Motif ID: Nfatc4

Z-value: 0.572


Transcription factors associated with Nfatc4:

Gene SymbolEntrez IDGene Name
Nfatc4 ENSMUSG00000023411.5 Nfatc4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc4mm10_v2_chr14_+_55824795_55824889-0.802.4e-13Click!


Activity profile for motif Nfatc4.

activity profile for motif Nfatc4


Sorted Z-values histogram for motif Nfatc4

Sorted Z-values for motif Nfatc4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc4

PNG image of the network

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Top targets:


Showing 1 to 20 of 59 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_83504032 7.983 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr1_-_56978534 6.777 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr4_+_48049080 5.051 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr19_+_26623419 5.025 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr1_-_56969864 4.937 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr15_+_92051153 4.499 ENSMUST00000169825.1
 Cntn1
contactin 1
chr11_+_97415527 4.066 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr19_-_4943049 3.440 ENSMUST00000133254.1
ENSMUST00000120475.1
ENSMUST00000025834.7
 Peli3


pellino 3


chr15_+_3270767 3.404 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr13_+_31806627 2.674 ENSMUST00000062292.2
 Foxc1
forkhead box C1
chr2_+_125136692 2.457 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr1_-_193370225 2.416 ENSMUST00000169907.1
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr14_+_70555900 2.359 ENSMUST00000163060.1
 Hr
hairless
chr1_-_193370260 2.357 ENSMUST00000016323.4
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr2_+_55435918 2.235 ENSMUST00000067101.3
 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr5_+_117363513 2.165 ENSMUST00000111959.1
 Wsb2
WD repeat and SOCS box-containing 2
chr6_-_59024470 2.134 ENSMUST00000089860.5
 Fam13a
family with sequence similarity 13, member A
chr10_+_21993890 2.074 ENSMUST00000092673.4
 Sgk1
serum/glucocorticoid regulated kinase 1
chr6_-_59024340 2.058 ENSMUST00000173193.1
 Fam13a
family with sequence similarity 13, member A
chr13_-_52981027 1.995 ENSMUST00000071065.7
 Nfil3
nuclear factor, interleukin 3, regulated

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 11.7 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
2.7 8.0 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
1.7 5.1 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.6 5.0 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 4.8 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.1 4.2 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.0 4.1 GO:0043547 positive regulation of GTPase activity(GO:0043547)
1.1 3.4 GO:0070428 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432)
0.9 2.7 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.1 2.4 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.3 2.2 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 2.1 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 2.0 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.1 1.6 GO:0008090 retrograde axonal transport(GO:0008090)
0.2 1.5 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 1.5 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 1.4 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.2 1.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.3 1.0 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.0 0.9 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 8.0 GO:0030017 sarcomere(GO:0030017)
0.3 5.0 GO:0071564 npBAF complex(GO:0071564)
0.0 4.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.7 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 2.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.4 1.6 GO:0031673 H zone(GO:0031673)
0.4 1.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 1.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 1.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.3 1.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.9 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.3 GO:0090568 nuclear transcriptional repressor complex(GO:0090568) RNA polymerase II transcription repressor complex(GO:0090571)
0.1 0.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.3 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 8.0 GO:0003680 AT DNA binding(GO:0003680)
0.1 5.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 5.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 4.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 3.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 3.0 GO:0030246 carbohydrate binding(GO:0030246)
0.2 2.7 GO:0008301 DNA binding, bending(GO:0008301)
0.1 2.4 GO:0042809 vitamin D receptor binding(GO:0042809)
0.4 2.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3 2.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 1.5 GO:0002162 dystroglycan binding(GO:0002162)
0.1 1.5 GO:0031402 sodium ion binding(GO:0031402)
0.2 1.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 1.1 GO:0035064 methylated histone binding(GO:0035064)
0.1 1.0 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 1.0 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.3 0.8 GO:0003963 RNA-3'-phosphate cyclase activity(GO:0003963)
0.0 0.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.8 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.6 GO:0046875 ephrin receptor binding(GO:0046875)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.0 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.2 5.1 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 5.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 2.5 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.1 2.2 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.4 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 1.1 PID_MYC_PATHWAY C-MYC pathway
0.0 0.9 PID_NOTCH_PATHWAY Notch signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.5 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 4.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.5 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.3 3.4 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 3.3 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 2.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.4 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 1.1 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.0 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.4 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1