Motif ID: Nfat5
Z-value: 0.710
Transcription factors associated with Nfat5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nfat5 | ENSMUSG00000003847.10 | Nfat5 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfat5 | mm10_v2_chr8_+_107293500_107293559 | 0.44 | 8.5e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 6.2 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 1.4 | 8.3 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
| 1.4 | 5.5 | GO:0006710 | androgen catabolic process(GO:0006710) |
| 1.0 | 3.1 | GO:1904347 | intestine smooth muscle contraction(GO:0014827) regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) regulation of small intestine smooth muscle contraction(GO:1904347) small intestine smooth muscle contraction(GO:1990770) |
| 0.4 | 1.3 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.4 | 3.7 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.4 | 2.0 | GO:0045347 | negative regulation of MHC class II biosynthetic process(GO:0045347) negative regulation of cytolysis(GO:0045918) |
| 0.3 | 1.7 | GO:0007262 | STAT protein import into nucleus(GO:0007262) negative regulation of cholesterol efflux(GO:0090370) positive regulation of hyaluronan biosynthetic process(GO:1900127) |
| 0.3 | 5.6 | GO:0071378 | growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378) |
| 0.3 | 1.2 | GO:0071638 | negative regulation of monocyte chemotactic protein-1 production(GO:0071638) |
| 0.3 | 1.2 | GO:0090472 | dibasic protein processing(GO:0090472) |
| 0.3 | 2.0 | GO:0019254 | carnitine metabolic process, CoA-linked(GO:0019254) |
| 0.3 | 2.3 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
| 0.3 | 3.8 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.2 | 1.7 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
| 0.2 | 0.7 | GO:1902915 | negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915) |
| 0.2 | 0.7 | GO:0007621 | negative regulation of female receptivity(GO:0007621) |
| 0.2 | 2.2 | GO:0048149 | behavioral response to ethanol(GO:0048149) |
| 0.2 | 1.2 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
| 0.2 | 0.6 | GO:1900369 | negative regulation of RNA interference(GO:1900369) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173) |
| 0.2 | 2.8 | GO:0015809 | arginine transport(GO:0015809) |
| 0.2 | 1.5 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
| 0.1 | 1.1 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.1 | 2.8 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.1 | 5.3 | GO:0007528 | neuromuscular junction development(GO:0007528) |
| 0.1 | 0.4 | GO:0035609 | C-terminal protein deglutamylation(GO:0035609) |
| 0.1 | 0.2 | GO:1902527 | positive regulation of protein monoubiquitination(GO:1902527) |
| 0.1 | 2.1 | GO:0010866 | regulation of triglyceride biosynthetic process(GO:0010866) |
| 0.1 | 0.6 | GO:2000194 | regulation of female gonad development(GO:2000194) |
| 0.1 | 0.3 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
| 0.1 | 0.2 | GO:0010579 | regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) positive regulation of vascular smooth muscle cell differentiation(GO:1905065) |
| 0.1 | 0.8 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.1 | 1.3 | GO:0036010 | protein localization to endosome(GO:0036010) |
| 0.1 | 2.9 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 0.5 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 0.0 | 6.6 | GO:0008654 | phospholipid biosynthetic process(GO:0008654) |
| 0.0 | 1.5 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 1.1 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.0 | 0.3 | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394) |
| 0.0 | 2.5 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity(GO:0051092) |
| 0.0 | 2.5 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 3.0 | GO:0030048 | actin filament-based movement(GO:0030048) |
| 0.0 | 0.4 | GO:0030575 | nuclear body organization(GO:0030575) |
| 0.0 | 1.9 | GO:0031623 | receptor internalization(GO:0031623) |
| 0.0 | 0.2 | GO:0006044 | N-acetylglucosamine metabolic process(GO:0006044) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 8.3 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.4 | 2.1 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.3 | 6.2 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.3 | 3.1 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.2 | 2.8 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.2 | 2.0 | GO:0031091 | platelet alpha granule(GO:0031091) |
| 0.2 | 1.3 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 7.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 1.9 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.1 | 1.2 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.1 | 1.5 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.1 | 1.1 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 5.3 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 0.8 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 0.4 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 0.2 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 0.6 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.0 | 2.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 0.2 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.0 | 4.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 1.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 3.3 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 2.0 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.6 | GO:0016459 | myosin complex(GO:0016459) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 8.3 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
| 1.1 | 5.6 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 1.0 | 3.1 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.9 | 3.7 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |
| 0.8 | 5.5 | GO:0004303 | estradiol 17-beta-dehydrogenase activity(GO:0004303) |
| 0.5 | 2.0 | GO:0004092 | carnitine O-acetyltransferase activity(GO:0004092) |
| 0.5 | 2.9 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.5 | 3.8 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.4 | 2.0 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.4 | 2.8 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
| 0.3 | 6.6 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.3 | 1.9 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.3 | 1.1 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.3 | 0.8 | GO:1990450 | linear polyubiquitin binding(GO:1990450) |
| 0.2 | 6.2 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.2 | 2.3 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
| 0.1 | 0.7 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.1 | 1.2 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 1.3 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.1 | 2.9 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 1.5 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.1 | 1.1 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.1 | 3.0 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.1 | 0.9 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
| 0.1 | 1.2 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.1 | 0.6 | GO:0003964 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 0.1 | 0.2 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.1 | 0.7 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.0 | 1.0 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 0.2 | GO:0004342 | glucosamine-6-phosphate deaminase activity(GO:0004342) |
| 0.0 | 0.2 | GO:0098519 | nucleotide phosphatase activity, acting on free nucleotides(GO:0098519) |
| 0.0 | 0.2 | GO:1990239 | steroid hormone binding(GO:1990239) |
| 0.0 | 0.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 1.3 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 5.3 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.3 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 2.0 | PID_CXCR3_PATHWAY | CXCR3-mediated signaling events |
| 0.1 | 1.7 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.1 | 3.8 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
| 0.1 | 5.6 | PID_IL2_1PATHWAY | IL2-mediated signaling events |
| 0.1 | 3.2 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.1 | 2.0 | PID_IL1_PATHWAY | IL1-mediated signaling events |
| 0.1 | 1.9 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.5 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 1.2 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
| 0.0 | 1.3 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.6 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 2.3 | PID_VEGFR1_2_PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 1.1 | SIG_CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 1.3 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.0 | REACTOME_COMMON_PATHWAY | Genes involved in Common Pathway |
| 0.3 | 7.7 | REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.2 | 8.3 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.2 | 6.6 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.2 | 5.6 | REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.2 | 1.2 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 1.1 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.1 | 1.1 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 1.7 | REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.1 | 2.8 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 0.8 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.1 | 2.0 | REACTOME_PEROXISOMAL_LIPID_METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 1.3 | REACTOME_IL1_SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 0.6 | REACTOME_EXTENSION_OF_TELOMERES | Genes involved in Extension of Telomeres |
| 0.0 | 2.3 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.2 | REACTOME_NOD1_2_SIGNALING_PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
