Motif ID: Neurod2_Bhlha15_Bhlhe22_Olig1

Z-value: 0.532

Transcription factors associated with Neurod2_Bhlha15_Bhlhe22_Olig1:

Gene SymbolEntrez IDGene Name
Bhlha15 ENSMUSG00000052271.7 Bhlha15
Bhlhe22 ENSMUSG00000025128.6 Bhlhe22
Neurod2 ENSMUSG00000038255.6 Neurod2
Olig1 ENSMUSG00000046160.5 Olig1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bhlhe22mm10_v2_chr3_+_18054258_180543250.664.2e-08Click!
Neurod2mm10_v2_chr11_-_98329641_983296540.632.0e-07Click!
Olig1mm10_v2_chr16_+_91269759_91269778-0.057.3e-01Click!


Activity profile for motif Neurod2_Bhlha15_Bhlhe22_Olig1.

activity profile for motif Neurod2_Bhlha15_Bhlhe22_Olig1


Sorted Z-values histogram for motif Neurod2_Bhlha15_Bhlhe22_Olig1

Sorted Z-values for motif Neurod2_Bhlha15_Bhlhe22_Olig1



Network of associatons between targets according to the STRING database.



First level regulatory network of Neurod2_Bhlha15_Bhlhe22_Olig1

PNG image of the network

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Top targets:


Showing 1 to 20 of 154 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_120886691 5.769 ENSMUST00000182099.1
ENSMUST00000183168.1
ENSMUST00000183276.1
ENSMUST00000182124.1
 6530403H02Rik



RIKEN cDNA 6530403H02 gene



chr11_-_75796048 4.620 ENSMUST00000021209.7
 Doc2b
double C2, beta
chr2_+_65930117 3.820 ENSMUST00000176109.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr4_-_42034726 3.764 ENSMUST00000084677.2
 Gm21093
predicted gene, 21093
chr4_-_141598206 3.704 ENSMUST00000131317.1
ENSMUST00000006381.4
ENSMUST00000129602.1
 Fblim1


filamin binding LIM protein 1


chr1_+_177444653 3.171 ENSMUST00000094276.3
 Zbtb18
zinc finger and BTB domain containing 18
chr3_+_138065052 3.108 ENSMUST00000163080.2
 1110002E22Rik
RIKEN cDNA 1110002E22 gene
chr10_-_25200110 3.048 ENSMUST00000100012.2
 Akap7
A kinase (PRKA) anchor protein 7
chr1_-_150392719 2.513 ENSMUST00000006167.6
ENSMUST00000094477.2
ENSMUST00000097547.3
 BC003331


cDNA sequence BC003331


chr16_+_43235856 2.337 ENSMUST00000146708.1
 Zbtb20
zinc finger and BTB domain containing 20
chr19_-_37176055 2.312 ENSMUST00000142973.1
ENSMUST00000154376.1
 Cpeb3

cytoplasmic polyadenylation element binding protein 3

chr4_+_42035113 2.302 ENSMUST00000098127.1
 Gm10597
predicted gene 10597
chr3_-_126998408 2.291 ENSMUST00000182764.1
ENSMUST00000044443.8
 Ank2

ankyrin 2, brain

chr1_-_111864869 2.254 ENSMUST00000035462.5
 Dsel
dermatan sulfate epimerase-like
chr17_-_36989504 2.087 ENSMUST00000169189.1
 H2-M5
histocompatibility 2, M region locus 5
chr5_+_124194894 1.869 ENSMUST00000159053.1
ENSMUST00000162577.1
 Gm16338

predicted gene 16338

chr1_+_177445660 1.765 ENSMUST00000077225.6
 Zbtb18
zinc finger and BTB domain containing 18
chr5_-_66618636 1.744 ENSMUST00000162382.1
ENSMUST00000160870.1
ENSMUST00000087256.5
ENSMUST00000160103.1
ENSMUST00000162349.1
 Apbb2




amyloid beta (A4) precursor protein-binding, family B, member 2




chr11_+_58954675 1.741 ENSMUST00000047697.5
ENSMUST00000108817.3
 Trim17
Hist3h2a
tripartite motif-containing 17
histone cluster 3, H2a
chr8_+_104170513 1.709 ENSMUST00000171018.1
ENSMUST00000167633.1
ENSMUST00000093245.5
ENSMUST00000164076.1
 Bean1



brain expressed, associated with Nedd4, 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.6 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
1.0 3.9 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.2 3.7 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 3.6 GO:0021766 hippocampus development(GO:0021766)
0.0 3.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 3.1 GO:0021860 pyramidal neuron development(GO:0021860)
0.5 3.0 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 2.9 GO:0050821 protein stabilization(GO:0050821)
0.8 2.3 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.5 2.3 GO:0030205 dermatan sulfate metabolic process(GO:0030205)
0.3 2.3 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.3 2.3 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 2.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 2.0 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391) cGMP catabolic process(GO:0046069)
0.1 2.0 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1 1.7 GO:0070914 nucleosome disassembly(GO:0006337) UV-damage excision repair(GO:0070914)
0.3 1.5 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.4 1.3 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923)
0.4 1.2 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.2 1.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 GO:0045171 intercellular bridge(GO:0045171)
0.1 4.6 GO:0031201 SNARE complex(GO:0031201)
0.2 3.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.6 3.1 GO:0097441 basilar dendrite(GO:0097441)
0.1 3.0 GO:0031430 M band(GO:0031430)
0.0 3.0 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 2.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 2.3 GO:0071564 npBAF complex(GO:0071564)
0.1 1.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 1.5 GO:0042588 zymogen granule(GO:0042588)
0.1 1.3 GO:0032433 filopodium tip(GO:0032433)
0.0 1.3 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.1 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 1.1 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 1.0 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 1.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.8 GO:0005776 autophagosome(GO:0005776)
0.1 0.6 GO:0044316 cone cell pedicle(GO:0044316)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.3 3.7 GO:0031005 filamin binding(GO:0031005)
0.2 3.5 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 3.4 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 3.0 GO:0016208 AMP binding(GO:0016208)
0.1 2.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 2.3 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 2.3 GO:0030507 spectrin binding(GO:0030507)
0.1 2.1 GO:0042605 peptide antigen binding(GO:0042605)
0.3 2.0 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 1.6 GO:0030674 protein binding, bridging(GO:0030674)
0.1 1.5 GO:0031489 myosin V binding(GO:0031489)
0.1 1.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.1 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.0 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 1.0 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 1.0 GO:0030275 LRR domain binding(GO:0030275)
0.0 1.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 0.8 GO:0005225 volume-sensitive anion channel activity(GO:0005225)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.3 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 1.0 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 1.0 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.6 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.6 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 0.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.2 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.0 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 1.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.0 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.0 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 1.0 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.0 0.8 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.7 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 0.6 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.6 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.6 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 0.5 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.4 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.3 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions