Motif ID: Nanog

Z-value: 0.806


Transcription factors associated with Nanog:

Gene SymbolEntrez IDGene Name
Nanog ENSMUSG00000012396.6 Nanog

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nanogmm10_v2_chr6_+_122707489_1227076080.182.0e-01Click!


Activity profile for motif Nanog.

activity profile for motif Nanog


Sorted Z-values histogram for motif Nanog

Sorted Z-values for motif Nanog



Network of associatons between targets according to the STRING database.



First level regulatory network of Nanog

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_154960915 7.501 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr9_+_65890237 7.161 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr7_-_115846080 5.450 ENSMUST00000166207.1
 Sox6
SRY-box containing gene 6
chr7_+_67647405 5.282 ENSMUST00000032774.8
ENSMUST00000107471.1
 Ttc23

tetratricopeptide repeat domain 23

chr3_+_88081997 4.978 ENSMUST00000071812.5
 Iqgap3
IQ motif containing GTPase activating protein 3
chr4_-_109665249 4.459 ENSMUST00000063531.4
 Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr8_-_89044162 4.251 ENSMUST00000034090.6
 Sall1
sal-like 1 (Drosophila)
chr8_-_61902669 4.084 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr10_-_42583628 3.988 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr15_-_71954395 3.887 ENSMUST00000159410.1
 Col22a1
collagen, type XXII, alpha 1
chr2_+_20737306 3.862 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr15_+_25773985 3.754 ENSMUST00000125667.1
 Myo10
myosin X
chr5_+_33658123 3.725 ENSMUST00000074849.6
ENSMUST00000079534.4
 Tacc3

transforming, acidic coiled-coil containing protein 3

chr5_+_33658567 3.551 ENSMUST00000114426.3
 Tacc3
transforming, acidic coiled-coil containing protein 3
chrX_-_60893430 3.491 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chrX_+_134308084 3.331 ENSMUST00000081064.5
ENSMUST00000101251.1
ENSMUST00000129782.1
 Cenpi


centromere protein I


chr14_+_73237891 3.302 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr10_+_58394381 3.265 ENSMUST00000105468.1
 Lims1
LIM and senescent cell antigen-like domains 1
chr2_+_134786154 3.177 ENSMUST00000110116.1
 Plcb1
phospholipase C, beta 1
chr1_-_52490736 3.053 ENSMUST00000170269.1
 Nab1
Ngfi-A binding protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 11.7 GO:0022027 interkinetic nuclear migration(GO:0022027)
1.9 7.5 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.7 6.7 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
1.2 6.0 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.8 5.4 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.2 4.5 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
1.4 4.3 GO:0072092 ureteric bud invasion(GO:0072092)
0.2 4.1 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.8 4.0 GO:0021764 amygdala development(GO:0021764)
0.1 4.0 GO:0008347 glial cell migration(GO:0008347)
0.1 3.8 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 3.5 GO:0060009 Sertoli cell development(GO:0060009)
0.2 3.3 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
1.1 3.2 GO:0070671 monocyte extravasation(GO:0035696) activation of meiosis involved in egg activation(GO:0060466) response to interleukin-12(GO:0070671) positive regulation of acrosome reaction(GO:2000344) regulation of monocyte extravasation(GO:2000437)
0.1 3.1 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.4 3.0 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.4 2.9 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.2 2.9 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.9 2.7 GO:0071918 urea transmembrane transport(GO:0071918)
0.1 2.7 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.3 GO:0005813 centrosome(GO:0005813)
0.0 7.6 GO:0016607 nuclear speck(GO:0016607)
0.0 6.0 GO:0005667 transcription factor complex(GO:0005667)
0.1 5.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 5.2 GO:0005925 focal adhesion(GO:0005925)
0.2 4.3 GO:0010369 chromocenter(GO:0010369)
0.1 4.1 GO:0002102 podosome(GO:0002102)
0.1 4.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 3.8 GO:0016459 myosin complex(GO:0016459)
0.1 2.7 GO:0005720 nuclear heterochromatin(GO:0005720)
0.6 2.5 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.8 2.4 GO:0000801 central element(GO:0000801)
0.1 2.4 GO:0001891 phagocytic cup(GO:0001891)
0.1 2.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 2.4 GO:0000776 kinetochore(GO:0000776)
0.4 2.2 GO:0044305 calyx of Held(GO:0044305)
0.0 2.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 2.1 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.2 2.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.2 1.9 GO:0030478 actin cap(GO:0030478)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.8 5.9 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.3 5.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 5.7 GO:0004407 histone deacetylase activity(GO:0004407)
1.0 5.0 GO:0032027 myosin light chain binding(GO:0032027)
0.3 4.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.3 4.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 4.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 4.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 3.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 3.8 GO:0030507 spectrin binding(GO:0030507)
0.2 3.3 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.4 3.0 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 3.0 GO:0002039 p53 binding(GO:0002039)
0.4 2.7 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 2.7 GO:0001047 core promoter binding(GO:0001047)
0.3 2.4 GO:0001849 complement component C1q binding(GO:0001849)
0.1 2.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.7 2.2 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.2 2.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 14.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 12.3 PID_CDC42_PATHWAY CDC42 signaling events
0.1 7.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 5.9 PID_E2F_PATHWAY E2F transcription factor network
0.1 4.2 NABA_COLLAGENS Genes encoding collagen proteins
0.1 4.0 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 3.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 3.2 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.1 2.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 2.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.2 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 1.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.4 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.3 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.9 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.9 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.8 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 0.7 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.9 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 6.0 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 5.1 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 4.2 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 4.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 4.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 4.0 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 3.6 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 3.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.4 3.3 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.4 3.2 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 3.0 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 2.6 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 2.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 2.4 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 2.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 2.1 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 1.7 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.7 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins