Motif ID: Nfe2l2
Z-value: 0.486
Transcription factors associated with Nfe2l2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nfe2l2 | ENSMUSG00000015839.6 | Nfe2l2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfe2l2 | mm10_v2_chr2_-_75704535_75704641 | 0.22 | 1.1e-01 | Click! |
Top targets:
Showing 1 to 20 of 177 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 68 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.1 | GO:0071451 | cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) |
| 0.9 | 2.7 | GO:0072180 | mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180) |
| 0.8 | 2.4 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.2 | 2.4 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.2 | 2.2 | GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166) |
| 0.2 | 1.4 | GO:0038030 | non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031) |
| 0.0 | 1.4 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 1.4 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.0 | 1.3 | GO:1903077 | negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376) |
| 0.4 | 1.1 | GO:0072034 | renal vesicle induction(GO:0072034) |
| 0.0 | 1.1 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.3 | 1.0 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) |
| 0.1 | 1.0 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 0.0 | 1.0 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.2 | 0.9 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
| 0.1 | 0.9 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
| 0.0 | 0.9 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.3 | 0.8 | GO:0070488 | negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) neutrophil aggregation(GO:0070488) |
| 0.2 | 0.8 | GO:0000454 | snoRNA guided rRNA pseudouridine synthesis(GO:0000454) |
| 0.2 | 0.7 | GO:0060830 | ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 36 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 2.7 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.6 | 2.4 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.2 | 2.4 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.2 | 2.1 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.2 | 2.1 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.0 | 1.4 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.4 | 1.2 | GO:0097057 | TRAF2-GSTP1 complex(GO:0097057) |
| 0.2 | 1.1 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.1 | 1.0 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.1 | 1.0 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.0 | 0.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.2 | 0.8 | GO:0090661 | box H/ACA telomerase RNP complex(GO:0090661) |
| 0.0 | 0.8 | GO:0031045 | dense core granule(GO:0031045) |
| 0.2 | 0.6 | GO:0036387 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
| 0.1 | 0.6 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 0.0 | 0.6 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 0.6 | GO:0016460 | myosin II complex(GO:0016460) |
| 0.0 | 0.6 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.0 | 0.5 | GO:0098827 | endoplasmic reticulum subcompartment(GO:0098827) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 57 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.2 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.1 | 2.6 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.1 | 2.5 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.4 | 2.4 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.0 | 2.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 2.2 | GO:0002039 | p53 binding(GO:0002039) |
| 0.2 | 1.4 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.1 | 1.4 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 1.3 | GO:0005522 | profilin binding(GO:0005522) |
| 0.1 | 1.2 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.3 | 1.1 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.2 | 1.1 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.0 | 1.1 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.2 | 1.0 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 0.1 | 1.0 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.1 | 1.0 | GO:0005024 | transforming growth factor beta-activated receptor activity(GO:0005024) |
| 0.0 | 1.0 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 1.0 | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) |
| 0.2 | 0.9 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.1 | 0.9 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
Gene overrepresentation in C2:CP category:
Showing 1 to 15 of 15 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 2.4 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 2.2 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.4 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 1.3 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 1.0 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.9 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.8 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.7 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.0 | 0.7 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
| 0.0 | 0.6 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 0.5 | PID_S1P_S1P1_PATHWAY | S1P1 pathway |
| 0.0 | 0.4 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.0 | 0.4 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.3 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 20 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.3 | REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 2.7 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 2.4 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 1.3 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 1.3 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.2 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.0 | 0.8 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.7 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 0.7 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.6 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.6 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 0.4 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 0.4 | REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.0 | 0.4 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.4 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 0.3 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.0 | 0.3 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 0.3 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.2 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.2 | REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
