Motif ID: Nfic_Nfib

Z-value: 1.724

Transcription factors associated with Nfic_Nfib:

Gene SymbolEntrez IDGene Name
Nfib ENSMUSG00000008575.11 Nfib
Nfic ENSMUSG00000055053.11 Nfic

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nficmm10_v2_chr10_-_81427114_814271870.331.4e-02Click!
Nfibmm10_v2_chr4_-_82705735_82705754-0.143.0e-01Click!


Activity profile for motif Nfic_Nfib.

activity profile for motif Nfic_Nfib


Sorted Z-values histogram for motif Nfic_Nfib

Sorted Z-values for motif Nfic_Nfib



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfic_Nfib

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78324200 29.708 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr14_-_118052235 20.831 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr10_+_57784859 20.704 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr18_-_80986578 16.368 ENSMUST00000057950.7
 Sall3
sal-like 3 (Drosophila)
chr11_-_77894096 14.843 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr3_+_94933041 14.361 ENSMUST00000090839.5
 Selenbp1
selenium binding protein 1
chr10_+_57784914 12.576 ENSMUST00000165013.1
 Fabp7
fatty acid binding protein 7, brain
chr16_+_90831113 12.451 ENSMUST00000037539.7
ENSMUST00000099543.3
 Eva1c

eva-1 homolog C (C. elegans)

chr6_+_135362931 12.380 ENSMUST00000032330.9
 Emp1
epithelial membrane protein 1
chr2_+_13573927 11.799 ENSMUST00000141365.1
ENSMUST00000028062.2
 Vim

vimentin

chr11_+_78322965 11.634 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr7_+_45017953 11.601 ENSMUST00000044111.7
 Rras
Harvey rat sarcoma oncogene, subgroup R
chr1_+_43730593 11.348 ENSMUST00000027217.8
 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr11_+_61485431 10.970 ENSMUST00000064783.3
ENSMUST00000040522.6
 Mfap4

microfibrillar-associated protein 4

chr6_+_17306335 10.336 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
 Cav1



caveolin 1, caveolae protein



chr7_-_116237767 10.278 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr9_+_44134562 9.881 ENSMUST00000034650.8
ENSMUST00000098852.2
 Mcam

melanoma cell adhesion molecule

chr19_-_42752710 9.689 ENSMUST00000076505.3
 Pyroxd2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr3_-_131272077 8.931 ENSMUST00000029610.8
 Hadh
hydroxyacyl-Coenzyme A dehydrogenase
chr3_+_94693556 8.867 ENSMUST00000090848.3
ENSMUST00000173981.1
ENSMUST00000173849.1
ENSMUST00000174223.1
 Selenbp2



selenium binding protein 2




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 181 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.1 40.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.8 33.3 GO:0060134 prepulse inhibition(GO:0060134)
3.5 20.8 GO:0006570 tyrosine metabolic process(GO:0006570)
1.0 16.4 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.5 15.2 GO:0050873 brown fat cell differentiation(GO:0050873)
4.9 14.8 GO:0006553 lysine metabolic process(GO:0006553)
2.9 14.6 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.6 12.6 GO:0032060 bleb assembly(GO:0032060)
0.2 12.6 GO:0060325 face morphogenesis(GO:0060325)
0.0 12.2 GO:0008380 RNA splicing(GO:0008380)
2.4 11.8 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.2 11.5 GO:0048747 muscle fiber development(GO:0048747)
1.4 11.3 GO:0070314 G1 to G0 transition(GO:0070314)
3.7 11.0 GO:0071918 urea transmembrane transport(GO:0071918)
1.6 11.0 GO:0048251 elastic fiber assembly(GO:0048251)
1.7 10.3 GO:0045218 zonula adherens maintenance(GO:0045218)
1.0 9.8 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
1.1 9.6 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.9 9.6 GO:2000653 regulation of genetic imprinting(GO:2000653)
1.5 9.1 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 31.0 GO:0005925 focal adhesion(GO:0005925)
0.1 25.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 24.9 GO:0030424 axon(GO:0030424)
0.1 21.2 GO:0005911 cell-cell junction(GO:0005911)
0.7 19.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 18.1 GO:0001650 fibrillar center(GO:0001650)
4.9 14.6 GO:0071953 elastic fiber(GO:0071953)
1.1 14.6 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 12.4 GO:0008021 synaptic vesicle(GO:0008021)
2.9 11.8 GO:0045098 type III intermediate filament(GO:0045098)
0.7 11.8 GO:0031045 dense core granule(GO:0031045)
0.5 10.7 GO:0005682 U5 snRNP(GO:0005682)
0.9 10.3 GO:0005915 zonula adherens(GO:0005915)
0.1 9.9 GO:0005581 collagen trimer(GO:0005581)
1.3 9.1 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
1.5 9.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
3.0 8.9 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.1 8.9 GO:0005844 polysome(GO:0005844)
0.0 7.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
1.0 7.3 GO:0008278 cohesin complex(GO:0008278)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 123 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.9 41.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.9 34.5 GO:0005504 fatty acid binding(GO:0005504)
2.1 23.4 GO:0008430 selenium binding(GO:0008430)
1.7 22.6 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 18.0 GO:0000975 regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212)
3.7 14.8 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
2.9 14.6 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.5 12.9 GO:0030506 ankyrin binding(GO:0030506)
2.9 11.8 GO:1990254 keratin filament binding(GO:1990254)
1.9 11.2 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.9 10.3 GO:0070097 delta-catenin binding(GO:0070097)
0.1 9.9 GO:0005178 integrin binding(GO:0005178)
0.2 9.8 GO:0019003 GDP binding(GO:0019003)
0.6 9.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.4 9.1 GO:0051787 misfolded protein binding(GO:0051787)
0.0 9.1 GO:0005198 structural molecule activity(GO:0005198)
1.3 9.0 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
2.2 8.9 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
1.1 8.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)
1.0 8.9 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 17.0 NABA_COLLAGENS Genes encoding collagen proteins
0.1 16.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 15.7 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.5 15.4 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.3 13.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 12.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 10.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 10.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 10.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 10.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.6 8.6 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 6.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.4 6.6 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.1 5.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.7 5.4 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 4.5 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.4 3.9 PID_ALK1_PATHWAY ALK1 signaling events
0.3 3.0 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
2.8 2.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.6 PID_INSULIN_PATHWAY Insulin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 39.8 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.5 12.9 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 12.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.5 11.8 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.5 11.7 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.7 11.6 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.6 11.0 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.6 8.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.5 8.9 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.3 7.9 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 7.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.4 7.5 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 7.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 7.3 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 7.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 6.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.4 6.4 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.3 5.3 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.2 5.2 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 5.1 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism