Motif ID: Nfatc1

Z-value: 5.051


Transcription factors associated with Nfatc1:

Gene SymbolEntrez IDGene Name
Nfatc1 ENSMUSG00000033016.9 Nfatc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc1mm10_v2_chr18_-_80708115_807081800.123.7e-01Click!


Activity profile for motif Nfatc1.

activity profile for motif Nfatc1


Sorted Z-values histogram for motif Nfatc1

Sorted Z-values for motif Nfatc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3027439 223.691 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3000922 223.263 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3004457 199.041 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3013140 198.014 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3023547 193.602 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3037111 182.561 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3036877 169.795 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3025417 168.936 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3017408 165.555 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3034599 163.700 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3005125 158.182 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr14_-_19418930 140.433 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3015654 137.850 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr2_-_98667264 136.902 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3018753 120.222 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr2_+_98662227 107.897 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr7_+_134670667 17.946 ENSMUST00000084488.4
 Dock1
dedicator of cytokinesis 1
chr3_+_94377432 17.563 ENSMUST00000107292.1
 Rorc
RAR-related orphan receptor gamma
chr10_+_4611971 17.291 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr3_-_145649970 17.077 ENSMUST00000029846.3
 Cyr61
cysteine rich protein 61

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1124.6 GO:0008150 biological_process(GO:0008150)
4.2 34.0 GO:0072615 interleukin-17 secretion(GO:0072615)
8.4 25.1 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
3.4 23.5 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.4 17.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
5.8 17.3 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
3.4 17.1 GO:0060591 chondroblast differentiation(GO:0060591)
5.6 16.8 GO:0035622 intrahepatic bile duct development(GO:0035622) renal vesicle induction(GO:0072034)
1.2 15.8 GO:0035881 amacrine cell differentiation(GO:0035881)
4.8 14.5 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
2.5 12.6 GO:1901526 negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
1.6 12.5 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
1.3 11.4 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
1.0 11.0 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
3.6 10.8 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.1 10.8 GO:0000910 cytokinesis(GO:0000910)
0.9 10.6 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
1.5 10.5 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.6 9.9 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
3.2 9.7 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1453.1 GO:0005575 cellular_component(GO:0005575)
0.1 25.2 GO:0005667 transcription factor complex(GO:0005667)
0.1 24.8 GO:0044798 nuclear transcription factor complex(GO:0044798)
1.3 17.9 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
3.6 14.5 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
1.8 12.4 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.2 11.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
3.2 9.7 GO:0071914 prominosome(GO:0071914)
0.1 9.7 GO:0036126 sperm flagellum(GO:0036126)
0.2 9.3 GO:0005581 collagen trimer(GO:0005581)
0.5 8.6 GO:0005614 interstitial matrix(GO:0005614)
0.6 8.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.2 7.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.4 6.7 GO:0097449 astrocyte projection(GO:0097449)
0.9 6.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 5.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 4.9 GO:0036038 MKS complex(GO:0036038)
0.4 4.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.3 4.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 4.2 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1318.0 GO:0003674 molecular_function(GO:0003674)
8.4 33.6 GO:0008142 oxysterol binding(GO:0008142)
0.1 23.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.7 23.0 GO:0042805 actinin binding(GO:0042805)
0.3 22.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.9 18.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
1.7 18.3 GO:0097157 pre-mRNA intronic binding(GO:0097157)
5.8 17.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
3.7 14.9 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
3.6 14.5 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
2.5 12.6 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
4.2 12.5 GO:0098770 FBXO family protein binding(GO:0098770)
1.0 9.0 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.3 8.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.6 7.8 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.4 7.3 GO:0070300 phosphatidic acid binding(GO:0070300)
2.2 6.7 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
1.3 6.5 GO:0005534 galactose binding(GO:0005534)
1.1 6.4 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.5 5.5 GO:0016500 protein-hormone receptor activity(GO:0016500)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 49.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.5 30.4 PID_IL12_2PATHWAY IL12-mediated signaling events
0.3 22.3 PID_P73PATHWAY p73 transcription factor network
0.6 17.9 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
1.2 17.1 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.4 16.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.2 15.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 13.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 10.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 6.9 NABA_COLLAGENS Genes encoding collagen proteins
0.1 6.0 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.8 5.3 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.1 5.3 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 5.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 4.7 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 3.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.4 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 2.8 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 2.6 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.1 2.3 PID_IL6_7_PATHWAY IL6-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 57.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.9 23.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
1.5 14.5 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.3 12.6 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.3 12.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 10.7 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 10.5 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.3 8.4 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 6.7 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 6.5 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 6.3 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 5.6 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
1.8 5.5 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.5 5.5 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.2 5.2 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.2 4.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 3.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.5 3.1 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.3 2.5 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 2.1 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA