Motif ID: Neurog2
Z-value: 0.399
Transcription factors associated with Neurog2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Neurog2 | ENSMUSG00000027967.7 | Neurog2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Neurog2 | mm10_v2_chr3_+_127633134_127633140 | -0.30 | 2.5e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.9 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) negative regulation of lymphocyte migration(GO:2000402) |
| 0.3 | 0.9 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
| 0.2 | 1.2 | GO:0042701 | progesterone secretion(GO:0042701) |
| 0.2 | 1.0 | GO:0030205 | dermatan sulfate metabolic process(GO:0030205) |
| 0.2 | 0.7 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.2 | 0.5 | GO:0001928 | regulation of exocyst assembly(GO:0001928) |
| 0.2 | 0.5 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 0.2 | 1.0 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.1 | 0.9 | GO:0060040 | retinal bipolar neuron differentiation(GO:0060040) |
| 0.1 | 0.5 | GO:1903288 | positive regulation of potassium ion import(GO:1903288) |
| 0.1 | 1.4 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.1 | 0.8 | GO:2000304 | positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304) |
| 0.1 | 0.5 | GO:0042822 | pyridoxal phosphate metabolic process(GO:0042822) |
| 0.1 | 0.5 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
| 0.1 | 0.3 | GO:0071544 | diphosphoinositol polyphosphate catabolic process(GO:0071544) |
| 0.1 | 0.5 | GO:0032796 | uropod organization(GO:0032796) |
| 0.1 | 0.7 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
| 0.1 | 0.4 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
| 0.1 | 1.1 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.1 | 0.5 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.1 | 0.5 | GO:0030397 | membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081) |
| 0.1 | 0.2 | GO:0072236 | DCT cell differentiation(GO:0072069) metanephric loop of Henle development(GO:0072236) metanephric DCT cell differentiation(GO:0072240) |
| 0.1 | 0.4 | GO:0043416 | regulation of skeletal muscle tissue regeneration(GO:0043416) |
| 0.0 | 0.2 | GO:0048539 | bone marrow development(GO:0048539) |
| 0.0 | 0.1 | GO:0015882 | L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904) |
| 0.0 | 0.6 | GO:0070914 | nucleosome disassembly(GO:0006337) UV-damage excision repair(GO:0070914) |
| 0.0 | 0.2 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.0 | 0.1 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.0 | 0.3 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.0 | 0.7 | GO:0014051 | gamma-aminobutyric acid secretion(GO:0014051) |
| 0.0 | 0.3 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.0 | 0.2 | GO:1905169 | protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171) |
| 0.0 | 0.2 | GO:0000480 | endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) |
| 0.0 | 0.3 | GO:0035845 | photoreceptor cell outer segment organization(GO:0035845) |
| 0.0 | 0.3 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.0 | 0.5 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.0 | 0.4 | GO:0034390 | smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391) cGMP catabolic process(GO:0046069) |
| 0.0 | 0.4 | GO:0031340 | positive regulation of vesicle fusion(GO:0031340) |
| 0.0 | 0.1 | GO:0046294 | formaldehyde catabolic process(GO:0046294) |
| 0.0 | 0.1 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.0 | 0.7 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.0 | 0.1 | GO:0002143 | tRNA wobble position uridine thiolation(GO:0002143) |
| 0.0 | 0.8 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 0.1 | GO:0015879 | carnitine transport(GO:0015879) |
| 0.0 | 0.1 | GO:0051418 | interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418) |
| 0.0 | 0.5 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.0 | 0.1 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 0.0 | 0.1 | GO:0090292 | nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.0 | 0.1 | GO:0031272 | regulation of pseudopodium assembly(GO:0031272) |
| 0.0 | 0.3 | GO:0095500 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.0 | 0.3 | GO:0097435 | fibril organization(GO:0097435) |
| 0.0 | 0.4 | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.6 | GO:0043512 | inhibin A complex(GO:0043512) |
| 0.1 | 0.7 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.1 | 0.5 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 1.4 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.1 | 0.8 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.1 | 0.5 | GO:0060053 | neurofilament cytoskeleton(GO:0060053) |
| 0.1 | 1.2 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.5 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.0 | 0.6 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
| 0.0 | 0.5 | GO:0070938 | contractile ring(GO:0070938) |
| 0.0 | 0.1 | GO:0000931 | gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274) |
| 0.0 | 0.5 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 0.2 | GO:0000783 | telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) |
| 0.0 | 0.4 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.0 | 0.4 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 0.6 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 0.3 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 0.4 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 0.7 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.0 | 0.1 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 0.7 | GO:0034704 | calcium channel complex(GO:0034704) |
| 0.0 | 1.0 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.0 | 0.1 | GO:0046930 | pore complex(GO:0046930) |
| 0.0 | 0.6 | GO:0009925 | basal plasma membrane(GO:0009925) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
| 0.1 | 0.5 | GO:0070012 | oligopeptidase activity(GO:0070012) |
| 0.1 | 0.5 | GO:0033883 | pyridoxal phosphatase activity(GO:0033883) |
| 0.1 | 0.6 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.1 | 1.4 | GO:0031005 | filamin binding(GO:0031005) |
| 0.1 | 0.8 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.1 | 0.5 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 1.2 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.1 | 0.4 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.1 | 0.4 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.1 | 0.7 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.1 | 0.4 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.1 | 1.0 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.1 | 0.5 | GO:0008556 | sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556) |
| 0.0 | 0.5 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.0 | 0.3 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.0 | 0.3 | GO:0000298 | endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) |
| 0.0 | 1.0 | GO:0016208 | AMP binding(GO:0016208) |
| 0.0 | 0.1 | GO:0070890 | L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890) |
| 0.0 | 0.7 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.1 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.0 | 0.1 | GO:0018738 | S-formylglutathione hydrolase activity(GO:0018738) |
| 0.0 | 0.3 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.0 | 1.7 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.5 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.0 | 0.1 | GO:0015226 | amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226) |
| 0.0 | 0.1 | GO:0019841 | retinol binding(GO:0019841) |
| 0.0 | 0.4 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 0.5 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 1.1 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 0.9 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.0 | 0.2 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
| 0.0 | 0.9 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 0.6 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.1 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.0 | 0.2 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.0 | 0.2 | GO:0098811 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.0 | 0.6 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.0 | 0.3 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 0.0 | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) |
| 0.0 | 0.2 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.0 | 0.6 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.0 | 0.5 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.8 | PID_CERAMIDE_PATHWAY | Ceramide signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.7 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 0.6 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.1 | 0.7 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.1 | 0.5 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 1.2 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 1.4 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.3 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 0.8 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.5 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.5 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.4 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.0 | 0.4 | REACTOME_G_PROTEIN_ACTIVATION | Genes involved in G-protein activation |
| 0.0 | 0.1 | REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 0.5 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 0.1 | REACTOME_COMPLEMENT_CASCADE | Genes involved in Complement cascade |
