Motif ID: Neurog2

Z-value: 0.399


Transcription factors associated with Neurog2:

Gene SymbolEntrez IDGene Name
Neurog2 ENSMUSG00000027967.7 Neurog2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Neurog2mm10_v2_chr3_+_127633134_127633140-0.302.5e-02Click!


Activity profile for motif Neurog2.

activity profile for motif Neurog2


Sorted Z-values histogram for motif Neurog2

Sorted Z-values for motif Neurog2



Network of associatons between targets according to the STRING database.



First level regulatory network of Neurog2

PNG image of the network

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Top targets:


Showing 1 to 20 of 174 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_58158498 1.166 ENSMUST00000168864.2
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr4_-_141598206 1.085 ENSMUST00000131317.1
ENSMUST00000006381.4
ENSMUST00000129602.1
 Fblim1


filamin binding LIM protein 1


chr5_+_129096740 1.074 ENSMUST00000056617.7
ENSMUST00000156437.1
 Gpr133

G protein-coupled receptor 133

chr9_-_58159201 1.060 ENSMUST00000041477.7
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr1_-_111864869 0.971 ENSMUST00000035462.5
 Dsel
dermatan sulfate epimerase-like
chr10_-_25200110 0.965 ENSMUST00000100012.2
 Akap7
A kinase (PRKA) anchor protein 7
chr16_-_31314804 0.932 ENSMUST00000115230.1
ENSMUST00000130560.1
 Apod

apolipoprotein D

chr10_+_69706326 0.882 ENSMUST00000182992.1
 Ank3
ankyrin 3, epithelial
chr3_+_18054258 0.858 ENSMUST00000026120.6
 Bhlhe22
basic helix-loop-helix family, member e22
chr8_+_33428709 0.837 ENSMUST00000059351.7
 5930422O12Rik
RIKEN cDNA 5930422O12 gene
chr8_+_104170513 0.787 ENSMUST00000171018.1
ENSMUST00000167633.1
ENSMUST00000093245.5
ENSMUST00000164076.1
 Bean1



brain expressed, associated with Nedd4, 1



chr3_+_138065052 0.785 ENSMUST00000163080.2
 1110002E22Rik
RIKEN cDNA 1110002E22 gene
chr16_+_43235856 0.773 ENSMUST00000146708.1
 Zbtb20
zinc finger and BTB domain containing 20
chr8_-_106337987 0.759 ENSMUST00000067512.7
 Smpd3
sphingomyelin phosphodiesterase 3, neutral
chr19_+_20601958 0.750 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr3_+_54156039 0.720 ENSMUST00000029311.6
 Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr13_+_37345338 0.680 ENSMUST00000021860.5
 Ly86
lymphocyte antigen 86
chr3_-_84259812 0.677 ENSMUST00000107691.1
 Trim2
tripartite motif-containing 2
chr6_+_51544513 0.669 ENSMUST00000179365.1
ENSMUST00000114439.1
 Snx10

sorting nexin 10

chr13_-_97747399 0.660 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.4 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 1.2 GO:0042701 progesterone secretion(GO:0042701)
0.1 1.1 GO:0033623 regulation of integrin activation(GO:0033623)
0.2 1.0 GO:0030205 dermatan sulfate metabolic process(GO:0030205)
0.2 1.0 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.3 0.9 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097) negative regulation of lymphocyte migration(GO:2000402)
0.3 0.9 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 0.9 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.1 0.8 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0 0.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 0.7 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 0.7 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.0 0.7 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.0 0.7 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.6 GO:0070914 nucleosome disassembly(GO:0006337) UV-damage excision repair(GO:0070914)
0.2 0.5 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.2 0.5 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.5 GO:1903288 positive regulation of potassium ion import(GO:1903288)
0.1 0.5 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822)
0.1 0.5 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 1.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.0 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 0.8 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 0.7 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.7 GO:0034704 calcium channel complex(GO:0034704)
0.2 0.6 GO:0043512 inhibin A complex(GO:0043512)
0.0 0.6 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.6 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 0.5 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.5 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.5 GO:0070938 contractile ring(GO:0070938)
0.0 0.5 GO:0071564 npBAF complex(GO:0071564)
0.0 0.4 GO:0042588 zymogen granule(GO:0042588)
0.0 0.4 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.4 GO:0031430 M band(GO:0031430)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 GO:0030507 spectrin binding(GO:0030507)
0.1 1.4 GO:0031005 filamin binding(GO:0031005)
0.1 1.2 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 1.1 GO:0017022 myosin binding(GO:0017022)
0.1 1.0 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 1.0 GO:0016208 AMP binding(GO:0016208)
0.0 0.9 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 0.8 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.7 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1 0.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.7 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.6 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 0.5 GO:0070012 oligopeptidase activity(GO:0070012)
0.1 0.5 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.1 0.5 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.5 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.0 0.5 GO:0032036 myosin heavy chain binding(GO:0032036)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.6 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.4 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.2 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.8 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.2 0.7 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 0.7 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 0.6 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 0.5 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.5 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.5 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.5 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.0 0.4 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.4 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 0.3 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.1 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.1 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade