.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
1.3 5.0 GO:0030348 syntaxin-3 binding(GO:0030348)
0.8 5.0 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.5 4.8 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.3 4.8 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 4.6 GO:0030507 spectrin binding(GO:0030507)
0.3 4.4 GO:0045499 chemorepellent activity(GO:0045499)
1.4 4.3 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.1 4.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.6 3.8 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 3.8 GO:0005246 calcium channel regulator activity(GO:0005246)
0.3 3.7 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 3.7 GO:0005057 receptor signaling protein activity(GO:0005057)
0.1 3.6 GO:0046965 retinoid X receptor binding(GO:0046965)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.0 ST_GA12_PATHWAY G alpha 12 Pathway
0.3 10.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 8.9 PID_LKB1_PATHWAY LKB1 signaling events
0.2 7.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 5.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.3 4.7 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 4.6 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.2 3.8 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 3.1 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 3.0 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 2.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.8 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 2.3 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 2.2 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 2.1 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 1.9 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 1.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.6 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.5 1.4 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.4 PID_CERAMIDE_PATHWAY Ceramide signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.5 7.5 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.5 6.8 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 6.6 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.2 5.7 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 5.6 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.5 5.0 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2 4.7 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.2 4.6 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 4.1 REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES Genes involved in Recruitment of mitotic centrosome proteins and complexes
0.1 3.7 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.2 3.4 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 3.3 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.6 3.2 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES Genes involved in Transmission across Chemical Synapses
0.1 3.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 3.1 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.9 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.2 2.7 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1 2.5 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 2.4 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions