Motif ID: Nfatc4
Z-value: 0.572
Transcription factors associated with Nfatc4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nfatc4 | ENSMUSG00000023411.5 | Nfatc4 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfatc4 | mm10_v2_chr14_+_55824795_55824889 | -0.80 | 2.4e-13 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 8.0 | GO:0007521 | muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111) |
| 1.7 | 5.1 | GO:0038095 | positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095) |
| 1.1 | 3.4 | GO:0070428 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432) |
| 0.9 | 2.7 | GO:1902256 | apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) |
| 0.7 | 11.7 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.6 | 5.0 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.3 | 1.0 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
| 0.3 | 2.2 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 0.2 | 1.4 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.2 | 0.7 | GO:0038003 | opioid receptor signaling pathway(GO:0038003) regulation of opioid receptor signaling pathway(GO:2000474) |
| 0.2 | 1.5 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) |
| 0.2 | 1.1 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.2 | 0.8 | GO:0000480 | endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) |
| 0.1 | 2.1 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.1 | 1.5 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.1 | 2.4 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 0.1 | 0.4 | GO:0046013 | regulation of T cell homeostatic proliferation(GO:0046013) negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320) |
| 0.1 | 0.5 | GO:0060467 | negative regulation of fertilization(GO:0060467) |
| 0.1 | 1.6 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.1 | 4.2 | GO:0010765 | positive regulation of sodium ion transport(GO:0010765) |
| 0.1 | 2.0 | GO:0071353 | cellular response to interleukin-4(GO:0071353) |
| 0.1 | 0.2 | GO:1903756 | regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 0.0 | 0.8 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.0 | 0.9 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) |
| 0.0 | 0.1 | GO:1902527 | positive regulation of protein monoubiquitination(GO:1902527) |
| 0.0 | 4.8 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
| 0.0 | 0.5 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.0 | 0.6 | GO:0045648 | positive regulation of erythrocyte differentiation(GO:0045648) |
| 0.0 | 4.1 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 0.0 | 0.6 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.0 | 0.3 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.6 | GO:0031673 | H zone(GO:0031673) |
| 0.4 | 1.5 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
| 0.3 | 5.0 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.3 | 1.1 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.1 | 14.1 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 1.5 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 0.3 | GO:0090568 | nuclear transcriptional repressor complex(GO:0090568) RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.1 | 0.3 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.1 | 1.4 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 0.9 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 2.7 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 8.0 | GO:0030017 | sarcomere(GO:0030017) |
| 0.0 | 4.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 0.8 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 2.2 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 0.3 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.0 | 0.8 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 0.2 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 8.0 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.4 | 2.2 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.3 | 0.8 | GO:0003963 | RNA-3'-phosphate cyclase activity(GO:0003963) |
| 0.3 | 2.1 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.2 | 2.7 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.2 | 1.1 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.1 | 2.4 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.1 | 5.1 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 4.8 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 1.5 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.1 | 5.0 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 0.4 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.1 | 1.5 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.1 | 1.0 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.0 | 0.8 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 0.8 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 1.0 | GO:0016790 | thiolester hydrolase activity(GO:0016790) |
| 0.0 | 1.1 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 3.0 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 3.4 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 0.6 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 0.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.1 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.2 | 8.0 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 2.2 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 5.0 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 2.5 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 1.1 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 1.6 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.4 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 0.9 | PID_NOTCH_PATHWAY | Notch signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.4 | REACTOME_IRAK1_RECRUITS_IKK_COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.2 | 7.5 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 4.5 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 3.3 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 1.0 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 2.9 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.4 | REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 4.8 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.1 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.4 | REACTOME_IL_RECEPTOR_SHC_SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 0.3 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
