Motif ID: Nfe2_Bach1_Mafk

Z-value: 1.199

Transcription factors associated with Nfe2_Bach1_Mafk:

Gene SymbolEntrez IDGene Name
Bach1 ENSMUSG00000025612.5 Bach1
Mafk ENSMUSG00000018143.4 Mafk
Nfe2 ENSMUSG00000058794.6 Nfe2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafkmm10_v2_chr5_+_139791513_1397915390.584.0e-06Click!
Nfe2mm10_v2_chr15_-_103251465_103251705-0.524.3e-05Click!
Bach1mm10_v2_chr16_+_87698904_876989590.181.8e-01Click!


Activity profile for motif Nfe2_Bach1_Mafk.

activity profile for motif Nfe2_Bach1_Mafk


Sorted Z-values histogram for motif Nfe2_Bach1_Mafk

Sorted Z-values for motif Nfe2_Bach1_Mafk



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfe2_Bach1_Mafk

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_5725639 32.485 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr1_-_33907721 22.214 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr9_-_86695897 9.874 ENSMUST00000034989.8
 Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr6_+_5725812 8.605 ENSMUST00000115554.1
ENSMUST00000153942.1
 Dync1i1

dynein cytoplasmic 1 intermediate chain 1

chr3_+_123267445 8.162 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr5_-_139484420 7.358 ENSMUST00000150992.1
 Zfand2a
zinc finger, AN1-type domain 2A
chr5_-_139484475 7.272 ENSMUST00000110851.1
ENSMUST00000079996.6
 Zfand2a

zinc finger, AN1-type domain 2A

chr16_+_17561885 7.011 ENSMUST00000171002.1
ENSMUST00000023441.4
 P2rx6

purinergic receptor P2X, ligand-gated ion channel, 6

chr13_-_54611274 6.651 ENSMUST00000049575.7
 Cltb
clathrin, light polypeptide (Lcb)
chr13_-_54611332 6.412 ENSMUST00000091609.4
 Cltb
clathrin, light polypeptide (Lcb)
chr2_+_136713444 6.358 ENSMUST00000028727.4
ENSMUST00000110098.3
 Snap25

synaptosomal-associated protein 25

chr2_+_155775333 6.033 ENSMUST00000029141.5
 Mmp24
matrix metallopeptidase 24
chr1_-_134235420 5.888 ENSMUST00000038191.6
ENSMUST00000086465.4
 Adora1

adenosine A1 receptor

chr2_+_156475803 5.771 ENSMUST00000029155.8
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr4_-_136886187 5.542 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr2_+_156475844 5.497 ENSMUST00000103135.1
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr13_-_113663670 5.400 ENSMUST00000054650.4
 Hspb3
heat shock protein 3
chr6_-_13838432 5.081 ENSMUST00000115492.1
 Gpr85
G protein-coupled receptor 85
chr17_-_56133817 4.978 ENSMUST00000167545.1
 Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr11_+_103171081 4.876 ENSMUST00000042286.5
 Fmnl1
formin-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 41.1 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.6 22.2 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.9 13.2 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.2 12.9 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
2.0 9.9 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.0 8.4 GO:0007266 Rho protein signal transduction(GO:0007266)
0.6 8.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
1.2 8.1 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.8 7.3 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.9 7.2 GO:0005513 detection of calcium ion(GO:0005513)
0.3 7.0 GO:0033198 response to ATP(GO:0033198)
0.8 6.4 GO:0098967 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.1 6.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
2.0 5.9 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
1.1 5.6 GO:0035617 stress granule disassembly(GO:0035617)
0.3 5.5 GO:0006958 complement activation, classical pathway(GO:0006958)
1.0 5.0 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.5 4.9 GO:0051014 actin filament severing(GO:0051014)
0.8 4.8 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.8 4.8 GO:0009405 pathogenesis(GO:0009405)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
13.7 41.1 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
1.2 13.7 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 10.6 GO:0000502 proteasome complex(GO:0000502)
0.1 10.6 GO:0005604 basement membrane(GO:0005604)
0.4 10.3 GO:0071565 nBAF complex(GO:0071565)
0.1 8.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.5 8.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 8.2 GO:0001650 fibrillar center(GO:0001650)
0.2 7.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.5 7.5 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 7.4 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 7.2 GO:0009925 basal plasma membrane(GO:0009925)
1.6 6.4 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.2 6.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.3 5.9 GO:0032279 asymmetric synapse(GO:0032279)
0.3 5.6 GO:0035253 ciliary rootlet(GO:0035253)
0.1 5.3 GO:0005581 collagen trimer(GO:0005581)
0.5 5.0 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.3 5.0 GO:0031045 dense core granule(GO:0031045)
0.0 4.5 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 41.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.6 22.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.1 13.1 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 10.8 GO:0008270 zinc ion binding(GO:0008270)
3.3 9.9 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.0 9.2 GO:0005096 GTPase activator activity(GO:0005096)
0.1 8.2 GO:0000149 SNARE binding(GO:0000149)
2.0 8.1 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 7.6 GO:0005518 collagen binding(GO:0005518)
0.1 7.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.4 7.1 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.2 7.1 GO:0046965 retinoid X receptor binding(GO:0046965)
1.2 7.0 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.2 6.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.8 5.9 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.1 5.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 5.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 5.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 4.9 GO:0032794 GTPase activating protein binding(GO:0032794)
1.0 4.8 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 13.1 PID_ARF_3PATHWAY Arf1 pathway
0.1 11.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 11.2 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 7.3 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 6.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 6.3 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 6.3 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 5.9 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 5.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 5.4 PID_MTOR_4PATHWAY mTOR signaling pathway
0.2 5.2 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 5.1 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.3 4.8 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 4.2 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 3.9 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 3.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.1 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.1 3.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.2 2.9 PID_IL27_PATHWAY IL27-mediated signaling events
0.1 2.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 58.9 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.9 17.8 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.8 12.0 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 10.0 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.2 8.3 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.3 7.1 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.6 6.4 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.5 5.9 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.9 5.5 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
1.0 5.2 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 5.2 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 4.8 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.5 4.7 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.3 4.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.6 4.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 3.7 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 3.4 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 3.2 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 3.1 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 3.0 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation