Motif ID: Nfia

Z-value: 1.747


Transcription factors associated with Nfia:

Gene SymbolEntrez IDGene Name
Nfia ENSMUSG00000028565.12 Nfia

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfiamm10_v2_chr4_+_97777780_977778340.274.8e-02Click!


Activity profile for motif Nfia.

activity profile for motif Nfia


Sorted Z-values histogram for motif Nfia

Sorted Z-values for motif Nfia



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfia

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78324200 19.044 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr18_+_20665250 17.701 ENSMUST00000075312.3
 Ttr
transthyretin
chr19_+_5740885 15.708 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr7_+_130936172 13.802 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr3_-_116129615 11.708 ENSMUST00000029574.8
 Vcam1
vascular cell adhesion molecule 1
chr14_-_118052235 11.522 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr13_-_97747373 9.940 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr11_-_77894096 9.297 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr10_+_127725392 8.734 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr10_+_57784859 8.597 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr6_+_141524379 8.222 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr16_+_30065333 7.586 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr8_+_71406003 7.551 ENSMUST00000119976.1
ENSMUST00000120725.1
 Ankle1

ankyrin repeat and LEM domain containing 1

chr2_+_33216051 7.316 ENSMUST00000004208.5
 Angptl2
angiopoietin-like 2
chr7_-_97417730 7.152 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr1_+_42229726 6.893 ENSMUST00000066196.1
 Gm9915
predicted gene 9915
chr14_-_118237016 6.889 ENSMUST00000170662.1
 Sox21
SRY-box containing gene 21
chr2_+_25180737 6.837 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr9_-_54661870 6.818 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr12_+_85473883 6.626 ENSMUST00000021674.6
 Fos
FBJ osteosarcoma oncogene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 395 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 19.3 GO:0070327 thyroid hormone transport(GO:0070327)
1.9 19.0 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
5.2 15.7 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
2.2 15.6 GO:0021847 ventricular zone neuroblast division(GO:0021847)
2.3 13.8 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
1.1 12.5 GO:0061032 visceral serous pericardium development(GO:0061032)
0.6 11.2 GO:0040034 regulation of development, heterochronic(GO:0040034)
3.4 10.1 GO:0045168 cell-cell signaling involved in cell fate commitment(GO:0045168)
1.0 10.0 GO:0090527 actin filament reorganization(GO:0090527)
1.1 9.7 GO:0048251 elastic fiber assembly(GO:0048251)
2.9 8.8 GO:0006553 lysine metabolic process(GO:0006553)
2.2 8.7 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
1.4 8.7 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
1.1 8.6 GO:0072615 interleukin-17 secretion(GO:0072615)
0.5 8.6 GO:0060134 prepulse inhibition(GO:0060134)
0.7 8.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
1.6 7.9 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
1.6 7.9 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.7 7.9 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.8 7.8 GO:0014807 regulation of somitogenesis(GO:0014807)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 55.3 GO:0005615 extracellular space(GO:0005615)
0.1 43.3 GO:0031012 extracellular matrix(GO:0031012)
0.1 17.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 14.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 12.6 GO:0000790 nuclear chromatin(GO:0000790)
0.4 11.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 9.0 GO:0002102 podosome(GO:0002102)
0.1 8.9 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 8.8 GO:0044798 nuclear transcription factor complex(GO:0044798)
2.2 8.7 GO:0097450 astrocyte end-foot(GO:0097450)
0.2 8.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.5 7.6 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 7.5 GO:0005884 actin filament(GO:0005884)
0.0 7.3 GO:0005925 focal adhesion(GO:0005925)
0.2 7.1 GO:0051233 spindle midzone(GO:0051233)
0.1 7.1 GO:0016363 nuclear matrix(GO:0016363)
0.1 6.8 GO:0031594 neuromuscular junction(GO:0031594)
0.5 6.6 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.4 6.6 GO:0005605 basal lamina(GO:0005605)
0.3 6.5 GO:0043657 host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 263 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 19.3 GO:0070324 thyroid hormone binding(GO:0070324)
3.2 19.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.8 18.4 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.4 14.5 GO:0070412 R-SMAD binding(GO:0070412)
0.6 12.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
2.9 11.7 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 11.7 GO:0005178 integrin binding(GO:0005178)
0.9 11.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
1.3 10.5 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
2.3 9.3 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 9.2 GO:0019003 GDP binding(GO:0019003)
0.8 8.8 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 8.8 GO:0005504 fatty acid binding(GO:0005504)
2.2 8.6 GO:0008142 oxysterol binding(GO:0008142)
0.0 8.5 GO:0003735 structural constituent of ribosome(GO:0003735)
2.1 8.2 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
1.9 7.5 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.1 7.2 GO:0004519 endonuclease activity(GO:0004519)
0.8 7.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.4 7.1 GO:0004602 glutathione peroxidase activity(GO:0004602)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 27.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 25.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 17.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 16.5 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.3 14.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 13.6 PID_PLK1_PATHWAY PLK1 signaling events
0.2 12.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.8 11.7 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.2 10.7 PID_BMP_PATHWAY BMP receptor signaling
0.7 10.3 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.3 8.8 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.2 7.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.4 7.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.2 6.7 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.2 6.5 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.5 6.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 5.8 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 5.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.6 5.0 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 5.0 PID_CDC42_PATHWAY CDC42 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 20.1 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.3 18.7 REACTOME_AMYLOIDS Genes involved in Amyloids
0.6 17.7 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.2 15.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 14.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.6 13.7 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.5 10.8 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.7 10.4 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 10.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.4 10.2 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.3 9.3 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.3 8.0 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.3 7.7 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.4 7.2 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.4 6.9 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 6.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.6 6.7 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 5.9 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.3 5.7 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3 5.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion