Motif ID: Nfatc3

Z-value: 1.126


Transcription factors associated with Nfatc3:

Gene SymbolEntrez IDGene Name
Nfatc3 ENSMUSG00000031902.9 Nfatc3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc3mm10_v2_chr8_+_106059562_106059623-0.114.2e-01Click!


Activity profile for motif Nfatc3.

activity profile for motif Nfatc3


Sorted Z-values histogram for motif Nfatc3

Sorted Z-values for motif Nfatc3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 6.091 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr4_-_97584605 5.451 ENSMUST00000107067.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584612 5.362 ENSMUST00000107068.2
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr9_+_118478344 5.159 ENSMUST00000035020.8
Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478182 4.955 ENSMUST00000111763.1
Eomes
eomesodermin homolog (Xenopus laevis)
chr10_+_4611971 4.198 ENSMUST00000105590.1
ENSMUST00000067086.7
Esr1

estrogen receptor 1 (alpha)

chr15_-_91191733 3.560 ENSMUST00000069511.6
Abcd2
ATP-binding cassette, sub-family D (ALD), member 2
chr18_-_80713062 3.364 ENSMUST00000170905.1
ENSMUST00000078049.4
Nfatc1

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1

chr17_-_70849644 3.075 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
Tgif1


TGFB-induced factor homeobox 1


chr6_+_48841476 3.000 ENSMUST00000101426.4
Tmem176a
transmembrane protein 176A
chr6_+_48841633 2.888 ENSMUST00000168406.1
Tmem176a
transmembrane protein 176A
chr14_-_16575456 2.763 ENSMUST00000063750.6
Rarb
retinoic acid receptor, beta
chr6_-_48841098 2.747 ENSMUST00000101429.4
Tmem176b
transmembrane protein 176B
chr6_-_48840988 2.741 ENSMUST00000164733.1
Tmem176b
transmembrane protein 176B
chr6_-_48841373 2.691 ENSMUST00000166247.1
Tmem176b
transmembrane protein 176B
chr6_+_47244359 2.635 ENSMUST00000060839.6
Cntnap2
contactin associated protein-like 2
chr3_-_86548268 2.330 ENSMUST00000077524.3
Mab21l2
mab-21-like 2 (C. elegans)
chr16_-_59555752 2.303 ENSMUST00000179383.1
ENSMUST00000044604.8
Crybg3

beta-gamma crystallin domain containing 3

chr7_-_49636847 2.266 ENSMUST00000032717.6
Dbx1
developing brain homeobox 1
chr1_+_12718496 2.223 ENSMUST00000088585.3
Sulf1
sulfatase 1
chr7_+_100494044 2.202 ENSMUST00000153287.1
Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr16_-_22161450 2.195 ENSMUST00000115379.1
Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr7_+_100493795 2.187 ENSMUST00000129324.1
Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr2_-_118549668 2.135 ENSMUST00000090219.6
Bmf
BCL2 modifying factor
chr2_+_157560078 2.028 ENSMUST00000153739.2
ENSMUST00000173595.1
ENSMUST00000109526.1
ENSMUST00000173839.1
ENSMUST00000173041.1
ENSMUST00000173793.1
ENSMUST00000172487.1
ENSMUST00000088484.5
Nnat







neuronatin







chrX_-_60893430 1.999 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr3_+_94377432 1.959 ENSMUST00000107292.1
Rorc
RAR-related orphan receptor gamma
chr3_-_61365951 1.906 ENSMUST00000066298.2
B430305J03Rik
RIKEN cDNA B430305J03 gene
chrX_-_23285532 1.887 ENSMUST00000115319.2
Klhl13
kelch-like 13
chr3_-_37125943 1.879 ENSMUST00000029275.5
Il2
interleukin 2
chr4_-_43523595 1.846 ENSMUST00000107914.3
Tpm2
tropomyosin 2, beta
chr12_-_10900296 1.814 ENSMUST00000085735.2
Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr7_-_70360593 1.810 ENSMUST00000032768.7
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr8_+_84970068 1.781 ENSMUST00000164807.1
Prdx2
peroxiredoxin 2
chr5_-_114273702 1.769 ENSMUST00000144050.1
ENSMUST00000044790.5
Foxn4

forkhead box N4

chr7_+_99466004 1.718 ENSMUST00000037359.2
Klhl35
kelch-like 35
chr1_+_153665274 1.717 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8

regulator of G-protein signaling 8

chr1_+_153652943 1.708 ENSMUST00000041776.5
Rgs8
regulator of G-protein signaling 8
chr15_+_25752860 1.688 ENSMUST00000022882.5
ENSMUST00000135173.1
Myo10

myosin X

chr7_-_70366735 1.678 ENSMUST00000089565.5
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr3_+_94377505 1.676 ENSMUST00000098877.2
Rorc
RAR-related orphan receptor gamma
chr11_+_63133068 1.623 ENSMUST00000108700.1
Pmp22
peripheral myelin protein 22
chr5_-_88527841 1.567 ENSMUST00000087033.3
Igj
immunoglobulin joining chain
chr14_+_55824795 1.504 ENSMUST00000024179.5
ENSMUST00000172271.1
Nfatc4

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4

chr5_-_124354671 1.483 ENSMUST00000031341.4
Cdk2ap1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr13_-_114388057 1.465 ENSMUST00000022286.6
Ndufs4
NADH dehydrogenase (ubiquinone) Fe-S protein 4
chr11_+_99047311 1.450 ENSMUST00000140772.1
Igfbp4
insulin-like growth factor binding protein 4
chr5_+_53590215 1.422 ENSMUST00000037618.6
Rbpj
recombination signal binding protein for immunoglobulin kappa J region
chr2_+_3114220 1.404 ENSMUST00000072955.5
Fam171a1
family with sequence similarity 171, member A1
chr2_+_84839395 1.368 ENSMUST00000146816.1
ENSMUST00000028469.7
Slc43a1

solute carrier family 43, member 1

chrX_+_161717498 1.359 ENSMUST00000061514.7
Rai2
retinoic acid induced 2
chr4_-_43523746 1.330 ENSMUST00000150592.1
Tpm2
tropomyosin 2, beta
chr15_-_99820072 1.318 ENSMUST00000109024.2
Lima1
LIM domain and actin binding 1
chr3_-_145649970 1.318 ENSMUST00000029846.3
Cyr61
cysteine rich protein 61
chr5_+_53590453 1.318 ENSMUST00000113865.1
Rbpj
recombination signal binding protein for immunoglobulin kappa J region
chr4_+_116708571 1.302 ENSMUST00000106462.2
ENSMUST00000138305.1
ENSMUST00000125671.1
ENSMUST00000130828.1
Ccdc163



coiled-coil domain containing 163



chr2_+_174415804 1.274 ENSMUST00000109075.1
ENSMUST00000016397.6
Nelfcd

negative elongation factor complex member C/D, Th1l

chr10_+_50895651 1.271 ENSMUST00000020071.3
Sim1
single-minded homolog 1 (Drosophila)
chr17_-_70851710 1.267 ENSMUST00000166395.2
Tgif1
TGFB-induced factor homeobox 1
chr9_+_65265173 1.258 ENSMUST00000048762.1
Cilp
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr13_+_44731265 1.243 ENSMUST00000173246.1
Jarid2
jumonji, AT rich interactive domain 2
chr14_-_46788267 1.204 ENSMUST00000015903.4
Cnih1
cornichon homolog 1 (Drosophila)
chr2_+_35282380 1.172 ENSMUST00000028239.6
Gsn
gelsolin
chr4_+_116708624 1.161 ENSMUST00000106463.1
Ccdc163
coiled-coil domain containing 163
chrX_-_155216444 1.153 ENSMUST00000026318.8
Sat1
spermidine/spermine N1-acetyl transferase 1
chr7_+_27486910 1.153 ENSMUST00000008528.7
Sertad1
SERTA domain containing 1
chr6_+_120773633 1.144 ENSMUST00000112682.2
Slc25a18
solute carrier family 25 (mitochondrial carrier), member 18
chr10_+_77829467 1.125 ENSMUST00000092368.2
Tspear
thrombospondin type laminin G domain and EAR repeats
chr2_+_155751117 1.103 ENSMUST00000029140.5
ENSMUST00000132608.1
Procr

protein C receptor, endothelial

chr11_+_63132569 1.091 ENSMUST00000108701.1
Pmp22
peripheral myelin protein 22
chr11_+_62077018 1.084 ENSMUST00000092415.5
Specc1
sperm antigen with calponin homology and coiled-coil domains 1
chrX_-_143827391 1.076 ENSMUST00000087316.5
Capn6
calpain 6
chr7_-_101921175 1.074 ENSMUST00000098236.2
Lrrc51
leucine rich repeat containing 51
chr10_-_96409038 1.068 ENSMUST00000179683.1
Gm20091
predicted gene, 20091
chr11_+_60140066 1.063 ENSMUST00000171108.1
ENSMUST00000090806.4
Rai1

retinoic acid induced 1

chr17_-_35516780 1.058 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
Tcf19


transcription factor 19


chr6_+_128644838 1.045 ENSMUST00000036712.4
Gm5884
predicted pseudogene 5884
chr1_-_4880669 0.989 ENSMUST00000078030.3
Gm6104
predicted gene 6104
chr19_+_5689131 0.979 ENSMUST00000004156.8
Map3k11
mitogen-activated protein kinase kinase kinase 11
chr1_-_144177259 0.976 ENSMUST00000111941.1
ENSMUST00000052375.1
Rgs13

regulator of G-protein signaling 13

chr7_+_90426312 0.974 ENSMUST00000061391.7
Ccdc89
coiled-coil domain containing 89
chr7_+_46847128 0.946 ENSMUST00000005051.4
Ldha
lactate dehydrogenase A
chr5_+_149411749 0.944 ENSMUST00000093110.5
Medag
mesenteric estrogen dependent adipogenesis
chr15_+_72913357 0.938 ENSMUST00000166418.2
Gm3150
predicted gene 3150
chr12_+_37241633 0.937 ENSMUST00000049874.7
Agmo
alkylglycerol monooxygenase
chr8_+_45507768 0.922 ENSMUST00000067065.7
ENSMUST00000098788.3
ENSMUST00000067107.7
ENSMUST00000171337.2
ENSMUST00000138049.1
ENSMUST00000141039.1
Sorbs2





sorbin and SH3 domain containing 2





chr17_+_52602700 0.919 ENSMUST00000039366.10
Kcnh8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr16_+_30065333 0.918 ENSMUST00000023171.7
Hes1
hairy and enhancer of split 1 (Drosophila)
chr5_+_30105161 0.915 ENSMUST00000058045.4
Gareml
GRB2 associated, regulator of MAPK1-like
chrX_-_155216338 0.895 ENSMUST00000112551.3
Sat1
spermidine/spermine N1-acetyl transferase 1
chr7_-_110061319 0.891 ENSMUST00000098110.2
AA474408
expressed sequence AA474408
chr4_-_84674989 0.890 ENSMUST00000175800.1
ENSMUST00000176418.1
ENSMUST00000175969.1
ENSMUST00000176370.1
ENSMUST00000176947.1
ENSMUST00000102820.2
ENSMUST00000107198.2
ENSMUST00000175756.1
ENSMUST00000176691.1
Bnc2








basonuclin 2








chr3_-_152266320 0.886 ENSMUST00000046045.8
Nexn
nexilin
chr15_-_83432819 0.885 ENSMUST00000165095.1
Pacsin2
protein kinase C and casein kinase substrate in neurons 2
chr6_+_127446819 0.884 ENSMUST00000112191.1
Parp11
poly (ADP-ribose) polymerase family, member 11
chr6_-_136875794 0.882 ENSMUST00000032342.1
Mgp
matrix Gla protein
chr11_+_108682602 0.880 ENSMUST00000106718.3
ENSMUST00000106715.1
ENSMUST00000106724.3
Cep112


centrosomal protein 112


chr15_-_71954395 0.871 ENSMUST00000159410.1
Col22a1
collagen, type XXII, alpha 1
chr19_+_41593363 0.870 ENSMUST00000099454.3
AI606181
expressed sequence AI606181
chr3_-_33083016 0.858 ENSMUST00000078226.3
ENSMUST00000108224.1
Pex5l

peroxisomal biogenesis factor 5-like

chr11_-_76027726 0.847 ENSMUST00000021207.6
Fam101b
family with sequence similarity 101, member B
chr5_+_110330697 0.826 ENSMUST00000112481.1
Pole
polymerase (DNA directed), epsilon
chr8_-_84969740 0.822 ENSMUST00000109736.2
ENSMUST00000140561.1
Rnaseh2a

ribonuclease H2, large subunit

chr17_-_36958437 0.816 ENSMUST00000113669.2
Znrd1
zinc ribbon domain containing, 1
chr14_+_55559993 0.813 ENSMUST00000117236.1
Dcaf11
DDB1 and CUL4 associated factor 11
chr3_-_101836223 0.810 ENSMUST00000061831.4
Mab21l3
mab-21-like 3 (C. elegans)
chr12_-_86079019 0.807 ENSMUST00000003687.6
Tgfb3
transforming growth factor, beta 3
chr1_-_170110491 0.797 ENSMUST00000027985.2
Ddr2
discoidin domain receptor family, member 2
chr19_+_53310495 0.777 ENSMUST00000003870.7
Mxi1
Max interacting protein 1
chr17_-_36958533 0.773 ENSMUST00000172518.1
Znrd1
zinc ribbon domain containing, 1
chr7_-_45510400 0.772 ENSMUST00000033096.7
Nucb1
nucleobindin 1
chrX_+_71555918 0.772 ENSMUST00000072699.6
ENSMUST00000114582.2
ENSMUST00000015361.4
ENSMUST00000088874.3
Hmgb3



high mobility group box 3



chr14_+_55560010 0.753 ENSMUST00000147981.1
ENSMUST00000133256.1
Dcaf11

DDB1 and CUL4 associated factor 11

chr3_-_95995662 0.753 ENSMUST00000123006.1
Plekho1
pleckstrin homology domain containing, family O member 1
chr19_-_50030735 0.748 ENSMUST00000071866.1
Rpl13a-ps1
ribosomal protein 13A, pseudogene 1
chr10_+_21377290 0.740 ENSMUST00000042699.7
ENSMUST00000159163.1
Aldh8a1

aldehyde dehydrogenase 8 family, member A1

chr16_-_76403673 0.737 ENSMUST00000052867.7
Gm9843
predicted gene 9843
chr6_-_71632897 0.727 ENSMUST00000065509.4
Kdm3a
lysine (K)-specific demethylase 3A
chr3_-_95995698 0.726 ENSMUST00000130043.1
Plekho1
pleckstrin homology domain containing, family O member 1
chr7_-_134232005 0.724 ENSMUST00000134504.1
Adam12
a disintegrin and metallopeptidase domain 12 (meltrin alpha)
chr19_-_53589067 0.719 ENSMUST00000095978.3
Nutf2-ps1
nuclear transport factor 2, pseudogene 1
chr2_-_121235689 0.714 ENSMUST00000142400.1
Trp53bp1
transformation related protein 53 binding protein 1
chr12_+_76533540 0.712 ENSMUST00000075249.4
Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr3_-_95995999 0.707 ENSMUST00000015889.3
Plekho1
pleckstrin homology domain containing, family O member 1
chrX_-_48513518 0.701 ENSMUST00000114945.2
ENSMUST00000037349.7
Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr3_+_142620596 0.696 ENSMUST00000165774.1
Gbp2
guanylate binding protein 2
chr7_+_130577334 0.693 ENSMUST00000059145.7
ENSMUST00000084513.4
Tacc2

transforming, acidic coiled-coil containing protein 2

chr6_+_18848571 0.691 ENSMUST00000056398.8
Naa38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr13_-_103920508 0.689 ENSMUST00000053927.5
ENSMUST00000091269.4
ENSMUST00000022222.5
Erbb2ip


Erbb2 interacting protein


chr3_-_101307079 0.671 ENSMUST00000097146.2
Gm10355
predicted gene 10355
chr2_+_18677002 0.667 ENSMUST00000028071.6
Bmi1
Bmi1 polycomb ring finger oncogene
chr16_-_20716101 0.664 ENSMUST00000120099.1
ENSMUST00000007207.8
Clcn2

chloride channel 2

chr4_-_117125618 0.649 ENSMUST00000183310.1
Btbd19
BTB (POZ) domain containing 19
chr18_+_4994600 0.647 ENSMUST00000140448.1
Svil
supervillin
chr9_+_54951104 0.638 ENSMUST00000171900.1
Psma4
proteasome (prosome, macropain) subunit, alpha type 4
chr6_+_30723541 0.630 ENSMUST00000115127.1
Mest
mesoderm specific transcript
chr11_+_114765363 0.630 ENSMUST00000138804.1
ENSMUST00000084368.5
Kif19a

kinesin family member 19A

chr17_+_36958623 0.628 ENSMUST00000173814.1
Znrd1as
Znrd1 antisense
chr2_+_155517948 0.628 ENSMUST00000029135.8
ENSMUST00000065973.2
ENSMUST00000103142.5
Acss2


acyl-CoA synthetase short-chain family member 2


chr14_+_79515618 0.622 ENSMUST00000110835.1
Elf1
E74-like factor 1
chr1_-_66863265 0.621 ENSMUST00000027153.5
Acadl
acyl-Coenzyme A dehydrogenase, long-chain
chr8_+_62951195 0.619 ENSMUST00000118003.1
Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr8_+_25017211 0.615 ENSMUST00000033961.5
Tm2d2
TM2 domain containing 2
chr4_-_148159838 0.615 ENSMUST00000151127.1
ENSMUST00000105705.2
Fbxo44

F-box protein 44

chr13_+_40859768 0.610 ENSMUST00000110191.2
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr5_+_3343893 0.601 ENSMUST00000165117.1
Cdk6
cyclin-dependent kinase 6
chr11_-_54962903 0.598 ENSMUST00000108885.1
ENSMUST00000102730.2
ENSMUST00000018482.6
ENSMUST00000108886.1
ENSMUST00000102731.1
Tnip1




TNFAIP3 interacting protein 1




chr7_+_16842896 0.585 ENSMUST00000168093.2
Prkd2
protein kinase D2
chr3_+_138143799 0.585 ENSMUST00000159622.1
Trmt10a
tRNA methyltransferase 10A
chr13_+_43370710 0.581 ENSMUST00000066804.4
Sirt5
sirtuin 5
chr15_+_41830921 0.579 ENSMUST00000166917.1
Oxr1
oxidation resistance 1
chr2_+_174330006 0.579 ENSMUST00000109085.1
ENSMUST00000109087.1
ENSMUST00000109084.1
Gnas


GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus


chr10_-_80900749 0.576 ENSMUST00000020440.6
Timm13
translocase of inner mitochondrial membrane 13
chrX_+_56963325 0.576 ENSMUST00000096431.3
Gpr112
G protein-coupled receptor 112
chr18_-_34931931 0.575 ENSMUST00000180351.1
Etf1
eukaryotic translation termination factor 1
chr5_+_96997676 0.572 ENSMUST00000112974.1
ENSMUST00000035635.7
Bmp2k

BMP2 inducible kinase

chr4_+_130047840 0.568 ENSMUST00000044565.8
ENSMUST00000132251.1
Col16a1

collagen, type XVI, alpha 1

chr19_+_58670358 0.564 ENSMUST00000057270.7
Pnlip
pancreatic lipase
chr8_-_107403197 0.557 ENSMUST00000003947.8
Nqo1
NAD(P)H dehydrogenase, quinone 1
chr13_-_97747399 0.554 ENSMUST00000144993.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr7_+_16843049 0.552 ENSMUST00000086104.4
Prkd2
protein kinase D2
chr3_+_88214474 0.550 ENSMUST00000181356.1
ENSMUST00000181396.1
Gm3764

predicted gene 3764

chr10_+_25359798 0.548 ENSMUST00000053748.8
Epb4.1l2
erythrocyte protein band 4.1-like 2
chr14_-_55660397 0.544 ENSMUST00000002400.6
Mdp1
magnesium-dependent phosphatase 1
chr2_-_173276144 0.542 ENSMUST00000139306.1
Pmepa1
prostate transmembrane protein, androgen induced 1
chr18_+_27598582 0.537 ENSMUST00000050143.3
Gm7729
predicted gene 7729
chr11_-_70656467 0.532 ENSMUST00000131642.1
Gm12319
predicted gene 12319
chr4_-_129558387 0.529 ENSMUST00000067240.4
Lck
lymphocyte protein tyrosine kinase
chr3_+_88616133 0.525 ENSMUST00000176500.1
ENSMUST00000177498.1
Arhgef2

rho/rac guanine nucleotide exchange factor (GEF) 2

chr19_-_29334646 0.525 ENSMUST00000044143.5
Rln1
relaxin 1
chr2_-_34913976 0.525 ENSMUST00000028232.3
Phf19
PHD finger protein 19
chr9_-_13446753 0.516 ENSMUST00000167906.2
Gm17571
predicted gene, 17571
chr19_-_5912771 0.516 ENSMUST00000118623.1
Dpf2
D4, zinc and double PHD fingers family 2
chr19_-_5912834 0.514 ENSMUST00000136983.1
Dpf2
D4, zinc and double PHD fingers family 2
chr17_+_24736673 0.514 ENSMUST00000101800.5
Msrb1
methionine sulfoxide reductase B1
chr8_-_84067283 0.500 ENSMUST00000071067.3
C330011M18Rik
RIKEN cDNA C330011M18 gene
chr17_-_48432723 0.497 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr19_+_24875679 0.495 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chr3_-_95995835 0.488 ENSMUST00000143485.1
Plekho1
pleckstrin homology domain containing, family O member 1
chr17_+_36958571 0.487 ENSMUST00000040177.6
Znrd1as
Znrd1 antisense
chr13_-_103920295 0.477 ENSMUST00000169083.1
Erbb2ip
Erbb2 interacting protein
chr4_+_130107556 0.473 ENSMUST00000030563.5
Pef1
penta-EF hand domain containing 1
chr11_-_3914664 0.473 ENSMUST00000109995.1
ENSMUST00000051207.1
Slc35e4

solute carrier family 35, member E4

chr19_-_6969746 0.472 ENSMUST00000025912.8
Plcb3
phospholipase C, beta 3
chrX_-_8193387 0.470 ENSMUST00000143223.1
ENSMUST00000033509.8
Ebp

phenylalkylamine Ca2+ antagonist (emopamil) binding protein

chr8_-_41041828 0.470 ENSMUST00000051379.7
Mtus1
mitochondrial tumor suppressor 1
chr4_-_129558355 0.469 ENSMUST00000167288.1
ENSMUST00000134336.1
Lck

lymphocyte protein tyrosine kinase

chr4_-_11965699 0.467 ENSMUST00000108301.1
ENSMUST00000095144.3
ENSMUST00000108302.1
Pdp1


pyruvate dehyrogenase phosphatase catalytic subunit 1


chr14_-_72602945 0.466 ENSMUST00000162825.1
Fndc3a
fibronectin type III domain containing 3A
chr7_-_134232125 0.456 ENSMUST00000127524.1
Adam12
a disintegrin and metallopeptidase domain 12 (meltrin alpha)
chr11_-_32222233 0.454 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
Rhbdf1


rhomboid family 1 (Drosophila)


chr3_+_51559973 0.452 ENSMUST00000180404.1
5031434O11Rik
RIKEN cDNA 5031434O11 gene
chr18_-_37997543 0.450 ENSMUST00000042944.7
Arap3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr5_-_51567717 0.449 ENSMUST00000127135.1
ENSMUST00000151104.1
Ppargc1a

peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

chr12_-_54862783 0.444 ENSMUST00000078124.7
Cfl2
cofilin 2, muscle
chr7_-_30559828 0.442 ENSMUST00000108164.1
Lin37
lin-37 homolog (C. elegans)
chr8_+_104101625 0.439 ENSMUST00000034339.8
Cdh5
cadherin 5
chr7_-_38227975 0.433 ENSMUST00000098513.4
Plekhf1
pleckstrin homology domain containing, family F (with FYVE domain) member 1
chr2_-_130629994 0.432 ENSMUST00000028761.4
ENSMUST00000110262.1
Ubox5
Fastkd5
U box domain containing 5
FAST kinase domains 5
chr7_+_119900099 0.432 ENSMUST00000106516.1
Lyrm1
LYR motif containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 10.1 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
2.0 14.1 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
1.1 3.4 GO:0060854 patterning of lymph vessels(GO:0060854)
1.0 4.2 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
1.0 6.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.9 2.7 GO:0072554 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel lumenization(GO:0072554) blood vessel endothelial cell fate specification(GO:0097101) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.7 3.5 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.7 2.0 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.6 0.6 GO:0042758 long-chain fatty acid catabolic process(GO:0042758)
0.6 2.2 GO:2000319 negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.6 2.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.6 2.8 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.5 2.6 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.5 1.5 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.5 4.4 GO:1990845 adaptive thermogenesis(GO:1990845)
0.5 3.6 GO:0072615 interleukin-17 secretion(GO:0072615)
0.4 3.9 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.4 1.2 GO:1903903 striated muscle atrophy(GO:0014891) positive regulation of keratinocyte apoptotic process(GO:1902174) regulation of establishment of T cell polarity(GO:1903903)
0.3 0.9 GO:2000977 inhibition of neuroepithelial cell differentiation(GO:0002085) oculomotor nerve development(GO:0021557) negative regulation of auditory receptor cell differentiation(GO:0045608) regulation of forebrain neuron differentiation(GO:2000977)
0.3 0.8 GO:0045004 DNA replication proofreading(GO:0045004)
0.3 1.7 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.3 4.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.3 0.8 GO:0003032 detection of oxygen(GO:0003032) negative regulation of macrophage cytokine production(GO:0010936)
0.3 1.6 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.2 3.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.2 0.7 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.2 2.1 GO:0048102 autophagic cell death(GO:0048102)
0.2 0.7 GO:0033092 positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.2 0.9 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.2 0.9 GO:0030091 protein repair(GO:0030091)
0.2 0.6 GO:0006083 acetate metabolic process(GO:0006083)
0.2 4.0 GO:0060579 ventral spinal cord interneuron fate commitment(GO:0060579) cell fate commitment involved in pattern specification(GO:0060581)
0.2 1.0 GO:0007256 activation of JNKK activity(GO:0007256)
0.2 0.9 GO:0019659 fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.2 0.7 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.2 1.4 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.2 1.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.2 1.8 GO:0002536 respiratory burst involved in inflammatory response(GO:0002536) negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.2 0.5 GO:0016554 cytidine to uridine editing(GO:0016554)
0.2 1.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.2 0.5 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.2 0.5 GO:0031161 phosphatidylinositol catabolic process(GO:0031161)
0.2 0.8 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.1 2.7 GO:0051451 myoblast migration(GO:0051451)
0.1 2.7 GO:0032060 bleb assembly(GO:0032060)
0.1 0.8 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 0.5 GO:0010749 regulation of nitric oxide mediated signal transduction(GO:0010749)
0.1 1.0 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474)
0.1 1.6 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.1 0.9 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 0.6 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.6 GO:0044838 cell quiescence(GO:0044838)
0.1 0.6 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.1 0.6 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.8 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 0.4 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 0.4 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)
0.1 0.7 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.1 0.4 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 0.5 GO:0010991 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.3 GO:1902220 positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902220)
0.1 0.4 GO:0055071 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071)
0.1 2.0 GO:0007530 sex determination(GO:0007530)
0.1 2.3 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 0.8 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.1 0.4 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.1 0.3 GO:0009838 abscission(GO:0009838)
0.1 0.7 GO:1902510 regulation of apoptotic DNA fragmentation(GO:1902510)
0.1 0.9 GO:0043586 tongue development(GO:0043586)
0.1 0.2 GO:0046671 regulation of cellular pH reduction(GO:0032847) negative regulation of retinal cell programmed cell death(GO:0046671)
0.1 0.5 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.1 0.6 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.1 1.8 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.1 0.4 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.1 0.9 GO:0046485 ether lipid metabolic process(GO:0046485)
0.1 0.3 GO:2001170 negative regulation of ATP biosynthetic process(GO:2001170)
0.1 0.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.4 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 0.5 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.1 0.3 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.1 0.6 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 0.3 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.1 0.4 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.2 GO:0071918 urea transmembrane transport(GO:0071918)
0.1 0.2 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.1 0.2 GO:0048539 bone marrow development(GO:0048539)
0.1 0.5 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.1 1.8 GO:0015804 neutral amino acid transport(GO:0015804)
0.1 0.7 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.7 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.6 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)
0.0 0.3 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 0.9 GO:0036010 protein localization to endosome(GO:0036010)
0.0 0.4 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.0 0.6 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.7 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.0 0.2 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
0.0 0.3 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.0 0.1 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.0 0.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 1.5 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.4 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.6 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 0.3 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 1.5 GO:0060325 face morphogenesis(GO:0060325)
0.0 1.1 GO:0050819 negative regulation of coagulation(GO:0050819)
0.0 0.3 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.2 GO:0019348 dolichol metabolic process(GO:0019348)
0.0 0.6 GO:0006415 translational termination(GO:0006415)
0.0 0.1 GO:0030202 heparin metabolic process(GO:0030202) ureteric bud formation(GO:0060676)
0.0 0.1 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.0 0.1 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.2 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.0 0.4 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 0.2 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.6 GO:0010883 regulation of lipid storage(GO:0010883)
0.0 0.3 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.3 GO:0050892 intestinal absorption(GO:0050892)
0.0 0.3 GO:0007135 meiosis II(GO:0007135) positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 1.8 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.0 0.1 GO:0071638 cellular triglyceride homeostasis(GO:0035356) negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.0 1.7 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.5 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.5 GO:0060009 Sertoli cell development(GO:0060009)
0.0 2.8 GO:0051028 mRNA transport(GO:0051028)
0.0 0.9 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.2 GO:0060689 cell differentiation involved in salivary gland development(GO:0060689)
0.0 0.3 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.1 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) dibasic protein processing(GO:0090472)
0.0 0.5 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 1.0 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.6 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.6 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.1 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.2 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.0 0.4 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 0.2 GO:0009950 dorsal/ventral axis specification(GO:0009950)
0.0 0.2 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.6 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 1.3 GO:0072164 ureteric bud development(GO:0001657) mesonephric epithelium development(GO:0072163) mesonephric tubule development(GO:0072164)
0.0 0.1 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.4 GO:0045214 sarcomere organization(GO:0045214)
0.0 0.3 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.4 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 0.5 GO:0006040 amino sugar metabolic process(GO:0006040)
0.0 0.1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.3 GO:0000027 ribosomal large subunit assembly(GO:0000027)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.5 2.7 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.4 2.7 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.3 1.3 GO:0032021 NELF complex(GO:0032021)
0.2 0.7 GO:0031417 NatC complex(GO:0031417)
0.2 2.9 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.2 0.9 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 0.8 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.2 0.8 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.2 3.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 0.8 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 1.2 GO:0030478 actin cap(GO:0030478)
0.1 0.6 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 2.7 GO:0043218 compact myelin(GO:0043218)
0.1 1.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 3.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 2.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.4 GO:1990131 Iml1 complex(GO:1990130) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 0.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.6 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 0.7 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.1 0.3 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 1.5 GO:0000242 pericentriolar material(GO:0000242)
0.1 4.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 3.3 GO:0016459 myosin complex(GO:0016459)
0.1 0.4 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 1.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 3.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 1.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.0 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.3 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 1.1 GO:0032420 stereocilium(GO:0032420)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.3 GO:0090543 Flemming body(GO:0090543)
0.0 0.9 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.1 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.7 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.2 GO:0046930 pore complex(GO:0046930)
0.0 0.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.3 GO:0005605 basal lamina(GO:0005605)
0.0 0.2 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.2 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 5.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.6 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.5 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 1.2 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.5 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.4 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.1 GO:0008623 CHRAC(GO:0008623)
0.0 0.6 GO:0031519 PcG protein complex(GO:0031519)
0.0 2.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.9 GO:0005643 nuclear pore(GO:0005643)
0.0 0.4 GO:0031941 filamentous actin(GO:0031941)
0.0 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.6 GO:0005871 kinesin complex(GO:0005871)
0.0 0.7 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.1 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 1.5 GO:0005925 focal adhesion(GO:0005925)
0.0 2.8 GO:0000790 nuclear chromatin(GO:0000790)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
1.1 3.4 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
1.1 4.4 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.9 3.6 GO:0008142 oxysterol binding(GO:0008142)
0.7 2.0 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.4 2.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.4 1.9 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.3 0.8 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.3 3.5 GO:0001972 retinoic acid binding(GO:0001972)
0.2 1.0 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.2 0.9 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.2 0.7 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.2 2.8 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.2 0.6 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.2 1.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 0.6 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.2 0.8 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 0.6 GO:0098770 FBXO family protein binding(GO:0098770)
0.2 1.0 GO:0042610 CD8 receptor binding(GO:0042610)
0.2 5.2 GO:0008432 JUN kinase binding(GO:0008432)
0.2 1.8 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 0.9 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.2 10.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 0.5 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.2 0.6 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.1 0.7 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 0.8 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1 0.6 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 0.9 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.1 0.5 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 0.7 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.1 0.4 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 0.8 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 0.5 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.1 4.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.4 GO:0003998 acylphosphatase activity(GO:0003998)
0.1 3.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 0.4 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.1 1.6 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 2.0 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 1.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.8 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 1.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 2.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.3 GO:0004096 catalase activity(GO:0004096)
0.1 0.6 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 0.6 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 0.3 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.1 0.2 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 0.4 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 0.2 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 0.3 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 2.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 0.3 GO:0051525 NFAT protein binding(GO:0051525)
0.1 0.2 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 1.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 2.3 GO:0032452 histone demethylase activity(GO:0032452)
0.0 1.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 1.1 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.4 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.6 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.9 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.3 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 1.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.2 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.1 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.0 0.4 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.8 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 1.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.3 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.0 3.8 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.2 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.3 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.1 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.3 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.6 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 1.2 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.3 GO:0030346 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656) protein phosphatase 2B binding(GO:0030346)
0.0 0.3 GO:0019956 chemokine binding(GO:0019956)
0.0 2.8 GO:0035326 enhancer binding(GO:0035326)
0.0 0.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.7 GO:0002020 protease binding(GO:0002020)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.7 GO:0070888 E-box binding(GO:0070888)
0.0 0.3 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 3.7 GO:0051015 actin filament binding(GO:0051015)
0.0 0.3 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.6 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931) calcium-dependent protein kinase activity(GO:0010857)
0.0 0.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.2 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 0.6 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 4.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 2.4 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.4 GO:0001671 ATPase activator activity(GO:0001671)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 15.1 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 7.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 3.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 1.6 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 4.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 7.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 3.7 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 1.8 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 2.7 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 1.7 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.1 1.0 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 1.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.4 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.5 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.0 0.7 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 0.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.6 PID_IL2_1PATHWAY IL2-mediated signaling events
0.0 1.3 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.3 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 2.1 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 0.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.0 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.2 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.5 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 2.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.4 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.1 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.5 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.3 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.3 PID_BCR_5PATHWAY BCR signaling pathway
0.0 0.4 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.9 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 1.0 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 2.7 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.2 0.6 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 2.0 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 4.4 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 4.3 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 2.7 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 5.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 1.4 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.1 0.5 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.7 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 0.8 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 1.2 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 4.1 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.8 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.4 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.6 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.9 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.7 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.6 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 1.7 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.4 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.5 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.5 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.7 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.1 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS Genes involved in TGF-beta receptor signaling activates SMADs
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.5 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 2.7 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 0.2 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 1.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.7 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.0 0.2 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.3 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 2.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.3 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.3 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 0.2 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.2 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.0 0.3 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus