Motif ID: Nfatc3

Z-value: 1.126


Transcription factors associated with Nfatc3:

Gene SymbolEntrez IDGene Name
Nfatc3 ENSMUSG00000031902.9 Nfatc3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc3mm10_v2_chr8_+_106059562_106059623-0.114.2e-01Click!


Activity profile for motif Nfatc3.

activity profile for motif Nfatc3


Sorted Z-values histogram for motif Nfatc3

Sorted Z-values for motif Nfatc3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 6.091 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr4_-_97584605 5.451 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584612 5.362 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr9_+_118478344 5.159 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478182 4.955 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr10_+_4611971 4.198 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr15_-_91191733 3.560 ENSMUST00000069511.6
 Abcd2
ATP-binding cassette, sub-family D (ALD), member 2
chr18_-_80713062 3.364 ENSMUST00000170905.1
ENSMUST00000078049.4
 Nfatc1

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1

chr17_-_70849644 3.075 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
 Tgif1


TGFB-induced factor homeobox 1


chr6_+_48841476 3.000 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr6_+_48841633 2.888 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A
chr14_-_16575456 2.763 ENSMUST00000063750.6
 Rarb
retinoic acid receptor, beta
chr6_-_48841098 2.747 ENSMUST00000101429.4
 Tmem176b
transmembrane protein 176B
chr6_-_48840988 2.741 ENSMUST00000164733.1
 Tmem176b
transmembrane protein 176B
chr6_-_48841373 2.691 ENSMUST00000166247.1
 Tmem176b
transmembrane protein 176B
chr6_+_47244359 2.635 ENSMUST00000060839.6
 Cntnap2
contactin associated protein-like 2
chr3_-_86548268 2.330 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr16_-_59555752 2.303 ENSMUST00000179383.1
ENSMUST00000044604.8
 Crybg3

beta-gamma crystallin domain containing 3

chr7_-_49636847 2.266 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr1_+_12718496 2.223 ENSMUST00000088585.3
 Sulf1
sulfatase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 14.1 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
3.4 10.1 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.0 6.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.5 4.4 GO:1990845 adaptive thermogenesis(GO:1990845)
0.3 4.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.0 4.2 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.2 4.0 GO:0060579 ventral spinal cord interneuron fate commitment(GO:0060579) cell fate commitment involved in pattern specification(GO:0060581)
0.4 3.9 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.5 3.6 GO:0072615 interleukin-17 secretion(GO:0072615)
0.7 3.5 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
1.1 3.4 GO:0060854 patterning of lymph vessels(GO:0060854)
0.2 3.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.6 2.8 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 2.8 GO:0051028 mRNA transport(GO:0051028)
0.9 2.7 GO:0072554 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel lumenization(GO:0072554) blood vessel endothelial cell fate specification(GO:0097101) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.1 2.7 GO:0051451 myoblast migration(GO:0051451)
0.1 2.7 GO:0032060 bleb assembly(GO:0032060)
0.5 2.6 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 2.3 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.6 2.2 GO:2000319 negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.6 4.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 4.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 3.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 3.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 3.3 GO:0016459 myosin complex(GO:0016459)
0.2 3.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 3.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2 2.9 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 2.8 GO:0000790 nuclear chromatin(GO:0000790)
0.5 2.7 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.4 2.7 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 2.7 GO:0043218 compact myelin(GO:0043218)
0.1 2.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 2.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 1.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 1.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 1.5 GO:0000242 pericentriolar material(GO:0000242)
0.0 1.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 5.2 GO:0008432 JUN kinase binding(GO:0008432)
0.1 4.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 4.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
1.1 4.4 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
1.4 4.2 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 3.8 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 3.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 3.7 GO:0051015 actin filament binding(GO:0051015)
0.9 3.6 GO:0008142 oxysterol binding(GO:0008142)
0.3 3.5 GO:0001972 retinoic acid binding(GO:0001972)
1.1 3.4 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.2 2.8 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 2.8 GO:0035326 enhancer binding(GO:0035326)
0.0 2.7 GO:0002020 protease binding(GO:0002020)
0.0 2.4 GO:0030246 carbohydrate binding(GO:0030246)
0.1 2.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 2.3 GO:0032452 histone demethylase activity(GO:0032452)
0.4 2.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 2.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.1 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 7.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 7.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 4.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.7 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 3.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 3.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.7 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 2.1 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 2.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 1.8 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 1.7 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.1 1.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 1.6 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.3 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.0 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 4.4 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 4.3 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 4.1 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 3.9 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 2.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 2.7 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 2.7 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 2.7 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 2.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.0 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.7 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.7 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 1.7 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.0 1.5 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 1.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.4 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.1 1.2 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.2 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.2 1.0 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse