Motif ID: Nfe2l2
Z-value: 0.486
Transcription factors associated with Nfe2l2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nfe2l2 | ENSMUSG00000015839.6 | Nfe2l2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nfe2l2 | mm10_v2_chr2_-_75704535_75704641 | 0.22 | 1.1e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 2.7 | GO:0072180 | mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180) |
0.8 | 2.4 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
0.4 | 1.1 | GO:0072034 | renal vesicle induction(GO:0072034) |
0.3 | 1.0 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) |
0.3 | 0.8 | GO:0070488 | negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) neutrophil aggregation(GO:0070488) |
0.2 | 0.2 | GO:0014722 | regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) |
0.2 | 2.4 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
0.2 | 2.2 | GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166) |
0.2 | 0.6 | GO:0036388 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
0.2 | 5.1 | GO:0071451 | cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) |
0.2 | 0.6 | GO:0090274 | positive regulation of somatostatin secretion(GO:0090274) |
0.2 | 0.7 | GO:0060830 | ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) |
0.2 | 1.4 | GO:0038030 | non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031) |
0.2 | 0.7 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
0.2 | 0.5 | GO:0035441 | cell migration involved in vasculogenesis(GO:0035441) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262) |
0.2 | 0.8 | GO:0000454 | snoRNA guided rRNA pseudouridine synthesis(GO:0000454) |
0.2 | 0.9 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
0.1 | 0.5 | GO:0070213 | protein auto-ADP-ribosylation(GO:0070213) |
0.1 | 0.4 | GO:2000659 | regulation of interleukin-1-mediated signaling pathway(GO:2000659) |
0.1 | 0.4 | GO:0009446 | putrescine biosynthetic process(GO:0009446) |
0.1 | 0.4 | GO:0060821 | inactivation of X chromosome by DNA methylation(GO:0060821) |
0.1 | 0.3 | GO:1902037 | negative regulation of hematopoietic stem cell differentiation(GO:1902037) |
0.1 | 0.3 | GO:0051794 | regulation of catagen(GO:0051794) |
0.1 | 0.6 | GO:0046826 | negative regulation of protein export from nucleus(GO:0046826) |
0.1 | 0.4 | GO:0006624 | vacuolar protein processing(GO:0006624) |
0.1 | 0.3 | GO:0003274 | endocardial cushion fusion(GO:0003274) |
0.1 | 0.4 | GO:0007412 | axon target recognition(GO:0007412) |
0.1 | 0.3 | GO:0035553 | oxidative single-stranded RNA demethylation(GO:0035553) |
0.1 | 1.0 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
0.1 | 0.6 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
0.1 | 0.3 | GO:0051661 | maintenance of centrosome location(GO:0051661) |
0.1 | 0.2 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
0.1 | 0.4 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) |
0.1 | 0.4 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
0.1 | 0.9 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
0.0 | 0.6 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
0.0 | 1.4 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
0.0 | 1.1 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
0.0 | 0.7 | GO:0043248 | proteasome assembly(GO:0043248) |
0.0 | 0.3 | GO:0035754 | B cell chemotaxis(GO:0035754) |
0.0 | 1.3 | GO:1903077 | negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376) |
0.0 | 0.3 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
0.0 | 0.3 | GO:0009181 | purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181) |
0.0 | 0.2 | GO:0002934 | desmosome organization(GO:0002934) |
0.0 | 0.3 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
0.0 | 0.3 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
0.0 | 0.6 | GO:0032620 | interleukin-17 production(GO:0032620) |
0.0 | 0.2 | GO:0019240 | citrulline biosynthetic process(GO:0019240) |
0.0 | 0.1 | GO:0009174 | UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049) |
0.0 | 1.4 | GO:0032543 | mitochondrial translation(GO:0032543) |
0.0 | 0.5 | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) |
0.0 | 0.4 | GO:0006298 | mismatch repair(GO:0006298) |
0.0 | 1.0 | GO:0006749 | glutathione metabolic process(GO:0006749) |
0.0 | 0.1 | GO:0008078 | zygotic determination of anterior/posterior axis, embryo(GO:0007354) mesodermal cell migration(GO:0008078) |
0.0 | 0.4 | GO:1900027 | regulation of ruffle assembly(GO:1900027) |
0.0 | 0.1 | GO:0042148 | strand invasion(GO:0042148) |
0.0 | 0.2 | GO:0045792 | negative regulation of cell size(GO:0045792) |
0.0 | 0.2 | GO:0060219 | camera-type eye photoreceptor cell differentiation(GO:0060219) |
0.0 | 0.2 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
0.0 | 0.2 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
0.0 | 0.3 | GO:0010831 | positive regulation of myotube differentiation(GO:0010831) |
0.0 | 0.9 | GO:0002181 | cytoplasmic translation(GO:0002181) |
0.0 | 0.3 | GO:0055012 | ventricular cardiac muscle cell differentiation(GO:0055012) |
0.0 | 0.3 | GO:0048671 | negative regulation of collateral sprouting(GO:0048671) |
0.0 | 0.1 | GO:0019532 | oxalate transport(GO:0019532) |
0.0 | 0.2 | GO:0006044 | N-acetylglucosamine metabolic process(GO:0006044) |
0.0 | 0.1 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
0.0 | 0.2 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 2.4 | GO:0014802 | terminal cisterna(GO:0014802) |
0.4 | 1.2 | GO:0097057 | TRAF2-GSTP1 complex(GO:0097057) |
0.2 | 0.6 | GO:0036387 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
0.2 | 2.1 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
0.2 | 0.8 | GO:0090661 | box H/ACA telomerase RNP complex(GO:0090661) |
0.2 | 2.1 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
0.2 | 1.1 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
0.2 | 2.4 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
0.1 | 0.4 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
0.1 | 3.2 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
0.1 | 1.0 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
0.1 | 1.0 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
0.1 | 2.7 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
0.1 | 0.6 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
0.1 | 0.3 | GO:0000235 | astral microtubule(GO:0000235) |
0.0 | 0.8 | GO:0031045 | dense core granule(GO:0031045) |
0.0 | 0.6 | GO:0042612 | MHC class I protein complex(GO:0042612) |
0.0 | 0.2 | GO:1990590 | ATF1-ATF4 transcription factor complex(GO:1990590) |
0.0 | 0.2 | GO:1990462 | omegasome(GO:1990462) |
0.0 | 1.4 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
0.0 | 0.3 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
0.0 | 0.3 | GO:0070652 | HAUS complex(GO:0070652) |
0.0 | 0.4 | GO:0005839 | proteasome core complex(GO:0005839) |
0.0 | 0.6 | GO:0016460 | myosin II complex(GO:0016460) |
0.0 | 0.6 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
0.0 | 0.5 | GO:0098827 | endoplasmic reticulum subcompartment(GO:0098827) |
0.0 | 0.3 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
0.0 | 0.2 | GO:0031931 | TORC1 complex(GO:0031931) |
0.0 | 0.2 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
0.0 | 0.2 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
0.0 | 0.1 | GO:1990745 | EARP complex(GO:1990745) |
0.0 | 0.2 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
0.0 | 0.3 | GO:0005605 | basal lamina(GO:0005605) |
0.0 | 0.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
0.0 | 0.1 | GO:0036157 | outer dynein arm(GO:0036157) |
0.0 | 0.1 | GO:0072487 | MSL complex(GO:0072487) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 2.4 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
0.3 | 3.2 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
0.3 | 1.1 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
0.2 | 0.9 | GO:0003998 | acylphosphatase activity(GO:0003998) |
0.2 | 0.6 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) |
0.2 | 1.4 | GO:0016018 | cyclosporin A binding(GO:0016018) |
0.2 | 0.7 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
0.2 | 1.0 | GO:0030284 | estrogen receptor activity(GO:0030284) |
0.2 | 1.1 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
0.1 | 0.6 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
0.1 | 1.0 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
0.1 | 0.4 | GO:0004155 | 6,7-dihydropteridine reductase activity(GO:0004155) |
0.1 | 0.6 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
0.1 | 2.5 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
0.1 | 0.8 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
0.1 | 2.6 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
0.1 | 0.9 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
0.1 | 0.5 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
0.1 | 1.3 | GO:0005522 | profilin binding(GO:0005522) |
0.1 | 0.4 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
0.1 | 0.3 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
0.1 | 1.0 | GO:0005024 | transforming growth factor beta-activated receptor activity(GO:0005024) |
0.1 | 1.4 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.1 | 0.3 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
0.1 | 0.2 | GO:0034618 | arginine binding(GO:0034618) |
0.1 | 1.2 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
0.1 | 0.3 | GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) |
0.1 | 0.4 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
0.0 | 0.6 | GO:0003688 | DNA replication origin binding(GO:0003688) |
0.0 | 0.4 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
0.0 | 0.3 | GO:0030375 | thyroid hormone receptor coactivator activity(GO:0030375) |
0.0 | 0.2 | GO:0004342 | glucosamine-6-phosphate deaminase activity(GO:0004342) |
0.0 | 0.2 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
0.0 | 0.5 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
0.0 | 0.5 | GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641) |
0.0 | 0.3 | GO:0003785 | actin monomer binding(GO:0003785) |
0.0 | 0.3 | GO:0043262 | adenosine-diphosphatase activity(GO:0043262) |
0.0 | 0.5 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
0.0 | 0.5 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
0.0 | 0.2 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
0.0 | 0.2 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
0.0 | 2.2 | GO:0002039 | p53 binding(GO:0002039) |
0.0 | 1.0 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
0.0 | 0.3 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
0.0 | 0.1 | GO:0000150 | recombinase activity(GO:0000150) |
0.0 | 0.0 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
0.0 | 0.3 | GO:0034185 | apolipoprotein binding(GO:0034185) |
0.0 | 0.5 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
0.0 | 0.3 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
0.0 | 0.1 | GO:0004849 | uridine kinase activity(GO:0004849) |
0.0 | 2.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
0.0 | 0.3 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
0.0 | 1.0 | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) |
0.0 | 1.1 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
0.0 | 0.2 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
0.0 | 0.6 | GO:0008528 | G-protein coupled peptide receptor activity(GO:0008528) |
0.0 | 0.1 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 3.2 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |
0.0 | 1.4 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
0.0 | 1.3 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
0.0 | 0.5 | PID_S1P_S1P1_PATHWAY | S1P1 pathway |
0.0 | 2.4 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
0.0 | 0.8 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
0.0 | 2.2 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 0.9 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
0.0 | 0.7 | PID_BMP_PATHWAY | BMP receptor signaling |
0.0 | 0.3 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
0.0 | 0.4 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
0.0 | 0.6 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
0.0 | 1.0 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
0.0 | 0.7 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
0.0 | 0.4 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 2.7 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
0.1 | 5.3 | REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
0.1 | 2.4 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
0.1 | 0.4 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
0.0 | 0.4 | REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
0.0 | 0.6 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
0.0 | 0.3 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
0.0 | 0.7 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
0.0 | 0.8 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
0.0 | 1.2 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
0.0 | 0.6 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
0.0 | 0.3 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
0.0 | 0.7 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
0.0 | 0.2 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
0.0 | 1.3 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
0.0 | 1.3 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
0.0 | 0.4 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
0.0 | 0.3 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
0.0 | 0.2 | REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
0.0 | 0.4 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |