Motif ID: Nfic_Nfib
Z-value: 1.724
Transcription factors associated with Nfic_Nfib:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nfib | ENSMUSG00000008575.11 | Nfib |
| Nfic | ENSMUSG00000055053.11 | Nfic |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfic | mm10_v2_chr10_-_81427114_81427187 | 0.33 | 1.4e-02 | Click! |
| Nfib | mm10_v2_chr4_-_82705735_82705754 | -0.14 | 3.0e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 14.8 | GO:0006553 | lysine metabolic process(GO:0006553) |
| 4.1 | 40.6 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 3.7 | 11.0 | GO:0071918 | urea transmembrane transport(GO:0071918) |
| 3.5 | 20.8 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
| 3.0 | 3.0 | GO:1903977 | positive regulation of glial cell migration(GO:1903977) |
| 2.9 | 14.6 | GO:1903609 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 2.4 | 7.3 | GO:0071921 | establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) |
| 2.4 | 11.8 | GO:1900147 | Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147) |
| 2.1 | 6.4 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 2.1 | 6.3 | GO:1904020 | regulation of G-protein coupled receptor internalization(GO:1904020) |
| 1.9 | 7.7 | GO:0043415 | positive regulation of skeletal muscle tissue regeneration(GO:0043415) |
| 1.9 | 5.6 | GO:0071579 | regulation of zinc ion transport(GO:0071579) |
| 1.8 | 33.3 | GO:0060134 | prepulse inhibition(GO:0060134) |
| 1.8 | 7.3 | GO:0051933 | amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935) |
| 1.8 | 5.4 | GO:0072180 | mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180) |
| 1.8 | 8.9 | GO:0052428 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
| 1.8 | 5.3 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 1.7 | 6.9 | GO:2000820 | negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820) |
| 1.7 | 10.3 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 1.6 | 4.8 | GO:0090274 | positive regulation of somatostatin secretion(GO:0090274) |
| 1.6 | 11.0 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 1.5 | 9.1 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 1.4 | 11.3 | GO:0070314 | G1 to G0 transition(GO:0070314) |
| 1.4 | 6.8 | GO:2000255 | negative regulation of male germ cell proliferation(GO:2000255) |
| 1.3 | 3.9 | GO:1905072 | detection of oxygen(GO:0003032) cardiac jelly development(GO:1905072) |
| 1.2 | 6.0 | GO:0036151 | phosphatidylcholine acyl-chain remodeling(GO:0036151) |
| 1.2 | 3.6 | GO:0045004 | DNA replication proofreading(GO:0045004) |
| 1.1 | 4.5 | GO:1990022 | RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022) |
| 1.1 | 6.5 | GO:0060718 | chorionic trophoblast cell differentiation(GO:0060718) |
| 1.1 | 9.6 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 1.0 | 2.1 | GO:0021759 | globus pallidus development(GO:0021759) |
| 1.0 | 16.4 | GO:0021891 | olfactory bulb interneuron development(GO:0021891) |
| 1.0 | 9.8 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.9 | 5.4 | GO:1904715 | negative regulation of chaperone-mediated autophagy(GO:1904715) |
| 0.9 | 9.6 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
| 0.9 | 3.4 | GO:0010046 | arginine biosynthetic process(GO:0006526) response to mycotoxin(GO:0010046) |
| 0.8 | 3.4 | GO:2000256 | endomitotic cell cycle(GO:0007113) thrombopoietin-mediated signaling pathway(GO:0038163) positive regulation of male germ cell proliferation(GO:2000256) |
| 0.7 | 3.0 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449) |
| 0.7 | 7.4 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.7 | 3.5 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
| 0.7 | 7.5 | GO:0061032 | visceral serous pericardium development(GO:0061032) |
| 0.7 | 2.0 | GO:1903984 | positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
| 0.7 | 2.0 | GO:0044339 | canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339) |
| 0.7 | 2.7 | GO:0060709 | glycogen cell differentiation involved in embryonic placenta development(GO:0060709) |
| 0.6 | 1.9 | GO:0042713 | operant conditioning(GO:0035106) sperm ejaculation(GO:0042713) |
| 0.6 | 12.6 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.6 | 4.5 | GO:0042167 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) |
| 0.5 | 3.7 | GO:0060907 | positive regulation of macrophage cytokine production(GO:0060907) |
| 0.5 | 5.2 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
| 0.5 | 2.1 | GO:0046210 | nitrate catabolic process(GO:0043602) nitric oxide catabolic process(GO:0046210) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346) |
| 0.5 | 2.0 | GO:0043973 | histone H3-K4 acetylation(GO:0043973) |
| 0.5 | 15.2 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.5 | 1.5 | GO:0035811 | negative regulation of urine volume(GO:0035811) |
| 0.5 | 4.4 | GO:0035428 | hexose transmembrane transport(GO:0035428) |
| 0.5 | 3.3 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 0.5 | 1.4 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.5 | 8.2 | GO:0014823 | response to activity(GO:0014823) |
| 0.4 | 6.6 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.4 | 9.0 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.4 | 6.0 | GO:0046697 | decidualization(GO:0046697) |
| 0.4 | 1.9 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.4 | 3.0 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
| 0.4 | 4.1 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.4 | 1.4 | GO:2000319 | negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320) |
| 0.4 | 6.0 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.3 | 1.0 | GO:0007161 | calcium-independent cell-matrix adhesion(GO:0007161) |
| 0.3 | 3.0 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
| 0.3 | 3.0 | GO:0006691 | leukotriene metabolic process(GO:0006691) |
| 0.3 | 1.7 | GO:2001185 | regulation of CD8-positive, alpha-beta T cell activation(GO:2001185) |
| 0.3 | 0.8 | GO:0002030 | inhibitory G-protein coupled receptor phosphorylation(GO:0002030) |
| 0.3 | 3.4 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.3 | 1.6 | GO:0044351 | macropinocytosis(GO:0044351) |
| 0.3 | 0.5 | GO:0046013 | regulation of T cell homeostatic proliferation(GO:0046013) |
| 0.3 | 0.8 | GO:2000659 | regulation of interleukin-1-mediated signaling pathway(GO:2000659) |
| 0.3 | 2.6 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.3 | 0.8 | GO:0060489 | muscular septum morphogenesis(GO:0003150) epicardial cell to mesenchymal cell transition(GO:0003347) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346) |
| 0.2 | 1.2 | GO:0002317 | plasma cell differentiation(GO:0002317) |
| 0.2 | 12.6 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.2 | 0.7 | GO:0002408 | myeloid dendritic cell chemotaxis(GO:0002408) |
| 0.2 | 2.8 | GO:0035336 | cardiolipin metabolic process(GO:0032048) long-chain fatty-acyl-CoA metabolic process(GO:0035336) |
| 0.2 | 2.9 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
| 0.2 | 0.7 | GO:0014063 | negative regulation of serotonin secretion(GO:0014063) |
| 0.2 | 0.7 | GO:1904207 | chemokine (C-C motif) ligand 2 secretion(GO:0035926) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 0.2 | 1.2 | GO:0046549 | retinal cone cell development(GO:0046549) |
| 0.2 | 11.5 | GO:0048747 | muscle fiber development(GO:0048747) |
| 0.2 | 0.6 | GO:0090271 | positive regulation of fibroblast growth factor production(GO:0090271) |
| 0.2 | 0.8 | GO:0048319 | axial mesoderm morphogenesis(GO:0048319) |
| 0.2 | 4.3 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) |
| 0.2 | 1.7 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation(GO:0010745) |
| 0.2 | 0.6 | GO:2000435 | regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435) |
| 0.2 | 1.7 | GO:1901386 | negative regulation of voltage-gated calcium channel activity(GO:1901386) |
| 0.2 | 2.4 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.2 | 1.1 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.2 | 1.1 | GO:0097473 | cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) |
| 0.2 | 0.5 | GO:0034035 | sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) |
| 0.2 | 2.8 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037) |
| 0.2 | 1.0 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.2 | 1.0 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.2 | 0.3 | GO:0006566 | threonine metabolic process(GO:0006566) |
| 0.2 | 1.5 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.2 | 6.2 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 0.2 | 4.5 | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.2 | 1.8 | GO:0042060 | wound healing(GO:0042060) |
| 0.2 | 0.3 | GO:0002432 | granuloma formation(GO:0002432) |
| 0.2 | 0.5 | GO:0030070 | insulin processing(GO:0030070) |
| 0.2 | 4.8 | GO:0060445 | branching involved in salivary gland morphogenesis(GO:0060445) |
| 0.2 | 0.9 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.1 | 2.4 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.1 | 0.7 | GO:0034162 | toll-like receptor 9 signaling pathway(GO:0034162) |
| 0.1 | 1.8 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.1 | 2.6 | GO:0010866 | regulation of triglyceride biosynthetic process(GO:0010866) |
| 0.1 | 0.4 | GO:0019074 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
| 0.1 | 0.9 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.1 | 1.6 | GO:0045199 | maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.1 | 1.8 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 4.8 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.1 | 0.5 | GO:0060576 | intestinal epithelial cell development(GO:0060576) |
| 0.1 | 3.7 | GO:0006379 | mRNA cleavage(GO:0006379) |
| 0.1 | 0.4 | GO:0033522 | histone H2A ubiquitination(GO:0033522) histone H2A monoubiquitination(GO:0035518) |
| 0.1 | 0.5 | GO:0021562 | vestibulocochlear nerve development(GO:0021562) |
| 0.1 | 0.6 | GO:0001980 | regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980) |
| 0.1 | 1.1 | GO:0031639 | plasminogen activation(GO:0031639) |
| 0.1 | 3.3 | GO:0006182 | cGMP biosynthetic process(GO:0006182) |
| 0.1 | 0.2 | GO:0002238 | response to molecule of fungal origin(GO:0002238) |
| 0.1 | 1.3 | GO:0042407 | cristae formation(GO:0042407) |
| 0.1 | 2.8 | GO:0060351 | cartilage development involved in endochondral bone morphogenesis(GO:0060351) |
| 0.1 | 0.3 | GO:0035633 | maintenance of blood-brain barrier(GO:0035633) |
| 0.1 | 0.6 | GO:0001880 | Mullerian duct regression(GO:0001880) |
| 0.1 | 0.5 | GO:0071455 | response to hyperoxia(GO:0055093) cellular response to hyperoxia(GO:0071455) |
| 0.1 | 0.2 | GO:0010872 | regulation of cholesterol esterification(GO:0010872) |
| 0.1 | 0.8 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 1.4 | GO:0042311 | vasodilation(GO:0042311) |
| 0.1 | 3.1 | GO:0006631 | fatty acid metabolic process(GO:0006631) |
| 0.1 | 0.8 | GO:0060481 | lobar bronchus epithelium development(GO:0060481) |
| 0.1 | 2.1 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.1 | 0.3 | GO:0006409 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.1 | 0.9 | GO:0006490 | oligosaccharide-lipid intermediate biosynthetic process(GO:0006490) |
| 0.1 | 0.5 | GO:0051409 | response to nitrosative stress(GO:0051409) |
| 0.1 | 2.3 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.1 | 0.2 | GO:0006438 | valyl-tRNA aminoacylation(GO:0006438) |
| 0.1 | 1.7 | GO:0051607 | defense response to virus(GO:0051607) |
| 0.1 | 2.1 | GO:0046329 | negative regulation of JNK cascade(GO:0046329) |
| 0.1 | 0.3 | GO:0014887 | muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898) |
| 0.0 | 0.1 | GO:0006011 | UDP-glucose metabolic process(GO:0006011) |
| 0.0 | 0.2 | GO:0072365 | regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365) |
| 0.0 | 0.2 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.0 | 3.3 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 0.2 | GO:0033580 | protein glycosylation at cell surface(GO:0033575) protein galactosylation at cell surface(GO:0033580) protein galactosylation(GO:0042125) |
| 0.0 | 0.5 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.0 | 0.3 | GO:0033689 | negative regulation of osteoblast proliferation(GO:0033689) |
| 0.0 | 0.1 | GO:0000957 | mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) |
| 0.0 | 1.7 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.0 | 3.2 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
| 0.0 | 0.3 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.0 | 0.3 | GO:0015914 | phospholipid transport(GO:0015914) |
| 0.0 | 1.6 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
| 0.0 | 12.2 | GO:0008380 | RNA splicing(GO:0008380) |
| 0.0 | 0.2 | GO:0006701 | progesterone biosynthetic process(GO:0006701) |
| 0.0 | 1.0 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.0 | 0.2 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.0 | 1.3 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
| 0.0 | 0.2 | GO:0015791 | polyol transport(GO:0015791) response to mercury ion(GO:0046689) |
| 0.0 | 0.4 | GO:0031954 | positive regulation of protein autophosphorylation(GO:0031954) |
| 0.0 | 0.1 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.0 | 0.1 | GO:0031665 | negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665) |
| 0.0 | 2.9 | GO:0016042 | lipid catabolic process(GO:0016042) |
| 0.0 | 1.2 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.0 | 0.1 | GO:0015862 | uridine transport(GO:0015862) |
| 0.0 | 0.4 | GO:0016242 | negative regulation of macroautophagy(GO:0016242) |
| 0.0 | 0.0 | GO:0061743 | motor learning(GO:0061743) |
| 0.0 | 1.1 | GO:0006821 | chloride transport(GO:0006821) |
| 0.0 | 0.6 | GO:0009880 | embryonic pattern specification(GO:0009880) |
| 0.0 | 0.6 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.0 | 0.1 | GO:1905146 | lysosomal protein catabolic process(GO:1905146) |
| 0.0 | 0.6 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
| 0.0 | 4.0 | GO:0016311 | dephosphorylation(GO:0016311) |
| 0.0 | 1.4 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 0.5 | GO:0007219 | Notch signaling pathway(GO:0007219) |
| 0.0 | 0.0 | GO:0036506 | maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) |
| 0.0 | 0.2 | GO:0019884 | antigen processing and presentation of exogenous antigen(GO:0019884) |
| 0.0 | 0.0 | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 14.6 | GO:0071953 | elastic fiber(GO:0071953) |
| 3.0 | 8.9 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 2.9 | 11.8 | GO:0045098 | type III intermediate filament(GO:0045098) |
| 2.4 | 7.1 | GO:0030934 | collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934) |
| 1.6 | 6.3 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 1.5 | 9.0 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 1.3 | 5.4 | GO:0043259 | laminin-10 complex(GO:0043259) |
| 1.3 | 9.1 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 1.1 | 14.6 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 1.0 | 7.3 | GO:0008278 | cohesin complex(GO:0008278) |
| 1.0 | 3.0 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.9 | 10.3 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.7 | 19.8 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.7 | 3.6 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 0.7 | 11.8 | GO:0031045 | dense core granule(GO:0031045) |
| 0.5 | 6.4 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.5 | 10.7 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.5 | 6.5 | GO:0097449 | astrocyte projection(GO:0097449) |
| 0.3 | 6.6 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.3 | 1.9 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.3 | 0.8 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.3 | 1.0 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) tertiary granule(GO:0070820) |
| 0.2 | 4.7 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.2 | 3.7 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.2 | 3.4 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.2 | 0.8 | GO:0060187 | cell pole(GO:0060187) |
| 0.2 | 2.6 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.2 | 0.5 | GO:0017109 | glutamate-cysteine ligase complex(GO:0017109) |
| 0.2 | 2.8 | GO:0005605 | basal lamina(GO:0005605) |
| 0.2 | 0.6 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.1 | 9.9 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 4.8 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 1.3 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.1 | 0.1 | GO:0098835 | presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) |
| 0.1 | 25.3 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 0.9 | GO:0031415 | NatA complex(GO:0031415) |
| 0.1 | 1.0 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.1 | 3.0 | GO:0001741 | XY body(GO:0001741) |
| 0.1 | 8.9 | GO:0005844 | polysome(GO:0005844) |
| 0.1 | 5.0 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 18.1 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 1.3 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 1.0 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.1 | 1.3 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.1 | 0.3 | GO:0031251 | PAN complex(GO:0031251) |
| 0.1 | 0.6 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) TAP complex(GO:0042825) |
| 0.1 | 0.8 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.1 | 0.7 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 1.1 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.1 | 2.4 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.1 | 6.0 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 31.0 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 2.8 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 5.1 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.1 | 12.4 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.1 | 21.2 | GO:0005911 | cell-cell junction(GO:0005911) |
| 0.1 | 24.9 | GO:0030424 | axon(GO:0030424) |
| 0.0 | 0.5 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.0 | 0.1 | GO:0036156 | inner dynein arm(GO:0036156) |
| 0.0 | 2.1 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 1.6 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 1.0 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.0 | 2.8 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 1.2 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 2.3 | GO:0005903 | brush border(GO:0005903) |
| 0.0 | 0.1 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 6.6 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 1.4 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 7.8 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 0.2 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.0 | 0.8 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 1.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 0.3 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 1.9 | GO:0005938 | cell cortex(GO:0005938) |
| 0.0 | 5.4 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 2.2 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 0.5 | GO:0005770 | late endosome(GO:0005770) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.9 | 41.3 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 3.7 | 14.8 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
| 2.9 | 11.8 | GO:1990254 | keratin filament binding(GO:1990254) |
| 2.9 | 14.6 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 2.4 | 7.3 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
| 2.3 | 6.9 | GO:0035939 | microsatellite binding(GO:0035939) |
| 2.2 | 8.9 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834) |
| 2.1 | 23.4 | GO:0008430 | selenium binding(GO:0008430) |
| 2.0 | 6.0 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
| 1.9 | 7.5 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 1.9 | 11.2 | GO:0015204 | urea transmembrane transporter activity(GO:0015204) |
| 1.7 | 22.6 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 1.7 | 6.8 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 1.5 | 6.0 | GO:0004921 | interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970) |
| 1.3 | 9.0 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 1.2 | 3.6 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) |
| 1.1 | 4.5 | GO:0004074 | biliverdin reductase activity(GO:0004074) |
| 1.1 | 8.9 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 1.1 | 6.4 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 1.0 | 8.9 | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857) |
| 0.9 | 34.5 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.9 | 10.3 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.8 | 3.9 | GO:0005534 | galactose binding(GO:0005534) |
| 0.7 | 4.2 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.7 | 3.4 | GO:0008427 | calcium-dependent protein kinase inhibitor activity(GO:0008427) |
| 0.7 | 3.4 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.6 | 9.4 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.6 | 5.9 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.6 | 2.3 | GO:0008422 | beta-glucosidase activity(GO:0008422) |
| 0.6 | 3.3 | GO:0019841 | retinol binding(GO:0019841) |
| 0.5 | 12.9 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.5 | 2.1 | GO:0016708 | nitric oxide dioxygenase activity(GO:0008941) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor(GO:0016708) iron-cytochrome-c reductase activity(GO:0047726) |
| 0.4 | 3.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.4 | 3.7 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.4 | 3.4 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.4 | 9.1 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.4 | 3.0 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.4 | 4.1 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.4 | 1.4 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 0.4 | 1.4 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.3 | 6.3 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.3 | 0.9 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.3 | 0.9 | GO:0005118 | sevenless binding(GO:0005118) |
| 0.3 | 5.3 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.3 | 1.7 | GO:0004920 | interleukin-10 receptor activity(GO:0004920) |
| 0.3 | 3.6 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.2 | 4.7 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.2 | 3.7 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
| 0.2 | 5.4 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.2 | 1.9 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.2 | 6.5 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.2 | 2.0 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.2 | 0.6 | GO:0030172 | troponin C binding(GO:0030172) |
| 0.2 | 0.8 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.2 | 4.7 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.2 | 2.3 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.2 | 1.9 | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity(GO:0051575) |
| 0.2 | 2.1 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
| 0.2 | 2.8 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.2 | 0.5 | GO:0004357 | glutamate-cysteine ligase activity(GO:0004357) |
| 0.2 | 0.6 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980) |
| 0.2 | 9.8 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 6.7 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.1 | 1.7 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.1 | 6.7 | GO:0008528 | G-protein coupled peptide receptor activity(GO:0008528) |
| 0.1 | 0.5 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.1 | 2.6 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 1.2 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 9.9 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 2.7 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.1 | 0.3 | GO:0008732 | threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.1 | 5.2 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 0.9 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.1 | 7.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 0.2 | GO:0070976 | TIR domain binding(GO:0070976) |
| 0.1 | 3.2 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 0.4 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.1 | 1.0 | GO:0015299 | solute:proton antiporter activity(GO:0015299) |
| 0.1 | 1.6 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.1 | 0.7 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.1 | 0.6 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
| 0.1 | 0.8 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.1 | 1.5 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.1 | 1.4 | GO:0020037 | heme binding(GO:0020037) |
| 0.1 | 0.4 | GO:0009374 | biotin binding(GO:0009374) |
| 0.1 | 1.6 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.1 | 0.9 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.1 | 0.2 | GO:0004832 | valine-tRNA ligase activity(GO:0004832) |
| 0.1 | 0.8 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.1 | 0.9 | GO:0046527 | glucosyltransferase activity(GO:0046527) |
| 0.1 | 1.1 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) |
| 0.0 | 0.6 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
| 0.0 | 0.3 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 0.8 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.0 | 4.4 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 1.6 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.0 | 3.2 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 0.2 | GO:0022821 | calcium, potassium:sodium antiporter activity(GO:0008273) potassium ion antiporter activity(GO:0022821) |
| 0.0 | 0.6 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 0.1 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.0 | 5.9 | GO:0016874 | ligase activity(GO:0016874) |
| 0.0 | 3.7 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 0.7 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 0.5 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
| 0.0 | 2.6 | GO:0002020 | protease binding(GO:0002020) |
| 0.0 | 0.2 | GO:0047276 | N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276) |
| 0.0 | 1.1 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 0.2 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.0 | 1.1 | GO:0030170 | pyridoxal phosphate binding(GO:0030170) |
| 0.0 | 0.1 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.0 | 4.0 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 9.1 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.0 | 0.1 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 0.3 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.0 | 18.0 | GO:0000975 | regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212) |
| 0.0 | 0.1 | GO:0070569 | uridylyltransferase activity(GO:0070569) |
| 0.0 | 0.5 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 0.0 | 0.5 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.0 | 0.3 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 0.2 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
| 0.0 | 1.9 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 0.0 | 0.3 | GO:0004601 | peroxidase activity(GO:0004601) |
| 0.0 | 0.1 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 2.8 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.7 | 5.4 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.6 | 8.6 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.5 | 15.4 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
| 0.4 | 3.9 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.4 | 6.6 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.4 | 17.0 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.3 | 3.0 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.3 | 13.6 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 15.7 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.3 | 12.3 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.2 | 10.4 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.2 | 0.7 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 10.3 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 5.5 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 16.5 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 6.9 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 4.5 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
| 0.1 | 2.1 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 10.1 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 1.7 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.1 | 10.8 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 2.3 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 0.8 | ST_STAT3_PATHWAY | STAT3 Pathway |
| 0.1 | 2.0 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
| 0.1 | 2.6 | PID_INSULIN_PATHWAY | Insulin Pathway |
| 0.1 | 1.7 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 1.8 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 0.6 | PID_ALK2_PATHWAY | ALK2 signaling events |
| 0.0 | 0.4 | PID_SHP2_PATHWAY | SHP2 signaling |
| 0.0 | 0.5 | PID_PI3KCI_AKT_PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.0 | 1.2 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
| 0.0 | 0.5 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 0.0 | 0.3 | PID_CD40_PATHWAY | CD40/CD40L signaling |
| 0.0 | 0.8 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 39.8 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.7 | 11.6 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.6 | 8.9 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.6 | 11.0 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.5 | 8.9 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.5 | 11.8 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.5 | 11.7 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.5 | 12.9 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.5 | 3.6 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.4 | 6.4 | REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.4 | 7.5 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.3 | 7.9 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.3 | 3.7 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.3 | 5.3 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.3 | 3.7 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.2 | 3.6 | REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.2 | 1.9 | REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.2 | 4.1 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.2 | 4.5 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.2 | 2.6 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
| 0.2 | 5.1 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.2 | 4.8 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.2 | 7.4 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.2 | 5.2 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 12.0 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 2.1 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 7.6 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.1 | 3.6 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 1.5 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
| 0.1 | 3.7 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 4.9 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
| 0.1 | 7.3 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 1.2 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 7.1 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 6.8 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 1.7 | REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.1 | 0.5 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 0.8 | REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| 0.1 | 1.9 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 0.8 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 0.8 | REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.1 | 0.2 | REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE | Genes involved in Cell death signalling via NRAGE, NRIF and NADE |
| 0.0 | 1.4 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.0 | 0.9 | REACTOME_IL1_SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 0.3 | REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 0.5 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.3 | REACTOME_NOD1_2_SIGNALING_PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 1.0 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| 0.0 | 0.4 | REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK | Genes involved in Gastrin-CREB signalling pathway via PKC and MAPK |
| 0.0 | 1.1 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.0 | 0.9 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.9 | REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 1.1 | REACTOME_MUSCLE_CONTRACTION | Genes involved in Muscle contraction |
| 0.0 | 0.5 | REACTOME_IL_RECEPTOR_SHC_SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 0.2 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 0.5 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 1.0 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 0.4 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
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