Motif ID: Nfil3_Tef

Z-value: 1.763

Transcription factors associated with Nfil3_Tef:

Gene SymbolEntrez IDGene Name
Nfil3 ENSMUSG00000056749.7 Nfil3
Tef ENSMUSG00000022389.8 Tef

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfil3mm10_v2_chr13_-_52981027_529810830.665.5e-08Click!
Tefmm10_v2_chr15_+_81811414_818114910.491.4e-04Click!


Activity profile for motif Nfil3_Tef.

activity profile for motif Nfil3_Tef


Sorted Z-values histogram for motif Nfil3_Tef

Sorted Z-values for motif Nfil3_Tef



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfil3_Tef

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_51681703 19.040 ENSMUST00000088172.5
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chrX_-_51681856 18.293 ENSMUST00000114871.1
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr9_-_40346290 17.597 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr13_+_76579670 17.160 ENSMUST00000126960.1
ENSMUST00000109583.2
 Mctp1

multiple C2 domains, transmembrane 1

chr1_-_91459254 16.479 ENSMUST00000069620.8
 Per2
period circadian clock 2
chr5_+_117841839 15.992 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr16_-_22439570 14.601 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr2_-_25469742 14.369 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr2_-_25470031 13.114 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr3_+_141465564 12.989 ENSMUST00000106236.2
ENSMUST00000075282.3
 Unc5c

unc-5 homolog C (C. elegans)

chr4_+_85205417 12.051 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr12_+_74288735 11.794 ENSMUST00000095617.1
 1700086L19Rik
RIKEN cDNA 1700086L19 gene
chr2_+_131909928 10.971 ENSMUST00000091288.6
 Prnp
prion protein
chr9_-_21037775 10.853 ENSMUST00000180870.1
 Gm26592
predicted gene, 26592
chr18_+_23803962 10.774 ENSMUST00000025127.3
 Mapre2
microtubule-associated protein, RP/EB family, member 2
chr7_+_92062392 10.209 ENSMUST00000098308.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr4_+_101507947 10.184 ENSMUST00000149047.1
ENSMUST00000106929.3
 Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr4_+_101507855 9.975 ENSMUST00000038207.5
 Dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr2_+_131909951 9.924 ENSMUST00000124100.1
ENSMUST00000136783.1
 PRND

prion protein gene complex (Prn), transcript variant 1, mRNA

chr13_+_16011851 9.816 ENSMUST00000042603.6
 Inhba
inhibin beta-A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.2 37.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
5.5 27.5 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
4.4 26.5 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
3.4 23.7 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
3.4 20.2 GO:0072318 clathrin coat disassembly(GO:0072318)
2.8 19.9 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 17.0 GO:0031032 actomyosin structure organization(GO:0031032)
5.5 16.5 GO:0031554 regulation of DNA-templated transcription, termination(GO:0031554)
5.3 16.0 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
3.2 16.0 GO:0051012 microtubule sliding(GO:0051012)
1.6 13.0 GO:0033564 anterior/posterior axon guidance(GO:0033564)
1.2 11.9 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
3.7 11.0 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
0.8 10.2 GO:0045161 neuronal ion channel clustering(GO:0045161)
2.0 9.8 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
1.2 9.7 GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371)
2.4 9.6 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.3 9.6 GO:0071625 positive regulation of synaptic transmission, glutamatergic(GO:0051968) vocalization behavior(GO:0071625)
0.1 8.1 GO:0007416 synapse assembly(GO:0007416)
2.0 8.0 GO:0032289 central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 65.1 GO:0016021 integral component of membrane(GO:0016021)
0.0 30.2 GO:0045202 synapse(GO:0045202)
3.8 26.5 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 25.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.3 23.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
1.4 20.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 19.6 GO:0005886 plasma membrane(GO:0005886)
0.0 18.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
1.5 16.0 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.2 16.0 GO:0005930 axoneme(GO:0005930)
0.2 13.9 GO:0016234 inclusion body(GO:0016234)
0.1 11.8 GO:0005769 early endosome(GO:0005769)
0.3 10.8 GO:0035371 microtubule plus-end(GO:0035371)
0.1 10.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.5 10.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
3.3 9.8 GO:0043512 inhibin A complex(GO:0043512)
1.1 9.6 GO:0005883 neurofilament(GO:0005883)
0.1 8.7 GO:0009925 basal plasma membrane(GO:0009925)
2.1 8.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 8.3 GO:0005730 nucleolus(GO:0005730)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.3 37.3 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
6.9 27.5 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
1.1 26.5 GO:0051787 misfolded protein binding(GO:0051787)
0.0 23.9 GO:0005509 calcium ion binding(GO:0005509)
0.1 21.6 GO:0017124 SH3 domain binding(GO:0017124)
5.8 17.5 GO:0004517 nitric-oxide synthase activity(GO:0004517)
1.0 16.5 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 14.5 GO:0008289 lipid binding(GO:0008289)
0.1 14.2 GO:0008017 microtubule binding(GO:0008017)
2.2 13.0 GO:0005042 netrin receptor activity(GO:0005042)
2.7 11.0 GO:1903135 cupric ion binding(GO:1903135)
0.6 10.6 GO:0031402 sodium ion binding(GO:0031402)
0.4 10.2 GO:0004385 guanylate kinase activity(GO:0004385)
1.6 9.8 GO:0070699 type II activin receptor binding(GO:0070699)
1.4 9.7 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
2.4 9.6 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.3 9.6 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 9.6 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 9.3 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.3 8.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 26.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.4 19.9 PID_RHOA_PATHWAY RhoA signaling pathway
0.9 16.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.5 14.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.3 13.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.4 12.4 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.2 10.9 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.3 9.8 PID_ALK1_PATHWAY ALK1 signaling events
0.1 9.1 PID_LKB1_PATHWAY LKB1 signaling events
0.2 7.0 PID_IL3_PATHWAY IL3-mediated signaling events
0.2 6.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 5.8 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 5.5 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 4.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 3.7 PID_MYC_PATHWAY C-MYC pathway
0.0 3.3 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 3.1 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 2.9 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 2.1 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.7 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 41.8 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
1.0 37.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.3 26.3 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.4 18.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.6 17.5 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.4 16.5 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 14.4 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
2.5 9.8 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.3 9.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.6 7.6 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
1.4 7.0 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.8 7.0 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.3 7.0 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 6.2 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 6.1 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 5.9 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 5.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 5.4 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.5 5.1 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 4.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis